Terbinaforce Plus Nf Cream: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe burning, blistering, or swelling at the application site
- Signs of a serious allergic reaction such as swelling of the face, lips, or throat, or difficulty breathing
- Increasing pain, heat, pus, or foul smell from the treated area
- Rash that spreads rapidly or does not improve after 2 weeks
- Unusual tiredness, dizziness, weakness, or nausea after long-term use
- Yellowing of the skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is gracederm cream used for?
This medicine is a topical cream that combines clotrimazole, an antifungal, with clobetasol, a strong steroid. It is used for inflamed fungal skin infections such as ringworm and jock itch. Apply a thin film only as prescribed, usually for short periods, and do not use it on the face or groin unless your doctor tells you to.
- Generic Name: Clotrimazole (1% w/w) + Clobetasol (0.05% w/w)
- Manufacturer: Glenmark Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 gracederm cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें क्लोट्रिमाज़ोल और क्लोबेटासोल होते हैं। यह फंगल संक्रमण जैसे दाद, खुजली और पैरों के फंगस के कारण होने वाली सूजन और लालिमा के इलाज के लिए इस्तेमाल की जाती है। इसे डॉक्टर के बताए अनुसार ही लगाएं और बिना पूछे चेहरे या जांघों पर न लगाएं।
साइड इफेक्ट्स: इस क्रीम को लगाने पर कुछ लोगों को हल्की जलन, खुजली, सूखापन या लालिमा हो सकती है। लंबे समय तक इस्तेमाल करने से त्वचा पतली हो सकती है और निशान पड़ सकते हैं। अगर त्वचा पर गंभीर जलन, सूजन या संक्रमण दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस क्रीम को सिर्फ प्रभावित जगह पर पतली परत में लगाएं। आंखों, मुंह और शरीर के अन्य नाजुक हिस्सों से दूर रखें। डॉक्टर की सलाह के बिना इसे लंबे समय तक इस्तेमाल न करें। गर्भवती महिलाएं और स्तनपान कराने वाली महिलाएं इस्तेमाल से पहले डॉक्टर से सलाह लें।
💊 gracederm cream Uses & Benefits
[{"condition":"Tinea corporis with inflammation","description":"Treats ringworm of the body when the rash is red, swollen, and itchy, by killing the fungus and reducing inflammation.","evidence":"Well-established"},{"condition":"Tinea cruris with inflammation","description":"Used for jock itch with marked redness and itching, but only for short periods and not as first-line routine therapy.","evidence":"Established"},{"condition":"Tinea pedis with inflammation","description":"Helps athlete's foot with significant inflammation, itching, and scaling when prescribed by a clinician.","evidence":"Established"},{"condition":"Cutaneous candidiasis with inflammation","description":"May be used for inflamed yeast infections of the skin folds when confirmed by a clinician.","evidence":"Limited"}]
Off-label uses: [{"condition":"Inflammatory dermatophytosis unresponsive to plain antifungals","description":"Sometimes prescribed for short courses when a fungal infection is highly inflamed, but this practice is debated because steroids can mask worsening infection.","evidence":"Limited"}]
Primary treatment for: Inflammatory fungal skin infections
Also treats: Tinea corporis, Tinea cruris, Tinea pedis, Cutaneous candidiasis
📋 Drug Information
| Generic Name(s) | Clotrimazole (1% w/w) + Clobetasol (0.05% w/w) |
| Brand Name | gracederm cream |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | |
| Route of Administration | Topical |
| Storage | Store at room temperature between 15°C and 30°C. Keep the tube tightly closed and away from direct sunlight and moisture. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. Topical corticosteroid-antifungal combinations are generally not recommended as first-line therapy for uncomplicated fungal infections by major guidelines. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary actions. Clotrimazole blocks the fungal enzyme lanosterol 14-alpha-demethylase, which prevents the fungus from making ergosterol, a key component of its cell membrane. Without ergosterol, the fungal cell membrane becomes leaky and the fungus dies. Clobetasol binds to glucocorticoid receptors inside skin cells and reduces the release of inflammatory chemicals, which quickly calms redness, swelling, and itching. Together, the antifungal clears the infection while the steroid controls the inflammatory response.
