Medroxyprogesterone Acetate 150 mg/mL Injectable Contraceptive: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, tongue, or throat, difficulty breathing, or severe rash.
- Blood clots: sudden shortness of breath, chest pain, or swelling and pain in one leg.
- Severe depression or suicidal thoughts.
- Jaundice: yellowing of skin or eyes, dark urine, or severe abdominal pain.
- Sudden vision changes or loss of vision.
- Severe headache with visual disturbances or confusion.
- Heavy vaginal bleeding that soaks through a pad every hour for several hours.
If experiencing severe symptoms, call emergency services immediately.
What is freedom inject contraceptive injection used for?
This medicine is a long-acting injectable contraceptive containing medroxyprogesterone acetate 150 mg/mL. It is given as a deep intramuscular injection every 12 to 13 weeks to prevent pregnancy by stopping ovulation. It is highly effective but does not protect against sexually transmitted infections.
- Generic Name: Medroxyprogesterone acetate (150mg/ml)
- Manufacturer: PSI India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 freedom inject contraceptive injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक दीर्घकालिक गर्भनिरोधक इंजेक्शन है जिसमें मेड्रोक्सीप्रोजेस्टेरोन एसीटेट 150 मिलीग्राम/मिलीलीटर होता है। इसे हर 12 से 13 सप्ताह में एक बार गहरे इंट्रामस्कुलर इंजेक्शन के रूप में दिया जाता है। यह गर्भावस्था को रोकने के लिए ओव्यूलेशन को रोकता है। यह महिलाओं के लिए एक प्रभावी और प्रतिवर्ती गर्भनिरोधक विकल्प है। यह एसटीआई से सुरक्षा नहीं देता, इसलिए कंडोम का उपयोग करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में अनियमित योनि रक्तस्राव, वजन बढ़ना, सिरदर्द, स्तन में कोमलता, मूड में बदलाव और पेट में असुविधा शामिल हैं। कुछ महिलाओं में मासिक धर्म बंद हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, रक्त के थक्के और दीर्घकालिक उपयोग से हड्डियों के घनत्व में कमी शामिल हो सकती है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। स्वयं इंजेक्शन न लगाएं। हर 12 से 13 सप्ताह में अपना इंजेक्शन समय पर लगवाएं। यदि आप 2 सप्ताह से अधिक देर कर देती हैं, तो गर्भावस्था परीक्षण करें और बैकअप गर्भनिरोधक का उपयोग करें। धूम्रपान से बचें क्योंकि इससे हृदय संबंधी जोखिम बढ़ सकता है। स्तन कैंसर, यकृत रोग या रक्त के थक्के की history हो तो डॉक्टर को बताएं।
💊 freedom inject contraceptive injection Uses & Benefits
- [{"condition":"Contraception","description":"Prevents pregnancy by inhibiting ovulation, thickening cervical mucus, and thinning the endometrial lining.
- It is a reversible, long-acting injectable method given every 12 to 13 weeks.","evidence":"Well-established"},{"condition":"Endometriosis","description":"Sometimes used off-label to reduce pain and suppress endometrial growth by inducing amenorrhea.","evidence":"Limited"},{"condition":"Abnormal uterine bleeding","description":"May be used off-label to control heavy or irregular bleeding in selected patients after other causes are ruled out.","evidence":"Limited"}]
Off-label uses: [{"condition":"Endometrial hyperplasia","description":"Occasionally prescribed to reduce endometrial proliferation in women who cannot take other progestins.","evidence":"Limited"},{"condition":"Catamenial epilepsy","description":"Rarely used to reduce seizure frequency linked to menstrual cycles.","evidence":"Limited"}]
Primary treatment for: Prevention of pregnancy
Also treats: Endometriosis, Abnormal uterine bleeding
📋 Drug Information
| Generic Name(s) | Medroxyprogesterone acetate (150mg/ml) |
| Brand Name | freedom inject contraceptive injection |
| Manufacturer | PSI India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Progestins (First generation) |
| Route of Administration | Parenteral (deep intramuscular injection) |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and freezing. Do not refrigerate. Keep out of reach of children. |
| Shelf Life | Refer to the packaging for the expiry date. Do not use after the expiry date. |
| WHO Guideline | The World Health Organization recognizes medroxyprogesterone acetate injectable as a safe and effective contraceptive method for most women. It is included in the WHO Model List of Essential Medicines. WHO guidelines support its use with counseling about side effects and return to fertility. |
| ICMR Guideline | The Indian Council of Medical Research has included injectable contraceptives in the national family planning program. ICMR guidelines recommend proper counseling about side effects, especially irregular bleeding, and regular follow-up every 3 months. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by delivering a synthetic progestin, medroxyprogesterone acetate, which acts on the hypothalamus and pituitary to suppress the mid-cycle surge of luteinizing hormone. Without this surge, ovulation does not occur. It also thickens the cervical mucus, making it difficult for sperm to pass through, and causes the uterine lining to become thin and unsuitable for implantation. These combined actions provide highly effective contraception when the injection is given on schedule.
