Agizone 1gm Injection (Ceftriaxone 1gm): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- A rapidly spreading rash with fever, skin peeling, or blisters
- Severe, watery, or bloody diarrhoea with abdominal cramps or fever
- Severe upper abdominal pain spreading to the back, with nausea and vomiting
- Yellowing of the skin or eyes, dark urine, or severe fatigue
- Unusual bruising or bleeding, or a sudden high fever with sore throat
- Seizures or sudden confusion, especially in people with kidney problems
- Decreased urine output or swelling of the legs and feet
If experiencing severe symptoms, call emergency services immediately.
What is doczone 1gm injection used for?
This medicine is a ceftriaxone 1 gram injection, a third-generation cephalosporin antibiotic given by a healthcare professional to treat serious bacterial infections such as pneumonia, meningitis, gonorrhoea, and complicated urinary tract infections. It works by breaking down the bacterial cell wall, causing the bacteria to die. It is not effective against viral infections and must only be used under medical supervision.
- Generic Name: Ceftriaxone (1gm)
- Manufacturer: Docventures pharmaceutical Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 doczone 1gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्ट्रिएक्सोन 1 ग्राम इंजेक्शन है, जो एक तीसरी पीढ़ी का सेफलोस्पोरिन एंटीबायोटिक है। यह अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है। इसका उपयोग निमोनिया, मेनिनजाइटिस, गोनोरिया, गुर्दे और मूत्र मार्ग के गंभीर संक्रमण, रक्त संक्रमण, त्वचा और हड्डियों के संक्रमण जैसी गंभीर बैक्टीरियल बीमारियों के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया की कोशिका भित्ति को तोड़कर उन्हें मार देती है। यह वायरल संक्रमण जैसे सर्दी-जुकाम या फ्लू पर असर नहीं करती। इस दवा का उपयोग केवल डॉक्टर की सलाह और निगरानी में ही किया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, सूजन या लालिमा, दस्त, जी मिचलाना, उल्टी, सिरदर्द, चक्कर आना और त्वचा पर दाने या खुजली शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव कम होते हैं, लेकिन इन पर तुरंत ध्यान देना जरूरी है। इनमें चेहरे, होंठ, जीभ या गले में सूजन, सांस लेने में कठिनाई, तेज बुखार के साथ त्वचा पर फफोले, गंभीर या खूनी दस्त, पेट में तेज दर्द, पीलिया, बहुत ज्यादा थकान, असामान्य रक्तस्राव या चक्कर आना शामिल हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। अगर आपको पेनिसिलिन या सेफलोस्पोरिन एंटीबायोटिक से कभी एलर्जी हुई है, तो डॉक्टर को जरूर बताएं। अपनी सभी दवाओं, खासकर खून पतला करने वाली दवाओं और कैल्शियम वाले इंजेक्शन के बारे में डॉक्टर को जानकारी दें। नवजात शिशुओं को कैल्शियम वाले घोल के साथ यह दवा नहीं दी जानी चाहिए। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। गुर्दे या लीवर की बीमारी होने पर डॉक्टर खुराक कम कर सकते हैं या निगरानी बढ़ा सकते हैं। इलाज का पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। बिना डॉक्टर की सलाह के यह इंजेक्शन खुद न लगाएं और न ही किसी और को दें।
💊 doczone 1gm injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used as a first-line injectable antibiotic for moderate to severe community-acquired pneumonia, often combined with a macrolide or given alone depending on local guidelines.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Used in hospital treatment of meningitis caused by susceptible bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Gonorrhoea","description":"Given as a single intramuscular dose for uncomplicated gonorrhoea, including infections of the urethra, cervix, rectum, and pharynx.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Used for kidney and complicated bladder infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections and sepsis","description":"Used as part of initial intravenous therapy for sepsis and bacteraemia while culture results are pending.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for serious cellulitis, abscesses, and wound infections requiring injectable antibiotics.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used in the treatment of osteomyelitis and septic arthritis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"Given before certain surgical procedures to reduce the risk of postoperative infection.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Used as part of combination therapy for pelvic inflammatory disease in hospitalised patients.","evidence":"Well-established"},{"condition":"Typhoid fever","description":"Used as an alternative injectable treatment for enteric fever caused by Salmonella typhi in some settings.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Lyme disease with neurological involvement","description":"Sometimes used as an alternative to other intravenous antibiotics for certain manifestations of Lyme disease.","evidence":"Limited"},{"condition":"Melioidosis","description":"Used in some treatment protocols for melioidosis, often in combination with other antibiotics.","evidence":"Limited"},{"condition":"Whipple's disease","description":"Occasionally used as part of antibiotic regimens for this rare chronic infection.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms, including pneumonia, meningitis, gonorrhoea, and complicated urinary tract infections.
