gracof br syrup - Guaifenesin (NA) + Terbutaline (NA) medicine

Asmotone Liquid: Complete Medicine Guide

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🏭 GRAF Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited to moderate for symptomatic relief.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction: rash, itching, swelling of face, lips, tongue, or throat, difficulty breathing.
  • Irregular heartbeat, palpitations, or chest pain.
  • Seizures or convulsions.
  • Severe dizziness or fainting.
  • Persistent vomiting or inability to keep fluids down.
  • Yellowing of skin or eyes (jaundice).
  • Decreased urine output.

If experiencing severe symptoms, call emergency services immediately.

What is gracof br syrup used for?

This medicine is a combination of guaifenesin (an expectorant) and terbutaline (a bronchodilator) used to relieve cough with thick mucus and mild bronchospasm. It helps loosen mucus and open airways, making it easier to cough. It is available as a liquid and is taken orally as prescribed by a doctor.

  • Generic Name: Guaifenesin (NA) + Terbutaline (NA)
  • Manufacturer: GRAF Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 gracof br syrup के बारे में (Hindi Summary)

उपयोग: यह दवा ग्वाइफेनेसिन और टर्ब्यूटलाइन का संयोजन है, जिसका उपयोग बलगम वाली खांसी और सांस की नली में सिकुड़न के इलाज के लिए किया जाता है। ग्वाइफेनेसिन बलगम को पतला करता है जिससे खांसी में आसानी होती है, और टर्ब्यूटलाइन सांस की नलियों को फैलाता है जिससे सांस लेने में सुधार होता है। यह दवा केवल डॉक्टर के परामर्श से ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बेचैनी, घबराहट, कंपन, सिरदर्द, जी मिचलाना, उल्टी और दिल की धड़कन तेज होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, अनियमित दिल की धड़कन, सीने में दर्द और दौरे पड़ सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक बढ़ाने या घटाने से पहले डॉक्टर से सलाह लें। दवा लेने से पहले बोतल को अच्छी तरह हिलाएं और मापने वाले कप से ही खुराक लें। यदि आपको चक्कर, घबराहट या कंपन महसूस हो तो वाहन न चलाएं। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको हृदय रोग, उच्च रक्तचाप, मधुमेह या दौरे की समस्या है तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 gracof br syrup Uses & Benefits

[{"condition":"Productive cough with thick mucus","description":"Helps loosen and thin mucus in the airways, making it easier to cough out, while terbutaline helps open airways.","evidence":"Established for short-term relief"},{"condition":"Acute bronchitis","description":"May be used to relieve cough and wheezing associated with acute bronchitis, but only under medical supervision.","evidence":"Limited, symptomatic relief"},{"condition":"Asthma with mucus plugging","description":"Sometimes used as an adjunct to relieve bronchospasm and mucus in asthma exacerbations, though not a first-line treatment.","evidence":"Limited, specialist use"}]

Off-label uses: [{"condition":"COPD with mucus hypersecretion","description":"Occasionally prescribed off-label to help with mucus clearance in chronic obstructive pulmonary disease, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Productive cough associated with respiratory conditions

Also treats: Acute bronchitis, Asthma with mucus plugging, COPD with mucus hypersecretion

📋 Drug Information

Generic Name(s)Guaifenesin (NA) + Terbutaline (NA)
Brand Namegracof br syrup
ManufacturerGRAF Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed.
Shelf LifeNot established from the available information. Check the expiry date on the package.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine for short-term use only, as prolonged use of terbutaline can lead to tolerance and cardiac side effects.
2
Advise patients to shake the bottle well before each dose to ensure uniform suspension.
3
Warn patients about the potential for tremor and nervousness, and advise them to avoid driving if affected.
4
Check for contraindications such as cardiovascular disease, hyperthyroidism, and diabetes before prescribing.
5
Instruct patients to avoid caffeine and alcohol while taking this medicine to reduce side effects.
6
Monitor potassium levels if the patient is also on diuretics or corticosteroids.
7
Educate patients that this medicine is not for dry cough and should not be used without a prescription.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
Wheezing
Terbutaline helps open airways.
Likely Use
Dry cough
This medicine is not for dry cough.
Not Primary
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGuaifenesin is rapidly absorbed from the gastrointestinal tract after oral administration. Terbutaline is also well absorbed orally, but undergoes some first-pass metabolism. Exact bioavailability data for the combination liquid is not established from the available information.
DistributionGuaifenesin distributes widely into body tissues and fluids. Terbutaline distributes into various tissues, including the lungs, but specific volume of distribution data for this combination is not established from the available information.
Protein BindingGuaifenesin protein binding is not well established. Terbutaline is approximately 25% bound to plasma proteins. Specific data for the combination is not established from the available information.
MetabolismGuaifenesin is metabolized in the liver, primarily by oxidation and conjugation. Terbutaline undergoes conjugation in the liver and possibly in the gut wall. Specific metabolic pathways for the combination are not fully established from the available information.
Half-LifeThe elimination half-life of guaifenesin is approximately 1 hour. Terbutaline has a half-life of about 3 to 4 hours. The half-life of the combination may not differ significantly from individual components.
ExcretionGuaifenesin and its metabolites are excreted primarily in the urine. Terbutaline is excreted mainly in the urine as unchanged drug and conjugates. Specific excretion data for the combination is not established from the available information.
BioavailabilityOral bioavailability of guaifenesin is not well established. Terbutaline oral bioavailability is approximately 10-15% due to first-pass metabolism. Specific bioavailability for this combination liquid is not established from the available information.
Onset of ActionBronchodilation from terbutaline typically occurs within 30 minutes after oral administration. Guaifenesin's expectorant effect may take longer, often within 1-2 hours. Onset for the combination is not precisely established.
Peak Plasma TimePeak plasma concentrations for guaifenesin occur within 1 hour; for terbutaline, peak levels are reached in about 2-3 hours. Specific data for the combination is not established from the available information.
Duration of ActionThe bronchodilator effect of terbutaline lasts about 4-6 hours. Guaifenesin's effect lasts as long as it is taken regularly. Duration for the combination is not precisely established.

