Auratrex 2.5mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Signs of infection (fever, chills, sore throat)
- New or worsening cough or shortness of breath
If experiencing severe symptoms, call emergency services immediately.
What is extrate 2.5mg tablet used for?
This medicine contains methotrexate, a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis, psoriasis, certain cancers, and other conditions. It works by suppressing the immune system and slowing cell growth. It must be taken exactly as prescribed, with regular blood tests to monitor for side effects.
- Generic Name: Methotrexate (2.5mg)
- Manufacturer: Zanetaz Medicorp
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 extrate 2.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेथोट्रेक्सेट नामक सक्रिय तत्व से बनी है और इसका उपयोग रूमेटॉइड गठिया, सोरायसिस, कुछ प्रकार के कैंसर और अन्य स्थितियों के इलाज के लिए किया जाता है। यह शरीर की प्रतिरक्षा प्रणाली को दबाकर और कोशिकाओं की वृद्धि को धीमा करके काम करती है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, भूख न लगना, मुंह के छाले, सिरदर्द और थकान शामिल हैं। गंभीर दुष्प्रभावों में हड्डी मज्जा का दमन, जिगर की क्षति, गुर्दे की क्षति, फेफड़ों की सूजन और गंभीर त्वचा प्रतिक्रियाएं शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर के पर्चे के अनुसार ही लें। खुराक खुद से न बदलें। नियमित रूप से रक्त परीक्षण करवाएं। शराब का सेवन पूरी तरह बंद कर दें। गर्भावस्था के दौरान इस दवा का सेवन न करें। डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। धूप से बचें और सनस्क्रीन का उपयोग करें।
💊 extrate 2.5mg tablet Uses & Benefits
[{"condition":"Rheumatoid arthritis","description":"Used to reduce joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and damage in adults with active rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Juvenile idiopathic arthritis","description":"Used to treat children with severe juvenile idiopathic arthritis who have not responded to other treatments.","evidence":"Well-established"},{"condition":"Psoriasis","description":"Used to treat severe psoriasis that has not responded to other therapies.","evidence":"Well-established"},{"condition":"Certain cancers","description":"Used in the treatment of various cancers including breast cancer, leukemia, lymphoma, and lung cancer.","evidence":"Well-established"},{"condition":"Ectopic pregnancy","description":"Used to treat early ectopic pregnancy in selected cases.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Crohn's disease","description":"Sometimes used to maintain remission in Crohn's disease.","evidence":"Limited"},{"condition":"Lupus","description":"Occasionally used to treat systemic lupus erythematosus.","evidence":"Limited"},{"condition":"Sarcoidosis","description":"May be used in some cases of sarcoidosis.","evidence":"Limited"}]
Primary treatment for: Rheumatoid arthritis
Also treats: Juvenile idiopathic arthritis, Psoriasis, Certain cancers, Ectopic pregnancy
📋 Drug Information
| Generic Name(s) | Methotrexate (2.5mg) |
| Brand Name | extrate 2.5mg tablet |
| Manufacturer | Zanetaz Medicorp |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolite- Methotrexate |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the enzyme dihydrofolate reductase, which is needed to make folate, a vitamin essential for cell growth and division. By blocking this enzyme, it interferes with the production of DNA and RNA, thereby slowing down the growth of rapidly dividing cells such as cancer cells and immune cells. In autoimmune diseases, this action helps to suppress the overactive immune system and reduce inflammation.
Mechanism Steps
💡 How to Take extrate 2.5mg tablet
Strength: 2.5 mg immediate-release tablet
Dosage Information
| Adult Dosage | The dose of this medicine varies widely depending on the condition being treated. For rheumatoid arthritis, the usual starting dose is 7.5 mg to 10 mg once weekly, which may be adjusted based on response and side effects. For psoriasis, similar weekly doses are used. For certain cancers, doses are much higher and are determined by a cancer specialist. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and liver toxicity. Doses may need to be reduced, and monitoring should be more frequent. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced or the medicine may be contraindicated. Close monitoring of kidney function is required. Consult a doctor for dose adjustments. |
| Hepatic Impairment | In patients with liver impairment, the dose of this medicine may need to be reduced or the medicine may be contraindicated. Regular monitoring of liver function is essential. Consult a doctor for dose adjustments. |
| Maximum Daily Dose | The maximum dose varies by indication and is determined by the prescribing doctor. For rheumatoid arthritis, the maximum weekly dose is typically 20-25 mg. For cancer, higher doses may be used under specialist supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of extrate 2.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| NSAIDs | Major | |
| Aspirin | Major | |
| Probenecid | Major | |
| Trimethoprim-sulfamethoxazole | Major | |
| Live vaccines | Major | |
| Corticosteroids | Moderate | |
| Phenytoin | Moderate | |
| Theophylline | Moderate | |
| Penicillins | Moderate | |
| Folic acid | Minor |
🚨 Major Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Aspirin
- Probenecid
- Trimethoprim-sulfamethoxazole
- Live vaccines
⚡ Moderate Interactions
- Corticosteroids
- Phenytoin
- Theophylline
- Penicillins
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine because it increases the risk of liver damage and can worsen side effects. Even moderate alcohol consumption can be harmful.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or planning to become pregnant","Breastfeeding","Severe liver disease","Severe kidney disease","Blood disorders such as bone marrow hypoplasia","Active infection","Known hypersensitivity to methotrexate"]
⚠️ Warnings & Precautions
["This medicine should only be used under the supervision of a qualified healthcare professional.","Regular blood tests are required to monitor for side effects.","Avoid alcohol completely.","Do not receive live vaccines during treatment.","Use effective contraception during treatment and for a period after stopping.","Avoid prolonged sun exposure and use sunscreen.","Report any signs of infection, bleeding, or unusual symptoms immediately.","Do not take NSAIDs or aspirin without consulting your doctor.","Inform your doctor about all other medicines you are taking.","This medicine may cause dizziness or fatigue; avoid driving or operating machinery if affected."]
