etimax beta 0.25mg/20mg tablet - Etizolam (0.25mg) + Propranolol (20mg) medicine

Etizola Beta 0.25 mg/20 mg Tablet: Complete Information

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🏭 Thyone Health Care 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in anxiety; limited for long-term use.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe drowsiness or difficulty staying awake
  • Slow, shallow, or irregular breathing
  • Fainting or severe dizziness
  • Chest pain or palpitations
  • Confusion or hallucinations
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Yellowing of eyes or skin
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is etimax beta 0.25mg/20mg tablet used for?

This medicine is a combination of Etizolam and Propranolol used for short-term treatment of anxiety with prominent physical symptoms. It works by calming the brain and reducing the physical effects of adrenaline.

  • Generic Name: Etizolam (0.25mg) + Propranolol (20mg)
  • Manufacturer: Thyone Health Care
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 etimax beta 0.25mg/20mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एटिजोलम और प्रोप्रानोलोल का संयोजन है, जिसका उपयोग चिंता विकारों के अल्पकालिक उपचार के लिए किया जाता है। यह मस्तिष्क को शांत करने और एड्रेनालाईन के शारीरिक प्रभावों को कम करने में मदद करती है। इसका उपयोग घबराहट, धड़कन तेज होना, कंपन और पसीना जैसे लक्षणों को कम करने के लिए किया जाता है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और इसका लंबे समय तक उपयोग नहीं करना चाहिए क्योंकि इससे निर्भरता हो सकती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, थकान, हाथ-पैर ठंडे होना और मतली शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें धीमी हृदय गति, निम्न रक्तचाप, सांस लेने में कठिनाई और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को केवल डॉक्टर के निर्देशानुसार ही लें। शराब और अन्य नींद लाने वाली दवाओं के साथ इसका सेवन न करें क्योंकि इससे गंभीर नींद और सांस की समस्या हो सकती है। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इस दवा का प्रभाव पता न चल जाए। इस दवा को अचानक बंद न करें, इससे withdrawal के लक्षण हो सकते हैं। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 etimax beta 0.25mg/20mg tablet Uses & Benefits

[{"condition":"Anxiety disorders with prominent physical symptoms","description":"This combination helps reduce both the psychological symptoms of anxiety, such as excessive worry, and the physical symptoms, such as palpitations, tremors, and sweating.","evidence":"Moderate"},{"condition":"Short-term management of acute stress reactions","description":"May be used for a brief period to manage severe stress or panic symptoms, but it is not a first-line long-term treatment.","evidence":"Limited"}]

Off-label uses: [{"condition":"Performance anxiety (e.g., public speaking)","description":"Propranolol is sometimes used off-label for performance anxiety, but the addition of Etizolam makes this combination less suitable for situational use due to sedation and dependence risk.","evidence":"Limited"}]

Primary treatment for: Anxiety disorders

Also treats: Panic disorder, Stress-related disorders

📋 Drug Information

Generic Name(s)Etizolam (0.25mg) + Propranolol (20mg)
Brand Nameetimax beta 0.25mg/20mg tablet
ManufacturerThyone Health Care
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Prescribe this combination only for short-term use, typically not exceeding 2-4 weeks.
2
Assess for a history of substance abuse before prescribing.
3
Warn patients about the risk of dependence and withdrawal symptoms.
4
Advise patients to avoid alcohol and other CNS depressants.
5
Monitor heart rate and blood pressure regularly during treatment.
6
Taper the dose gradually when discontinuing to prevent withdrawal.
7
Consider alternative non-benzodiazepine treatments for long-term anxiety management.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Anxiety with palpitations
This medicine is commonly prescribed for this.
Likely Use
✅
Tremors
Propranolol helps reduce tremors.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionEtizolam is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours. Propranolol is also well absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism, resulting in a bioavailability of about 25-30%.
DistributionEtizolam is highly lipophilic and distributes widely into body tissues, including the brain. Propranolol is also highly lipophilic and crosses the blood-brain barrier; it is distributed extensively to tissues including the lungs, liver, kidneys, and brain.
Protein BindingEtizolam is approximately 95% bound to plasma proteins. Propranolol is about 90% bound to plasma proteins, primarily albumin.
MetabolismEtizolam is metabolized in the liver by cytochrome P450 enzymes, primarily CYP3A4, into inactive metabolites. Propranolol undergoes extensive hepatic metabolism, mainly by CYP2D6, CYP1A2, and CYP2C19, with a significant first-pass effect.
Half-LifeThe elimination half-life of Etizolam is approximately 6 hours, while that of Propranolol ranges from 3 to 6 hours.
ExcretionEtizolam metabolites are excreted primarily in the urine. Propranolol metabolites are excreted in the urine, with less than 1% excreted unchanged.
BioavailabilityEtizolam oral bioavailability is approximately 90%. Propranolol oral bioavailability is about 25-30% due to first-pass metabolism.
Onset of ActionAnxiolytic effects of Etizolam may begin within 30 to 60 minutes. Propranolol's effects on heart rate and tremor begin within 1 to 2 hours.
Peak Plasma TimeEtizolam: 1-2 hours; Propranolol: 1-2 hours (immediate-release).
Duration of ActionEtizolam: 6-8 hours; Propranolol: 6-12 hours depending on dose and individual factors.

