Etova-MR 400/4 Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is etobling th 400mg/4mg tablet used for?
This medicine is a combination of Etodolac (an NSAID) and Thiocolchicoside (a muscle relaxant) used for short-term relief of acute musculoskeletal pain and muscle spasm. It reduces pain, inflammation, and muscle stiffness. It should be taken with food and only as prescribed by a doctor.
- Generic Name: Etodolac (400mg) + Thiocolchicoside (4mg)
- Manufacturer: Nusmith Pharma Pvt. Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 etobling th 400mg/4mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एटोडोलैक और थायोकोलचिकोसाइड का संयोजन है, जिसका उपयोग तीव्र मस्कुलोस्केलेटल दर्द और मांसपेशियों की ऐंठन के अल्पकालिक उपचार के लिए किया जाता है। यह दर्द, सूजन और मांसपेशियों की अकड़न को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, गुर्दे की समस्या, यकृत विषाक्तता और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, सांस लेने में कठिनाई, या चेहरे पर सूजन दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक न बढ़ाएं और न ही अनुशंसित अवधि से अधिक समय तक लें। इसे हमेशा भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन बिल्कुल न करें। यदि आपको चक्कर या नींद आती है तो वाहन न चलाएं। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 etobling th 400mg/4mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Relieves pain and reduces muscle spasm in conditions such as acute low back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established for short-term use"},{"condition":"Post-traumatic pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling","description":"Used after sprains, strains, and soft tissue injuries to reduce pain, inflammation, and associated muscle spasm.","evidence":"Commonly used in clinical practice"},{"condition":"Post-operative pain and spasm","description":"May be prescribed after certain surgeries to manage pain and muscle spasm, but only under strict medical supervision.","evidence":"Limited to specific clinical settings"},{"condition":"Osteoarthritis flare-ups","description":"Provides short-term relief of pain and stiffness during acute flare-ups of osteoarthritis, especially when muscle spasm is present.","evidence":"Symptomatic relief; not disease-modifying"}]
Off-label uses: [{"condition":"Tension-type headache with neck muscle spasm","description":"Sometimes prescribed off-label when headache is associated with significant neck muscle spasm.","evidence":"Limited; not a standard first-line treatment"},{"condition":"Dysmenorrhea with pelvic muscle spasm","description":"Rarely used off-label for painful menstrual cramps accompanied by muscle spasm.","evidence":"Limited; NSAIDs alone are more commonly used"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Low back pain, Neck pain, Myofascial pain syndrome, Post-traumatic pain, Osteoarthritis flare-ups
📋 Drug Information
| Generic Name(s) | Etodolac (400mg) + Thiocolchicoside (4mg) |
| Brand Name | etobling th 400mg/4mg tablet |
| Manufacturer | Nusmith Pharma Pvt. Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Etodolac is a nonsteroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2 (COX-2) enzyme, thereby reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Thiocolchicoside is a centrally acting muscle relaxant that acts on GABA-A receptors and glycine receptors in the spinal cord and brainstem, reducing excessive muscle tone and spasms. The combination provides both anti-inflammatory and muscle relaxant effects, which is beneficial for painful musculoskeletal conditions where both inflammation and muscle spasm are present.
Mechanism Steps
💡 How to Take etobling th 400mg/4mg tablet
Strength: Tablet containing Etodolac 400 mg and Thiocolchicoside 4 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, depending on the severity of pain and muscle spasm. The maximum recommended daily dose is 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Take with food or milk to reduce stomach upset. Use for the shortest duration necessary to control symptoms. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely. Consult a doctor for individualized dosing. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. Dose adjustment may be necessary. Avoid use in severe renal impairment (eGFR <30 mL/min). Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. Dose adjustment may be necessary. Avoid use in severe hepatic impairment. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (Etodolac 1200 mg + Thiocolchicoside 12 mg) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of etobling th 400mg/4mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Aspirin | Moderate | |
| Lisinopril | Moderate | |
| Furosemide | Moderate | |
| Methotrexate | Major | |
| Lithium | Major | |
| Prednisone | Major | |
| Sertraline | Moderate | |
| Cyclosporine | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics
- SSRIs
- Cyclosporine
🍷 Alcohol Interaction
Avoid alcohol completely while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity. It may also worsen drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers","Severe kidney disease (eGFR
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol completely.","Do not drive or operate machinery if you feel dizzy or drowsy.","Do not take other NSAIDs or pain relievers without consulting your doctor.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma.","Do not use for longer than prescribed without medical supervision.","Report any unusual bleeding, bruising, or signs of infection immediately."]
