Dicloplus 50 mg/350 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is dicloplus 50 mg/350 mg tablet used for?
This medicine is a combination of Diclofenac 50 mg and Paracetamol 350 mg used for short-term relief of acute pain and inflammation. It works by reducing pain and swelling. Take it with food and avoid alcohol.
- Generic Name: Diclofenac + Paracetamol
- Manufacturer: Hindustan Antibiotics Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dicloplus 50 mg/350 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक 50 मिलीग्राम और पैरासिटामोल 350 मिलीग्राम का संयोजन है। इसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है, जैसे कि जोड़ों का दर्द, मांसपेशियों का दर्द, दांत का दर्द, और मासिक धर्म के दर्द में। यह दवा दर्द को कम करने और सूजन को कम करने में मदद करती है। इसे भोजन के साथ लें और शराब से बचें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट के अल्सर, रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट की जलन कम हो। शराब का सेवन न करें। यदि आपको गुर्दे या यकृत की समस्या है, तो डॉक्टर को बताएं। गर्भवती महिलाओं को इस दवा से बचना चाहिए। बच्चों की पहुंच से दूर रखें।
💊 dicloplus 50 mg/350 mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgical procedures.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces pain and improves joint mobility in osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps reduce pain and swelling in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Renal colic","description":"May be used for pain relief in kidney stones, but other options are preferred.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Musculoskeletal pain, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Diclofenac + Paracetamol |
| Brand Name | At Sp Tablet |
| Manufacturer | Hindustan Antibiotics Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Diclofenac is a non-selective non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, anti-inflammatory, and antipyretic effects. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis. The combination provides additive pain relief through complementary mechanisms.
Mechanism Steps
💡 How to Take dicloplus 50 mg/350 mg tablet
Strength: Tablet containing Diclofenac 50 mg and Paracetamol 350 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, as needed for pain. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose adjustment may be necessary. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | Maximum daily dose: Diclofenac 150 mg and Paracetamol 1050 mg (3 tablets). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dicloplus 50 mg/350 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| ACE inhibitors | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antihypertensives | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- ACE inhibitors
- Methotrexate
- Lithium
⚡ Moderate Interactions
- Diuretics
- Corticosteroids
- SSRIs
- Antihypertensives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen liver damage, especially with paracetamol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Heart failure","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Third trimester of pregnancy","Allergy to diclofenac or paracetamol"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol.","Do not exceed recommended dose.","Use with caution in elderly patients.","Use with caution in patients with kidney or liver disease.","May increase risk of cardiovascular events.","May cause drowsiness; avoid driving if affected.","Do not use for more than 7 days without consulting a doctor."]
🤱 Lactation Safety
Diclofenac and paracetamol are excreted in breast milk in small amounts. Consult your doctor before use during breastfeeding. Short-term use may be considered if necessary, but monitor the infant for any adverse effects.
💊 Overdose Management
Overdose can cause severe liver damage, especially from paracetamol. Symptoms may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than advised. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not take other pain relievers or NSAIDs without consulting your doctor. If you have kidney or liver problems, heart failure, or high blood pressure, inform your doctor before taking this medicine. Do not use this medicine if you are allergic to diclofenac, paracetamol, or any other NSAID. Pregnant women, especially in the third trimester, should avoid this medicine unless specifically advised by a doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney damage, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
Avoid this medicine if you are planning pregnancy or are pregnant. Consult your doctor for alternative pain relief options.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but consult your surgeon before taking it as it may increase bleeding risk.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine as it may increase the risk of bleeding or injury. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to perform tasks requiring alertness.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects, if your pain persists beyond 7 days, or if you develop new symptoms. Do not stop abruptly without consulting your doctor if you have been taking it for a long time.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney damage, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce pain and inflammation.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30-60 minutes after taking this medicine.
A: It is best to take this medicine with food or milk to reduce stomach upset.
A: Avoid use during pregnancy, especially in the third trimester, unless specifically advised by a doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Long-term use can increase the risk of stomach bleeding, heart problems, and kidney damage. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of stomach bleeding and liver damage. Avoid alcohol while taking this medicine. - Myth: This medicine can be taken on an empty stomach.
Fact: Taking this medicine with food reduces the risk of stomach upset.
🔄 Alternative Options
Generic Alternatives
- Diclofenac 50 mg + Paracetamol 350 mg tablet
Brand Alternatives
- Dicloplus 50 mg/350 mg tablet