How It Works

Etizolam enhances the inhibitory neurotransmitter GABA at GABA-A receptors, producing anxiolytic, sedative, and muscle relaxant effects. Propranolol blocks beta-adrenergic receptors, reducing the physical manifestations of anxiety such as tachycardia, tremor, and sweating. The combination targets both central and peripheral symptoms of anxiety.

Mechanism Steps

1
Etizolam binds to GABA-A receptors: Etizolam binds to the benzodiazepine site on GABA-A receptors, enhancing the inhibitory effect of GABA and leading to neuronal hyperpolarization and reduced excitability.
2
Propranolol blocks beta-adrenergic receptors: Propranolol competitively blocks beta-1 and beta-2 adrenergic receptors, reducing the effects of catecholamines like adrenaline and noradrenaline on the heart and blood vessels.
3
Combined effect on anxiety: The central anxiolytic effect of Etizolam and the peripheral sympatholytic effect of Propranolol together alleviate both the emotional and physical symptoms of anxiety.

💡 How to Take etimax beta 0.25mg/20mg tablet

Strength: Tablet containing Etizolam 0.25 mg and Propranolol 20 mg.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with food to reduce stomach upset.
4Follow your doctor's instructions regarding timing and frequency.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally once or twice daily, as prescribed by your doctor. The dose may be adjusted based on your response and tolerance. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Monitor for sedation, dizziness, and falls.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult your doctor for personalized dosing.
Hepatic ImpairmentDose reduction is recommended in patients with hepatic impairment. Use with caution and monitor liver function.
Maximum Daily DoseThe maximum daily dose should not exceed what is prescribed by your doctor. Typically, the maximum is 2 tablets per day, but this may vary based on individual factors.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves tolerability.
Grapefruit
Avoid
May increase Etizolam levels and side effects.
Alcohol
Avoid completely
Dangerous additive CNS depression.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of etimax beta 0.25mg/20mg tablet

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Stay hydrated.
Fatigue (Common (5-10%))
Ensure adequate rest. If severe, consult your doctor.
Cold extremities (Common (5-10%))
Keep warm. If persistent or painful, consult your doctor.
Nausea (Common (5-10%))
Take with food. If vomiting occurs, contact your doctor.

🚨 Serious Side Effects

Severe bradycardia (slow heart rate) (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, extreme weakness, or confusion.
Hypotension (low blood pressure) (Rare (<0.1%))
If you feel faint or have blurred vision, lie down and seek medical help.
Respiratory depression (Rare (<0.1%))
This is a medical emergency. Call for help immediately if breathing becomes slow or shallow.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Seek emergency care if you develop rash, swelling of face/lips/throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis)
Report unusual bruising, bleeding, or infections to your doctor immediately.
Hallucinations
Discontinue and seek medical advice promptly.
Paradoxical anxiety or agitation
Contact your doctor; dose adjustment may be needed.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Alcohol Major
Verapamil Major
Digoxin Major
Ketoconazole Moderate
Fluoxetine Moderate
Ibuprofen Moderate
Antacids Minor
Grapefruit juice Minor
Rifampicin Moderate
Clonidine Moderate

🚨 Major Interactions

  • Other CNS depressants (e.g., alcohol, opioids, barbiturates)
  • Calcium channel blockers (e.g., verapamil, diltiazem)
  • Digoxin

⚡ Moderate Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • NSAIDs

🍷 Alcohol Interaction

Alcohol should be strictly avoided while taking this medicine. Both Etizolam and Propranolol can enhance the central nervous system depressant effects of alcohol, leading to severe drowsiness, respiratory depression, and dangerous drops in blood pressure. This combination can be life-threatening.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to Etizolam, Propranolol, or any component of the formulation","Severe asthma or chronic obstructive pulmonary disease (COPD)","Severe bradycardia, second- or third-degree heart block, or cardiogenic shock","Uncontrolled heart failure","Severe liver disease","Myasthenia gravis","History of substance abuse or dependence"]

⚠️ Warnings & Precautions

["This medicine can cause physical and psychological dependence. Use for the shortest duration possible.","Abrupt discontinuation may cause withdrawal symptoms; taper gradually under medical supervision.","May impair ability to drive or operate machinery; avoid these activities until you know how it affects you.","Use with caution in elderly patients due to increased risk of falls and confusion.","Do not use in patients with respiratory depression or sleep apnea.","Propranolol may mask symptoms of hypoglycemia in diabetic patients.","Inform your doctor if you have a history of depression or suicidal thoughts."]

🤱 Lactation Safety

Etizolam and Propranolol are excreted in breast milk. Breastfeeding is not recommended while taking this medicine due to potential sedation and other effects on the infant. Consult your doctor for alternative options.

