Divi A 500mg Injection (Metamizole): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fever, sore throat, or mouth ulcers (may indicate agranulocytosis).
- Difficulty breathing, swelling of face or throat (anaphylaxis).
- Severe skin rash with blisters or peeling (Stevens-Johnson syndrome).
- Decreased urine output or swelling in legs (kidney injury).
- Yellowing of eyes or skin (liver toxicity).
- Unusual bleeding or bruising (blood disorder).
- Severe abdominal pain or blood in vomit/stool (GI bleeding).
If experiencing severe symptoms, call emergency services immediately.
What is divi a 500mg injection used for?
This medicine is a 500mg injection of Metamizole, a strong pain reliever and fever reducer. It is given by a healthcare professional for moderate to severe pain or high fever when oral medicines are not suitable. It works by blocking pain and fever signals in the body. It is not recommended for routine use due to rare but serious blood-related side effects.
- Generic Name: Metamizole (500mg)
- Manufacturer: Flagship Biotech International
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 divi a 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मेटामिज़ोल का 500 मिलीग्राम इंजेक्शन है, जिसका उपयोग तेज दर्द और तेज बुखार के इलाज के लिए किया जाता है। यह आमतौर पर तब दी जाती है जब मरीज मुंह से दवा नहीं ले सकता या अन्य दर्द निवारक दवाएं काम नहीं कर रही हों। यह दवा डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है। यह दर्द और बुखार को कम करने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, लालिमा, मतली, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में एग्रानुलोसाइटोसिस (खून की गंभीर बीमारी), एलर्जी, और किडनी की समस्या हो सकती है। अगर आपको बुखार, गले में खराश, या मुंह में छाले हों तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में ही दी जानी चाहिए। खुद से इंजेक्शन न लगवाएं। अगर आपको खून की बीमारी, किडनी या लिवर की समस्या है, या दर्द निवारक दवाओं से एलर्जी है, तो डॉक्टर को बताएं। इलाज के दौरान शराब न पिएं। बिना डॉक्टर की सलाह के लंबे समय तक इसका इस्तेमाल न करें।
💊 divi a 500mg injection Uses & Benefits
[{"condition":"Acute severe pain","description":"Used for rapid relief of moderate to severe pain when oral administration is not possible, such as in postoperative pain or trauma.","evidence":"Well-established"},{"condition":"High fever","description":"Effective in reducing high fever that does not respond to other antipyretics, especially in emergency settings.","evidence":"Well-established"},{"condition":"Colicky pain","description":"Due to its antispasmodic properties, it is used for renal or biliary colic.","evidence":"Moderate"},{"condition":"Cancer pain","description":"May be used as an adjunct for cancer-related pain when other analgesics are inadequate.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"}]
Primary treatment for: Acute severe pain
Also treats: High fever, Colicky pain, Postoperative pain, Cancer pain
📋 Drug Information
| Generic Name(s) | Metamizole (500mg) |
| Brand Name | divi a 500mg injection |
| Manufacturer | Flagship Biotech International |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's-Non-Selective COX 1&2 Inhibitors (Others) |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store below 25°C, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Metamizole is a prodrug that is hydrolyzed to 4-methylaminoantipyrine (MAA), which inhibits cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins. It also activates the endogenous opioid system and inhibits prostaglandin synthesis in the central nervous system, contributing to analgesia and antipyresis. Additionally, it has antispasmodic effects on smooth muscle.
Mechanism Steps
💡 How to Take divi a 500mg injection
Strength: 500 mg injection (2 mL ampoule).
Dosage Information
| Adult Dosage | The usual adult dose is 500 mg to 1000 mg (1-2 ampoules) given intramuscularly or intravenously every 6-8 hours as needed, not exceeding 4000 mg per day. For intravenous use, inject slowly over 5-10 minutes. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In some countries, metamizole is used in children over 3 months at a dose of 10-20 mg/kg per dose, but this must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may require lower doses due to reduced renal and hepatic function. Start with the lowest effective dose and monitor closely. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment (eGFR <30 mL/min). |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. |
| Maximum Daily Dose | 4000 mg per day (8 ampoules of 500 mg). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of divi a 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Cyclosporine | Major | |
| Aspirin | Moderate | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Corticosteroids | Moderate | |
| Phenytoin | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Cyclosporine
⚡ Moderate Interactions
- Aspirin
- ACE inhibitors
- Diuretics
🍷 Alcohol Interaction
Avoid alcohol consumption while receiving this medicine. Alcohol can increase the risk of stomach bleeding, liver damage, and may worsen side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to metamizole or other pyrazolones.","History of agranulocytosis or bone marrow suppression.","Genetic deficiency of glucose-6-phosphate dehydrogenase (G6PD).","Acute hepatic porphyria.","Third trimester of pregnancy and lactation.","Severe renal or hepatic impairment.","Children under 3 months or under 5 kg body weight."]
