Ayufen P Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe skin rash or blisters
If experiencing severe symptoms, call emergency services immediately.
What is hardiv p 25mg/75mg injection used for?
This medicine is an injectable combination of diclofenac and paracetamol used for short-term relief of moderate to severe acute pain and fever when oral medicines are not suitable. It is given by a healthcare professional and should not be self-administered.
- Generic Name: Diclofenac (25mg) + Paracetamol (75mg)
- Manufacturer: LifeCare Formulation Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hardiv p 25mg/75mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक और पैरासिटामोल का इंजेक्शन है, जिसका उपयोग तेज दर्द और बुखार के इलाज के लिए किया जाता है। यह मुख्य रूप से सर्जरी के बाद, चोट लगने पर, गुर्दे की पथरी के दर्द में और गठिया के तीव्र दौरे में दिया जाता है। यह इंजेक्शन डॉक्टर या नर्स द्वारा ही लगाया जाता है, घर पर खुद नहीं लगाया जाना चाहिए। यह दर्द को कम करने और सूजन तथा बुखार को नियंत्रित करने में मदद करता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, जलन, मतली, उल्टी, चक्कर आना, सिरदर्द और पेट में असहजता शामिल हैं। गंभीर दुष्प्रभावों में पेट में तेज दर्द, काला मल, उल्टी में खून, सांस लेने में कठिनाई, चेहरे या गले में सूजन, पीलिया, पेशाब कम आना और त्वचा पर गंभीर दाने हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे घर पर खुद न लगाएं। अगर आपको पेट के अल्सर, गुर्दे या लीवर की बीमारी, दिल की बीमारी, दमा या दर्द निवारक दवाओं से एलर्जी है, तो डॉक्टर को पहले बताएं। इस दवा के साथ शराब न पिएं। बिना डॉक्टर की सलाह के कोई अन्य दर्द या बुखार की दवा न लें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर को जरूर बताएं।
💊 hardiv p 25mg/75mg injection Uses & Benefits
[{"condition":"Acute postoperative pain","description":"Used for short-term relief of moderate to severe pain after surgery when oral medicines are not suitable.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Helps reduce pain and inflammation in conditions such as muscle strain, ligament injury, and acute low back pain.","evidence":"Well-established"},{"condition":"Renal colic","description":"Provides rapid pain relief in acute kidney stone pain when injectable therapy is needed.","evidence":"Well-established"},{"condition":"Acute gout flare","description":"May be used for short-term relief of severe gout pain and inflammation under medical supervision.","evidence":"Moderate"},{"condition":"Fever with severe pain","description":"Used when both pain and fever need rapid control and oral treatment is not possible.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Acute migraine attack","description":"Sometimes used in emergency settings for severe migraine pain when other treatments fail.","evidence":"Limited"},{"condition":"Postoperative shivering","description":"Occasionally used off-label to reduce shivering after surgery, though not a standard first choice.","evidence":"Limited"}]
Primary treatment for: Acute moderate to severe pain
Also treats: Postoperative pain, Musculoskeletal injury, Renal colic, Acute gout, Fever with severe pain
📋 Drug Information
| Generic Name(s) | Diclofenac (25mg) + Paracetamol (75mg) |
| Brand Name | hardiv p 25mg/75mg injection |
| Manufacturer | LifeCare Formulation Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Parenteral |
| Storage | Store in a cool, dry place below 30°C, away from direct sunlight. Do not freeze. Keep the injection in its original packaging until use. |
| Shelf Life | Not established from the available information. Check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two pain-relieving ingredients with different mechanisms. Diclofenac is a nonsteroidal anti-inflammatory drug that inhibits cyclo-oxygenase enzymes, which reduces the production of prostaglandins that cause pain, swelling, and fever. Paracetamol acts mainly in the central nervous system by reducing prostaglandin synthesis in the brain and affecting pain signal transmission. Together, they provide stronger pain relief than either ingredient alone in many acute pain settings.
Mechanism Steps
💡 How to Take hardiv p 25mg/75mg injection
Strength: Injection containing Diclofenac 25 mg and Paracetamol 75 mg per dose.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, severity of pain, age, weight, kidney function, and liver function. It is usually given as a single intramuscular injection for acute pain, and repeated doses are decided by the doctor. Do not self-administer. The maximum daily dose must not be exceeded, and the duration of use should be as short as possible. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the side effects of this medicine, especially stomach bleeding, kidney problems, and heart effects. Use the lowest effective dose for the shortest possible time, and monitor kidney and liver function closely. |
| Renal Impairment | Use with caution in kidney disease. Dose reduction or avoidance may be needed depending on the degree of kidney impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in liver disease. Dose reduction or avoidance may be needed. Paracetamol can worsen liver injury, and diclofenac can raise liver enzymes. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by a qualified clinician based on the patient's condition and should not be exceeded. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hardiv p 25mg/75mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Other NSAIDs | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Cyclosporine | Moderate | |
| Digoxin | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Methotrexate
- Other NSAIDs including aspirin
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs and SNRIs
- Lithium
- Cyclosporine
- Digoxin
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol increases the risk of stomach bleeding, ulcers, and liver damage, especially when paracetamol and diclofenac are used together.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to diclofenac, paracetamol, or any ingredient of this medicine","Active stomach or intestinal ulcer or bleeding","Severe kidney disease","Severe liver disease","Severe heart failure","Third trimester of pregnancy","Use before or during coronary artery bypass graft surgery","Children unless specifically prescribed by a specialist"]
⚠️ Warnings & Precautions
["This medicine must be given only by a healthcare professional.","Do not use for more than the recommended duration without medical advice.","Avoid alcohol during treatment.","Use with caution in elderly patients and those with kidney or liver disease.","Do not take other paracetamol-containing products without consulting your doctor.","Stop and seek medical help if you notice signs of an allergic reaction.","Inform your doctor if you have asthma, as NSAIDs can trigger bronchospasm in some people."]
