DPM Injection (Diazepam): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow breathing or difficulty breathing
- Severe dizziness or fainting
- Slow or irregular heartbeat
- Unusual agitation, hallucinations, or confusion
- Rash, swelling of face, lips, or throat
- Yellowing of skin or eyes
- Seizures after stopping the medicine suddenly
- Inability to pass urine
If experiencing severe symptoms, call emergency services immediately.
What is dpm injection used for?
This medicine is a prescription injection of diazepam, a benzodiazepine used in hospitals for severe anxiety, alcohol withdrawal, muscle spasms, and seizures. It is given by a healthcare professional and must not be self-administered.
- Generic Name: Diazepam
- Manufacturer: Arrow Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dpm injection के बारे में (Hindi Summary)
उपयोग: यह दवा डायजेपाम का इंजेक्शन है, जिसका उपयोग गंभीर चिंता, अल्कोहल विथड्रॉल, मांसपेशियों में ऐंठन और दौरे के इलाज के लिए अस्पताल में किया जाता है। यह दवा केवल डॉक्टर या नर्स द्वारा ही दी जाती है। इसे घर पर स्वयं न लगाएं। यह दवा मस्तिष्क में शांति पैदा करने वाले रसायन को बढ़ाकर काम करती है, जिससे घबराहट कम होती है, मांसपेशियां ढीली होती हैं और दौरे नियंत्रित होते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, मांसपेशियों में कमजोरी और अस्थिरता शामिल हैं। कुछ लोगों को भ्रम, धुंधली दृष्टि या मुंह सूखना भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन सांस लेने में कठिनाई, धीमी धड़कन, निम्न रक्तचाप, या एलर्जी प्रतिक्रिया हो सकती है। लंबे समय तक उपयोग से निर्भरता और विथड्रॉल लक्षण हो सकते हैं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित स्वास्थ्यकर्मी द्वारा दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। अपने डॉक्टर को सभी दवाओं के बारे में बताएं, खासकर ओपिओइड, अवसादरोधी, या अल्कोहल। इस दवा को लेने के बाद कम से कम 24 घंटे तक वाहन न चलाएं। शराब का सेवन बिल्कुल न करें। यदि आपको लीवर, किडनी या फेफड़ों की बीमारी है, तो डॉक्टर को बताएं।
💊 dpm injection Uses & Benefits
[{"condition":"Severe acute anxiety","description":"Used for rapid relief of severe anxiety or panic when oral therapy is not feasible.","evidence":"Well-established"},{"condition":"Acute alcohol withdrawal","description":"Helps control agitation, tremors, and seizures during alcohol withdrawal.","evidence":"Well-established"},{"condition":"Muscle spasms","description":"Relaxes skeletal muscle in conditions such as tetanus, cerebral palsy, and acute muscle spasm.","evidence":"Well-established"},{"condition":"Status epilepticus","description":"Used as an emergency anticonvulsant for prolonged seizures.","evidence":"Well-established"},{"condition":"Preoperative sedation","description":"Provides sedation and anxiety relief before certain procedures.","evidence":"Well-established"},{"condition":"Sedation for diagnostic procedures","description":"Used to calm patients during endoscopy, cardioversion, and other brief procedures.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chemotherapy-induced nausea","description":"Occasionally used as an add-on for nausea and vomiting associated with chemotherapy.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Rarely used when other treatments are ineffective.","evidence":"Limited"},{"condition":"Catatonia","description":"Sometimes used for short-term management of catatonic symptoms.","evidence":"Limited"}]
Primary treatment for: Severe acute anxiety
Also treats: Acute alcohol withdrawal, Muscle spasms, Status epilepticus, Preoperative sedation
📋 Drug Information
| Generic Name(s) | Diazepam |
| Brand Name | Alzepam |
| Manufacturer | Arrow Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepines |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep in the original container until ready to use. |
| Shelf Life | Typically 24-36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine belongs to the benzodiazepine class. It binds to a specific site on the GABA-A receptor in the brain, which is a protein that controls the flow of chloride ions into nerve cells. By binding to this receptor, it enhances the effect of GABA, the brain's main inhibitory neurotransmitter. This increased inhibition reduces the excitability of nerve cells, leading to anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.
Mechanism Steps
💡 How to Take dpm injection
Strength: Injection: 5 mg/mL in 2 mL ampoules (10 mg per ampoule).