💊 Overdose Management

Overdose can cause severe drowsiness, confusion, bradycardia, hypotension, respiratory depression, and coma. Seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, gastric lavage, intravenous fluids, atropine for bradycardia, and vasopressors for hypotension. Flumazenil may be used cautiously for benzodiazepine overdose but is contraindicated in mixed overdoses with propranolol due to risk of seizures.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you miss multiple doses, consult your doctor.

Additional Safety Advice

General Safety

This medicine should only be taken exactly as prescribed by a qualified doctor. Do not increase or decrease the dose without medical advice. Avoid alcohol and other central nervous system depressants because they can dangerously increase sedation and respiratory depression. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have asthma, heart problems, liver or kidney disease, or a history of substance abuse. Do not stop this medicine abruptly, as it can cause withdrawal symptoms such as anxiety, insomnia, and tremors. Keep this medicine out of reach of children and store it in a cool, dry place. Regular follow-up with your doctor is essential to monitor your response and adjust the dose if needed.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of sedation, dizziness, falls, and cognitive impairment. Use with caution, start with a lower dose, and monitor closely.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Both Etizolam and Propranolol may harm the fetus. Alternative treatments may be recommended.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with anesthetic agents and affect heart rate and blood pressure. It may need to be stopped before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, as it can interact with local anesthetics containing epinephrine and affect blood pressure and heart rate.

💚 Lifestyle Tips for Better Results

🏃
Practice relaxation techniques such as deep breathing and meditation.
🥗
Maintain a regular sleep schedule.
😴
Engage in regular physical activity, but avoid excessive stimulation.
💧
Limit caffeine and nicotine intake as they can worsen anxiety.
🧘
Seek counseling or therapy for long-term anxiety management.
🌞
Stay connected with supportive friends and family.

🏋️ Exercise Considerations

Avoid strenuous exercise until you know how this medicine affects you, as it can cause dizziness and fatigue. Propranolol may reduce exercise tolerance by blunting heart rate response. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits, vegetables, and whole grains.
Avoid excessive caffeine and sugar.
Stay well hydrated.
Include omega-3 fatty acids for brain health.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and impair concentration, affecting your ability to work or drive. It is advisable to avoid operating heavy machinery until you know how it affects you. Discuss with your employer if you need temporary adjustments.

🛑 When to Stop This Medicine

Do not stop this medicine abruptly without consulting your doctor. Your doctor will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects, contact your doctor immediately for guidance.

📅 Long-Term Use Effects

Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It may also cause cognitive impairment, memory problems, and mood changes. Regular monitoring by a doctor is essential, and the medicine should be tapered gradually when stopping. Long-term use is generally not recommended.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive behavioral therapy (CBT)

A first-line treatment for anxiety disorders that helps change negative thought patterns.

Evidence: Well-established
Selective serotonin reuptake inhibitors (SSRIs)

Long-term treatment for anxiety with a better safety profile.

Evidence: Well-established
Mindfulness and relaxation techniques

Can help manage mild anxiety symptoms.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations regarding controlled substances before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with generalized anxiety disorder and palpitations
She was prescribed this medicine for short-term management of severe anxiety. After starting, she noticed significant reduction in her palpitations and tremors within a few days. However, she experienced drowsiness initially, which improved after a week. She was advised to avoid driving and alcohol. After 3 weeks, her doctor gradually tapered the dose to prevent withdrawal.
💡 Lesson: This medicine can effectively reduce both psychological and physical anxiety symptoms, but it should be used short-term and tapered gradually.
👤 A 50-year-old man with performance anxiety
He was given this medicine before a major presentation. While it helped with his tremors and rapid heartbeat, he felt excessively sedated and had difficulty concentrating. His doctor later switched him to a lower dose of Propranolol alone, which controlled his physical symptoms without sedation.
💡 Lesson: The combination may be too sedating for some individuals; alternative treatments may be more suitable for situational anxiety.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling the calming effects within 30 to 60 minutes after taking a dose. However, the full benefits for anxiety may take a few days of regular use.

Q: Can I take this medicine if I have asthma?

A: No, this medicine contains Propranolol, which can worsen asthma. It is contraindicated in people with asthma.

Q: Is it safe to drive after taking this medicine?

A: This medicine can cause drowsiness and dizziness. Do not drive or operate machinery until you know how it affects you.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for etimax beta 0.25mg/20mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a permanent cure for anxiety.
    Fact: This medicine provides short-term relief but is not a cure. Long-term anxiety management often requires therapy and lifestyle changes.
  • Myth: It is safe to take extra doses if I feel more anxious.
    Fact: Taking more than the prescribed dose can lead to severe sedation, respiratory depression, and dependence. Always follow your doctor's instructions.

🔄 Alternative Options

Generic Alternatives

  • Etizolam + Propranolol combination (generic)

📊 Comparison with Similar Medicines

[{"medicine":"Etizolam + Propranolol","composition":"Etizolam 0.25 mg + Propranolol 20 mg","onset":"30-60 minutes","duration":"6-8 hours","sedation":"Moderate to high"},{"medicine":"Alprazolam + Propranolol","composition":"Alprazolam 0.25 mg + Propranolol 20 mg","onset":"30-60 minutes","duration":"6-8 hours","sedation":"Moderate to high"}]

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