⚠️ Warnings & Precautions
["Risk of agranulocytosis: Inform patients to report early signs of infection.","Anaphylactic reactions: Have emergency equipment ready.","Hypotension: Can occur with rapid intravenous injection. Inject slowly.","Renal impairment: Use with caution and monitor.","Hepatic impairment: Use with caution and monitor.","Elderly: Increased risk of side effects. Use lower doses.","Avoid in patients with active peptic ulcer or bleeding disorders."]
🤱 Lactation Safety
Metamizole and its metabolites are excreted in breast milk. Breastfeeding is not recommended during treatment. If treatment is essential, consider pumping and discarding milk during therapy and for 48 hours after the last dose.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, dizziness, drowsiness, and in severe cases, seizures, coma, and acute renal failure. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if oral ingestion is recent. Monitor vital signs, renal and hepatic function. Hemodialysis may be effective in removing metabolites.
⏰ Missed Dose
This medicine is usually given as a single dose or as needed under medical supervision. If you miss a scheduled dose, contact your healthcare provider for instructions. Do not self-administer an extra dose.
Additional Safety Advice
This medicine must only be administered by a healthcare professional. Do not self-administer. Inform your doctor if you have a history of blood disorders, kidney or liver disease, or allergies to pain relievers. Avoid alcohol during treatment as it may increase the risk of stomach bleeding and liver toxicity. Do not use for prolonged periods without medical supervision. If you experience fever, sore throat, or mouth sores, seek immediate medical attention as these may be signs of a serious blood disorder. Keep all follow-up appointments for blood tests if advised.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects, especially agranulocytosis, kidney injury, and gastrointestinal bleeding. Lower doses may be needed. Monitor renal and hepatic function closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the first and third trimesters. If you are planning pregnancy, discuss alternative pain management options with your doctor. Use effective contraception while on this medicine.
🏥 Post-Surgery Considerations
This medicine may be used for postoperative pain. It should be administered under medical supervision. Monitor for signs of infection, bleeding, and allergic reactions. Ensure adequate hydration.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may increase bleeding risk during dental procedures. Your dentist may recommend postponing elective procedures until you have completed treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that could cause injury while you are experiencing pain. If you feel dizzy or drowsy after the injection, do not drive or operate heavy machinery. Gentle movement may be beneficial once acute pain subsides, but consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, so avoid driving or operating machinery until you know how it affects you. You may need to take rest after the injection. It is usually given in a hospital or clinic setting, so you may need to arrange for transportation home.
🛑 When to Stop This Medicine
This medicine is usually given for a short duration. Stop using it and consult your doctor immediately if you experience any signs of allergic reaction, infection, or unusual bleeding. Do not stop prescribed treatment without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of agranulocytosis, which can occur at any time. Prolonged use may also lead to kidney or liver damage. Regular monitoring of blood counts, liver, and kidney function is advised if long-term therapy is necessary. The risk of agranulocytosis may increase with duration of use, so the lowest effective dose for the shortest duration should be used.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Safer alternative for mild to moderate pain and fever.
Evidence: Well-establishedEffective for pain and inflammation but carry GI and renal risks.
Evidence: Well-establishedFor severe pain, but have risk of dependence.
Evidence: Well-establishedCan complement medicine for chronic pain.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you have a fever, vaccination may be postponed until you recover. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Check expiry date before use
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Keep a copy of your prescription and a letter from your doctor explaining the medical need. Store it in a cool, dry place away from direct sunlight. If traveling by air, keep it in your carry-on luggage. Check the customs regulations of your destination country regarding injectable medicines. For time zone changes, consult your doctor for dose adjustment if you are on a scheduled regimen.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 20-30 minutes after intramuscular injection and within 5-10 minutes after intravenous injection.
A: The pain-relieving effect lasts approximately 4-6 hours.
A: No, this medicine must be administered by a healthcare professional in a clinical setting.
A: Report any side effects to your doctor immediately. Seek emergency care if you have difficulty breathing, swelling, or severe rash.
🤔 Common Patient Concerns
🔄 Substitutes for divi a 500mg injection
View AllAlternative brands with exact same active ingredient:
-
analgin 500mg tabletAlkem Laboratories Ltd ₹5.16 93.9% CHEAPER
-
bral 500mg tabletMicro Labs Ltd ₹15.08 82.1% CHEAPER
-
ultragin 500mg injectionPfizer Ltd ₹25.78 69.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Metamizole is a safe alternative to morphine.
Fact: Metamizole is effective for pain but carries a rare risk of agranulocytosis, so it is not entirely safe and is not a direct substitute for morphine. - Myth: Metamizole can be used for any type of pain.
Fact: It is indicated for moderate to severe pain and fever, but not for mild pain or routine use. - Myth: Metamizole is banned worldwide.
Fact: It is banned in some countries like the USA, but available in many others including India, Mexico, and parts of Europe.
🔄 Alternative Options
Generic Alternatives
- Metamizole 500mg injection
Brand Alternatives
- Divi A 500mg injection