duraject 30mg tablet

4.2 (19 reviews)

Dapoxetine (30mg)

🏭 Akumentis Healthcare Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is duraject 30mg tablet used for?

Appynite (Dapoxetine) is used to treat UROLOGY. It contains Dapoxetine (30mg), which Selective serotonin reuptake inhibitor (SSRI) that increases serotonin activity . Always consult your doctor before use. Take as prescribed.

Generic Name: Dapoxetine
Manufacturer: Akumentis Healthcare Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 duraject 30mg tablet Uses & Benefits

Treatment of premature ejaculation in men aged 18-64 years.

Off-label uses: None established.

📋 Drug Information

Generic Name(s)	Dapoxetine
Brand Name	Appynite
Manufacturer	Akumentis Healthcare Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	UROLOGY
Action Class	Selective Seretonin Reuptake inhibitors (SSRIs)
Route of Administration	Oral.
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentration reached in 1-2 hours.

DistributionDistributed widely; volume of distribution approximately 1.5 L/kg.

Protein BindingApproximately 99% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP2D6, CYP3A4, and flavin-containing monooxygenase (FMO1) to multiple metabolites.

Half-LifeApproximately 1.5 hours (range 0.5-2.5 hours).

ExcretionPrimarily excreted in urine as metabolites; less than 3% excreted unchanged.

BioavailabilityApproximately 42% (due to first-pass metabolism).

Onset of ActionWithin 1 hour.

Peak Plasma Time1-2 hours.

Duration of ActionUp to 4-6 hours.

How It Works

Selective serotonin reuptake inhibitor (SSRI) that increases serotonin activity in the synaptic cleft, delaying ejaculation.

Mechanism Steps

1Dapoxetine binds to the serotonin transporter (SERT) on presynaptic neurons.

2Inhibition of serotonin reuptake increases serotonin concentration in the synaptic cleft.

3Enhanced serotonergic neurotransmission activates postsynaptic serotonin receptors.

💡 How to Take duraject 30mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of duraject 30mg tablet

✅ Common Side Effects

Nausea
Dizziness
Headache
Diarrhea
Insomnia
Fatigue

🚨 Serious Side Effects

Syncope
Orthostatic hypotension
Serotonin syndrome
Suicidal ideation
Seizures

⚠️ Rare Side Effects

QT prolongation
Allergic reactions
Liver injury
Mania

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
MAOIs	Major	Risk of serotonin syndrome
Thioridazine	Major	QT prolongation
Linezolid	Major	Serotonin syndrome
Methylene blue	Major	Serotonin syndrome
Serotonergic drugs	Major	Serotonin syndrome
CYP2D6 inhibitors	Major	Increased dapoxetine exposure
CYP3A4 inhibitors	Moderate	Increased dapoxetine exposure
Alcohol	Moderate	Orthostatic hypotension, dizziness
CNS depressants	Moderate	Additive CNS depression

🚨 Major Interactions

MAOIs
Thioridazine
Linezolid
Methylene blue
Serotonergic drugs (e.g., SSRIs, SNRIs, triptans)
CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine)

⚡ Moderate Interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Alcohol
CNS depressants

ℹ️ Minor Interactions

CYP2D6 substrates
CYP3A4 substrates

🍽️ Food Interactions

No significant food interactions; may be taken with or without food.

🍷 Alcohol Interaction

Increased risk of orthostatic hypotension, dizziness, and syncope; avoid alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to dapoxetine, concurrent MAOI use, severe hepatic impairment, moderate to severe renal impairment, history of syncope, mania, or bipolar disorder.

📊 Monitoring Parameters

Blood pressure, heart rate, signs of serotonin syndrome, syncope, orthostatic hypotension.

🤱 Lactation Safety

Not indicated for use in women; excretion in breast milk unknown.

💊 Overdose Management

No specific antidote; supportive care, monitor for serotonin syndrome, ECG monitoring.

⏰ Missed Dose

Take as needed 1-3 hours before sexual activity; do not take more than once daily.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for duraject 30mg tablet

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Alternative brands with exact same active ingredient (Dapoxetine (30mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026