Avimol D 20mg/325mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe abdominal pain or blood in vomit/stool
- Yellowing of skin or eyes (jaundice)
- Muscle stiffness, tremors, or involuntary movements
- Swelling of face, lips, or throat
- Difficulty breathing or chest pain
- Decreased urine output or dark urine
If experiencing severe symptoms, call emergency services immediately.
What is domfen-p tablet used for?
This medicine is a combination of Domperidone and Paracetamol used to treat nausea, vomiting, and mild to moderate pain. It works by improving stomach emptying and reducing pain signals in the brain. It should be taken as prescribed by a doctor, usually before meals.
- Generic Name: Domperidone (20mg) + Paracetamol (325mg)
- Manufacturer: Medfence Labs
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 domfen-p tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और पैरासिटामोल का संयोजन है, जिसका उपयोग मतली, उल्टी और हल्के से मध्यम दर्द के इलाज के लिए किया जाता है। यह पेट की गतिशीलता को बढ़ाकर और दर्द संकेतों को कम करके काम करती है। इसे डॉक्टर के निर्देशानुसार, आमतौर पर भोजन से पहले लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, नींद आना और पेट में हल्की ऐंठन शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, मांसपेशियों में अकड़न, और त्वचा पर गंभीर एलर्जी प्रतिक्रियाएँ शामिल हो सकती हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसके साथ शराब का सेवन न करें। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएँ। यकृत या गुर्दे की बीमारी हो तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग बिना डॉक्टर की सलाह के न करें।
💊 domfen-p tablet Uses & Benefits
[{"condition":"Nausea and vomiting associated with gastroparesis","description":"This medicine helps relieve nausea and vomiting by enhancing gastric emptying and blocking dopamine receptors in the brain.","evidence":"Well-established"},{"condition":"Functional dyspepsia with pain","description":"It reduces upper abdominal discomfort, bloating, and pain by improving gastric motility and providing analgesic effect.","evidence":"Moderate"},{"condition":"Migraine-associated nausea and pain","description":"Used to alleviate nausea and mild pain during migraine attacks, though not a primary migraine treatment.","evidence":"Limited"},{"condition":"Post-operative nausea and vomiting","description":"Sometimes used to manage nausea after surgery, but only under medical supervision.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Gastroesophageal reflux disease (GERD) with pain","description":"Occasionally prescribed to reduce reflux symptoms and associated chest discomfort, though not first-line.","evidence":"Limited"},{"condition":"Diabetic gastroparesis","description":"May be used off-label to improve gastric emptying in diabetic patients with gastroparesis.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting with associated pain
Also treats: Functional dyspepsia, Gastroparesis, Migraine-associated nausea
📋 Drug Information
| Generic Name(s) | Domperidone (20mg) + Paracetamol (325mg) |
| Brand Name | domfen-p tablet |
| Manufacturer | Medfence Labs |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and in the gastrointestinal tract. This action enhances gastric motility and accelerates gastric emptying without significant central nervous system penetration. Paracetamol acts centrally by inhibiting prostaglandin synthesis in the brain, thereby reducing pain and fever. The combination provides symptomatic relief from nausea, vomiting, and mild to moderate pain.
