Benzydol 5 mg/2 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with severe muscle rigidity and confusion (possible neuroleptic malignant syndrome)
- Involuntary movements of the face, tongue, lips, or limbs (possible tardive dyskinesia)
- Irregular heartbeat, palpitations, or fainting (possible QT prolongation)
- Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (possible liver problems)
- Seizures or loss of consciousness
- Difficulty urinating or inability to pass urine
- Severe dizziness or fainting spells
If experiencing severe symptoms, call emergency services immediately.
What is hexidol plus 5 mg/2 mg tablet used for?
This medicine is a combination of haloperidol (an antipsychotic) and trihexyphenidyl (an anticholinergic) used to treat schizophrenia and other psychotic disorders. Haloperidol reduces hallucinations and delusions, while trihexyphenidyl helps prevent movement side effects caused by haloperidol. It is taken orally and must be used under medical supervision.
- Generic Name: Haloperidol (5mg) + Trihexyphenidyl (2mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hexidol plus 5 mg/2 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा हेलोपेरिडोल और ट्राइहेक्सीफेनिडाइल का संयोजन है, जिसका उपयोग सिज़ोफ्रेनिया और अन्य मानसिक विकारों के इलाज के लिए किया जाता है। हेलोपेरिडोल मतिभ्रम और भ्रम को कम करता है, जबकि ट्राइहेक्सीफेनिडाइल हेलोपेरिडोल के कारण होने वाले मांसपेशियों की अकड़न, कंपन और असामान्य हरकतों को रोकने में मदद करता है। यह दवा मुँह से ली जाती है और इसे डॉक्टर की देखरेख में ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, धुंधली दृष्टि, कब्ज, नींद आना, चक्कर आना और पेशाब करने में कठिनाई शामिल हैं। गंभीर दुष्प्रभावों में टार्डिव डिस्किनेसिया (चेहरे, जीभ या अंगों की अनैच्छिक हरकतें), न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम (तेज बुखार, मांसपेशियों में अकड़न और मानसिक भ्रम) और गंभीर एलर्जी प्रतिक्रियाएँ शामिल हो सकती हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से दवा की मात्रा न बदलें और न ही अचानक बंद करें, क्योंकि इससे आपकी बीमारी फिर से बढ़ सकती है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। इस दवा के साथ शराब न लें। अपने डॉक्टर को अपनी सभी दवाओं और स्वास्थ्य समस्याओं के बारे में बताएं। नियमित जांच के लिए डॉक्टर के पास जाते रहें।
💊 hexidol plus 5 mg/2 mg tablet Uses & Benefits
- [{"condition":"Schizophrenia","description":"This medicine helps control hallucinations, delusions, and disorganized thinking in patients with schizophrenia.
- The haloperidol component provides antipsychotic effects, while trihexyphenidyl reduces movement-related side effects.","evidence":"Well-established"},{"condition":"Acute psychosis","description":"Used for short-term management of acute psychotic episodes, including agitation and aggressive behavior.
- It helps stabilize mood and reduce psychotic symptoms.","evidence":"Well-established"},{"condition":"Tourette syndrome","description":"Haloperidol is effective in reducing tics associated with Tourette syndrome.
- Trihexyphenidyl helps manage medication-induced movement side effects.","evidence":"Well-established"},{"condition":"Severe agitation in psychiatric disorders","description":"This combination may be used to manage severe agitation and aggression in conditions such as bipolar disorder or dementia, though caution is needed in elderly patients.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Nausea and vomiting","description":"Haloperidol alone is sometimes used off-label for severe nausea and vomiting, but the combination with trihexyphenidyl is not standard for this purpose.","evidence":"Limited"},{"condition":"Delirium","description":"Haloperidol is sometimes used off-label for delirium in hospitalized patients, but the combination with trihexyphenidyl is not typically used due to anticholinergic risks.","evidence":"Limited"}]
Primary treatment for: Schizophrenia
Also treats: Acute psychosis, Tourette syndrome, Severe agitation in psychiatric disorders
📋 Drug Information
| Generic Name(s) | Haloperidol (5mg) + Trihexyphenidyl (2mg) |
| Brand Name | hexidol plus 5 mg/2 mg tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Haloperidol is a typical antipsychotic that works by blocking dopamine D2 receptors in the brain, particularly in the mesolimbic and mesocortical pathways. This blockade helps reduce positive symptoms of psychosis such as hallucinations and delusions. Trihexyphenidyl is a centrally acting anticholinergic agent that blocks acetylcholine receptors. It helps balance the dopamine-acetylcholine imbalance caused by haloperidol, thereby reducing extrapyramidal side effects like muscle rigidity and tremors. The combination allows for antipsychotic efficacy while minimizing movement-related adverse effects.
