Evalon Cream (Estriol 1mg): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden severe headache or vision changes
- Chest pain or shortness of breath
- Swelling or pain in the legs
- Unusual vaginal bleeding
- Breast lump or nipple discharge
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is evalon cream used for?
This medicine is a topical cream containing estriol, used to treat vaginal dryness, burning, and irritation caused by menopause. It works by restoring the health of vaginal tissues. Apply a thin layer as directed by your doctor, usually once daily.
- Generic Name: Estriol (1mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 evalon cream के बारे में (Hindi Summary)
उपयोग: यह दवा एस्ट्रियोल क्रीम है, जिसका उपयोग रजोनिवृत्ति के बाद योनि में सूखापन, जलन और खुजली के इलाज के लिए किया जाता है। यह योनि के ऊतकों को स्वस्थ बनाने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर जलन, खुजली या लालिमा शामिल हैं। कभी-कभी स्तन में कोमलता, सिरदर्द या मतली हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, रक्त के थक्के या असामान्य रक्तस्राव हो सकते हैं।
सुरक्षा सलाह: इस क्रीम को केवल त्वचा या योनि पर ही लगाएं। लगाने से पहले और बाद में हाथ धोएं। आंखों के संपर्क में न आने दें। गर्भावस्था में इसका उपयोग न करें। डॉक्टर के बताए अनुसार ही उपयोग करें।
💊 evalon cream Uses & Benefits
[{"condition":"Vulvar and vaginal atrophy","description":"Relieves vaginal dryness, burning, and irritation associated with menopause by restoring the thickness and elasticity of vaginal tissues.","evidence":"Well-established"},{"condition":"Dyspareunia due to vaginal atrophy","description":"Reduces pain during sexual intercourse caused by thinning and dryness of the vaginal lining.","evidence":"Well-established"},{"condition":"Atrophic vaginitis","description":"Treats inflammation and thinning of the vaginal walls due to estrogen deficiency.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Female sexual dysfunction","description":"Sometimes used off-label to improve sexual arousal and lubrication in postmenopausal women.","evidence":"Limited"},{"condition":"Skin aging","description":"Topical estriol has been studied for improving skin elasticity and reducing wrinkles, but this is not an approved indication.","evidence":"Limited"}]
Primary treatment for: Vulvar and vaginal atrophy
Also treats: Atrophic vaginitis, Dyspareunia
📋 Drug Information
| Generic Name(s) | Estriol (1mg) |
| Brand Name | evalon cream |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Estrogens |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Keep away from direct sunlight and moisture. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Estriol is a weak estrogen that binds to estrogen receptors alpha and beta in the nucleus of target cells. Upon binding, it activates gene transcription, leading to increased synthesis of proteins that promote cell growth, differentiation, and tissue repair. In the vaginal epithelium, this results in thickening of the mucosa, increased glycogen content, and restoration of the acidic pH, which helps maintain a healthy vaginal flora. It also improves blood flow and moisture retention in the treated area.
Mechanism Steps
💡 How to Take evalon cream
Strength: Cream containing 1 mg estriol per gram.
Dosage Information
| Adult Dosage | The usual adult dose is a thin layer of cream applied to the affected area once daily or as directed by your doctor. The exact dose and duration depend on the condition being treated and your response to therapy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but use with caution and monitor for side effects. |
| Renal Impairment | No dose adjustment is required for renal impairment, but use with caution. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. Typically, 1 mg of estriol per day is the maximum recommended for topical use. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of evalon cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Thyroid hormone | Major | |
| Corticosteroids | Moderate | |
| Antidiabetic drugs | Moderate | |
| Rifampicin | Minor | |
| St. John's wort | Minor |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin)
- Thyroid hormone
⚡ Moderate Interactions
- Corticosteroids
- Antidiabetic drugs
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and can exacerbate estrogen-related side effects such as headache and nausea. It is advisable to limit alcohol consumption while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known or suspected breast cancer","Known or suspected estrogen-dependent neoplasia","Undiagnosed abnormal genital bleeding","Active or history of thromboembolic disorders","Pregnancy","Hypersensitivity to estriol or any component of the cream"]
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest duration.","Estrogens increase the risk of endometrial cancer; monitor for abnormal bleeding.","Estrogens may increase the risk of breast cancer.","Estrogens can cause fluid retention; use with caution in cardiac or renal impairment.","Estrogens may worsen conditions like asthma, epilepsy, migraine, and porphyria.","Topical estrogens can be absorbed systemically; avoid excessive use.","Do not use on the face or breasts unless directed by a doctor."]