Mechanism Steps
💡 How to Take domfen-p tablet
Strength: Each tablet contains Domperidone 20 mg and Paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally up to three times daily, preferably before meals. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. Do not self-adjust the dose. The maximum daily dose should not exceed the prescribed limit, and treatment duration should be as short as possible. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac arrhythmias and extrapyramidal symptoms. Use with caution and lower doses may be considered. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment, dose reduction or avoidance may be necessary. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction or avoidance may be necessary due to reduced metabolism of both components. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of Paracetamol should not exceed 4 grams (4000 mg) from all sources. For this combination, the maximum daily dose of domperidone should not exceed 60 mg. Always follow the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of domfen-p tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Major | |
| Clarithromycin | Major | |
| Metoclopramide | Moderate | |
| Atropine | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Opioids | Minor | |
| Alcohol | Major | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Ketoconazole, Itraconazole, Clarithromycin, Ritonavir
- Warfarin
- Alcohol
⚡ Moderate Interactions
- Metoclopramide
- Anticholinergic drugs (e.g., Atropine, Hyoscyamine)
- Cholestyramine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol increases the risk of liver damage from Paracetamol and may worsen drowsiness and dizziness caused by domperidone. It can also increase the risk of gastrointestinal bleeding.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone, Paracetamol, or any component of the formulation","Gastrointestinal obstruction, perforation, or bleeding","Prolactin-releasing pituitary tumor (prolactinoma)","Severe hepatic impairment","Severe renal impairment","Known QT prolongation or history of cardiac arrhythmias","Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)","Children under 12 years of age"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose of Paracetamol; overdose can cause severe liver damage.","Use with caution in elderly patients due to increased risk of cardiac arrhythmias and extrapyramidal symptoms.","Avoid use in patients with underlying heart disease or electrolyte imbalances.","Do not use for more than 7 days without medical advice.","Inform your doctor if you have liver or kidney disease before taking this medicine.","Avoid alcohol consumption while taking this medicine.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not take other Paracetamol-containing products concurrently."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the infant. Paracetamol is considered safe during breastfeeding in standard doses. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to Paracetamol and cardiac arrhythmias due to domperidone. Symptoms of Paracetamol overdose include nausea, vomiting, abdominal pain, and yellowing of skin or eyes. If overdose is suspected, seek emergency medical attention immediately. Treatment may include activated charcoal, N-acetylcysteine for Paracetamol toxicity, and supportive care for domperidone-related effects. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and drowsiness. Do not drive or operate heavy machinery if you feel drowsy or dizzy after taking this medicine. Inform your doctor if you have a history of heart problems, liver disease, kidney disease, or electrolyte imbalances. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not take other medicines containing Paracetamol while on this medicine to avoid overdose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of cardiac arrhythmias and extrapyramidal symptoms from Domperidone. Use with caution and lower doses may be required. Regular monitoring of heart and kidney function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. The safety of Domperidone during pregnancy is not well established, and Paracetamol should be used at the lowest effective dose for the shortest duration.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative nausea and vomiting under medical supervision. However, it should be used with caution after surgery due to potential cardiac effects and interactions with anesthetic agents.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with medications used during dental procedures, and drowsiness could affect your ability to cooperate.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring balance if you experience drowsiness or dizziness after taking this medicine. Light walking may help digestion, but consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth, so keep water handy. Inform your employer if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as irregular heartbeat, muscle stiffness, or yellowing of skin. Do not stop abruptly without medical advice if you have been on long-term therapy.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver damage from Paracetamol and cardiac arrhythmias from Domperidone. Regular monitoring of liver and heart function may be required. It is not recommended for prolonged use without medical supervision. Consult your doctor for alternative treatments if symptoms persist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent, bland meals can help reduce nausea and dyspepsia.
Evidence: Well-establishedGinger has antiemetic properties and may help reduce nausea.
Evidence: ModerateMay help relieve nausea in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Check local customs regulations regarding prescription medicines before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: It is best taken 15-30 minutes before meals. If it causes stomach upset, take it with a small snack.
A: Consult your doctor before using this medicine during pregnancy. The safety profile is not well established.
A: Do not take other Paracetamol-containing products concurrently to avoid overdose. Consult your doctor before adding any medicine.
🤔 Common Patient Concerns
🔄 Substitutes for domfen-p tablet
View AllAlternative brands with exact same active ingredient:
-
albimol d 20mg/325mg tabletAlbia Biocare ₹38.44 7.9% COSTLIER
-
paratuf-d tabletMedishri Healthcare ₹42.19 18.4% COSTLIER
-
exadom p 20mg/325mg tabletAronex Life Sciences Pvt Ltd ₹46.88 31.6% COSTLIER
-
iramol d 20mg/325mg tabletKiama Lifesciences ₹47.81 34.2% COSTLIER
-
taldom tabletUnimarck Healthcare Ltd ₹48.47 36% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is specifically for nausea and vomiting with mild pain. It is not a general painkiller for all conditions. - Myth: It is safe to take extra doses if symptoms are severe.
Fact: Taking more than the prescribed dose can cause serious liver damage and heart problems. Always follow the prescribed dose. - Myth: This medicine can be taken long-term without any monitoring.
Fact: Prolonged use requires medical supervision and monitoring of liver and heart function.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Paracetamol generic tablets
Brand Alternatives
- Domperidone + Paracetamol combinations available under various brand names