Anvase 1500IU Injection (Hyaluronidase): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe rash or hives
- Rapid heartbeat or palpitations
- Dizziness or fainting
- Signs of infection at injection site (increasing redness, warmth, pus)
If experiencing severe symptoms, call emergency services immediately.
What is entodase injection used for?
This medicine is an injectable enzyme that helps other drugs spread more easily in the body. It is used to enhance absorption of medications given under the skin and to facilitate fluid administration.
- Generic Name: Hyaluronidase (1500IU)
- Manufacturer: Entod Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 entodase injection के बारे में (Hindi Summary)
उपयोग: यह दवा हायलूरोनिडेज एंजाइम का इंजेक्शन है, जिसका उपयोग अन्य दवाओं के अवशोषण को बढ़ाने के लिए किया जाता है। यह त्वचा के नीचे दी जाने वाली दवाओं को शरीर में अधिक तेजी से फैलने में मदद करती है। इसका उपयोग त्वचा के नीचे तरल पदार्थ चढ़ाने (हाइपोडर्मोक्लिसिस) में भी किया जाता है। यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा, सूजन या खुजली शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया हो सकती है जैसे चकत्ते, सांस लेने में कठिनाई, चेहरे या गले में सूजन। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। अगर आपको हायलूरोनिडेज से एलर्जी है तो डॉक्टर को बताएं। इंजेक्शन के बाद जगह को साफ रखें और किसी भी असामान्य लक्षण पर नजर रखें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 entodase injection Uses & Benefits
[{"condition":"Enhancement of drug absorption","description":"Used to increase the absorption and dispersion of other injected drugs, such as local anesthetics or antibiotics, when given subcutaneously.","evidence":"Well-established"},{"condition":"Hypodermoclysis","description":"Facilitates the subcutaneous administration of large volumes of fluids, especially in patients who cannot receive intravenous fluids.","evidence":"Well-established"},{"condition":"Extravasation management","description":"May be used to help disperse accidentally extravasated drugs (e.g., vinca alkaloids) to reduce tissue damage.","evidence":"Limited"},{"condition":"Improvement of contrast agent absorption","description":"Used in some imaging procedures to enhance the absorption of contrast media.","evidence":"Limited"}]
Off-label uses: [{"condition":"Cosmetic procedures","description":"Sometimes used off-label to improve the spread of fillers or anesthetics in cosmetic surgery.","evidence":"Limited"},{"condition":"Ophthalmic surgery","description":"Used off-label in some eye surgeries to improve anesthesia penetration.","evidence":"Limited"}]
Primary treatment for: Not applicable (adjunctive agent)
📋 Drug Information
| Generic Name(s) | Hyaluronidase (1500IU) |
| Brand Name | entodase injection |
| Manufacturer | Entod Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Additives, preservatives |
| Route of Administration | Parenteral |
| Storage | Store at 2°C to 8°C (refrigerate). Do not freeze. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by temporarily depolymerizing hyaluronic acid, a key component of the extracellular matrix in connective tissues. Hyaluronic acid normally acts as a barrier to fluid movement. By breaking it down, this medicine increases tissue permeability, allowing injected substances to spread more easily and be absorbed faster. This effect is reversible and lasts for about 24 to 48 hours.
Mechanism Steps
💡 How to Take entodase injection
Strength: Injection: 1500 IU per vial (lyophilized powder for reconstitution).
