hicet-ax syrup - Cetirizine (2.5mg/5ml) + Ambroxol (30mg/5ml) medicine

Ax Cold Syrup: Complete Medicine Guide

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🏭 Micro Labs Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for combination use in upper respiratory tract infections.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swallowing
  • Swelling of face, lips, or throat
  • Severe drowsiness or confusion
  • Irregular heartbeat
  • Blood in vomit or stool
  • Yellowing of eyes or skin

If experiencing severe symptoms, call emergency services immediately.

What is hicet-ax syrup used for?

This medicine is a combination of cetirizine (an antihistamine) and ambroxol (a mucolytic) used to treat symptoms of cold and allergies such as sneezing, runny nose, and cough with mucus. It works by blocking histamine and thinning mucus. It is available as a syrup for oral use.

  • Generic Name: Cetirizine (2.5mg/5ml) + Ambroxol (30mg/5ml)
  • Manufacturer: Micro Labs Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 hicet-ax syrup के बारे में (Hindi Summary)

उपयोग: यह दवा सर्दी-खांसी और एलर्जी के लक्षणों जैसे छींक, नाक बहना, खुजली और बलगम वाली खांसी में राहत देती है। यह सेटिरिज़िन और एम्ब्रोक्सोल का मिश्रण है। सेटिरिज़िन एलर्जी को कम करता है और एम्ब्रोक्सोल बलगम को पतला करता है।

साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुंह सूखना, थकान और हल्का पेट दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, धड़कन अनियमित होना या सांस लेने में कठिनाई हो सकती है।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 hicet-ax syrup Uses & Benefits

[{"condition":"Common cold with allergic symptoms","description":"Relieves sneezing, runny nose, and cough associated with excess mucus.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces nasal congestion, sneezing, and itching due to allergies.","evidence":"Well-established"},{"condition":"Productive cough","description":"Helps thin and clear mucus from the airways.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Sinusitis","description":"Sometimes used to relieve congestion and mucus in sinus infections.","evidence":"Limited"}]

Primary treatment for: Common cold with allergic symptoms

Also treats: Allergic rhinitis, Productive cough, Sinusitis

📋 Drug Information

Generic Name(s)Cetirizine (2.5mg/5ml) + Ambroxol (30mg/5ml)
Brand Namehicet-ax syrup
ManufacturerMicro Labs Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid driving or operating machinery until you know how it affects you.
3
Do not take alcohol while on this medicine.
4
Use the measuring cup provided to ensure accurate dosing.
5
Do not use for more than 7 days without consulting a doctor.
6
Keep out of reach of children.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Sneezing and runny nose
This medicine is commonly prescribed for these symptoms.
Likely Use
✅
Productive cough
Ambroxol helps thin mucus.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCetirizine is rapidly absorbed after oral administration, with peak levels reached in about 1 hour. Ambroxol is also well absorbed orally, with peak plasma concentrations occurring within 1-3 hours.
DistributionCetirizine is widely distributed in the body, with a volume of distribution of about 0.4 L/kg. Ambroxol distributes into lung tissue and bronchial secretions, achieving higher concentrations in the respiratory tract than in plasma.
Protein BindingCetirizine is about 93% bound to plasma proteins. Ambroxol is approximately 90% bound to plasma proteins.
MetabolismCetirizine undergoes minimal hepatic metabolism. Ambroxol is metabolized in the liver primarily by glucuronidation and some CYP3A4-mediated oxidation.
Half-LifeCetirizine has a half-life of about 8-10 hours in adults. Ambroxol has a half-life of approximately 7-12 hours.
ExcretionCetirizine is primarily excreted unchanged in the urine. Ambroxol is excreted mainly in the urine as metabolites, with a small amount in feces.
BioavailabilityCetirizine oral bioavailability is high, approximately 70-85%. Ambroxol bioavailability is about 70-80% due to first-pass metabolism.
Onset of ActionCetirizine begins to relieve allergic symptoms within 1 hour. Ambroxol's mucolytic effect starts within 30-60 minutes and peaks in a few hours.
Peak Plasma TimeCetirizine: 1 hour; Ambroxol: 1-3 hours.
Duration of ActionCetirizine: 24 hours; Ambroxol: 6-8 hours.

How It Works

Cetirizine is a second-generation antihistamine that selectively antagonizes peripheral H1 receptors, reducing allergic symptoms. Ambroxol is a mucolytic that increases serous bronchial secretion, reduces mucus viscosity, and promotes ciliary clearance. Together, they address both allergic and congestive components of respiratory conditions.

Mechanism Steps

1
Histamine H1 receptor blockade: Cetirizine binds to H1 receptors on cells in the respiratory tract and blood vessels, preventing histamine from causing allergy symptoms.
2
Mucus viscosity reduction: Ambroxol breaks down acidic mucopolysaccharide fibers in mucus, making it thinner and easier to expel.
3
Enhanced ciliary clearance: Ambroxol stimulates ciliary movement in the respiratory epithelium, helping to move loosened mucus out of the airways.

💡 How to Take hicet-ax syrup

Strength: Each 5 mL contains Cetirizine 2.5 mg and Ambroxol 30 mg.

