Eugraf 60mcg/gm Gel: A Complete Guide to Uses, Side Effects, and More
When to Call Your Doctor IMMEDIATELY
- Signs of severe allergic reaction such as difficulty breathing, swelling of face, lips, tongue, or throat.
- Severe pain, blistering, or peeling at the application site.
- Increased redness, warmth, swelling, or pus at the wound site, which may indicate infection.
- Fever or chills.
- No improvement in wound healing after several weeks of use.
- Unusual bleeding or discharge from the wound.
If experiencing severe symptoms, call emergency services immediately.
What is healace gel used for?
This medicine is a topical gel containing recombinant human epidermal growth factor, used to promote healing of chronic wounds such as diabetic foot ulcers and pressure sores. It works by stimulating cell growth and tissue repair.
- Generic Name: Recombinant Human Epidermal Growth Factor (60mcg/gm)
- Manufacturer: Virchow Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 healace gel के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल जेल है जिसमें रीकॉम्बिनेंट ह्यूमन एपिडर्मल ग्रोथ फैक्टर (rhEGF) 60 माइक्रोग्राम प्रति ग्राम की मात्रा में होता है। यह घाव भरने की प्रक्रिया को तेज करने के लिए उपयोग की जाती है, विशेष रूप से डायबिटिक फुट अल्सर, प्रेशर अल्सर, और वेनस लेग अल्सर जैसे पुराने घावों के इलाज में। यह त्वचा की कोशिकाओं के विकास और मरम्मत को उत्तेजित करती है, जिससे घाव जल्दी भर जाता है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे बाहरी उपयोग के लिए ही लगाया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभाव आमतौर पर हल्के होते हैं और लगाने की जगह पर ही सीमित रहते हैं। इनमें जलन, लालिमा, खुजली, या दाने शामिल हो सकते हैं। ये प्रभाव आमतौर पर अस्थायी होते हैं और उपचार जारी रखने पर ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी प्रतिक्रिया हो सकती है, जैसे सांस लेने में कठिनाई, चेहरे, होंठ, जीभ या गले में सूजन। ऐसा होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग करने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, खासकर अगर आपको एलर्जी, त्वचा संक्रमण, या प्रतिरक्षा प्रणाली से जुड़ी समस्या है। इस जेल को आंखों, मुंह, और अन्य श्लेष्मा झिल्ली के संपर्क में न आने दें। उपयोग से पहले और बाद में अपने हाथ धोएं। घाव में संक्रमण के लक्षण दिखने पर तुरंत डॉक्टर से मिलें। बिना डॉक्टर की सलाह के इसे निर्धारित अवधि से अधिक न लगाएं। बच्चों की पहुंच से दूर रखें।
💊 healace gel Uses & Benefits
[{"condition":"Diabetic foot ulcers","description":"This medicine is used to promote granulation tissue formation and accelerate healing of chronic diabetic foot ulcers when used as an adjunct to standard wound care.","evidence":"Well-established"},{"condition":"Pressure ulcers","description":"It helps in the healing of pressure sores by stimulating cell proliferation and migration, leading to faster wound closure.","evidence":"Moderate"},{"condition":"Venous leg ulcers","description":"This medicine may be applied to venous stasis ulcers to enhance tissue repair and reduce healing time.","evidence":"Moderate"},{"condition":"Skin graft donor sites","description":"It is used to accelerate re-epithelialization of donor sites after skin grafting procedures.","evidence":"Well-established"},{"condition":"Surgical wounds","description":"This medicine can be applied to clean surgical wounds to promote faster healing and reduce the risk of complications.","evidence":"Limited"}]
Off-label uses: [{"condition":"Burns","description":"Sometimes used off-label to promote healing of superficial and partial-thickness burns.","evidence":"Limited"},{"condition":"Radiation dermatitis","description":"May be used off-label to manage skin reactions caused by radiation therapy.","evidence":"Limited"}]
Primary treatment for: Chronic wounds (e.g., diabetic foot ulcers, pressure ulcers)
Also treats: Venous leg ulcers, Skin graft donor sites, Surgical wounds
📋 Drug Information
| Generic Name(s) | Recombinant Human Epidermal Growth Factor (60mcg/gm) |
| Brand Name | healace gel |
| Manufacturer | Virchow Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | HORMONES |
| Action Class | Recombinant human epidermal growth factor (rhEGF)- Diabetic foot ulcer |
| Route of Administration | Topical |
| Storage | Store in a refrigerator at 2-8°C. Do not freeze. Keep the tube tightly closed. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains recombinant human epidermal growth factor, which is a polypeptide that binds specifically to the epidermal growth factor receptor (EGFR) on the surface of target cells. Upon binding, it activates the receptor's intrinsic tyrosine kinase activity, leading to autophosphorylation and subsequent activation of multiple downstream signaling pathways, including the MAPK, PI3K/Akt, and JAK/STAT pathways. These signals promote cell proliferation, migration, differentiation, and survival, particularly in epithelial cells, fibroblasts, and endothelial cells. The result is enhanced tissue regeneration, angiogenesis, and extracellular matrix deposition, which collectively accelerate wound healing.
