cefonen 1gm injection

4.4 (15 reviews)

Ceftriaxone (1gm)

🏭 Lupin Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is cefonen 1gm injection used for?

Accuzon 1g Injection (Ceftriaxone) is used to treat ANTI INFECTIVES. It contains Ceftriaxone (1gm), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.

Generic Name: Ceftriaxone
Manufacturer: Lupin Ltd
Form: Allopathy
Pregnancy Category: B
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 cefonen 1gm injection Uses & Benefits

Lower respiratory tract infections, skin and soft tissue infections, urinary tract infections, pelvic inflammatory disease, bacterial septicemia, bone and joint infections, intra-abdominal infections, meningitis, surgical prophylaxis

Off-label uses: Lyme disease, Syphilis, Gonococcal infections

📋 Drug Information

Generic Name(s)	Ceftriaxone
Brand Name	Accuzon 1g Injection
Manufacturer	Lupin Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Cephalosporins: 3 generation
Route of Administration	Intramuscular or intravenous
Storage	Store at 20-25°C (68-77°F); protect from light; reconstituted solution stable for 24 hours at room temperature or 3 days refrigerated
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntramuscular administration: well absorbed; intravenous administration: immediate

DistributionWidely distributed into body tissues and fluids, including cerebrospinal fluid (inflamed meninges), bile, and pleural fluid

Protein Binding85-95%

MetabolismNot significantly metabolized; undergoes enterohepatic recirculation

Half-Life5.8-8.7 hours

ExcretionPrimarily renal (33-67%) and biliary (up to 40%)

Bioavailability100% (IV); ~100% (IM)

Onset of ActionRapid (within 30 minutes IV)

Peak Plasma TimeIM: 2-3 hours; IV: end of infusion

Duration of ActionApproximately 24 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase activity, and activating autolytic enzymes

Mechanism Steps

1Binds to penicillin-binding proteins (PBPs) on bacterial cell wall

2Inhibits transpeptidase enzyme, preventing cross-linking of peptidoglycan

3Activates autolytic enzymes (autolysins) in bacterial cell wall

💡 How to Take cefonen 1gm injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of cefonen 1gm injection

✅ Common Side Effects

Diarrhea
Injection site reactions (pain, induration)
Rash
Eosinophilia
Thrombocytosis

🚨 Serious Side Effects

Severe allergic reactions (anaphylaxis)
Stevens-Johnson syndrome
Clostridioides difficile-associated diarrhea
Hemolytic anemia
Seizures

⚠️ Rare Side Effects

Pseudomembranous colitis
Biliary sludge or pseudolithiasis
Agranulocytosis
Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Alcohol	Major	Disulfiram-like reaction
Calcium-containing solutions	Major	Precipitation risk, especially in neonates
Aminoglycosides	Moderate	Increased nephrotoxicity risk
Loop diuretics	Moderate	Increased nephrotoxicity risk
Probenecid	Moderate	Decreased ceftriaxone excretion
Oral contraceptives	Minor	Reduced contraceptive efficacy
BCG vaccine	Minor	Reduced vaccine efficacy
Typhoid vaccine	Minor	Reduced vaccine efficacy

🚨 Major Interactions

Warfarin
Alcohol
Calcium-containing solutions

⚡ Moderate Interactions

Aminoglycosides
Loop diuretics
Probenecid

ℹ️ Minor Interactions

Oral contraceptives
BCG vaccine
Typhoid vaccine

🍽️ Food Interactions

None known

🍷 Alcohol Interaction

Disulfiram-like reaction (flushing, headache, nausea, vomiting) possible

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to ceftriaxone or any cephalosporin; hyperbilirubinemic neonates (especially premature); concomitant use with calcium-containing IV solutions in neonates

📊 Monitoring Parameters

Renal function, hepatic function, CBC, signs of superinfection, bleeding tendencies

🤱 Lactation Safety

Excreted in breast milk in low concentrations; generally considered compatible with breastfeeding

💊 Overdose Management

Supportive care; hemodialysis may reduce serum levels

⏰ Missed Dose

Administer as soon as remembered; if near next dose, skip missed dose and resume regular schedule

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for cefonen 1gm injection

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Alternative brands with exact same active ingredient (Ceftriaxone (1gm)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.