heximar ointment - Calcipotriol (0.005% w/w) medicine

Calcipotriol 0.005% Ointment: A Complete Guide

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🏭 A. Menarini India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for plaque psoriasis.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe skin irritation, blistering, or peeling
  • Signs of hypercalcaemia such as nausea, vomiting, constipation, increased thirst, or confusion
  • Swelling of face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is heximar ointment used for?

This medicine is a topical ointment containing calcipotriol 0.005% w/w, used to treat plaque psoriasis by slowing down rapid skin cell growth and reducing inflammation.

  • Generic Name: Calcipotriol (0.005% w/w)
  • Manufacturer: A. Menarini India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 heximar ointment के बारे में (Hindi Summary)

उपयोग: यह दवा कैल्सीपोट्रियोल 0.005% w/w युक्त एक मरहम है, जिसका उपयोग प्लाक सोरायसिस (त्वचा पर सूखे, पपड़ीदार धब्बे) के इलाज के लिए किया जाता है। यह त्वचा कोशिकाओं की तेजी से वृद्धि को धीमा करता है और सूजन को कम करता है। यह केवल बाहरी उपयोग के लिए है और इसे चेहरे, आंखों, होंठों या श्लेष्मा झिल्ली पर नहीं लगाना चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में त्वचा में जलन, खुजली, जलन, लालिमा और सूखापन शामिल हैं। ये आमतौर पर हल्के होते हैं और उपयोग जारी रखने पर कम हो जाते हैं। दुर्लभ मामलों में रक्त में कैल्शियम का स्तर बढ़ सकता है, जिसके लिए डॉक्टर से परामर्श आवश्यक है।

सुरक्षा सलाह: इस दवा को केवल प्रभावित त्वचा पर ही लगाएं। आंखों, होंठों और श्लेष्मा झिल्ली से बचें। उपयोग से पहले और बाद में हाथ धोएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 heximar ointment Uses & Benefits

[{"condition":"Plaque psoriasis","description":"This medicine is used to treat mild to moderate plaque psoriasis, reducing scaling, thickening, and inflammation of the skin plaques.","evidence":"Well-established"},{"condition":"Scalp psoriasis","description":"It can be effective for psoriasis affecting the scalp, helping to reduce flaking and itching.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Nail psoriasis","description":"Sometimes used off-label for nail psoriasis, but evidence is limited and it is not a standard treatment.","evidence":"Limited"},{"condition":"Vitiligo","description":"Occasionally used off-label in combination with other treatments for vitiligo, but evidence is insufficient.","evidence":"Insufficient"}]

Primary treatment for: Plaque psoriasis

Also treats: Scalp psoriasis

📋 Drug Information

Generic Name(s)Calcipotriol (0.005% w/w)
Brand Nameheximar ointment
ManufacturerA. Menarini India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassTopical Vitamin D3 Analogues
Route of AdministrationTopical
StorageStore below 25°C. Do not freeze. Keep the tube tightly closed. Protect from light.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply a thin layer of this medicine only to the affected areas and rub it in gently.
2
Wash your hands before and after application unless the hands are being treated.
3
Avoid applying this medicine to the face, groin, or mucous membranes unless specifically instructed by your doctor.
4
Do not use more than the prescribed amount or frequency, as this can increase the risk of side effects.
5
If you are using other topical treatments, wait for the first one to dry before applying this medicine.
6
Protect treated areas from excessive sunlight and avoid using sunlamps.
7
Consult your doctor if you notice no improvement after 8 weeks of treatment.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Thick, scaly skin patches
This medicine is commonly prescribed for plaque psoriasis.
Likely Use
✅
Itching and redness on skin
This medicine can help reduce inflammation and itching associated with psoriasis.
Likely Use
❌
Fever
This medicine is not used for fever.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSystemic absorption of calcipotriol after topical application is low, typically less than 1% of the applied dose when used on affected skin. However, absorption can increase if the ointment is applied to large areas, under occlusion, or on damaged skin.
DistributionNot established from the available information.
Protein BindingNot established from the available information.
MetabolismCalcipotriol is rapidly metabolised in the liver, primarily via CYP24 and other enzymes, to inactive metabolites.
Half-LifeThe elimination half-life is estimated to be a few hours, but specific values are not well established for topical use.
ExcretionMetabolites are excreted mainly in the bile and faeces, with a small amount in urine.
BioavailabilitySystemic bioavailability after topical application is very low, typically less than 1%.
Onset of ActionImprovement in skin lesions may be noticed within 1-2 weeks, but significant benefit usually takes 4-8 weeks.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe effect on skin cell turnover is prolonged, but the clinical duration after a single application is not well defined.

How It Works

Calcipotriol binds to vitamin D receptors in the skin, leading to modulation of gene expression. This results in inhibition of keratinocyte proliferation and promotion of keratinocyte differentiation, which helps to normalise the rapid turnover of skin cells seen in psoriasis. Additionally, it exerts anti-inflammatory effects by inhibiting T-cell activation and cytokine production.