Mechanism Steps
💡 How to Take hexidol plus 5 mg/2 mg tablet
Strength: Immediate-release tablet containing haloperidol 5 mg and trihexyphenidyl 2 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. For schizophrenia, a common starting dose of haloperidol is 0.5 to 5 mg two to three times daily, with trihexyphenidyl 2 mg two to three times daily to manage extrapyramidal symptoms. The dose may be gradually increased based on response and tolerability. The maximum recommended daily dose of haloperidol is typically 20 mg, but higher doses may be used in some cases under close supervision. Always follow your doctor's prescription exactly. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine, especially sedation, anticholinergic effects, and extrapyramidal symptoms. The starting dose should be lower, typically half of the adult dose, and increased gradually if needed. Elderly patients with dementia-related psychosis are at an increased risk of stroke and death when treated with antipsychotics. This medicine should be used with extreme caution in this population, and only if other treatments have failed. Regular monitoring for side effects is essential. |
| Renal Impairment | Dose adjustment may be needed in patients with severe renal impairment. Haloperidol and trihexyphenidyl are partially excreted by the kidneys. In patients with creatinine clearance less than 30 mL/min, a lower starting dose and slower titration are recommended. Monitor renal function regularly. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Dose adjustment is recommended in patients with hepatic impairment, as both haloperidol and trihexyphenidyl are metabolized in the liver. In patients with severe liver disease, this medicine should be used with caution or avoided. A lower starting dose and slower titration are advised. Regular monitoring of liver function tests is recommended. |
| Maximum Daily Dose | The maximum daily dose of haloperidol is typically 20 mg, but in some severe cases, doses up to 30 mg or higher may be used under close supervision. The maximum daily dose of trihexyphenidyl is usually 15 mg. However, the exact maximum dose must be determined by a qualified clinician based on the patient's condition and response to treatment. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hexidol plus 5 mg/2 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Levodopa | Major | |
| Amiodarone | Major | |
| Clozapine | Major | |
| Ketoconazole | Moderate | |
| Carbamazepine | Moderate | |
| Benzodiazepines | Moderate | |
| Anticholinergics | Moderate | |
| Metoclopramide | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Other antipsychotics (e.g., clozapine, olanzapine)
- Levodopa and dopamine agonists
- QT-prolonging drugs (e.g., amiodarone, sotalol, methadone)
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine, oxybutynin)
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., carbamazepine, rifampin)
- Antihypertensive drugs
- Metoclopramide
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the sedative and central nervous system depressant effects of haloperidol, leading to excessive drowsiness, dizziness, impaired coordination, and increased risk of respiratory depression. It can also worsen antipsychotic side effects and impair judgment. If you consume alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Parkinson's disease","Severe central nervous system depression","Comatose states","Severe liver disease","Severe kidney disease","Known hypersensitivity to haloperidol, trihexyphenidyl, or any component of the formulation","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Myasthenia gravis","Severe cardiac disease or recent myocardial infarction","Use in elderly patients with dementia-related psychosis (increased risk of death)"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you.","Avoid alcohol and other CNS depressants while taking this medicine.","This medicine can cause tardive dyskinesia, which may be irreversible. Report any involuntary movements to your doctor immediately.","Neuroleptic malignant syndrome is a rare but life-threatening reaction. Seek emergency care for high fever, muscle rigidity, or altered mental status.","Use with caution in elderly patients, especially those with dementia, as there is an increased risk of stroke and death.","This medicine may prolong the QT interval. Inform your doctor if you have a history of heart problems or are taking other QT-prolonging drugs.","Do not stop this medicine abruptly, as it can cause withdrawal symptoms or relapse. Taper gradually under medical supervision.","This medicine may affect blood sugar and lipid levels. Monitor regularly if you have diabetes or high cholesterol.","Inform your doctor if you have glaucoma, prostate problems, or difficulty urinating, as trihexyphenidyl can worsen these conditions.","This medicine may reduce sweating and cause heat intolerance. Avoid excessive heat and stay hydrated."]