Also treats: Bloodstream infections and sepsis, Skin and soft tissue infections, Bone and joint infections, Pelvic inflammatory disease, Surgical site infection prophylaxis, Typhoid fever
📋 Drug Information
| Generic Name(s) | Ceftriaxone (1gm) |
| Brand Name | doczone 1gm injection |
| Manufacturer | Docventures pharmaceutical Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store the unreconstituted powder at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Do not freeze. Once reconstituted, the solution should be used as soon as possible; if not used immediately, follow the specific storage instructions provided by the pharmacy or manufacturer, which may include refrigeration for a limited time. Keep out of reach of children. |
| Shelf Life | The shelf life of the unreconstituted powder is usually 24 to 36 months from the date of manufacture, depending on the manufacturer and packaging. Always check the expiry date on the vial before use. Do not use the medicine if the powder is discoloured or if the expiry date has passed. |
| WHO Guideline | The World Health Organization includes ceftriaxone in its Model List of Essential Medicines and recommends it for several serious bacterial infections, including pneumonia, meningitis, and gonorrhoea, based on local resistance patterns and clinical guidelines. Always follow the most current national or institutional guidelines for specific indications. |
| ICMR Guideline | The Indian Council of Medical Research and national treatment guidelines in India recommend ceftriaxone for many serious bacterial infections, including community-acquired pneumonia, meningitis, enteric fever, and gonorrhoea, while emphasising culture-guided therapy and antimicrobial stewardship to limit resistance. Clinicians should refer to the latest ICMR treatment guidelines for specific dosing and duration. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a third-generation cephalosporin antibiotic that kills bacteria by interfering with the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins located inside the bacterial cell membrane and blocks the cross-linking of peptidoglycan strands, which are essential for the strength and shape of the bacterial cell wall. Without a properly formed cell wall, the bacterium cannot maintain its internal pressure and eventually bursts and dies. This medicine is bactericidal, meaning it actively kills susceptible bacteria rather than simply stopping their growth. It is stable against many beta-lactamase enzymes produced by bacteria, which gives it a broader spectrum of activity than earlier penicillins and cephalosporins. However, it can be destroyed by extended-spectrum beta-lactamases and carbapenemases, so susceptibility testing is important when resistant organisms are suspected.