Mechanism Steps
💡 How to Take freedom inject contraceptive injection
Strength: Injectable suspension: 150 mg/mL (1 mL prefilled syringe or vial)
Dosage Information
| Adult Dosage | The standard adult dose of this medicine is 150 mg (1 mL of the 150 mg/mL suspension) given as a deep intramuscular injection every 12 to 13 weeks (about 3 months). The first injection should be given within the first 5 days of the menstrual cycle to ensure immediate contraceptive protection. If given at other times, use backup contraception for 7 days. Dose must be individualized by a qualified clinician based on your medical history and needs. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or adolescent health specialist for guidance. This medicine is not recommended for use before menarche. |
| Elderly Dosage | This medicine is not intended for use in postmenopausal women for contraception. Safety and effectiveness in women over 65 years have not been established. Consult a doctor for appropriate contraceptive options. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution and consult your doctor for individualized advice. |
| Hepatic Impairment | This medicine is contraindicated in severe liver disease. In mild to moderate liver impairment, use with caution and only after consulting a doctor. Dose adjustment may be necessary based on clinical judgment. |
| Maximum Daily Dose | Not applicable. This medicine is given as a single injection every 12 to 13 weeks. The maximum recommended frequency is one 150 mg injection every 12 weeks. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of freedom inject contraceptive injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| St. John's wort | Major | |
| Aminoglutethimide | Major | |
| Warfarin | Moderate | |
| Insulin | Moderate | |
| Oral antidiabetics | Moderate | |
| Corticosteroids | Moderate | |
| Paracetamol | Minor |
🚨 Major Interactions
- Aminoglutethimide
- Rifampicin
- Carbamazepine
- Phenytoin
- St. John's wort
⚡ Moderate Interactions
- Warfarin
- Insulin and oral antidiabetics
- Corticosteroids
🍷 Alcohol Interaction
Alcohol does not directly interact with this medicine, but heavy drinking can increase the risk of liver problems and may worsen mood changes. It is advisable to limit alcohol intake while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known or suspected pregnancy","Unexplained vaginal bleeding","Known or suspected breast cancer","Severe liver disease","History of blood clots in the legs, lungs, or eyes","Known hypersensitivity to medroxyprogesterone acetate or any component of the formulation"]
⚠️ Warnings & Precautions
["This medicine must be administered by a healthcare professional only.","It does not protect against sexually transmitted infections, including HIV.","Use with caution in women with a history of depression.","May cause bone mineral density loss with long-term use, especially in adolescents.","Return to fertility may be delayed by up to 6 to 12 months after stopping.","Avoid smoking while using this medicine to reduce cardiovascular risk.","Inform your doctor if you have diabetes, as it may affect blood sugar control.","Do not use if you have a history of breast cancer or liver disease."]
🤱 Lactation Safety
This medicine is considered safe for use during breastfeeding. Small amounts of medroxyprogesterone acetate are excreted in breast milk, but no harmful effects on the infant have been established. It may be started as early as 6 weeks after delivery. Consult your doctor for personalized advice.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given as a single injection by a healthcare professional. If an excessive dose is accidentally administered, monitor the patient for signs of hormonal excess such as nausea, vomiting, or vaginal bleeding. Treatment is supportive and symptomatic. There is no specific antidote. Contact a poison control center or emergency department if you suspect an overdose.
⏰ Missed Dose
If you miss your scheduled injection, take a pregnancy test to rule out pregnancy. If the test is negative, you can receive the injection and use backup contraception for the next 7 days. If more than 13 weeks have passed since your last injection, you may need to use backup contraception for 7 days after the next injection. Consult your healthcare provider for personalized advice.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional as a deep intramuscular injection. Do not attempt to self-administer. Keep your appointment every 12 to 13 weeks; if you are late by more than two weeks, use backup contraception and take a pregnancy test. This medicine does not protect against HIV or other sexually transmitted infections, so use condoms consistently. Inform your doctor if you have a history of breast cancer, liver disease, blood clots, or unexplained vaginal bleeding. Avoid smoking while using this medicine, as it increases the risk of cardiovascular events. If you plan to become pregnant, stop the injection and be aware that return to fertility may take up to 6 to 12 months after the last dose. Regular monitoring of blood pressure and bone health may be advised for long-term users. Do not share this medicine with anyone else.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in postmenopausal women for contraception. Safety and effectiveness in women over 65 years have not been established. Elderly women should consult their doctor for appropriate health management.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, stop this medicine and be aware that return to fertility may take up to 6 to 12 months after the last injection. Use alternative contraception until you are ready to conceive. Consult your doctor for preconception counseling and to discuss any potential risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are using this medicine before any surgery. There is a potential risk of blood clots after surgery, especially if you have other risk factors. Your doctor may advise temporary discontinuation or alternative contraception around the time of surgery.