Mechanism Steps
💡 How to Take gracederm cream
Strength: Cream containing clotrimazole 1% w/w and clobetasol 0.05% w/w.
Dosage Information
| Adult Dosage | Apply a thin film of this medicine to the affected skin and surrounding area once or twice daily, or exactly as prescribed by your doctor. The duration of treatment depends on the type and severity of the fungal infection, and it is usually limited to 1 to 4 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use more than the prescribed amount or for longer than advised. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is generally not recommended for children under 12 years unless specifically prescribed by a doctor. |
| Elderly Dosage | Older adults may have thinner skin and are more prone to steroid side effects. Use the smallest effective amount for the shortest possible time, and follow your doctor's instructions closely. |
| Renal Impairment | No dose adjustment is usually needed for topical use. Use with caution in severe kidney disease and follow your doctor's advice. |
| Hepatic Impairment | No dose adjustment is usually needed for topical use. Use with caution in severe liver disease and follow your doctor's advice. |
| Maximum Daily Dose | The maximum daily dose depends on the area treated and the prescription. Do not exceed the amount and frequency recommended by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of gracederm cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other topical corticosteroids | Major | |
| CYP3A4 inhibitors | Major | |
| Topical retinoids | Moderate | |
| Exfoliating acids | Moderate | |
| Moisturizers | Minor |
🚨 Major Interactions
- Other topical corticosteroids
- CYP3A4 inhibitors such as ritonavir and ketoconazole
⚡ Moderate Interactions
- Nystatin or other topical antifungals
- Topical retinoids or exfoliating acids
🍷 Alcohol Interaction
Alcohol does not directly interact with this topical cream. However, alcohol can worsen inflammation and may delay healing of skin infections, so it is best to limit alcohol while you recover.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to clotrimazole, clobetasol, or any ingredient in the cream","Untreated bacterial, viral, or parasitic skin infections","Acne, rosacea, or perioral dermatitis","Use on the face, groin, or underarms unless specifically prescribed","Use in children under 12 years unless directed by a doctor","Use on broken skin or open wounds unless prescribed"]
⚠️ Warnings & Precautions
["Do not use this cream for more than the recommended duration without medical review.","Avoid using it on large areas of the body for long periods.","Do not cover the treated area with tight bandages or dressings unless your doctor tells you to.","Stop using the cream and consult your doctor if the infection worsens or does not improve.","Keep the cream away from the eyes, mouth, and other mucous membranes.","Do not use this medicine to treat diaper rash unless specifically prescribed.","Use with caution in people with diabetes, immune suppression, or liver disease.","Do not share this cream with others."]
🤱 Lactation Safety
Clotrimazole is considered compatible with breastfeeding when applied to small areas away from the breast. Clobetasol should be used with caution, and the cream should not be applied to the breast area before feeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Topical overdose is unlikely because the cream is applied to the skin. If someone swallows the cream, seek medical help immediately. Long-term excessive use over large areas can cause systemic steroid effects such as adrenal suppression. Treatment is supportive, and a doctor may need to check adrenal function.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double amount to make up for a missed dose.
Additional Safety Advice
Apply a thin film to the affected area only, and gently rub it in as directed by your doctor. Wash your hands before and after application unless your hands are the treated area. Do not cover the area with tight bandages or dressings unless your doctor specifically tells you to do so. Avoid contact with the eyes, mouth, and other mucous membranes. Do not use this medicine for more than the recommended duration without medical review. Do not share this cream with others, even if they have similar symptoms. Keep it out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before using this medicine. Do not use it on broken skin or open wounds unless prescribed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults have thinner skin and are more likely to experience skin thinning and other steroid side effects. Use the smallest effective amount for the shortest possible time, and follow your doctor's instructions closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Topical clotrimazole is generally considered acceptable, but clobetasol should be used only if clearly needed and for short periods.
