Epiclos 0.25ml Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden difficulty breathing or chest pain
- Severe allergic reaction (swelling of face, lips, throat)
- Signs of stroke (sudden weakness, confusion, trouble speaking)
- Severe pain or discoloration at the injection site
- Fever with chills
- Coughing up blood
If experiencing severe symptoms, call emergency services immediately.
What is epiclos 0.25ml injection used for?
This medicine is a surgical adhesive containing n-Butyl-2-cyanoacrylate. It is used by healthcare professionals to block abnormal blood vessels or close wounds. It works by rapidly solidifying upon contact with blood or tissue.
- Generic Name: n-Butyl-2-cyanoacrylate (0.25ml)
- Manufacturer: Quepreon Biologicals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 epiclos 0.25ml injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक विशेष चिकित्सा आसंजक है जिसका उपयोग असामान्य रक्त वाहिकाओं को बंद करने या घावों को बंद करने के लिए किया जाता है। इसका उपयोग केवल प्रशिक्षित डॉक्टर द्वारा अस्पताल में किया जाता है। यह आमतौर पर धमनी-शिरा विकृतियों (AVMs), वैरिकाज़ नसों, और गैस्ट्रिक वैरिकाज़ के इलाज में उपयोग किया जाता है। यह सर्जिकल घावों को बंद करने के लिए भी इस्तेमाल किया जा सकता है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, सूजन, या लालिमा शामिल हैं। गंभीर दुष्प्रभावों में अनपेक्षित एम्बोलिज़ेशन (रक्त वाहिका में रुकावट), एलर्जी प्रतिक्रिया, संक्रमण, या फुफ्फुसीय एम्बोलिज़्म शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, सीने में दर्द, या अचानक कमजोरी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। प्रक्रिया से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। प्रक्रिया के बाद डॉक्टर के निर्देशों का पालन करें। किसी भी असामान्य लक्षण को तुरंत रिपोर्ट करें।
💊 epiclos 0.25ml injection Uses & Benefits
[{"condition":"Arteriovenous malformations (AVMs)","description":"Used for endovascular embolization of abnormal connections between arteries and veins, especially in the brain and spine.","evidence":"Well-established"},{"condition":"Varicose veins","description":"Injected to close off enlarged, twisted veins, typically in the legs, to relieve symptoms and improve appearance.","evidence":"Well-established"},{"condition":"Gastric varices","description":"Used to obliterate bleeding gastric varices in patients with portal hypertension.","evidence":"Established"},{"condition":"Surgical wound closure","description":"Applied topically as a tissue adhesive for closing certain surgical incisions and lacerations.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lymphatic malformations","description":"Sometimes used off-label for sclerotherapy of lymphatic malformations.","evidence":"Limited"},{"condition":"Pelvic congestion syndrome","description":"May be used to embolize incompetent pelvic veins, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Vascular malformations
Also treats: Varicose veins, Gastric varices, Surgical wounds
📋 Drug Information
| Generic Name(s) | n-Butyl-2-cyanoacrylate (0.25ml) |
| Brand Name | epiclos 0.25ml injection |
| Manufacturer | Quepreon Biologicals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTHERS |
| Action Class | Haemostatic agent |
| Route of Administration | Parenteral (injection) or topical application, depending on the specific use. The product is supplied as an injection |
| Storage | Store in a cool, dry place, away from direct sunlight. Keep the vial in its original packaging. Do not freeze. Once opened, use immediately. |
| Shelf Life | Not established from the available information. Refer to the product label for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by a process called polymerization. When n-Butyl-2-cyanoacrylate comes into contact with blood or tissue fluids, it rapidly polymerizes into a solid, adhesive mass. This mass physically blocks the blood vessel, stopping blood flow. The polymerization is initiated by the presence of moisture or hydroxyl ions in the blood. The resulting plug is gradually degraded and replaced by fibrous tissue over time. This mechanism is used to occlude abnormal blood vessels or to seal wounds.