Mechanism Steps
💡 How to Take doczone 1gm injection
Strength: This medicine is supplied as a sterile powder for injection containing ceftriaxone 1 gram per vial. It must be reconstituted with a suitable diluent before use, as directed by the manufacturer or healthcare professional.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 gram to 2 grams given once daily by intramuscular or intravenous injection, depending on the type and severity of the infection. For uncomplicated gonorrhoea, a single 500 mg intramuscular dose is often used. For meningitis, higher doses such as 2 grams every 12 hours may be needed. The dose and duration must be individualized by a qualified clinician based on the indication, age, weight, kidney and liver function, and clinical response. Do not self-administer this medicine. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, children may receive 50 to 75 mg per kg of body weight once daily for many infections, but the exact dose depends on the infection, age, weight, and kidney function. Newborns have special restrictions, especially regarding calcium-containing solutions and jaundice risk. Only a qualified pediatrician should decide the dose and route for a child. |
| Elderly Dosage | Elderly patients usually receive the same adult dose as younger adults, but they are more likely to have reduced kidney function and to take other medicines. The dose may need to be adjusted if kidney function is impaired, and monitoring for side effects and interactions is especially important. A qualified clinician should individualize the dose. |
| Renal Impairment | In patients with mild to moderate kidney impairment, the usual adult dose can often be given without change. In severe kidney impairment, defined as a creatinine clearance below 10 mL per minute, the daily dose should generally not exceed 2 grams. For patients on haemodialysis, this medicine is not removed significantly by dialysis, so no extra dose is usually needed after dialysis, but the dose should be individualized by a qualified clinician. |
| Hepatic Impairment | Mild to moderate liver impairment usually does not require a dose change because this medicine is not significantly metabolised by the liver. However, if both liver and kidney function are impaired, the dose may need to be reduced and monitored closely. A qualified clinician should decide the appropriate dose. |
| Maximum Daily Dose | The maximum recommended daily dose is generally 4 grams, but doses up to 4 grams per day may be used in serious infections such as meningitis under close medical supervision. Doses above 4 grams per day are not recommended. The exact maximum must be determined by a qualified clinician based on the individual patient. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of doczone 1gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Calcium-containing IV solutions | Major | |
| Warfarin | Major | |
| Aminoglycosides | Major | |
| Chloramphenicol | Major | |
| Live bacterial vaccines | Major | |
| Loop diuretics | Moderate | |
| NSAIDs | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Calcium-containing intravenous solutions
- Warfarin and other vitamin K antagonists
- Aminoglycosides such as gentamicin
- Chloramphenicol
- Live bacterial vaccines such as typhoid vaccine
⚡ Moderate Interactions
- Loop diuretics such as furosemide
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
There is no direct chemical interaction between this medicine and alcohol. However, drinking alcohol while you are being treated for a serious bacterial infection can worsen dehydration, increase nausea and stomach upset, and put extra strain on your liver. It is best to avoid alcohol until you have completed treatment and your doctor confirms that you have recovered.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to ceftriaxone or any other cephalosporin antibiotic","Previous severe immediate allergic reaction to penicillin antibiotics","Use in newborns who are receiving or are expected to receive calcium-containing intravenous solutions","Use in newborns with jaundice or who are at risk of jaundice","Use in premature newborns up to a corrected age of 41 weeks","Use in patients who need calcium-containing intravenous fluids, unless the clinician decides the benefit clearly outweighs the risk and takes appropriate precautions"]
⚠️ Warnings & Precautions
["Tell your doctor about all allergies before receiving this medicine, especially to penicillin or cephalosporins.","Serious allergic reactions can occur; treatment should be stopped immediately if they develop.","Diarrhoea during or after treatment may be a sign of a serious bowel infection and should be reported.","This medicine can cause gallbladder sludge or stones, especially in children; report abdominal pain or vomiting.","Blood counts may need monitoring during prolonged treatment.","Kidney and liver function should be checked in people with existing organ problems.","Do not mix this medicine with calcium-containing solutions in newborns.","Use with caution in people with a history of seizures or brain conditions.","This medicine may interact with warfarin and other blood thinners; monitoring is needed.","Complete the full course prescribed by your doctor to prevent resistance."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is generally considered compatible with breastfeeding because the amount in milk is low and the drug is poorly absorbed from the infant's gut. However, if the breastfed baby develops diarrhoea, thrush, or a rash, consult a doctor. Mothers who are breastfeeding and need this medicine should discuss the benefits and risks with their clinician.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by a healthcare professional. If too much is given, the main risk is an increase in side effects such as nausea, diarrhoea, headache, and injection site reactions. There is no specific antidote. Treatment is supportive, with close monitoring of vital signs, kidney function, liver function, and blood counts. In severe cases, especially in people with kidney failure, haemodialysis may help remove the drug from the body, but this is rarely needed. Contact a poison control centre or emergency department if you suspect an overdose.