🤱 Lactation Safety
Haloperidol and trihexyphenidyl are excreted in breast milk. There is limited information on the effects of this combination on breastfed infants. Some infants may experience drowsiness, irritability, or poor feeding. Breastfeeding is not recommended while taking this medicine unless the benefits clearly outweigh the risks. Consult your doctor to discuss alternative feeding options or alternative medications.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, coma, hypotension, tachycardia, extrapyramidal symptoms, and anticholinergic effects such as dry mouth, flushing, and urinary retention. In severe cases, cardiac arrhythmias and respiratory depression may occur. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including airway management, monitoring of vital signs, and ECG. There is no specific antidote. Activated charcoal may be used if the patient presents early. Hemodialysis is not effective for removing haloperidol or trihexyphenidyl.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist. Consistency in taking this medicine is important for its effectiveness.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor, as sudden discontinuation can cause withdrawal symptoms or relapse of your condition. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness and dizziness. Avoid alcohol while taking this medicine, as it can increase drowsiness and other central nervous system effects. Inform your doctor if you have a history of heart problems, liver disease, kidney disease, glaucoma, or difficulty urinating. This medicine can interact with many other medicines, so always tell your doctor about all the medicines you are taking. Keep all appointments for monitoring, including blood tests and heart checks. Store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at an increased risk of side effects from this medicine, including sedation, confusion, falls, and extrapyramidal symptoms. Antipsychotics are associated with an increased risk of stroke and death in elderly patients with dementia-related psychosis. This medicine should be used with extreme caution in this population, and only if other treatments have failed. Lower starting doses and gradual titration are recommended. Regular monitoring for side effects is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before starting or continuing this medicine. Both haloperidol and trihexyphenidyl are classified as Pregnancy Category C, meaning risk to the fetus cannot be ruled out. Your doctor may consider alternative treatments or adjust the dose. Effective contraception should be used during treatment unless pregnancy is desired. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and other medications used during surgery. Your doctor may advise you to stop the medicine temporarily before surgery, but never do so without medical advice. Monitor for withdrawal symptoms or relapse during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can cause dry mouth, which may increase the risk of dental caries and gum disease. Regular dental check-ups and good oral hygiene are important. The anticholinergic effects may interact with medications used in dentistry. Your dentist may need to adjust the treatment plan accordingly.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and muscle stiffness, which may affect your ability to exercise safely. Avoid strenuous exercise or activities that require high coordination until you know how the medicine affects you. Stay hydrated during exercise, as trihexyphenidyl can reduce sweating and increase the risk of heat exhaustion. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive or operate heavy machinery. Avoid these activities until you know how the medicine affects you. It may also cause difficulty concentrating, affecting work performance. Discuss with your doctor if you experience significant impairment. Do not stop the medicine on your own; adjustments can be made to minimize impact.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as tardive dyskinesia, neuroleptic malignant syndrome, or severe allergic reactions, seek immediate medical attention. Your doctor may decide to stop the medicine or switch to an alternative based on your condition and response to treatment. Abrupt discontinuation can cause withdrawal symptoms or relapse.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tardive dyskinesia, a potentially irreversible movement disorder. Regular monitoring with the Abnormal Involuntary Movement Scale (AIMS) is recommended. Other long-term effects include metabolic changes such as weight gain, increased blood sugar, and lipid abnormalities. Hyperprolactinemia may occur, leading to breast enlargement, galactorrhea, or sexual dysfunction. Regular monitoring of weight, blood glucose, lipids, and prolactin levels is advised. Periodic assessment of the benefits and risks of continued treatment is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine in managing psychotic symptoms and improving coping skills.
Evidence: Well-establishedHelps family members understand the condition and support the patient.
Evidence: Well-establishedMay have a lower risk of extrapyramidal symptoms but higher metabolic side effects.
Evidence: Well-establishedRegular exercise, healthy diet, and stress management can improve overall well-being.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, patients with mental health conditions should stay up to date with routine vaccinations. Consult your doctor before receiving any live vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Carry enough supply for the entire trip. Check local customs regulations for controlled substances, as antipsychotics may be regulated. Always inform airport security about your medication.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antipsychotic effect may begin within hours to days, but full therapeutic benefit for psychosis typically takes 1 to 2 weeks or longer. The anticholinergic effect for movement symptoms starts within 30 to 60 minutes.
A: No, you should never stop this medicine suddenly. Abrupt discontinuation can cause withdrawal symptoms or relapse of your condition. Always consult your doctor before making any changes.
A: This medicine is classified as Pregnancy Category C. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Consult your doctor immediately if you are pregnant or planning to become pregnant.
A: No, alcohol should be completely avoided while taking this medicine. It increases sedation, dizziness, and the risk of respiratory depression.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Weight gain is a possible side effect of long-term use. Monitor your weight and discuss any concerns with your doctor. Diet and exercise can help manage this.
🤔 Common Patient Concerns
🔄 Substitutes for hexidol plus 5 mg/2 mg tablet
View AllAlternative brands with exact same active ingredient:
-
manodol 5 mg/2 mg kitOrchid Chemicals & Pharmaceuticals Ltd ₹11.75 24.5% CHEAPER
-
combidol 5mg/2mg kitIntas Pharmaceuticals Ltd ₹12.30 21% CHEAPER
-
Talendol Plus TabletTalent Healthcare ₹16.47 5.8% COSTLIER
-
cizoren plus 5mg/2mg tabletStadmed Pvt Ltd ₹16.99 9.2% COSTLIER
-
mindol plus 5mg/2mg tabletMicro Labs Ltd ₹19.69 26.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is an antipsychotic combination used for serious mental health conditions. It is not a sleeping pill and should only be used under psychiatric supervision. - Myth: You can stop taking this medicine once you feel better.
Fact: Stopping this medicine suddenly can cause withdrawal symptoms or relapse of your condition. Always consult your doctor before making any changes. - Myth: This medicine is addictive.
Fact: This medicine is not considered addictive in the traditional sense, but it can cause dependence. It should be tapered gradually under medical supervision. - Myth: This medicine can be taken during pregnancy without any risk.
Fact: This medicine may pose risks to the fetus. It should only be used during pregnancy if the benefits outweigh the risks, as determined by your doctor.
🔄 Alternative Options
Generic Alternatives
- Haloperidol 5 mg + Trihexyphenidyl 2 mg tablet (generic)
Brand Alternatives
- Benzydol 5 mg/2 mg tablet