Flexital 400mg Tablet (Pentoxifylline): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Irregular heartbeat or palpitations
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is flexital 400mg tablet used for?
This medicine is a prescription oral tablet containing Pentoxifylline 400 mg. It is used to improve blood flow in patients with peripheral arterial disease, reducing leg pain and improving walking distance. It works by making red blood cells more flexible and reducing blood viscosity.
- Generic Name: Pentoxifylline (400mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 flexital 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेंटोक्सिफिलिन 400 मिलीग्राम की एक प्रिस्क्रिप्शन टैबलेट है। इसका उपयोग पेरिफेरल आर्टरी डिजीज के कारण होने वाले इंटरमिटेंट क्लॉडिकेशन (चलने पर पैरों में दर्द) के इलाज के लिए किया जाता है। यह रक्त के प्रवाह को बेहतर बनाती है, जिससे पैरों में दर्द कम होता है और चलने की दूरी बढ़ती है। यह दवा रक्त की चिपचिपाहट को कम करती है और लाल रक्त कोशिकाओं को अधिक लचीला बनाती है। यह दवा डॉक्टर के परामर्श के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, चक्कर आना, सिरदर्द और चेहरे पर लालिमा शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। दवा को भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको गंभीर एलर्जी, रक्तस्राव, या अनियमित दिल की धड़कन महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से यदि आपको रक्तस्राव विकार, हाल ही में स्ट्रोक, दिल का दौरा, गुर्दे या यकृत की बीमारी, या निम्न रक्तचाप है। यह दवा रक्तस्राव का खतरा बढ़ा सकती है, इसलिए यदि आप रक्त पतला करने वाली दवाएं ले रहे हैं तो अपने डॉक्टर को बताएं। इस दवा के साथ शराब का सेवन न करें। जब तक आपको पता न चले कि यह दवा आपको कैसे प्रभावित करती है, तब तक वाहन न चलाएं। दवा को भोजन के साथ लें। टैबलेट को चबाएं या तोड़ें नहीं, पूरा निगल लें।
💊 flexital 400mg tablet Uses & Benefits
[{"condition":"Intermittent claudication","description":"This medicine is used to improve walking distance and reduce leg pain in patients with peripheral arterial disease.","evidence":"Well-established"},{"condition":"Peripheral arterial disease","description":"It helps improve blood flow to the limbs by reducing blood viscosity and improving red blood cell flexibility.","evidence":"Well-established"},{"condition":"Cerebrovascular insufficiency","description":"Sometimes used to improve blood flow in patients with certain cerebrovascular conditions, though evidence is more limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Venous ulcers","description":"Pentoxifylline may be used off-label to help heal venous leg ulcers, often in combination with compression therapy.","evidence":"Moderate"},{"condition":"Diabetic neuropathy","description":"Some studies suggest benefit in improving symptoms of diabetic peripheral neuropathy, but evidence is not conclusive.","evidence":"Limited"},{"condition":"Alcoholic hepatitis","description":"Off-label use to reduce inflammation in alcoholic hepatitis has been studied, but results are mixed.","evidence":"Limited"}]
Primary treatment for: Intermittent claudication
Also treats: Peripheral arterial disease, Cerebrovascular insufficiency, Venous ulcers
📋 Drug Information
| Generic Name(s) | Pentoxifylline (400mg) |
| Brand Name | flexital 400mg tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Rheologic modifier |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Pentoxifylline is a methylxanthine derivative that improves blood flow by increasing the deformability of red blood cells, reducing blood viscosity, and inhibiting platelet aggregation. It also has anti-inflammatory effects by inhibiting the production of tumor necrosis factor-alpha (TNF-alpha) and other cytokines. These actions collectively enhance microcirculation and tissue oxygenation, which is particularly beneficial in conditions like intermittent claudication.