Mechanism Steps

1
Binding to vitamin D receptor: Calcipotriol binds to the vitamin D receptor (VDR) in the nucleus of keratinocytes and other skin cells.
2
Gene expression modulation: The calcipotriol-VDR complex interacts with vitamin D response elements in DNA, altering the transcription of target genes.
3
Inhibition of keratinocyte proliferation: This leads to reduced proliferation of keratinocytes, slowing down the excessive skin cell turnover characteristic of psoriasis.
4
Promotion of keratinocyte differentiation: Calcipotriol promotes normal differentiation of keratinocytes, helping to restore a healthy skin barrier.
5
Anti-inflammatory effect: It also inhibits T-cell activation and reduces the production of pro-inflammatory cytokines, decreasing skin inflammation.

💡 How to Take heximar ointment

Strength: Ointment containing calcipotriol 0.005% w/w.

1Wash your hands thoroughly before applying the ointment.
2Clean and dry the affected skin area gently.
3Apply a thin layer of the ointment to the affected areas and rub it in gently.
4Wash your hands after application unless the hands are being treated.
5Do not cover the treated area with bandages or dressings unless instructed.
6Avoid contact with eyes, lips, and mucous membranes.
7Use the ointment exactly as prescribed by your doctor.

Dosage Information

Adult DosageApply a thin layer of this medicine to the affected areas once or twice daily as directed by your doctor. The usual maximum weekly dose is 100 grams of ointment. The dose must be individualized by a qualified clinician based on the extent and severity of the condition, and the patient's response to treatment. Do not exceed the recommended dose or duration without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but they should use it with caution and under medical supervision.
Renal ImpairmentUse with caution in patients with severe renal impairment due to the risk of hypercalcaemia. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with severe hepatic impairment. Consult a doctor.
Maximum Daily DoseThe maximum recommended weekly dose is 100 grams of ointment. Daily dose should not exceed approximately 15 grams.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not apply a double dose to catch up.

⚠️ Side Effects of heximar ointment

✅ Common Side Effects

Skin irritation (Common (up to 20%))
Usually resolves with continued use. If severe, consult your doctor.
Itching (Common (up to 15%))
Avoid scratching. Consult doctor if persistent.
Burning or stinging (Common (up to 10%))
Usually temporary. Discontinue if severe.
Redness (Common (up to 10%))
May indicate irritation. Consult doctor if worsens.
Dryness (Common (up to 10%))
Use a moisturiser if needed, but avoid applying immediately after this medicine.

🚨 Serious Side Effects

Hypercalcaemia (Rare (<0.1%))
Seek medical attention if you experience symptoms such as nausea, vomiting, constipation, increased thirst, or confusion.
Severe allergic reaction (Rare (<0.1%))
Stop use and seek immediate medical help if you experience rash, swelling of face/lips/throat, or difficulty breathing.
Skin atrophy (Rare (<0.1%))
Consult a dermatologist if skin thinning occurs.

⚠️ Rare Side Effects

Contact dermatitis
Discontinue and consult a doctor.
Pigmentation changes
Usually reversible. Consult doctor if concerned.

Consult your doctor if you experience any unusual symptoms.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to calcipotriol or any component of the ointment","Disorders of calcium metabolism","Severe renal impairment","Severe hepatic impairment","Use on the face, groin, or mucous membranes (unless directed by a doctor)"]

⚠️ Warnings & Precautions

["For external use only. Do not swallow.","Avoid contact with eyes, lips, and mucous membranes.","Do not apply to large areas of skin for prolonged periods without medical supervision.","Avoid excessive exposure to natural or artificial sunlight.","Use with caution in patients with renal or hepatic impairment.","Do not use under occlusive dressings unless instructed.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether calcipotriol is excreted in human breast milk after topical application. Because systemic absorption is low, the risk to a breastfed infant is likely low, but caution is advised. Avoid applying to the breast area to prevent infant exposure.

💊 Overdose Management

Topical overdose is unlikely to cause serious effects. If excessive amounts are applied, wash off the excess with soap and water. If ingested, seek medical attention immediately. Symptoms of hypercalcaemia may occur with systemic overdose and require supportive care and monitoring of serum calcium.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Apply this medicine only to the affected areas of skin as directed by your doctor. Wash your hands thoroughly before and after application unless the hands are being treated. Avoid applying to the face, eyes, lips, or mucous membranes. Do not cover the treated area with airtight dressings unless instructed. Avoid excessive sun exposure and the use of sunlamps while using this medicine. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for any condition other than the one for which it was prescribed. Keep out of reach of children. If you accidentally swallow this medicine, seek medical attention immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients should use this medicine with caution and under medical supervision, as they may be more susceptible to side effects such as skin irritation and hypercalcaemia.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

🏥 Post-Surgery Considerations

There are no specific restrictions after surgery, but avoid applying the ointment to surgical wounds or broken skin unless directed by your doctor.

🦷 Dental Procedures

No specific considerations for dental procedures. Inform your dentist about all medications you are using.