Mechanism Steps
💡 How to Take healace gel
Strength: Gel containing 60 micrograms of recombinant human epidermal growth factor per gram.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the type, size, and severity of the wound, as well as the patient's overall condition. Typically, a thin layer of the gel is applied to the affected area once or twice daily, or as directed by the physician. The duration of treatment varies depending on the healing progress. Do not exceed the recommended frequency or duration without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are required for elderly patients. However, they should be monitored for wound healing progress and any adverse effects. |
| Renal Impairment | No dosage adjustment is necessary for patients with renal impairment due to minimal systemic absorption. |
| Hepatic Impairment | No dosage adjustment is necessary for patients with hepatic impairment due to minimal systemic absorption. |
| Maximum Daily Dose | Not established from the available information. Use as prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of healace gel
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to recombinant human epidermal growth factor or any component of the gel","Application to infected wounds without appropriate antimicrobial therapy","Use in patients with known malignancy at the wound site (due to theoretical risk of growth factor stimulating tumor growth)"]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes, mouth, and mucous membranes.","Do not apply to large areas of broken skin without medical supervision.","Use with caution in patients with a history of cancer, as growth factors may theoretically promote tumor growth.","Do not use if the gel appears discolored or contains particles.","Keep out of reach of children.","Do not use beyond the expiry date."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Since it is applied topically, systemic absorption is minimal. However, consult your doctor before using this medicine while breastfeeding. Avoid applying to the breast area to prevent infant exposure.
💊 Overdose Management
Overdose with this topical medicine is unlikely. If accidental ingestion occurs, seek medical attention. In case of excessive application, wipe off the excess gel and consult your doctor if any adverse effects occur.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Before using this medicine, inform your doctor about all your medical conditions, especially if you have a history of allergies, skin infections, or immune system disorders. Do not apply this gel to areas of broken skin other than the intended wound, and avoid contact with eyes, mouth, and other mucous membranes. Wash your hands thoroughly before and after applying the gel. Do not cover the treated area with airtight dressings unless instructed by your doctor. If the wound shows signs of infection such as increased redness, warmth, swelling, or pus, consult your doctor immediately. Do not use this medicine for longer than prescribed without medical advice. Keep this product out of reach of children. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have slower wound healing due to age-related factors. They should be monitored closely for progress and any adverse effects. No dosage adjustment is required.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. There is no established data on its safety during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to promote healing of surgical wounds, but only under the guidance of your surgeon. Follow all postoperative care instructions.
🦷 Dental Procedures
This medicine is not intended for use in the mouth. If you have a dental procedure, inform your dentist about this medicine. It is unlikely to affect dental procedures, but your dentist may provide specific advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid putting weight on the affected area if the wound is on the foot or leg. Consult your doctor or physical therapist for appropriate exercises that do not stress the wound. Gentle range-of-motion exercises may be beneficial for overall circulation.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience any local reaction that causes discomfort, avoid such activities until it resolves. You can continue your normal daily activities, but protect the treated area from injury.
🛑 When to Stop This Medicine
Do not stop using this medicine without consulting your doctor. If the wound has healed completely or if you experience severe side effects, your doctor may advise you to stop. If you notice no improvement after several weeks, consult your doctor for reassessment.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. There is a theoretical risk that growth factors could stimulate the growth of pre-existing tumors, so it should be used with caution in patients with a history of cancer. Prolonged use may also lead to local skin reactions. Regular monitoring of the wound and overall health is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Regular cleaning, debridement, and dressing changes are essential for wound healing.
Evidence: Well-establishedA technique that uses suction to promote healing in chronic wounds.
Evidence: Well-establishedInvolves breathing pure oxygen in a pressurized chamber to enhance healing.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while using this medicine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2-8°C.
❌ DON'T
Do not freeze.
✅ DO
Keep the tube tightly closed.
❌ DON'T
Do not leave the cap off.
✅ DO
Protect from light.
❌ DON'T
Do not store in direct sunlight.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Since it requires refrigeration, use a cool pack or insulated bag to maintain the temperature between 2-8°C. Inform airport security about the medication and any cooling gel packs. If traveling across time zones, continue with your regular application schedule as prescribed. Do not leave the medicine in a hot car or checked luggage. Check the laws of your destination country regarding import of prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Visible improvement in wound healing may be seen within 1-2 weeks of consistent use, but complete healing can take several weeks to months depending on the wound type and severity.
A: This medicine is intended for chronic wounds and should not be used on the face unless specifically prescribed by your doctor for a particular condition.
A: Safety and effectiveness in children have not been established. Consult a pediatrician before use.
A: This medicine is for external use only. If swallowed, seek medical attention immediately.
🤔 Common Patient Concerns
🔄 Substitutes for healace gel
View AllAlternative brands with exact same active ingredient:
-
regen-d 60 gelBharat Biotech ₹735.00 45.8% CHEAPER
-
eugraf 60mcg/gm gelLupin Ltd ₹1,941.20 43.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can heal any wound quickly.
Fact: This medicine is specifically for certain types of chronic wounds and must be used under medical supervision. It is not a universal wound healer. - Myth: More frequent application leads to faster healing.
Fact: Applying more than prescribed does not necessarily speed up healing and may increase the risk of side effects. Follow your doctor's instructions. - Myth: This medicine is a cosmetic product for skin rejuvenation.
Fact: This is a prescription medicine for wound healing, not a cosmetic anti-aging product. Its use should be strictly as prescribed.