hihit p 500mg/4mg tablet - Paracetamol (500mg) + Thiocolchicoside (4mg) medicine

Hihit P 500mg/4mg Tablet: Complete Information

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🏭 Remark Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for combination use in acute musculoskeletal pain.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Yellowing of skin or eyes
  • Dark urine
  • Difficulty breathing or swelling of face
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is hihit p 500mg/4mg tablet used for?

This medicine is a combination of Paracetamol and Thiocolchicoside used for short-term relief of acute musculoskeletal pain and muscle spasms. It works by reducing pain and relaxing muscles.

  • Generic Name: Paracetamol (500mg) + Thiocolchicoside (4mg)
  • Manufacturer: Remark Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 hihit p 500mg/4mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और थायोकोलचिकोसाइड का संयोजन है, जिसका उपयोग मांसपेशियों में दर्द और ऐंठन के इलाज के लिए किया जाता है। यह पीठ दर्द, गर्दन दर्द, और चोट के बाद होने वाले दर्द में राहत देती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, नींद आना, चक्कर आना और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यकृत क्षति या एलर्जी की प्रतिक्रिया हो सकती है।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब का सेवन न करें। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएं। यकृत या गुर्दे की बीमारी हो तो डॉक्टर को बताएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 hihit p 500mg/4mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Relieves pain and reduces muscle spasm in conditions such as back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established"},{"condition":"Post-traumatic pain","description":"Used to manage pain and spasm following injuries, sprains, and strains.","evidence":"Moderate"},{"condition":"Post-operative pain","description":"May be used as part of a multimodal approach to manage post-surgical pain and spasm.","evidence":"Limited"}]

Off-label uses: [{"condition":"Tension-type headache","description":"Sometimes prescribed off-label for tension headaches associated with muscle tightness.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"Occasionally used off-label for menstrual cramps with associated muscle spasm.","evidence":"Limited"}]

Primary treatment for: Acute musculoskeletal pain with muscle spasm

Also treats: Post-traumatic pain, Post-operative pain, Tension headache, Dysmenorrhea

📋 Drug Information

Generic Name(s)Paracetamol (500mg) + Thiocolchicoside (4mg)
Brand Namehihit p 500mg/4mg tablet
ManufacturerRemark Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Do not exceed the prescribed dose or duration.
3
Avoid alcohol while taking this medicine.
4
Do not drive or operate machinery if you feel drowsy.
5
Consult your doctor if pain persists beyond 7 days.
6
Inform your doctor if you have liver or kidney disease.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Muscle pain and spasm
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Thiocolchicoside is also absorbed after oral administration. Food may delay the absorption of paracetamol slightly, but the overall extent is not significantly affected.
DistributionParacetamol distributes widely into most body tissues, with relatively high concentrations in the liver, kidney, and blood. Thiocolchicoside distribution is not well characterized but is believed to cross the blood-brain barrier to exert central effects.
Protein BindingParacetamol: Approximately 10-25% bound to plasma proteins. Thiocolchicoside: Not established from the available information.
MetabolismParacetamol is primarily metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Thiocolchicoside undergoes hepatic metabolism, but specific pathways are not fully established.
Half-LifeParacetamol: 2-3 hours in adults with normal liver function. Thiocolchicoside: Not established from the available information.
ExcretionParacetamol is excreted primarily in the urine as glucuronide and sulfate conjugates. Thiocolchicoside and its metabolites are also excreted in urine.
BioavailabilityParacetamol: Approximately 80-100% after oral administration. Thiocolchicoside: Not established from the available information.
Onset of ActionParacetamol: Pain relief typically begins within 30-60 minutes. Thiocolchicoside: Muscle relaxant effects may take a few hours to become noticeable.
Peak Plasma TimeParacetamol: 0.5-2 hours. Thiocolchicoside: Not established from the available information.
Duration of ActionParacetamol: 4-6 hours. Thiocolchicoside: Not established from the available information.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Paracetamol acts primarily in the central nervous system to relieve pain and reduce fever, though its exact mechanism is not fully understood. It is thought to inhibit prostaglandin synthesis in the brain and spinal cord. Thiocolchicoside is a centrally acting muscle relaxant that works by activating GABA-A receptors and inhibiting glycine receptors, leading to reduced muscle tone and relief from spasms. Together, they provide both analgesic and muscle relaxant effects.

Mechanism Steps

1
Paracetamol central action: Paracetamol inhibits prostaglandin synthesis in the central nervous system, reducing pain and fever.
2
Thiocolchicoside GABA-A activation: Thiocolchicoside binds to GABA-A receptors in the brain and spinal cord, enhancing inhibitory signals.
3
Reduction of muscle tone: Activation of GABA-A receptors leads to decreased muscle tone and relief from spasms.
4
Combined analgesic and relaxant effect: The two actions together alleviate pain and muscle spasm, improving mobility and comfort.

💡 How to Take hihit p 500mg/4mg tablet

Strength: Tablet containing Paracetamol 500 mg and Thiocolchicoside 4 mg.

