duonex respules 2.5ml - Levosalbutamol (1.25mg) + Ipratropium (500mcg) medicine

duonex respules 2.5ml - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Edolf Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is duonex respules 2.5ml used for?

Combimist-L CFC Free Inhaler (Levosalbutamol + Ipratropium) is used to treat RESPIRATORY. It contains Levosalbutamol (1.25mg) + Ipratropium (500mcg), which Levosalbutamol stimulates beta-2 receptors causing bronchodilation; Ipratropium . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Levosalbutamol + Ipratropium
  • Manufacturer: Edolf Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š duonex respules 2.5ml Uses & Benefits

COPD, asthma (maintenance and acute exacerbations)

Off-label uses: Bronchiolitis, acute respiratory distress syndrome (limited evidence)

๐Ÿ“‹ Drug Information

Generic Name(s)Levosalbutamol + Ipratropium
Brand NameCombimist-L CFC Free Inhaler
ManufacturerEdolf Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassBronchodilator (Beta-2 agonist + Anticholinergic)
Route of AdministrationInhalation (metered dose inhaler)
StorageStore at room temperature (15-30ยฐC), protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionInhaled; rapid absorption from lungs
DistributionDistributes to lungs and systemic circulation
Protein BindingLevosalbutamol: ~50%; Ipratropium: <20%
MetabolismLevosalbutamol: hepatic via COMT; Ipratropium: minimal hepatic
Half-LifeLevosalbutamol: 3-4 hours; Ipratropium: 2-3 hours
ExcretionRenal (mostly unchanged and metabolites)
BioavailabilityInhaled: ~10-20% systemic
Onset of ActionWithin 5-15 minutes
Peak Plasma TimeLevosalbutamol: 1-2 hours; Ipratropium: 1-2 hours
Duration of Action4-6 hours

How It Works

Levosalbutamol stimulates beta-2 receptors causing bronchodilation; Ipratropium blocks muscarinic receptors reducing bronchoconstriction

Mechanism Steps

1Levosalbutamol binds to beta-2 adrenergic receptors on bronchial smooth muscle
2Activates Gs protein, increasing cAMP
3cAMP activates protein kinase A, leading to relaxation of smooth muscle

๐Ÿ’ก How to Take duonex respules 2.5ml

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of duonex respules 2.5ml

โœ… Common Side Effects

  • Tremor
  • Headache
  • Cough
  • Dry mouth
  • Nausea
  • Palpitations

๐Ÿšจ Serious Side Effects

  • Paradoxical bronchospasm
  • Hypokalemia
  • Cardiac arrhythmias
  • Hypertension

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Angioedema
  • Urinary retention
  • Glaucoma exacerbation

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Beta-blockers Major Antagonism of bronchodilator effect
MAOIs Major Increased risk of hypertensive crisis
Tricyclic antidepressants Major Enhanced cardiovascular effects
Diuretics Major Hypokalemia risk
Other beta-agonists Major Additive side effects
Xanthine derivatives Moderate Increased CNS stimulation
Corticosteroids Moderate Hypokalemia risk
Anticholinergics Moderate Additive anticholinergic effects
Digoxin Minor Hypokalemia may increase digoxin toxicity
Halogenated anesthetics Minor Increased risk of arrhythmias

๐Ÿšจ Major Interactions

  • Beta-blockers
  • MAOIs
  • Tricyclic antidepressants
  • Diuretics
  • Other beta-agonists

โšก Moderate Interactions

  • Xanthine derivatives
  • Corticosteroids
  • Anticholinergics

โ„น๏ธ Minor Interactions

  • Digoxin
  • Halogenated anesthetics

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to any component, tachyarrhythmias, hypertrophic obstructive cardiomyopathy

๐Ÿ“Š Monitoring Parameters

Lung function (FEV1, PEFR), heart rate, serum potassium, blood pressure

๐Ÿคฑ Lactation Safety

Caution; limited data

๐Ÿ’Š Overdose Management

Supportive care; monitor cardiac function, electrolytes; consider beta-blockers cautiously

โฐ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

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