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and clinical response. For severe acute anxiety, a typical adult dose is 2-10 mg given intramuscularly or intravenously, repeated after 3-4 hours if necessary. For acute alcohol withdrawal, 5-10 mg may be given initially, followed by 5-10 mg every 2-4 hours as needed. For muscle spasms, 5-10 mg may be given every 4-6 hours. For status epilepticus, 5-10 mg is given intravenously slowly, repeated every 10-15 minutes up to a maximum of 30 mg. For preoperative sedation, 5-10 mg is given intramuscularly 30-60 minutes before surgery. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this injection in all age groups. For status epilepticus in children, a clinician may use 0.2-0.5 mg/kg intravenously slowly, but this must be determined by a pediatrician. Consult a pediatrician for any use in children. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine and are at increased risk of falls, confusion, and respiratory depression. The initial dose should be reduced, typically to half the usual adult dose, and titrated slowly. Use with caution and monitor closely. |
| Renal Impairment | Diazepam and its metabolites are excreted by the kidneys. In patients with renal impairment, the dose may need to be reduced, and the dosing interval extended. Monitor for increased sedation and adjust accordingly. |
| Hepatic Impairment | Diazepam is extensively metabolized in the liver. In patients with hepatic impairment, the half-life is prolonged, and the dose should be reduced. Use with caution and monitor for signs of toxicity. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the indication and patient factors. For status epilepticus, the maximum total dose is typically 30 mg. For other indications, the maximum daily dose should not exceed what is necessary to achieve the desired effect with minimal side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dpm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Alcohol | Major | |
| Clozapine | Major | |
| CNS depressants | Major | |
| Ketoconazole | Moderate | |
| Omeprazole | Moderate | |
| Rifampicin | Moderate | |
| Fluoxetine | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Opioids (e.g., morphine, fentanyl)
- Alcohol
- CNS depressants (e.g., barbiturates, antipsychotics)
- Clozapine
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP2C19 inhibitors (e.g., omeprazole, fluoxetine)
- Rifampicin
🍷 Alcohol Interaction
Alcohol should be completely avoided while receiving this medicine. Combining alcohol with diazepam can cause severe sedation, respiratory depression, coma, and even death. Inform your doctor if you consume alcohol regularly, as this may affect your treatment and increase the risk of withdrawal seizures.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diazepam or other benzodiazepines","Severe respiratory insufficiency","Severe hepatic impairment","Myasthenia gravis","Sleep apnoea syndrome","Acute narrow-angle glaucoma","Severe hypotension","Use in children under 6 months (for injection, except in specific emergencies)"]
⚠️ Warnings & Precautions
["This medicine can cause physical and psychological dependence. Use for the shortest duration possible.","Abrupt discontinuation after prolonged use can cause withdrawal symptoms, including seizures. Taper gradually.","Concurrent use with opioids may cause profound sedation, respiratory depression, coma, and death. Reserve for situations where alternatives are inadequate.","Use with caution in elderly patients, who are more sensitive to the effects and at higher risk of falls.","Avoid driving or operating machinery until the effects wear off.","Do not use in patients with severe liver disease, as it may precipitate coma.","Use with caution in patients with renal impairment.","May cause paradoxical reactions such as agitation, hallucinations, and aggression.","Injection should be given slowly into a large vein to reduce the risk of thrombophlebitis and hypotension.","Do not mix with other drugs in the same syringe or infusion fluid unless compatibility is established."]
🤱 Lactation Safety
Diazepam and its active metabolites are excreted in breast milk. Because of the potential for sedation and withdrawal symptoms in the infant, breastfeeding is not recommended while receiving this medicine, especially with repeated doses. If a single dose is necessary, breastfeeding should be avoided for at least 24 hours after administration.
💊 Overdose Management
Overdose of diazepam can cause severe drowsiness, confusion, respiratory depression, hypotension, and coma. Management includes immediate supportive care, ensuring a patent airway, assisted ventilation if needed, and monitoring of vital signs. The specific antidote is flumazenil, a benzodiazepine antagonist, but it should be used with caution as it can precipitate seizures in patients with benzodiazepine dependence or mixed overdose with tricyclic antidepressants. Activated charcoal may be considered if the overdose was oral and within 1-2 hours, but this is not applicable for injection. Hemodialysis is not effective for diazepam removal.
