Anexidep 5 mg/25 mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or slow, shallow breathing
- Chest pain or irregular heartbeat
- Severe dizziness or fainting
- Seizures or convulsions
- Signs of allergic reaction: rash, swelling of face, lips, or throat
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Severe confusion or agitation
If experiencing severe symptoms, call emergency services immediately.
What is dizy plus 5mg/25mg tablet used for?
This medicine is a combination of Diazepam 5 mg and Imipramine 25 mg used for short-term treatment of anxiety disorders and depression with anxiety. It works by enhancing GABA and inhibiting serotonin/norepinephrine reuptake. It is taken orally as prescribed by a doctor.
- Generic Name: Diazepam (5mg) + Imipramine (25mg)
- Manufacturer: Jpee Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dizy plus 5mg/25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डायजेपाम 5 मिलीग्राम और इमिप्रामाइन 25 मिलीग्राम का संयोजन है, जिसका उपयोग चिंता विकार और अवसाद के साथ चिंता के अल्पकालिक उपचार में किया जाता है। यह मस्तिष्क में GABA और सेरोटोनिन/नॉरएपिनेफ्रिन के स्तर को प्रभावित करके काम करती है। यह केवल डॉक्टर के परामर्श से ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि, कब्ज और थकान शामिल हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, अनियमित दिल की धड़कन, दौरे और एलर्जी की प्रतिक्रिया शामिल हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसे असर करती है। अचानक दवा बंद न करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 dizy plus 5mg/25mg tablet Uses & Benefits
[{"condition":"Anxiety disorders","description":"Short-term relief of severe anxiety symptoms, often as an adjunct to psychotherapy.","evidence":"Well-established for short-term use"},{"condition":"Depression with anxiety","description":"Used when depressive symptoms are accompanied by significant anxiety, leveraging the antidepressant and anxiolytic properties.","evidence":"Moderate evidence"},{"condition":"Psychosomatic disorders","description":"May help in conditions where psychological factors exacerbate physical symptoms.","evidence":"Limited evidence"}]
Off-label uses: [{"condition":"Insomnia with anxiety","description":"Sometimes prescribed off-label for short-term management of insomnia associated with anxiety.","evidence":"Limited"},{"condition":"Irritable bowel syndrome","description":"May be used off-label for IBS with prominent anxiety component.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders with depressive symptoms
Also treats: Depression, Psychosomatic disorders, Insomnia with anxiety
📋 Drug Information
| Generic Name(s) | Diazepam (5mg) + Imipramine (25mg) |
| Brand Name | dizy plus 5mg/25mg tablet |
| Manufacturer | Jpee Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Diazepam binds to the benzodiazepine site on the GABA-A receptor, enhancing the inhibitory effect of GABA, which leads to increased chloride ion influx, hyperpolarization of neurons, and reduced neuronal excitability. This produces anxiolytic, sedative, muscle relaxant, and anticonvulsant effects. Imipramine inhibits the reuptake of serotonin and norepinephrine at presynaptic nerve terminals, increasing their availability in the synaptic cleft. This leads to downregulation of beta-adrenergic receptors and increased serotonergic neurotransmission, which over time alleviates depression and anxiety. The combination provides rapid anxiolysis from diazepam and sustained antidepressant effect from imipramine.