⏰ Missed Dose
Because this medicine is usually given by a healthcare professional in a hospital or clinic, missed doses are uncommon. If you miss a scheduled appointment for your injection, contact your doctor or clinic as soon as possible to arrange the next dose. Do not try to catch up by taking a double dose. If you are receiving this medicine at home through a home infusion service, follow the specific instructions given by your healthcare team.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional, usually in a hospital or clinic setting. Always tell your doctor if you have ever had an allergic reaction to penicillin, cephalosporins, or any other antibiotic, because cross-reactivity can occur. Inform your doctor about all other medicines you take, especially blood thinners, calcium-containing intravenous fluids, and other antibiotics, as these can interact with this medicine. Do not use this medicine together with calcium-containing solutions in newborn babies because of the risk of dangerous lung and kidney deposits. If you are pregnant, planning pregnancy, or breastfeeding, discuss the benefits and risks with your doctor before receiving this medicine. People with kidney or liver problems may need a lower dose or extra monitoring. Complete the full course prescribed by your doctor, even if you feel better after the first dose, to reduce the risk of resistance and relapse. Report any severe diarrhoea, rash, swelling, breathing difficulty, or unusual bleeding immediately. Do not self-administer this injection at home, and do not share it with anyone else.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and to take multiple medicines, which increases the risk of side effects and interactions. The dose may need to be adjusted based on kidney function, and monitoring for allergic reactions, diarrhoea, and blood count changes is important. Older adults may also be more prone to dehydration and confusion during serious infections, so supportive care and close follow-up are essential.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive or planning a pregnancy, tell your doctor before receiving this medicine. This medicine is generally considered acceptable in pregnancy when needed for a bacterial infection, but the decision should be made by your doctor after weighing the benefits and risks. If you become pregnant during treatment, contact your doctor promptly for advice.
🏥 Post-Surgery Considerations
This medicine is sometimes given before or during surgery to prevent infection. After surgery, it may be continued if there is a confirmed or suspected bacterial infection. Follow your surgical team's instructions about wound care, follow-up appointments, and any signs of infection such as fever, redness, swelling, or discharge. Do not stop the medicine early unless your doctor advises it.
🦷 Dental Procedures
This medicine is not usually the first choice for routine dental infections, but it may be used for severe dental or jaw infections that require injectable antibiotics, especially if the infection has spread. Tell your dentist and doctor about all medicines you take and any allergies before any dental procedure. If you are receiving this medicine for another infection, inform your dentist so they can plan your dental care safely.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While you are recovering from a serious bacterial infection, avoid strenuous exercise and heavy lifting until your doctor says it is safe. Light activity such as short walks may be helpful once your fever has settled and you feel stronger. If you feel dizzy, breathless, or unusually tired, stop and rest. People who have received an intramuscular injection may have soreness at the injection site, so avoid vigorous activity involving that muscle for a day or two.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is usually given in a hospital or clinic, so you may need time off work or school during treatment, especially if you are admitted for a serious infection. You may feel tired, dizzy, or unwell for a few days, so avoid driving or operating heavy machinery until you feel fully alert. If you receive the injection as an outpatient, you can usually return to light activities, but follow your doctor's advice about rest and recovery.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your clinical response, culture results, and the recommended duration for your specific infection. If you develop a serious side effect such as a severe allergic reaction, severe diarrhoea, or yellowing of the skin or eyes, stop the medicine and seek medical help immediately. Always consult your doctor before stopping or changing treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not usually needed for most infections, but when it is used for prolonged periods, it can increase the risk of antibiotic resistance, Clostridioides difficile infection, gallbladder sludge or stones, and blood count changes. Regular monitoring of kidney and liver function, blood counts, and clinical response is important during prolonged treatment. If you need long-term therapy, your doctor will review the benefits and risks regularly and may switch to a narrower antibiotic once culture results are available.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Using laboratory tests to identify the exact bacteria and its susceptibility can help your doctor choose the most effective and narrowest antibiotic.