⏰ Missed Dose
This medicine is given by a healthcare professional in a controlled setting, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse for guidance. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional in a medical facility. Do not attempt to use it at home. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Tell your doctor about all medicines you take, especially opioids, antidepressants, antipsychotics, antihistamines, or alcohol, as these can increase sedation and breathing problems. Avoid driving or operating machinery for at least 24 hours after receiving this medicine, or longer if you feel drowsy. Do not drink alcohol while receiving this medicine. If you have liver, kidney, or lung disease, your doctor may adjust the dose or monitor you more closely. Do not stop this medicine suddenly if you have been using it regularly, as withdrawal seizures can occur. Always follow your doctor's instructions and attend follow-up appointments.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine and are at increased risk of falls, confusion, and respiratory depression. The initial dose should be reduced, typically to half the usual adult dose, and titrated slowly. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. Diazepam has been associated with an increased risk of congenital malformations, particularly cleft lip and palate, when used during the first trimester. Effective contraception should be used during treatment. If you become pregnant while receiving this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used before or during surgery for sedation and anxiety relief. After surgery, it can cause drowsiness and respiratory depression, so you will be monitored closely. Inform your surgeon and anesthesiologist if you have been taking this medicine regularly, as it may affect anesthesia and pain management.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it can cause drowsiness and interact with other sedatives used in dental procedures. You may need to postpone dental work until the effects wear off. Do not drive yourself to or from dental appointments if you have received this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that require alertness and coordination for at least 24 hours after receiving this medicine, as it can cause drowsiness, dizziness, and muscle weakness. Gradually resume activities as you feel alert. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness, dizziness, and impaired coordination, which can affect your ability to work, drive, or operate machinery. You should not drive or operate heavy machinery for at least 24 hours after receiving this medicine. If your job requires alertness, you may need to take time off. Discuss with your doctor when it is safe to return to work.
🛑 When to Stop This Medicine
This medicine is usually given for a short duration in a hospital setting. If you have been using it regularly for a long time, do not stop suddenly, as this can cause withdrawal seizures. Your doctor will gradually reduce the dose under medical supervision. If you experience side effects or your condition improves, consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning you need higher doses to get the same effect, and dependence, meaning you experience withdrawal symptoms when you stop. Withdrawal symptoms can include anxiety, insomnia, tremors, and seizures. Prolonged use may also cause cognitive impairment, memory problems, and falls, especially in the elderly. Regular monitoring and gradual tapering under medical supervision are essential if long-term use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be effective for long-term management of anxiety without the risks of dependence.
Evidence: Well-establishedDeep breathing, meditation, and yoga can help reduce anxiety.
Evidence: Well-establishedCan help with muscle spasms and improve mobility.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are receiving this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container until use
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Check expiry date before use
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic setting and is not for self-administration during travel. If you are prescribed this medicine for use during travel, carry it in its original packaging with a copy of your prescription. Store it at room temperature and protect it from light. Check the laws of your destination country regarding controlled substances, as diazepam may be regulated. Always declare it at customs if required. Do not pack it in checked luggage; keep it in your carry-on. If you need to cross time zones, consult your doctor for dose timing adjustments.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: When given intravenously, this medicine starts working within 1-5 minutes. When given intramuscularly, it takes about 15-30 minutes to start working.
A: The sedative and anxiolytic effects usually last 3-6 hours after a single dose, but the active metabolites can prolong the effects, especially with repeated dosing.
A: No, this medicine must only be given by a trained healthcare professional in a medical facility. It is not for self-administration at home.
A: This medicine may harm the unborn baby, especially in the first trimester. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
A: No, alcohol should be completely avoided while receiving this medicine. Combining alcohol with diazepam can cause severe sedation, respiratory depression, coma, and even death.
A: This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, inform your nurse or doctor immediately.
🤔 Common Patient Concerns
🔄 Substitutes for dpm injection
View AllAlternative brands with exact same active ingredient:
-
dizep injectionInd Swift Laboratories Ltd ₹4.10 63.6% CHEAPER
-
dpm tabletArrow Pharma ₹45.00 300% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller. It is a benzodiazepine used for anxiety, muscle spasms, and seizures. - Myth: This medicine can be taken at home for anxiety.
Fact: This injection must only be given by a healthcare professional in a medical facility. - Myth: This medicine is safe to use during pregnancy.
Fact: This medicine may harm the unborn baby, especially in the first trimester. Use only if clearly needed. - Myth: This medicine is not addictive.
Fact: This medicine can cause dependence and withdrawal symptoms with prolonged use.
🔄 Alternative Options
Generic Alternatives
- Diazepam injection
Brand Alternatives
- DPM Injection