Dosage Information
| Adult Dosage | The dosage of this medicine is determined by the healthcare provider based on the specific indication and the drug or fluid being administered. Typically, 1500 IU is used to enhance the absorption of a single injection. For hypodermoclysis, 1500 IU is added to each liter of fluid. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are established for elderly patients. Use as directed by a healthcare professional. |
| Renal Impairment | No dosage adjustments are established for renal impairment. Consult a healthcare professional. |
| Hepatic Impairment | No dosage adjustments are established for hepatic impairment. Consult a healthcare professional. |
| Maximum Daily Dose | Not established from the available information. Use as directed by a healthcare professional. |
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of entodase injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Dopamine | Major | |
| Epinephrine | Major | |
| Local anesthetics | Moderate | |
| Antibiotics | Moderate |
🚨 Major Interactions
- Dopamine
- Alpha-agonists (e.g., epinephrine)
⚡ Moderate Interactions
- Local anesthetics
- Antibiotics
🍷 Alcohol Interaction
No known interaction with alcohol. However, alcohol may worsen dehydration or other conditions; consult your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to hyaluronidase","Injection into infected or inflamed areas","Injection into areas with malignancy","Use in the eye","Concomitant use with dopamine or alpha-agonists"]
⚠️ Warnings & Precautions
["For professional use only; not for self-administration.","Use aseptic technique to prevent infection.","Avoid injection into blood vessels.","May increase systemic absorption of co-administered drugs; monitor accordingly.","Not to be used for intravenous administration."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor if you are breastfeeding.
💊 Overdose Management
Overdose is unlikely due to the local nature of administration. In case of accidental overdose, symptomatic and supportive care is recommended. Contact a poison control center if needed.
⏰ Missed Dose
This medicine is administered by a healthcare professional; missed dose instructions are not applicable.
Additional Safety Advice
This medicine must only be administered by a trained healthcare professional. Do not attempt to self-inject. Inform your doctor if you are allergic to hyaluronidase or any other medications. Before receiving this medicine, tell your doctor about all your medical conditions, especially infections, cancer, or kidney problems. Also, disclose all medications you are taking, as this medicine can affect how other drugs are absorbed. After the injection, monitor the site for any signs of infection or allergic reaction. Avoid rubbing or scratching the injection area. If you experience difficulty breathing, swelling of the face, lips, or throat, or a rapid heartbeat, seek emergency medical help immediately. Pregnant or breastfeeding women should consult their doctor before receiving this medicine. Keep all follow-up appointments as scheduled.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to fluid overload during hypodermoclysis. Monitor carefully.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy. Safety is not established.
🏥 Post-Surgery Considerations
This medicine may be used during surgery to enhance local anesthesia. Follow your surgeon's instructions.
🦷 Dental Procedures
This medicine may be used in dental procedures to improve local anesthesia spread. Inform your dentist if you have received this medicine recently.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are established. Follow your doctor's advice based on your condition.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is administered in a clinical setting. It may cause mild drowsiness or dizziness in some individuals; avoid driving or operating machinery until you know how it affects you.
🛑 When to Stop This Medicine
This medicine is given as a single dose or short course. Do not stop any co-administered medications without consulting your doctor.
📅 Long-Term Use Effects
This medicine is not intended for long-term use. It is administered as a single dose or for short-term therapy. No long-term effects are established from available information. Regular monitoring is not required beyond the immediate post-administration period.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For fluid administration, IV route is an alternative if accessible.
Evidence: Well-establishedNot applicable; hyaluronidase is unique.
Evidence: Not established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interaction with vaccines. Consult your doctor for specific advice.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store at room temperature for prolonged periods
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Keep it refrigerated (2°C to 8°C) using a cooler bag or ice pack. Carry a copy of your prescription to avoid customs issues. If traveling across time zones, consult your doctor for any adjustments. Always declare the medication if required by customs.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within minutes after injection.
A: The effects typically last for 24 to 48 hours.
A: Consult your doctor; safety is not established.
🤔 Common Patient Concerns
🔄 Substitutes for entodase injection
View AllAlternative brands with exact same active ingredient:
-
hylorase 1500iu injectionBiosena Lifescience ₹48.75 60.3% CHEAPER
-
anvase 1500iu injectionAjanta Pharma Ltd ₹64.28 47.7% CHEAPER
-
facidase 1500iu injectionSun Pharmaceutical Industries Ltd ₹110.70 9.9% CHEAPER
-
alldase 1500iu injectionUniword Pharma ₹124.00 1% COSTLIER
-
omnidase 1500iu injectionSunways India Pvt Ltd ₹143.44 16.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Hyaluronidase is a painkiller.
Fact: It is not a painkiller; it is an enzyme that helps other drugs spread. - Myth: Hyaluronidase can be self-injected.
Fact: It must only be administered by a healthcare professional.