Mechanism Steps
💡 How to Take epiclos 0.25ml injection
Strength: Injection: 0.25 ml
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the specific condition being treated, the size and location of the target vessel or wound, and the patient's overall health. It is administered by a qualified clinician during a procedure. The usual volume ranges from 0.1 ml to several milliliters, but the exact amount is determined by the clinician. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. The dose should be carefully determined by the clinician, taking into account overall health and kidney function. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution and consult a clinician. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and consult a clinician. |
| Maximum Daily Dose | Not applicable. This medicine is not given on a daily basis; it is used as a single procedure. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of epiclos 0.25ml injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| Ibuprofen | Moderate |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen)
🍷 Alcohol Interaction
Alcohol may increase the risk of bleeding and should be avoided before and after the procedure. Consult your doctor for specific advice.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cyanoacrylates","Active infection at the injection site","Severe bleeding disorders","Use in areas with known arteriovenous shunts unless specifically indicated","Not for intravascular use in coronary or cerebral vessels unless performed by a specialist"]
⚠️ Warnings & Precautions
["For professional use only. Must be administered by trained personnel.","Avoid injection into arteries unless intended, as it can cause tissue necrosis.","Use with caution in patients with known allergies.","Do not use if the product is discolored or contains particles.","Ensure sterile technique to prevent infection.","Monitor for signs of unintended embolization."]
🤱 Lactation Safety
Not established from the available information. It is not known if this medicine passes into breast milk. Consult your doctor before use during breastfeeding.
💊 Overdose Management
Overdose is unlikely as this medicine is administered by a healthcare professional in a controlled dose. If excessive glue is injected, it may cause extensive vessel occlusion or tissue damage. Treatment is supportive and may include surgical intervention if necessary. Seek immediate medical attention.
⏰ Missed Dose
This medicine is given as a single procedure by a healthcare professional. Missed dose instructions are not applicable.
Additional Safety Advice
This medicine must only be administered by a trained healthcare professional in a hospital or clinic setting. Do not attempt to use this product at home. Before the procedure, inform your doctor about all your medical conditions, especially if you have a history of allergies, bleeding disorders, or heart problems. Tell your doctor about all medications you are taking, including blood thinners, as they may increase the risk of bleeding or complications. After the procedure, follow your doctor's instructions carefully for wound care and activity restrictions. Avoid strenuous activities for a few days. Report any signs of infection, such as fever, chills, or increasing pain at the injection site. If you experience difficulty breathing, chest pain, or sudden weakness, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have a higher risk of complications such as bleeding or infection. The dose and procedure should be carefully planned by the clinician.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor. The safety of this medicine during pregnancy is not well established. It should be used only if clearly needed.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon before receiving this medicine. It may affect wound healing or interact with other treatments.
🦷 Dental Procedures
Inform your dentist if you have received this medicine recently, especially if you are on blood thinners. No specific precautions are established, but it is important for your dentist to know your medical history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise for at least a few days after the procedure, as advised by your doctor. Gentle walking is usually encouraged to promote circulation.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take a few days off work depending on the procedure and your recovery. Driving may be restricted for 24 hours if sedation was used. Follow your doctor's advice.
🛑 When to Stop This Medicine
This medicine is given as a single procedure, so there is no ongoing use to stop. If you experience severe side effects, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term effects are generally minimal as the glue is gradually degraded and replaced by fibrous tissue. However, there is a risk of delayed complications such as infection, nerve damage, or recurrence of the treated condition. Regular follow-up with your doctor is important to monitor for any issues.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Injection of a sclerosing agent to close varicose veins.
Evidence: Well-establishedSurgical removal or ligation of varicose veins.
Evidence: Well-establishedUsing laser energy to close small varicose veins.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine around the time of the procedure.
📦 Storage Guide
✅ DO
Store in a cool, dry place
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
If you need to travel after receiving this medicine, carry a copy of your prescription and medical records. This medicine is administered in a hospital, so you will not need to carry it yourself. Follow your doctor's advice regarding activity restrictions during travel. If you have a follow-up appointment, plan your travel accordingly.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine works immediately upon injection, solidifying within seconds to block the blood vessel or seal the wound.
A: You may feel some pain or discomfort during the injection, but local anesthesia is often used to minimize pain.
A: This depends on the procedure and your recovery. Some patients go home the same day, while others may need to stay overnight.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: No, it must only be administered by a trained healthcare professional in a medical setting. - Myth: This medicine is a painkiller.
Fact: No, it is a tissue adhesive and embolic agent, not a painkiller.
🔄 Alternative Options
Generic Alternatives
- n-Butyl-2-cyanoacrylate injection
Brand Alternatives
- Epiclos 0.25ml injection