Mechanism Steps
💡 How to Take dizy plus 5mg/25mg tablet
Strength: Each immediate-release tablet contains Diazepam 5 mg and Imipramine 25 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally 1 to 3 times daily, depending on the condition and response. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. This medicine is for short-term use unless otherwise directed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative and anticholinergic effects. Start with a lower dose and titrate slowly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose reduction may be required. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed 3 tablets (15 mg diazepam + 75 mg imipramine) unless directed by a clinician. Individual dosing must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dizy plus 5mg/25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Opioids | Major | |
| Alcohol | Major | |
| Fluoxetine | Moderate | |
| Ketoconazole | Moderate | |
| Warfarin | Moderate | |
| Clonidine | Moderate | |
| Levodopa | Moderate | |
| Anticholinergics | Moderate | |
| Cimetidine | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (opioids, alcohol, barbiturates)
- Anticholinergic drugs
⚡ Moderate Interactions
- CYP2D6 inhibitors (fluoxetine, paroxetine)
- CYP3A4 inhibitors (ketoconazole, clarithromycin)
🍷 Alcohol Interaction
Alcohol increases the sedative and respiratory depressant effects of diazepam and may worsen imipramine's central nervous system effects. Avoid alcohol completely while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to benzodiazepines or tricyclic antidepressants","Acute narrow-angle glaucoma","Severe respiratory depression","Severe hepatic or renal impairment","Concurrent use with MAO inhibitors","Pregnancy and breastfeeding (unless clearly needed)","Myasthenia gravis","Severe cardiovascular disease"]
⚠️ Warnings & Precautions
["Risk of dependence and withdrawal with prolonged use.","May impair ability to drive or operate machinery.","Avoid abrupt discontinuation.","Use with caution in elderly and debilitated patients.","May worsen depression and increase suicidal thoughts; monitor closely.","Avoid alcohol and other CNS depressants.","Use with caution in patients with glaucoma, urinary retention, or prostatic hypertrophy."]
🤱 Lactation Safety
Diazepam and imipramine are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose can cause severe sedation, respiratory depression, cardiac arrhythmias, and seizures. Seek emergency medical care immediately. Treatment is supportive and may include activated charcoal, gastric lavage, and management of cardiac and respiratory complications. Flumazenil may be used for benzodiazepine toxicity but is contraindicated in mixed overdose with tricyclics due to seizure risk.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless instructed. Avoid alcohol and other central nervous system depressants because they can increase sedation and respiratory depression. Do not drive or operate heavy machinery until you know how this medicine affects you. Do not stop this medicine abruptly, as it can cause withdrawal symptoms such as anxiety, insomnia, tremors, and seizures. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. Regular follow-up with your doctor is essential to monitor your response and adjust the dose if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of sedation, dizziness, falls, and anticholinergic effects. Lower doses are recommended, and close monitoring is essential.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor to discuss alternative treatments and to plan a safe approach.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist about this medicine before surgery. It may interact with anesthetic agents and increase sedation.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. It may cause dry mouth and interact with sedatives used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring alertness until you know how this medicine affects you. Dizziness and drowsiness may increase the risk of falls.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also affect concentration and work performance.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or wish to discontinue, your doctor will guide you on a gradual tapering schedule to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use can lead to tolerance, dependence, and withdrawal symptoms. Regular monitoring of liver function, blood counts, and mental status is required. Periodic review is necessary to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be effective for anxiety and depression, often used alongside medication.
Evidence: Well-establishedMay help reduce anxiety symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. Consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust dosing schedule gradually under medical advice. Store at room temperature and protect from moisture. Check customs regulations for controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Diazepam starts working within 30-60 minutes for anxiety, while imipramine takes 2-4 weeks for full antidepressant effect.
A: No, abrupt discontinuation can cause withdrawal symptoms. Always taper gradually under medical supervision.
A: It can interact with many medicines. Always inform your doctor about all medications you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for dizy plus 5mg/25mg tablet
View AllAlternative brands with exact same active ingredient:
-
Theodep 5 mg/25 mg TabletTheo Pharma Pvt Ltd ₹7.97 61.4% CHEAPER
-
prazep 5 mg/25 mg tabletSun Pharmaceutical Industries Ltd ₹8.63 58.2% CHEAPER
-
depnil forte 5 mg/25 mg tabletTas Med India Pvt Ltd ₹8.67 58% CHEAPER
-
Sycodep 5 mg/25 mg TabletGujarat Terce Laboratories Ltd ₹9.01 56.3% CHEAPER
-
imip 5mg/25mg tabletAan Pharma Pvt Ltd ₹9.38 54.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: It is a combination of an anxiolytic and an antidepressant, used for anxiety and depression, not just sleep. - Myth: It is safe to take indefinitely.
Fact: Prolonged use can lead to dependence and withdrawal; it is usually for short-term use.
🔄 Alternative Options
Generic Alternatives
- Diazepam + Imipramine combination (generic)