🦷 Dental Procedures
This medicine does not typically interfere with dental procedures. However, inform your dentist about all medications you are taking. If you are due for your injection around the time of a dental procedure, there is no need to reschedule unless your doctor advises otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is encouraged while using this medicine. Weight-bearing exercises such as walking, jogging, and strength training can help maintain bone mineral density. However, if you experience dizziness or fatigue after the injection, avoid strenuous activities until you feel better. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine generally does not affect your ability to work or perform daily activities. Some women may experience dizziness or fatigue after the injection, so avoid driving or operating heavy machinery until you know how it affects you. The injection is given every 3 months, so it has minimal impact on your daily routine compared to daily pills. You can continue your normal work and social activities.
🛑 When to Stop This Medicine
You should stop this medicine if you decide to become pregnant, if you experience serious side effects such as blood clots or severe allergic reactions, or if your doctor advises discontinuation due to health concerns. Do not stop without consulting your healthcare provider, as you may need alternative contraception. If you plan to stop, discuss the timing with your doctor to ensure a smooth transition and to understand the delayed return to fertility.
📅 Long-Term Use Effects
Long-term use of this medicine, especially for more than 2 years, may lead to a decrease in bone mineral density. This effect may not be completely reversible after stopping the injection. Regular monitoring of bone health may be advised, particularly for adolescents and women with risk factors for osteoporosis. Other long-term effects may include persistent amenorrhea and delayed return to fertility. Regular follow-up with your healthcare provider is important to assess the risks and benefits of continued use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A daily pill containing estrogen and progestin or progestin-only. Requires daily adherence but has a quicker return to fertility.
Evidence: Well-establishedA small rod placed under the skin of the upper arm that releases progestin for up to 3 years.
Evidence: Well-establishedA small device placed in the uterus that provides long-term contraception for 3 to 10 years, depending on the type.
Evidence: Well-establishedCondoms and diaphragms provide protection against pregnancy and, in the case of condoms, against sexually transmitted infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as recommended by your healthcare provider. However, if you are receiving live vaccines, inform your doctor about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate or freeze.
✅ DO
Keep in the original container or packaging.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Protect from direct sunlight.
❌ DON'T
Do not store in bathroom cabinets or near heat sources.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging with the prescription label. Keep a copy of your prescription with you. This medicine is given by a healthcare professional, so plan your travel around your injection schedule. If you will be away when your next injection is due, arrange to receive it at a clinic at your destination. Store the medicine at room temperature, away from direct sunlight and extreme temperatures. Do not freeze. If you are crossing time zones, the injection schedule remains the same; no adjustment is needed. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: If given within the first 5 days of your menstrual cycle, it works immediately. If given at other times, use backup contraception for 7 days.
A: Common side effects include irregular vaginal bleeding, weight gain, headaches, breast tenderness, and mood changes. These usually improve with continued use.
A: You need one injection every 12 to 13 weeks (about 3 months) to maintain contraceptive protection.
A: Yes, but return to fertility may be delayed by up to 6 to 12 months after your last injection. Plan ahead if you wish to conceive.
A: No, this medicine does not protect against HIV or other sexually transmitted infections. Use condoms for protection.
A: Yes, this medicine is considered safe during breastfeeding. It may be started as early as 6 weeks after delivery.
🤔 Common Patient Concerns
🔄 Substitutes for freedom inject contraceptive injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine causes permanent infertility.
Fact: This medicine does not cause permanent infertility. However, return to fertility may be delayed by up to 6 to 12 months after the last injection. - Myth: This medicine is only for women who have already had children.
Fact: This medicine can be used by any woman of reproductive age who is medically eligible, including those who have not had children. - Myth: This medicine protects against sexually transmitted infections.
Fact: This medicine does not protect against HIV or other sexually transmitted infections. Use condoms for protection. - Myth: This medicine causes abortion.
Fact: This medicine is a contraceptive and does not cause abortion. It prevents pregnancy from occurring.
🔄 Alternative Options
Generic Alternatives
- Medroxyprogesterone acetate injection
Brand Alternatives
- Depo-Provera
- Depo-Provera CI