🤱 Lactation Safety
Not established from the available information. It is not known whether etodolac or thiocolchicoside passes into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, stomach pain, drowsiness, and potentially kidney or liver damage. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor vital signs, renal and hepatic function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it for longer than recommended. Always take it with food or milk to reduce stomach irritation. Avoid alcohol completely while taking this medicine, as it increases the risk of stomach bleeding and liver problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Do not take other NSAIDs or pain relievers without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before taking this medicine. Keep all follow-up appointments and report any unusual symptoms immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at increased risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely. Consult a doctor for individualized dosing.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor for alternative treatment options. NSAIDs may affect ovulation and are generally avoided during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be prescribed after certain surgeries to manage pain and muscle spasm. However, it should be used with caution due to increased risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop the medicine temporarily before surgery.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have muscle spasm or pain. Gentle stretching and low-impact activities like walking or swimming may be beneficial. Consult your doctor or physiotherapist before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Take frequent breaks if your work involves prolonged sitting or standing. Inform your employer if your job requires heavy lifting or operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any serious side effects such as blood in stool or vomit, severe abdominal pain, chest pain, difficulty breathing, or signs of an allergic reaction. Do not stop taking this medicine abruptly without consulting your doctor, especially if you have been taking it for a prolonged period.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to increased risk of gastrointestinal bleeding, kidney problems, liver toxicity, and cardiovascular events. If long-term use is necessary, regular monitoring of renal and hepatic function, blood counts, and blood pressure is required. Consult your doctor for alternative treatment options if pain persists beyond the recommended duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle strength and flexibility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and muscle spasm.
Evidence: Commonly usedMay provide pain relief for some patients with musculoskeletal pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing schedule gradually as advised by your doctor. Do not pack in checked luggage; keep it in your carry-on bag. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Etodolac begins to provide pain relief within 30-60 minutes after oral administration. The muscle relaxant effect of thiocolchicoside may take a few hours to become noticeable.
A: No, it is recommended to take this medicine with food or milk to reduce the risk of stomach irritation and nausea.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for individualized advice.
A: Do not take other NSAIDs or pain relievers without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for etobling th 400mg/4mg tablet
View AllAlternative brands with exact same active ingredient:
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megtios th 400mg/4mg tabletRidhima Biocare ₹150.00 15.3% CHEAPER
-
etoxor th 400mg/4mg tabletTrireme Life Sciences Pvt Ltd ₹160.00 9.7% CHEAPER
-
thioage-e tabletAllenge India ₹166.88 5.8% CHEAPER
-
etoridac th 400mg/4mg tablet3D Healthcare ₹173.44 2.1% CHEAPER
-
etodo 400mg/4mg tabletD D Pharmaceuticals ₹178.13 0.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is intended for short-term use only. Long-term use increases the risk of serious side effects and should be avoided unless specifically prescribed by a doctor. - Myth: It is safe to take this medicine on an empty stomach.
Fact: Taking this medicine on an empty stomach increases the risk of stomach irritation and ulcers. Always take it with food or milk. - Myth: This medicine is a cure for back pain.
Fact: This medicine provides symptomatic relief but does not cure the underlying cause of back pain. Physical therapy and lifestyle changes are often necessary. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol should be completely avoided as it increases the risk of gastrointestinal bleeding and liver problems.
🔄 Alternative Options
Generic Alternatives
- Etodolac 400 mg + Thiocolchicoside 4 mg tablet (generic)
Brand Alternatives
- Etova-MR 400/4 Tablet