duzono 20mg tablet - Duloxetine (20mg) medicine

duzono 20mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Arinna Lifescience Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is duzono 20mg tablet used for?

Ambidext 40 Tablet (Duloxetine) is used to treat NEURO CNS. It contains Duloxetine (20mg), which Selective serotonin and norepinephrine reuptake inhibitor (SNRI).. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Duloxetine
  • Manufacturer: Arinna Lifescience Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š duzono 20mg tablet Uses & Benefits

Major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal pain.

Off-label uses: Stress urinary incontinence, hot flashes, chronic pain syndromes.

๐Ÿ“‹ Drug Information

Generic Name(s)Duloxetine
Brand NameAmbidext 40 Tablet
ManufacturerArinna Lifescience Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassSerotonin-norepinephrine reuptake inhibitors (SNRIs)
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture and light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; peak plasma concentration achieved in 6 hours.
DistributionDistributes widely into tissues; volume of distribution approximately 1640 L.
Protein Binding>90% bound to plasma proteins (albumin and alpha-1-acid glycoprotein).
MetabolismExtensively metabolized in the liver via CYP1A2 and CYP2D6; multiple metabolites formed.
Half-LifeApproximately 12 hours (range 8-17 hours).
ExcretionApproximately 70% excreted in urine as metabolites, 20% in feces.
BioavailabilityApproximately 50% (30-80%) after oral administration.
Onset of Action1-2 weeks for therapeutic effect in depression; may take longer for pain relief.
Peak Plasma Time6 hours (range 4-8 hours).
Duration of ActionApproximately 24 hours with once-daily dosing.

How It Works

Selective serotonin and norepinephrine reuptake inhibitor (SNRI).

Mechanism Steps

1Duloxetine binds to SERT and NET with high affinity.
2Inhibits reuptake of serotonin and norepinephrine into presynaptic neurons.
3Increases extracellular concentrations of serotonin and norepinephrine in synaptic cleft.

๐Ÿ’ก How to Take duzono 20mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of duzono 20mg tablet

โœ… Common Side Effects

  • Nausea
  • Dry mouth
  • Somnolence
  • Fatigue
  • Constipation
  • Insomnia
  • Dizziness
  • Sweating

๐Ÿšจ Serious Side Effects

  • Serotonin syndrome
  • Hepatotoxicity
  • Suicidal thoughts
  • Seizures
  • Hypertensive crisis
  • Angle-closure glaucoma

โš ๏ธ Rare Side Effects

  • Stevens-Johnson syndrome
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
  • Rhabdomyolysis
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Increased risk of serotonin syndrome
Warfarin Moderate Increased bleeding risk
NSAIDs Moderate Increased bleeding risk
Alcohol Moderate Increased CNS depression and hepatotoxicity
CYP1A2 inhibitors Major Increased duloxetine exposure

๐Ÿšจ Major Interactions

  • MAOIs
  • Linezolid
  • Methylene blue
  • CYP1A2 inhibitors (e.g., fluvoxamine)
  • CYP2D6 inhibitors (e.g., paroxetine)

โšก Moderate Interactions

  • Warfarin
  • NSAIDs
  • Aspirin
  • Alcohol
  • CNS depressants
  • Serotonergic drugs (e.g., SSRIs, triptans)

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Quinolone antibiotics
  • Caffeine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions; may be taken with or without food.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase risk of liver injury and CNS depression.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Concomitant use with MAOIs, uncontrolled narrow-angle glaucoma, severe hepatic impairment, end-stage renal disease.

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, liver function tests, renal function, signs of serotonin syndrome, suicidal ideation.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk, potential for adverse effects in infant.

๐Ÿ’Š Overdose Management

Supportive care; monitor for serotonin syndrome, seizures, and cardiac effects; activated charcoal may be considered.

โฐ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for duzono 20mg tablet

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Alternative brands with exact same active ingredient (Duloxetine (20mg)):

Medical Note: Always consult your doctor before switching medications.

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