How It Works

This medicine combines two active ingredients with different mechanisms. Guaifenesin is an expectorant that works by increasing the volume and reducing the viscosity of secretions in the respiratory tract, which helps to loosen mucus and make coughs more productive. Terbutaline is a selective beta-2 adrenergic receptor agonist that relaxes bronchial smooth muscle, leading to bronchodilation and improved airflow. Together, they aim to relieve cough by addressing both mucus thickness and airway constriction.

Mechanism Steps

1
Guaifenesin action: Guaifenesin stimulates respiratory tract secretions, reducing mucus viscosity and increasing its volume, which facilitates expectoration.
2
Terbutaline binding: Terbutaline binds to beta-2 adrenergic receptors on bronchial smooth muscle cells, activating adenylate cyclase and increasing cyclic AMP.
3
Bronchodilation: Increased cyclic AMP leads to relaxation of bronchial smooth muscle, resulting in widened airways and improved airflow.
4
Combined effect: The combination of loosened mucus and dilated airways helps relieve cough and improve breathing.

💡 How to Take gracof br syrup

Strength: Liquid (syrup/suspension) containing guaifenesin and terbutaline. Exact strengths not specified in the provided identity.

1Shake the bottle well before each use.
2Measure the dose using the measuring cup or spoon provided with the medicine.
3Take the medicine orally, with or without food, as directed by your doctor.
4If it upsets your stomach, take it with a meal or snack.
5Do not exceed the prescribed dose.
6Drink a glass of water after taking the medicine.

Dosage Information

Adult DosageThe adult dosage of this medicine is individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and severity of symptoms. Typically, it is taken 2 to 3 times a day, but the exact dose and frequency must be determined by your doctor. Do not self-medicate or adjust the dose without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the cardiovascular effects of terbutaline. Dose should be individualized by a clinician, and caution is advised.
Renal ImpairmentDose adjustment may be needed in patients with renal impairment. Consult your doctor.
Hepatic ImpairmentDose adjustment may be needed in patients with hepatic impairment. Consult your doctor.
Maximum Daily DoseNot established from the available information. Follow your doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Caffeine
Avoid or limit
May increase nervousness and rapid heart rate.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of gracof br syrup

✅ Common Side Effects

Nervousness (Common (5-10%))
Usually resolves on its own. If persistent or bothersome, consult your doctor.
Tremor (Common (5-10%))
Avoid caffeine and consult your doctor if tremor interferes with daily activities.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Increased heart rate (Common (5-10%))
Monitor your pulse. If persistent or accompanied by chest pain, seek medical attention.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face, lips, tongue, or throat, or difficulty breathing.
Irregular heartbeat (arrhythmia) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, dizziness, or fainting.
Chest pain (Rare (<0.1%))
Stop the medicine and seek emergency care if you experience chest pain.
Seizures (Rare (<0.1%))
Seek immediate medical attention if seizures occur.

⚠️ Rare Side Effects

Hypokalemia (low potassium)
Report muscle weakness or cramps to your doctor.
Hyperglycemia
Monitor blood sugar if diabetic; consult doctor if levels rise.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
MAOIs Major
Tricyclic antidepressants Major
Furosemide Moderate
Digoxin Moderate
Corticosteroids Moderate
Caffeine Moderate
Ipratropium Minor

🚨 Major Interactions

  • Beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Digoxin
  • Corticosteroids

🍷 Alcohol Interaction

Alcohol may increase the central nervous system side effects such as dizziness and drowsiness, and may also increase the risk of gastrointestinal upset. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to guaifenesin, terbutaline, or any component of the formulation","Severe cardiac disease or arrhythmias","Uncontrolled hypertension","Hyperthyroidism","Diabetes mellitus (relative)","Seizure disorders (relative)"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease, including coronary insufficiency, arrhythmias, and hypertension.","May cause tremor, nervousness, or restlessness; avoid driving or operating machinery if affected.","Not recommended for patients with a history of seizures.","Use with caution in patients with diabetes, as terbutaline may increase blood glucose.","Use with caution in patients with hyperthyroidism.","Do not exceed recommended dose; excessive use may cause cardiac effects.","Not for long-term use without medical supervision."]