1Take the tablet orally with a glass of water.
2Swallow whole; do not crush or chew.
3Take with food to reduce stomach upset.
4Follow the prescribed dose and duration.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally 1-2 times daily, or as directed by your doctor. The dose may vary depending on the condition being treated and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects, especially drowsiness and dizziness. Use with caution and adjust dose as needed under medical supervision.
Renal ImpairmentDose adjustment may be required in patients with kidney disease. Consult your doctor.
Hepatic ImpairmentDose adjustment may be required in patients with liver disease. Consult your doctor.
Maximum Daily DoseThe maximum daily dose of paracetamol should not exceed 4000 mg from all sources. The maximum daily dose of thiocolchicoside is not established from available information. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of hihit p 500mg/4mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Consult doctor if severe.
Dry mouth (Common (5-10%))
Stay hydrated. Chew sugar-free gum if needed.
Stomach pain (Common (5-10%))
Take with food. Consult doctor if pain persists.

🚨 Serious Side Effects

Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Liver damage (Rare (<0.1%))
Seek immediate medical attention if you experience yellowing of skin or eyes, dark urine, or severe abdominal pain.
Blood disorders (e.g., thrombocytopenia) (Rare (<0.1%))
Report unusual bleeding or bruising to your doctor immediately.
Anaphylaxis (Rare (<0.1%))
Seek emergency help if you have difficulty breathing, swelling of face or throat, or severe dizziness.

⚠️ Rare Side Effects

Photosensitivity
Avoid prolonged sun exposure. Use sunscreen.
Insomnia
Consult doctor if it persists.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Carbamazepine Moderate
Phenytoin Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol

⚡ Moderate Interactions

  • Carbamazepine
  • Phenytoin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol. It may also enhance the sedative effects of thiocolchicoside.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to paracetamol or thiocolchicoside","Severe liver disease","Severe kidney disease","Pregnancy and breastfeeding (unless advised by doctor)","Children under 12 years (unless prescribed)"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Avoid alcohol.","May cause drowsiness; avoid driving.","Use with caution in liver or kidney disease.","Do not use for prolonged periods without medical supervision."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use.

💊 Overdose Management

Seek immediate medical attention. Overdose can cause severe liver damage. Treatment includes activated charcoal, acetylcysteine, and supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid consuming alcohol while taking this medicine, as it can increase the risk of liver damage. Inform your doctor if you have any liver or kidney problems, or if you are taking other medications, especially blood thinners. Do not drive or operate heavy machinery if you feel drowsy or dizzy after taking this medicine. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects, especially drowsiness and dizziness. Use with caution and adjust dose as needed under medical supervision.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy or if you become pregnant while taking this medicine. Safety is not established.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain and spasm. Follow your surgeon's instructions regarding dosing and duration.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications used during dental work.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may worsen muscle spasm while taking this medicine. Gentle stretching and low-impact activities may be beneficial. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also affect your ability to perform tasks requiring mental alertness.

🛑 When to Stop This Medicine

Stop taking this medicine if you experience any serious side effects or allergic reactions. Do not stop abruptly if you have been taking it for a long time without consulting your doctor. Usually, it is prescribed for short-term use, and you should stop after the prescribed duration unless advised otherwise.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use of paracetamol can increase the risk of liver damage, especially with alcohol. Thiocolchicoside may cause dependence or other effects with prolonged use. Regular monitoring of liver and kidney function may be required.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot/cold packs

May help relieve muscle spasm and pain.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, consult your doctor before vaccination if you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute lower back pain and muscle spasm
Started this medicine as prescribed. Within a few days, noticed significant relief from pain and stiffness. Took it with food to avoid stomach upset. Completed the short course as advised.
💡 Lesson: Taking this medicine with food and for the prescribed duration helps achieve optimal relief.
👤 A 60-year-old with neck pain after a minor injury
Was prescribed this medicine for 5 days. Experienced mild drowsiness initially but it subsided. Avoided driving during that period. Pain and spasm improved considerably.
💡 Lesson: Be aware of drowsiness and avoid driving until you know how the medicine affects you.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Pain relief typically begins within 30-60 minutes, while muscle relaxant effects may take a few hours.

Q: Can I take it on an empty stomach?

A: It is best taken with food to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Consult your doctor before use. Safety is not established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for hihit p 500mg/4mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: It is intended for short-term use only. Long-term use requires medical supervision.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases the risk of liver damage and should be avoided.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Thiocolchicoside combination tablets from other manufacturers.

📊 Comparison with Similar Medicines

[{"medicine":"Paracetamol + Thiocolchicoside","composition":"Paracetamol 500mg + Thiocolchicoside 4mg","uses":"Acute musculoskeletal pain with spasm","notes":"Combination of analgesic and muscle relaxant."},{"medicine":"Paracetamol + Chlorzoxazone","composition":"Paracetamol 500mg + Chlorzoxazone 250mg","uses":"Muscle spasm and pain","notes":"Chlorzoxazone is another centrally acting muscle relaxant."}]

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