Mechanism Steps
💡 How to Take flexital 400mg tablet
Strength: Pentoxifylline 400 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400 mg (one tablet) taken orally three times a day with meals. The dose may be adjusted by your doctor based on your response and tolerability. It is important to take this medicine exactly as prescribed. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, particularly dizziness and cardiovascular effects. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, dose adjustment may be necessary. For patients with creatinine clearance less than 30 mL/min, a lower dose may be recommended. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, dose adjustment may be necessary. Use with caution and monitor liver function tests. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 1200 mg (400 mg three times a day). Do not exceed this dose unless directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of flexital 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| Theophylline | Major | |
| Cimetidine | Moderate | |
| Erythromycin | Moderate | |
| Ketoconazole | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- Theophylline
⚡ Moderate Interactions
- Cimetidine
- Erythromycin
- Ketoconazole
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness, drowsiness, and bleeding when taken with this medicine. It is advisable to avoid or limit alcohol consumption while on this medication.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to pentoxifylline or other methylxanthines (e.g., caffeine, theophylline)","Recent cerebral or retinal hemorrhage","Severe bleeding disorders","Active peptic ulcer disease","Severe cardiac arrhythmias","Recent myocardial infarction","Pregnancy (relative contraindication; use only if clearly needed)","Breastfeeding (relative contraindication; consider alternatives)"]
⚠️ Warnings & Precautions
["This medicine may increase the risk of bleeding. Use with caution in patients with bleeding disorders or those taking anticoagulants.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Use with caution in patients with low blood pressure or cardiovascular disease.","May cause nausea and vomiting; take with food to minimize gastrointestinal upset.","Dose adjustment may be needed in patients with renal or hepatic impairment.","Avoid alcohol while taking this medicine.","Do not crush, chew, or break the tablet; swallow it whole.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children.","Store at room temperature away from moisture and heat."]
🤱 Lactation Safety
Pentoxifylline is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose of pentoxifylline may cause symptoms such as nausea, vomiting, dizziness, flushing, hypotension, tachycardia, and seizures. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before taking this medicine, inform your doctor about all your medical conditions, especially if you have a history of bleeding disorders, recent stroke, heart attack, kidney or liver disease, or low blood pressure. This medicine can increase the risk of bleeding, so tell your doctor if you are taking anticoagulants or antiplatelet drugs. Avoid alcohol while taking this medicine as it may increase dizziness and the risk of bleeding. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause dizziness. Take this medicine exactly as prescribed, with meals to reduce stomach upset. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. Regular follow-up with your doctor is important to monitor your response and adjust treatment if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and cardiovascular effects. Dose adjustment may be necessary based on kidney function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is classified as Pregnancy Category C, and its use should be discussed with your healthcare provider to weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may increase the risk of bleeding during and after surgery. Your doctor may advise you to stop it temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may take precautions or consult your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While exercise is beneficial, start slowly and gradually increase your activity level. If you experience leg pain, stop and rest. Consult your doctor before starting any new exercise program, especially if you have heart or lung conditions.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue your usual work activities, but take precautions if you feel dizzy or lightheaded. Inform your employer if your job involves operating machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or if your doctor decides to discontinue it, follow their instructions. Stopping abruptly may cause your symptoms to return.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when taken as prescribed. However, regular monitoring of kidney and liver function may be advised, especially in patients with underlying conditions. It is important to have periodic follow-ups to assess the continued benefit and to watch for any rare side effects. Do not stop the medicine without consulting your doctor, as symptoms may return.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured walking program can improve symptoms of intermittent claudication.
Evidence: Well-establishedAnother medicine that can improve walking distance in peripheral arterial disease.
Evidence: Well-establishedProcedures to restore blood flow in severe cases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medication.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking the medicine at the same intervals as prescribed; you may need to adjust timing gradually. Check customs regulations for carrying prescription medicines in your destination country. Always carry enough supply for your trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 2 to 4 weeks of regular use to notice improvement in symptoms such as increased walking distance and reduced leg pain.
A: Yes, taking it with meals is recommended to reduce stomach upset.
A: Common side effects include nausea, dizziness, headache, and flushing. These are usually mild and temporary.
A: It may increase the risk of bleeding when taken with blood thinners. Inform your doctor if you are on such medications; close monitoring may be required.
🤔 Common Patient Concerns
🔄 Substitutes for flexital 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
rb flex 400mg tabletTorrent Pharmaceuticals Ltd ₹25.42 67.6% CHEAPER
-
flowpent 400mg tabletAbbott ₹26.08 66.8% CHEAPER
-
kinetal 400mg tabletCipla Ltd ₹26.22 66.6% CHEAPER
-
perital 400mg tabletPericles Pharma ₹70.31 10.4% CHEAPER
-
trental 400 tablet prSanofi India Ltd ₹85.68 9.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure peripheral arterial disease.
Fact: This medicine helps manage symptoms but does not cure the underlying disease. Lifestyle changes and other treatments are also important. - Myth: This medicine works immediately.
Fact: It may take 2 to 4 weeks of regular use to notice improvement in symptoms. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription medicine. It should only be taken under the supervision of a qualified healthcare provider.
🔄 Alternative Options
Generic Alternatives
- Pentoxifylline 400 mg tablet
Brand Alternatives
- Flexital 400 mg tablet