Evidence: Well-establishedOnce you improve, your doctor may switch you to oral antibiotics to complete the course, which can allow you to go home earlier.
Evidence: Well-establishedRest, fluids, fever control, and good nutrition support recovery alongside antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the immune response to live bacterial vaccines such as the typhoid vaccine. If you need a live bacterial vaccine, tell your doctor that you are receiving or have recently received this medicine, and follow their advice about timing. Inactivated vaccines are generally not affected. This medicine is not a vaccine and does not replace routine immunisation.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature between 15°C and 30°C.
❌ DON'T
Do not freeze the powder or the reconstituted solution.
✅ DO
Keep the vial in its original carton, away from direct sunlight and moisture.
❌ DON'T
Do not store it in a bathroom cabinet or near a heat source.
✅ DO
Check the expiry date before use and follow the pharmacy's instructions for the reconstituted solution.
❌ DON'T
Do not use the medicine if the powder is discoloured or the expiry date has passed.
✅ DO
Keep all medicines out of the reach of children.
❌ DON'T
Do not transfer the medicine to unmarked containers.
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, carry it in its original packaging with the prescription and a letter from your doctor explaining why it is needed. Keep the unreconstituted powder at room temperature and protect it from extreme heat, cold, and direct sunlight. If you are travelling across time zones, ask your doctor how to adjust the timing of your doses. Carry a copy of your medical records and allergy information. Check the customs rules of your destination country for injectable medicines, and declare them if required. If you are receiving treatment through a home infusion service, arrange for a trained professional to give the injection during travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Most people start to feel better within 24 to 72 hours after the first dose, but the full effect depends on the type and severity of the infection. Always complete the full course prescribed by your doctor.
A: No. You should complete the full course prescribed by your doctor, even if you feel better, to prevent the infection from returning and to reduce the risk of antibiotic resistance.
A: This medicine is generally considered acceptable in pregnancy when there is a clear bacterial infection that needs treatment, but the decision must be made by your doctor after weighing the benefits and risks.
A: It is best to avoid alcohol during treatment because it can worsen dehydration and stomach upset and put extra strain on your liver while your body is fighting an infection.
A: Contact your doctor or clinic as soon as possible. Do not try to catch up by taking a double dose. Your healthcare team will advise you on the next step.
A: Yes, it can interact with blood thinners such as warfarin, calcium-containing intravenous solutions, aminoglycosides, and some other medicines. Always tell your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for doczone 1gm injection
View AllAlternative brands with exact same active ingredient:
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agizone 1gm injectionInd Swift Laboratories Ltd ₹18.50 76.3% CHEAPER
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mahazone 1gm injectionMankind Pharma Ltd ₹21.09 73% CHEAPER
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synthocef 1gm injectionPCI Pharmaceuticals ₹21.25 72.8% CHEAPER
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cefprotec 1gm injectionRPG Life Sciences Ltd ₹22.88 70.7% CHEAPER
-
cefonen 1gm injectionLupin Ltd ₹29.29 62.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold or flu.
Fact: This medicine only works against susceptible bacteria and has no effect on viruses. - Myth: You can stop this medicine as soon as you feel better.
Fact: You must complete the full course prescribed by your doctor to prevent the infection from returning and to reduce the risk of antibiotic resistance. - Myth: This medicine is safe to self-administer at home without training.
Fact: This medicine is an injection that must be given by a trained healthcare professional, except in special home infusion programmes with proper supervision. - Myth: This medicine can be mixed with any intravenous fluid.
Fact: This medicine must not be mixed with calcium-containing intravenous solutions, especially in newborns, because of the risk of dangerous precipitates. - Myth: Antibiotics like this medicine weaken the immune system.
Fact: This medicine kills susceptible bacteria and does not weaken the immune system; it helps the body clear a bacterial infection.
🔄 Alternative Options
Generic Alternatives
- Ceftriaxone 1 gram injection
Brand Alternatives
- Agizone 1gm Injection