🤱 Lactation Safety
Estriol is excreted in breast milk and may affect milk production. It is not recommended during breastfeeding. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose with topical estriol is unlikely due to low systemic absorption. If accidental ingestion occurs, seek medical attention. Symptoms of overdose may include nausea, vomiting, and withdrawal bleeding. Treatment is symptomatic and supportive.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Use this medicine only on the skin or vaginal area as directed by your doctor. Wash your hands before and after applying the cream. Do not apply to broken or irritated skin. Avoid contact with the eyes. Do not use more than the prescribed amount or more often than instructed. If you are pregnant or planning to become pregnant, do not use this medicine without consulting your doctor. Inform your doctor about all other medicines you are taking, especially other hormonal products. Keep this medicine out of reach of children. Store it at room temperature and away from direct sunlight. Do not use it after the expiry date. If you experience any unusual symptoms like severe headache, vision changes, or leg pain, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of estrogens. Use with caution and monitor for side effects such as breast tenderness and vaginal bleeding.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are trying to conceive, consult your doctor for alternative treatments.
🏥 Post-Surgery Considerations
Inform your surgeon if you are using this medicine before any surgery, as estrogens may increase the risk of blood clots. Your doctor may advise you to stop temporarily.
🦷 Dental Procedures
No specific precautions are required for dental procedures. However, inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are required while using this medicine. However, if you experience any discomfort or pain during exercise, consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or headache, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Do not stop using this medicine without consulting your doctor. If you experience serious side effects or if your symptoms do not improve, your doctor may advise you to stop. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of topical estrogens may increase the risk of endometrial cancer, breast cancer, blood clots, and cardiovascular events. Regular monitoring and using the lowest effective dose for the shortest duration are recommended. Discuss with your doctor about periodic reevaluation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can provide relief from vaginal dryness without hormones.
Evidence: Well-establishedUsing lubricants during intercourse and avoiding irritants can help.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. Continue routine vaccinations as recommended by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Keep a copy of your prescription with you. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, continue your regular dosing schedule as closely as possible. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start noticing improvement in vaginal dryness and irritation within 2 to 4 weeks of regular use. Full benefits may take longer.
A: No, this medicine is contraindicated during pregnancy. Consult your doctor for alternative treatments.
A: No, you should not use this medicine if you have a history of breast cancer or other estrogen-sensitive cancers.
🤔 Common Patient Concerns
🔄 Substitutes for evalon cream
View AllAlternative brands with exact same active ingredient:
-
evalon 1mg tabletOrganon (India) Ltd ₹153.00 69.2% CHEAPER
-
evolon creamGlaxo SmithKline Pharmaceuticals Ltd ₹270.94 45.5% CHEAPER
-
vagimoist vaginal creamApple Therapeutics Pvt Ltd ₹289.00 41.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a hormone replacement therapy and has the same risks as oral hormones.
Fact: This medicine is a topical estrogen with low systemic absorption, so its risks are generally lower than oral hormone therapy, but it still carries some risks. - Myth: This medicine can be used by anyone for vaginal dryness.
Fact: This medicine is only for postmenopausal women with estrogen deficiency and should not be used without a doctor's evaluation.
🔄 Alternative Options
Generic Alternatives
- Estriol cream
Brand Alternatives
- Evalon cream