🤱 Lactation Safety
Diclofenac and paracetamol pass into breast milk in small amounts. Short-term use is generally considered acceptable, but consult your doctor before receiving this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver injury from paracetamol and stomach bleeding or kidney injury from diclofenac. Symptoms may include nausea, vomiting, abdominal pain, confusion, and drowsiness. If overdose is suspected, seek emergency medical care immediately. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
This medicine is usually given as a single dose or a short course in a hospital or clinic setting. If you miss a scheduled dose, contact your healthcare provider for advice. Do not try to inject yourself or double the next dose.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional. Do not attempt to inject it yourself at home. Tell your doctor if you have ever had a stomach ulcer, kidney disease, liver disease, heart failure, asthma, or an allergy to painkillers. Avoid alcohol while receiving this medicine because it increases the risk of stomach bleeding and liver problems. Do not take other painkillers or fever medicines without asking your doctor, because paracetamol is present in many over-the-counter products and too much can harm the liver. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before receiving this injection. Keep all follow-up appointments so your doctor can monitor your response and check for side effects. Do not drive or operate heavy machinery if you feel dizzy or drowsy after the injection.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of stomach bleeding, kidney problems, and heart effects from this medicine. Use the lowest effective dose for the shortest possible time, and monitor kidney and liver function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss all medicines with your doctor. This medicine should be avoided in the third trimester and used only if clearly needed in earlier stages. Paracetamol alone is generally preferred for pain relief during pregnancy.
🏥 Post-Surgery Considerations
This medicine is often used after surgery for short-term pain relief. It should be given only under medical supervision, and the dose should be adjusted based on your kidney and liver function. Switch to oral painkillers as soon as you can take them.
🦷 Dental Procedures
This medicine may be used for severe dental pain when oral medicines are not enough. Inform your dentist if you are taking blood thinners or have kidney or liver disease. Do not self-medicate before dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while you are in acute pain. Gentle stretching and low-impact activities may be helpful once the acute pain improves. Always follow your doctor's advice before returning to your normal exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. You may need to rest for a few hours after the injection. Inform your employer if your work involves physical strain or operating machinery.
🛑 When to Stop This Medicine
This medicine is usually given as a short course. Stop and seek medical advice if you develop severe stomach pain, black stools, signs of an allergic reaction, yellowing of the eyes or skin, or any other serious side effect. Do not stop or change your treatment without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of diclofenac can increase the risk of stomach ulcers, kidney problems, heart attack, and stroke. Long-term paracetamol use at high doses can cause liver injury. If you need pain relief for more than a few days, your doctor should review your condition and consider safer long-term options.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedCan help reduce pain and inflammation in acute injuries.
Evidence: ModerateMay help reduce pain perception and stress.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are unwell with a fever, your doctor may advise delaying vaccination until you recover.
📦 Storage Guide
✅ DO
Store below 30°C in a cool, dry place
❌ DON'T
Do not freeze the injection
✅ DO
Keep in original packaging until use
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is given by a healthcare professional and is not for self-administration during travel. If you are prescribed this injection while traveling, carry it in its original packaging with a copy of your prescription. Store it below 30°C and away from direct sunlight. Check customs rules for carrying injectable medicines across borders. Inform your doctor if you are traveling to a place where follow-up care may not be available.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief usually begins within 15 to 30 minutes after the injection, with peak effect within 20 to 60 minutes.
A: The effect typically lasts about 4 to 6 hours, but this can vary depending on the severity of pain and individual response.
A: No. This medicine must be given only by a trained healthcare professional.
A: It should be used with caution in kidney disease. Your doctor may adjust the dose or avoid it depending on your kidney function.
A: No. Alcohol increases the risk of stomach bleeding and liver injury.
🤔 Common Patient Concerns
🔄 Substitutes for hardiv p 25mg/75mg injection
View AllAlternative brands with exact same active ingredient:
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vivogesic plus 25 mg/75 mg injectionBestoChem Formulations India Ltd ₹12.14 48.2% CHEAPER
-
Fenlo Plus 25mg/75mg InjectionEvans Pharma ₹13.12 44% CHEAPER
-
dicnacx p 25mg/75mg injectionShince Pharmaceuticals Pvt Ltd ₹16.88 28% CHEAPER
-
diazox aqua 25mg/75mg injectionStrides shasun Ltd ₹18.75 20% CHEAPER
-
faconex plus 25mg/75mg injectionProtech Telelinks ₹19.69 16% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This injection can be taken at home like a tablet.
Fact: This medicine is an injection and must be given only by a trained healthcare professional. - Myth: More injections mean faster recovery.
Fact: Using more than the prescribed dose increases the risk of serious side effects and does not improve recovery. - Myth: It is safe to take other painkillers along with this injection.
Fact: Combining with other painkillers, especially paracetamol or NSAIDs, can cause harm. Always ask your doctor.
🔄 Alternative Options
Generic Alternatives
- Diclofenac and Paracetamol injection
Brand Alternatives
- Ayufen P Injection