1Shake the bottle well before each use.
2Use the measuring cup or spoon provided to measure the correct dose.
3Take the syrup orally, with or without food.
4Follow the prescribed frequency and duration.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 5-10 mL of this syrup two to three times daily, depending on the severity of symptoms and the doctor's prescription. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the sedative effects of cetirizine. Start with a lower dose and monitor for drowsiness and dizziness. Dose adjustment may be needed based on renal function.
Renal ImpairmentIn patients with moderate to severe renal impairment, dose reduction of cetirizine may be necessary. Consult a doctor for appropriate dosing.
Hepatic ImpairmentIn patients with severe hepatic impairment, use with caution and consider dose reduction. Consult a doctor.
Maximum Daily DoseThe maximum daily dose should not exceed 30 mL of this syrup in adults, unless otherwise directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of hicet-ax syrup

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Usually resolves with continued use.
Dry mouth (Common (5-10%))
Sip water or chew sugarless gum. Consult doctor if persistent.
Fatigue (Common (5-10%))
Get adequate rest. Consult doctor if severe.
Nausea (Uncommon (1-5%))
Take with food. Consult doctor if it continues.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical help if you experience rash, swelling, or difficulty breathing.
Irregular heartbeat (Rare (<0.1%))
Contact doctor immediately if you feel palpitations or dizziness.
Blood disorders (e.g., agranulocytosis) (Very rare (<0.01%))
Report unusual bruising, bleeding, or fever to your doctor.

⚠️ Rare Side Effects

Liver enzyme elevation
Regular monitoring if long-term use. Report jaundice or dark urine.
Seizures
Seek emergency care if seizures occur.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Alcohol Major
Benzodiazepines Major
MAO inhibitors Major
Ketoconazole Moderate
Erythromycin Moderate
Theophylline Minor

🚨 Major Interactions

  • CNS depressants (e.g., alcohol, benzodiazepines, opioids)
  • MAO inhibitors

⚡ Moderate Interactions

  • Anticholinergics (e.g., atropine, tricyclic antidepressants)
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)

🍷 Alcohol Interaction

Alcohol increases the sedative effects of cetirizine and should be avoided while taking this medicine. It can also worsen dizziness and impair your ability to drive or operate machinery.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to cetirizine, ambroxol, or any component","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in patients with renal or hepatic impairment.","Not recommended for children under 2 years.","Do not exceed recommended dose.","Consult doctor if symptoms persist beyond 7 days."]

🤱 Lactation Safety

Cetirizine passes into breast milk in small amounts and may cause drowsiness in the infant. Ambroxol is not known to pass into breast milk significantly. Consult your doctor before use while breastfeeding.

💊 Overdose Management

Overdose may cause severe drowsiness, agitation, or seizures. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, tell your doctor about all other medicines you are taking, especially sedatives, antidepressants, or other antihistamines. Keep this medicine out of reach of children. Store it at room temperature, away from direct sunlight and moisture. Do not use it after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to drowsiness and dizziness. Lower doses may be needed, and caution is advised while driving or walking.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy if you are taking this medicine. Cetirizine is generally considered safe, but ambroxol should be used with caution in the first trimester.

🏥 Post-Surgery Considerations

Inform your surgeon if you are taking this medicine before surgery, as it may interact with anesthesia or other medications.

🦷 Dental Procedures

This medicine may cause dry mouth, which can affect dental health. Inform your dentist if you are taking it before any dental procedure.

💚 Lifestyle Tips for Better Results

🏃
Stay hydrated to help thin mucus.
🥗
Use a humidifier to ease breathing.
😴
Avoid allergens like dust and pollen.
💧
Get plenty of rest.
🧘
Wash hands frequently to prevent infections.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel drowsy or dizzy from this medicine. Light activities are fine if you feel well.

🥗 Diet Recommendations

Drink warm fluids like soups and teas.
Avoid cold drinks and ice cream.
Include vitamin C-rich fruits.
Avoid spicy and oily foods if you have a sore throat.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, affecting your ability to drive or operate machinery. Avoid such activities until you know how it affects you. It is best to take it when you can rest.

🛑 When to Stop This Medicine

Stop taking this medicine if your symptoms improve or as advised by your doctor. Do not stop abruptly if you have been on it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to tolerance, increased side effects, or rare blood disorders. Regular monitoring of liver and kidney function may be advised.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and relieve congestion.

Evidence: Well-established
Saline nasal rinse

Clears nasal passages and reduces allergy symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, if you are unwell, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies and cough
She was prescribed this medicine for her sneezing, runny nose, and productive cough. After taking it twice daily for 5 days, her symptoms improved significantly. She reported mild drowsiness initially, which subsided after a few days.
💡 Lesson: This medicine effectively relieves both allergy and cough symptoms, but drowsiness may occur initially.
👤 A 50-year-old man with common cold and thick mucus
He started this medicine as prescribed and noticed that his cough became more productive and easier to clear within 2 days. He was advised to drink plenty of water, which helped further.
💡 Lesson: Ambroxol in this medicine helps thin mucus, and adequate hydration enhances its effect.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Cetirizine starts working within 1 hour, while ambroxol's mucolytic effect begins within 30-60 minutes.

Q: Can I take it with other cold medicines?

A: Consult your doctor before combining with other cold medicines to avoid overlapping ingredients or interactions.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for hicet-ax syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection.
  • Myth: It is safe to take this medicine for long periods.
    Fact: Prolonged use should be avoided unless advised by a doctor, as it may cause side effects.

🔄 Alternative Options

Generic Alternatives

  • Cetirizine + Ambroxol syrup (generic)

Brand Alternatives

  • Not applicable

📊 Comparison with Similar Medicines

[{"medicine":"Cetirizine + Ambroxol","composition":"Cetirizine 2.5mg/5ml + Ambroxol 30mg/5ml","onset":"1 hour","duration":"24 hours","sedation":"Moderate"},{"medicine":"Levocetirizine + Ambroxol","composition":"Levocetirizine 2.5mg/5ml + Ambroxol 30mg/5ml","onset":"1 hour","duration":"24 hours","sedation":"Low"}]

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