🤱 Lactation Safety

It is not known whether guaifenesin and terbutaline pass into breast milk. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe tachycardia, tremor, nervousness, seizures, and cardiac arrest. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase the dose or frequency without medical advice. Shake the bottle well before each use if it is a suspension. Measure the dose with a proper measuring cup or spoon, not a household spoon. Avoid driving or operating heavy machinery if you feel dizzy, nervous, or shaky after taking this medicine. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid problems, or seizures before using this medicine. Do not use this medicine for a longer period than recommended without consulting your doctor. Keep out of reach of children. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not share this medicine with others, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to experience cardiovascular side effects such as increased heart rate, palpitations, and changes in blood pressure. They may also be more sensitive to tremor and nervousness. Dose adjustment and close monitoring are advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established, and it should only be used if clearly needed and prescribed by a doctor.

🏥 Post-Surgery Considerations

If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine, as it can affect heart rate and blood pressure. It may need to be temporarily stopped before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure, as it can cause dry mouth and may interact with certain medications used in dentistry.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to add moisture to the air.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Practice good hand hygiene to prevent infections.
🌞
Avoid caffeine as it can worsen side effects like tremor and rapid heart rate.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you experience tremor, dizziness, or rapid heart rate. Light activity like walking may be fine, but listen to your body and rest if you feel unwell.

🥗 Diet Recommendations

Drink plenty of fluids, especially water and warm liquids.
Include honey and ginger in warm tea to soothe the throat.
Avoid cold drinks and ice cream which can worsen cough.
Eat light, nutritious meals.
Avoid spicy and oily foods that may irritate the throat.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, nervousness, or tremor, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to take it when you can rest if needed. Inform your employer if your job involves operating heavy machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop suddenly if you have been taking it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use of terbutaline may lead to tolerance, increased heart rate, and other cardiovascular effects. Guaifenesin is generally safe for short-term use. Regular monitoring of heart rate, blood pressure, and potassium levels may be required if used for extended periods. Always consult your doctor before using this medicine for more than a few days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and soothe airways.

Evidence: Well-established for symptom relief
Saline nasal irrigation

Can help clear nasal congestion and post-nasal drip.

Evidence: Moderate
Honey and warm fluids

Soothes the throat and may reduce cough.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are due for a vaccination, inform your healthcare provider that you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs or to a healthcare provider. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, continue taking your doses at the same intervals as prescribed, but adjust to local time gradually. Always pack it in your carry-on luggage to avoid loss or temperature extremes.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis and thick mucus
He was prescribed this medicine for a productive cough. After taking it as directed for 5 days, he noticed his cough became more productive and easier to clear. He experienced mild tremor initially, which subsided after a few days. He was advised to avoid caffeine, which helped reduce the tremor.
💡 Lesson: Taking the medicine as prescribed and avoiding caffeine can improve tolerability and effectiveness.
👤 A 60-year-old woman with COPD and mucus hypersecretion
She was given this medicine as an add-on to her regular inhalers. She reported improved breathing and easier expectoration. However, she experienced palpitations, and her doctor reduced the dose. She was monitored closely and advised to report any chest discomfort immediately.
💡 Lesson: Elderly patients may be more sensitive to cardiac side effects and require dose adjustment and monitoring.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Terbutaline starts working within 30 minutes to help open airways, while guaifenesin may take 1-2 hours to loosen mucus. You may notice easier coughing within a few hours.

Q: Can I take this medicine with other cough syrups?

A: No, you should not take other cough syrups without consulting your doctor, as they may contain overlapping ingredients and increase the risk of side effects.

Q: Is it safe to take during pregnancy?

A: The safety of this medicine during pregnancy is not well established. Consult your doctor before taking it if you are pregnant or planning to become pregnant.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for gracof br syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with mucus and bronchospasm. It is not effective for dry cough or other types.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This medicine contains terbutaline, which can cause serious cardiovascular effects. It should only be taken under medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Guaifenesin + Terbutaline oral liquid

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Guaifenesin + Terbutaline)","composition":"Guaifenesin + Terbutaline","uses":"Productive cough with bronchospasm","notes":"Combines expectorant and bronchodilator."},{"medicine":"Guaifenesin + Salbutamol","composition":"Guaifenesin + Salbutamol","uses":"Productive cough with bronchospasm","notes":"Salbutamol is a shorter-acting beta-2 agonist."},{"medicine":"Guaifenesin + Ambroxol","composition":"Guaifenesin + Ambroxol","uses":"Productive cough with thick mucus","notes":"Ambroxol is a mucolytic; no bronchodilator."}]

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