cefpra 1gm injection

4.5 (13 reviews)

Cefoperazone (1gm)

🏭 Ampra Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is cefpra 1gm injection used for?

Avucef 500mg Injection (Cefoperazone) is used to treat ANTI INFECTIVES. It contains Cefoperazone (1gm), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.

Generic Name: Cefoperazone
Manufacturer: Ampra Pharmaceuticals
Form: Allopathy
Pregnancy Category: B
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cefpra 1gm injection Uses & Benefits

Treatment of respiratory tract infections, urinary tract infections, skin and soft tissue infections, septicemia, intra-abdominal infections, gynecological infections

Off-label uses: Bacterial meningitis, Lyme disease, Typhoid fever

📋 Drug Information

Generic Name(s)	Cefoperazone
Brand Name	Avucef 500mg Injection
Manufacturer	Ampra Pharmaceuticals
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Cephalosporins: 3 generation
Route of Administration	Intravenous (IV) or intramuscular (IM)
Storage	Store at 20-25°C (68-77°F); protect from light
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionNot applicable (intravenous/intramuscular administration)

DistributionWidely distributed in body tissues and fluids including bile, sputum, pleural fluid, and peritoneal fluid

Protein Binding82-93%

MetabolismNot significantly metabolized

Half-Life1.7-2 hours

ExcretionPrimarily biliary (70-80%) and renal (20-30%)

Bioavailability100% (intravenous)

Onset of ActionRapid

Peak Plasma TimeImmediately after IV administration; 1-2 hours after IM administration

Duration of Action6-12 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

Mechanism Steps

1Binds to penicillin-binding proteins (PBPs) on bacterial cell wall

2Inhibits transpeptidase activity

3Prevents cross-linking of peptidoglycan chains

💡 How to Take cefpra 1gm injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of cefpra 1gm injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Rash
Injection site reactions

🚨 Serious Side Effects

Pseudomembranous colitis
Anaphylaxis
Stevens-Johnson syndrome
Bleeding tendencies
Seizures

⚠️ Rare Side Effects

Hemolytic anemia
Agranulocytosis
Interstitial nephritis
Hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Alcohol	Major	Disulfiram-like reaction
Warfarin	Major	Increased bleeding risk
Heparin	Major	Increased bleeding risk
Oral anticoagulants	Major	Increased bleeding risk
Aminoglycosides	Moderate	Increased nephrotoxicity risk
Loop diuretics	Moderate	Increased nephrotoxicity risk
Probenecid	Moderate	Decreased renal excretion of cefoperazone
Tetracyclines	Minor	Possible antagonism
Chloramphenicol	Minor	Possible antagonism

🚨 Major Interactions

Alcohol
Warfarin
Heparin
Oral anticoagulants

⚡ Moderate Interactions

Aminoglycosides
Loop diuretics
Probenecid

ℹ️ Minor Interactions

Tetracyclines
Chloramphenicol

🍷 Alcohol Interaction

Disulfiram-like reaction (flushing, headache, nausea, vomiting, tachycardia)

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefoperazone or other cephalosporins, severe penicillin allergy

📊 Monitoring Parameters

Renal function, hepatic function, CBC, signs of bleeding, superinfection

🤱 Lactation Safety

Excreted in breast milk in small amounts; use with caution

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination

⏰ Missed Dose

Administer as soon as remembered; do not double dose

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for cefpra 1gm injection

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Alternative brands with exact same active ingredient (Cefoperazone (1gm)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026