🏥 Post-Surgery Considerations
Do not apply this cream to surgical wounds or broken skin unless your doctor specifically tells you to. It can delay wound healing and increase the risk of infection.
🦷 Dental Procedures
This cream is for skin use only and does not affect dental procedures. Inform your dentist about all medicines you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can usually exercise while using this cream, but avoid activities that cause heavy sweating or friction on the treated area. Shower and dry the area well after exercise, and reapply the cream if your doctor has advised a dose at that time.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This cream is applied to the skin and is unlikely to affect your ability to drive or operate machinery. However, if you feel dizzy or unwell for any reason, avoid driving until you feel better. You can continue your usual work activities unless your doctor advises otherwise.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if the infection does not improve after 2 weeks, if it worsens, or if you develop severe irritation, blistering, or signs of a secondary infection. Do not stop early just because symptoms improve, as the infection may return.
📅 Long-Term Use Effects
Long-term use of this medicine can cause skin thinning, stretch marks, visible blood vessels, increased hair growth, and changes in skin color. It can also increase the risk of adrenal suppression if used on large areas for a long time. Regular medical review is needed if prolonged use is unavoidable.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Clotrimazole or terbinafine cream without a steroid may be enough for uncomplicated fungal infections.
Evidence: Well-establishedGood hygiene helps prevent and treat fungal infections.
Evidence: Well-establishedMay be needed for extensive or resistant infections, prescribed by a doctor.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known vaccine interactions with this topical cream. You can receive vaccines as scheduled while using this medicine.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep the tube tightly closed
❌ DON'T
Do not leave the cap off
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
Carry this cream in its original packaging with the prescription label visible. Keep a copy of your prescription with you, especially when traveling internationally. Store it at room temperature and protect it from direct sunlight and extreme heat. If you are crossing time zones, continue applying the cream at your usual times as closely as possible. Declare it to customs if required and keep it in your hand luggage for easy access.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Itching and redness may start improving within a few days. The full antifungal effect usually takes 1 to 4 weeks depending on the infection.
A: No, you should not use this cream on your face unless your doctor specifically tells you to. It can cause skin thinning and other side effects.
A: Topical clotrimazole is generally considered acceptable in pregnancy, but clobetasol is a strong steroid and should be used only for short courses on small areas after consulting your doctor.
A: Stopping suddenly is not dangerous, but if the infection is not fully treated, it may come back. Finish the course as prescribed.
A: No, this cream is only for specific fungal infections with inflammation. Using it on other rashes can make them worse.
🤔 Common Patient Concerns
🔄 Substitutes for gracederm cream
View AllAlternative brands with exact same active ingredient:
-
mixderm creamMDC Pharmaceuticals Pvt Ltd ₹21.68 45.3% CHEAPER
-
clojohn-gm creamJohnlee Pharmaceuticals Pvt Ltd ₹31.91 19.6% CHEAPER
-
cortaz nc ointmentTorrent Pharmaceuticals Ltd ₹40.00 0.8% COSTLIER
-
ring-out plus creamMankind Pharma Ltd ₹46.88 18.2% COSTLIER
-
terbinaforce lite creamMankind Pharma Ltd ₹48.75 22.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any rash.
Fact: This medicine is only for specific fungal infections with inflammation. Using it on other rashes can make them worse. - Myth: More cream means faster healing.
Fact: Applying more than prescribed can increase side effects such as skin thinning without improving results. - Myth: It is safe to use for months.
Fact: Prolonged use of strong steroid creams can damage the skin and mask worsening infection. - Myth: Once the itching stops, the infection is gone.
Fact: The infection may still be present even when symptoms improve. Finish the course as prescribed.
🔄 Alternative Options
Generic Alternatives
- Clotrimazole 1% w/w + Clobetasol 0.05% w/w cream