🤱 Lactation Safety
This medicine is excreted in breast milk and can cause serious adverse reactions in a nursing infant. Breastfeeding is not recommended while taking this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, liver damage, and kidney damage. If you suspect an overdose, seek immediate medical attention. Treatment may include administration of leucovorin (folinic acid) to counteract the effects of methotrexate, along with supportive care and monitoring of blood counts and organ function.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Consult your doctor if you are unsure.
Additional Safety Advice
This medicine must only be taken exactly as prescribed by your doctor. Never adjust the dose on your own. You must have regular blood tests to check your blood counts, liver function, and kidney function. Avoid alcohol completely while taking this medicine, as it increases the risk of liver damage. Do not take this medicine if you are pregnant or planning to become pregnant, as it can cause birth defects. Both men and women should use effective contraception during treatment and for a period after stopping the medicine as advised by the doctor. Do not receive any live vaccines while taking this medicine. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. Avoid prolonged sun exposure and use sunscreen, as this medicine can make your skin more sensitive to sunlight. If you miss a dose, do not double the next dose; consult your doctor for guidance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and liver toxicity. Doses may need to be reduced, and monitoring should be more frequent.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. Women of childbearing potential must use effective contraception during treatment and for at least 6 months after stopping. Men should use effective contraception for at least 3 months after stopping. Consult your doctor if you are planning pregnancy.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped before surgery due to increased risk of bleeding and infection. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase the risk of bleeding and infection. Your dentist may recommend stopping the medicine temporarily before dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience fatigue or dizziness. Avoid strenuous exercise if you feel unwell. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities if you are affected. Take regular breaks and manage stress.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will decide when to stop based on your condition and response to treatment. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver damage, bone marrow suppression, and certain cancers. Regular monitoring of blood counts, liver function, and kidney function is essential. Your doctor will adjust the dose or stop the medicine if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedAnti-inflammatory diet may help manage symptoms.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Do not receive live vaccines while taking this medicine. Inactivated vaccines may be less effective. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 3 to 6 weeks to see improvement in rheumatoid arthritis, with full effects after 3 to 6 months. For cancer, effects may be seen within days to weeks.
A: No, this medicine is contraindicated in pregnancy as it can cause birth defects. Use effective contraception during treatment and for a period after stopping.
A: Avoid alcohol, live vaccines, and NSAIDs without consulting your doctor. Also avoid prolonged sun exposure.
🤔 Common Patient Concerns
🔄 Substitutes for extrate 2.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
methorex 2.5mg tabletZydus Cadila ₹16.50 68.7% CHEAPER
-
auratrex 2.5mg tabletAbbott ₹18.00 65.9% CHEAPER
-
cytotrex 2.5mg tabletBDH Industries Ltd ₹31.50 40.2% CHEAPER
-
alltrex 2.5mg tabletMiracalus Pharma Pvt Ltd ₹34.00 35.5% CHEAPER
-
Trexglo 2.5mg TabletGlobela Pharma Pvt Ltd ₹34.00 35.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller; it is a DMARD that modifies the disease process and takes weeks to work. - Myth: This medicine can be taken without blood tests.
Fact: Regular blood tests are essential to monitor for serious side effects. - Myth: This medicine is safe during pregnancy.
Fact: This medicine can cause birth defects and is contraindicated in pregnancy. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of liver damage and should be avoided completely.
🔄 Alternative Options
Generic Alternatives
- Methotrexate 2.5 mg tablet
Brand Alternatives
- Auratrex 2.5mg tablet