💚 Lifestyle Tips for Better Results

🏃
Keep your skin moisturised to reduce dryness and scaling.
🥗
Avoid triggers such as stress, smoking, and excessive alcohol.
😴
Maintain a healthy weight and eat a balanced diet.
💧
Protect your skin from sunburn and use sunscreen on unaffected areas.
🧘
Manage stress through relaxation techniques like yoga or meditation.
🌞
Avoid scratching or picking at psoriasis plaques.

🏋️ Exercise Considerations

No specific exercise restrictions while using this medicine. However, avoid activities that may cause excessive sweating or friction on treated areas, as this can irritate the skin.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables.
Include omega-3 fatty acids from fish or flaxseed.
Limit processed foods and sugary drinks.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine is applied topically and is unlikely to affect your ability to work or drive. However, if you experience skin irritation, it may cause some discomfort. You can continue your normal activities unless your doctor advises otherwise.

🛑 When to Stop This Medicine

Do not stop using this medicine without consulting your doctor. If you experience severe side effects or no improvement after the recommended duration, your doctor may advise stopping or changing the treatment.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when used as directed. However, prolonged use over large areas may increase the risk of hypercalcaemia. Regular monitoring of serum calcium may be advised if used extensively. Skin atrophy and other local effects are rare but possible. It is important to have periodic reviews with your doctor to assess the continued need for treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Phototherapy

Controlled exposure to ultraviolet light under medical supervision can help treat psoriasis.

Evidence: Well-established
Systemic medications

For severe psoriasis, oral or injectable medications may be prescribed.

Evidence: Well-established
Stress management

Stress can trigger psoriasis flares; relaxation techniques may help.

Evidence: Supportive

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions between this medicine and vaccines. Continue with routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store below 25°C

❌ DON'T

Do not freeze

✅ DO

Keep the tube tightly closed

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Protect from light

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When travelling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store it below 25°C and protect it from light. If you are crossing time zones, continue applying it according to your usual schedule; no time adjustment is needed for topical medications. Keep it in your carry-on luggage if flying, as checked baggage may be exposed to extreme temperatures.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic plaque psoriasis on his elbows and knees
He started using this medicine as prescribed by his dermatologist. After 4 weeks, he noticed a significant reduction in scaling and thickness of the plaques. He applied it twice daily and made sure not to exceed the recommended weekly dose. He also used a moisturiser to manage dryness.
💡 Lesson: Consistent application and adherence to the prescribed dose are key to achieving good results with this medicine.
👤 A 32-year-old woman with scalp psoriasis
She was prescribed this medicine for her scalp psoriasis. She applied it once daily to the affected areas and washed it off after 8 hours as directed. Within 6 weeks, her scalp itching and flaking had reduced considerably. She was careful to avoid contact with her eyes.
💡 Lesson: Proper application technique and following the doctor's instructions can effectively manage scalp psoriasis with this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start to see improvement in 1-2 weeks, but it usually takes 4-8 weeks for significant benefit.

Q: Can I use this medicine on my face?

A: No, unless specifically directed by your doctor. It can cause irritation on sensitive areas.

Q: What are the side effects?

A: Common side effects include skin irritation, itching, burning, redness, and dryness at the application site. Rarely, it can cause high calcium levels.

Q: Is it safe during pregnancy?

A: Consult your doctor. It should be used during pregnancy only if clearly needed.

Q: Can I use it with other creams?

A: Yes, but inform your doctor about all other medications you are using. Apply them at different times as advised.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine on my face?
  • How long can I use this medicine?
  • Will this medicine affect my calcium levels?
  • Can I use this medicine with other psoriasis treatments?
  • What should I do if I miss a dose?
  • Is this medicine safe for children?

🔄 Substitutes for heximar ointment

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure psoriasis permanently.
    Fact: This medicine helps control symptoms but does not cure psoriasis. Psoriasis is a chronic condition that requires ongoing management.
  • Myth: More ointment means faster results.
    Fact: Using more than prescribed can increase the risk of side effects, including hypercalcaemia. Always follow your doctor's instructions.
  • Myth: This medicine is safe to use on any part of the body.
    Fact: It should not be used on the face, groin, or mucous membranes unless specifically directed by a doctor, as these areas are more sensitive.

🔄 Alternative Options

Generic Alternatives

  • Calcipotriol 0.005% w/w ointment (various manufacturers)

Brand Alternatives

  • Daivonex
  • Dovonex
  • Sorilux

📊 Comparison with Similar Medicines

[{"medicine":"Calcipotriol 0.005% ointment","class":"Vitamin D analogue","main_use":"Plaque psoriasis","route":"Topical"},{"medicine":"Betamethasone dipropionate 0.05% ointment","class":"Corticosteroid","main_use":"Plaque psoriasis","route":"Topical"},{"medicine":"Calcipotriol + betamethasone ointment","class":"Vitamin D analogue + corticosteroid","main_use":"Plaque psoriasis","route":"Topical"}]

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