derobin  ointment - Salicylic Acid (1.15% w/w) + Dithranol (1.15% w/w) medicine

derobin ointment

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🏭 USV Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
🤰 Pregnancy Category A 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

What is derobin ointment used for?

This medicine contains Salicylic Acid (1.15% w/w) + Dithranol (1.15% w/w) and is used to treat DERMA. Salicylic acid softens and removes dead skin cells; dithranol reduces epidermal proliferation and in. Always consult your doctor before use.

  • Generic Name: Salicylic Acid + Dithranol
  • Manufacturer: USV Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 derobin ointment Uses & Benefits

Psoriasis vulgaris, scalp psoriasis, chronic plaque psoriasis.

Off-label uses: Warts, Calluses, Seborrheic dermatitis

📋 Drug Information

Generic Name(s)Salicylic Acid + Dithranol
Brand NameDerobin Ointment
ManufacturerUSV Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassKeratolytic and Antipsoriatic
Route of AdministrationTopical
StorageStore below 25°C, protect from light, keep tightly closed.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption through intact skin; increased with damaged skin or prolonged use.
DistributionNot well characterized; primarily local action.
Protein BindingNot applicable for topical use.
MetabolismSalicylic acid is metabolized in the liver; dithranol is oxidized locally.
Half-LifeSalicylic acid: 2-3 hours (systemic); dithranol: not applicable.
ExcretionSalicylic acid: renal excretion; dithranol: local degradation.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin 1-2 weeks of regular use.
Peak Plasma TimeNot applicable for topical use.
Duration of ActionVaries; typically applied once daily.

How It Works

Salicylic acid softens and removes dead skin cells; dithranol reduces epidermal proliferation and inflammation.

Mechanism Steps

1Salicylic acid dissolves intercellular cement, causing desquamation.
2Dithranol inhibits DNA synthesis and reduces epidermal cell turnover.
3Dithranol also has anti-inflammatory effects by reducing neutrophil chemotaxis.

💡 How to Take derobin ointment

Follow your doctor's prescription exactly.

⚠️ Side Effects of derobin ointment

✅ Common Side Effects

Skin irritation
Redness
Staining of skin and clothing

🚨 Serious Side Effects

Severe allergic reaction
Salicylate toxicity (with extensive use)

⚠️ Rare Side Effects

Contact dermatitis
Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Methotrexate Major Increased methotrexate toxicity due to displacement from protein binding.
Warfarin Major Enhanced anticoagulant effect due to salicylic acid displacement.
Sulfonylureas Major Increased hypoglycemic effect.

🚨 Major Interactions

  • Methotrexate
  • Warfarin
  • Sulfonylureas

⚡ Moderate Interactions

  • Corticosteroids (topical)
  • Other keratolytic agents

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to salicylic acid or dithranol; acute psoriasis; broken or inflamed skin; renal impairment (systemic risk).

🤱 Lactation Safety

Avoid application on breast area; limited data.

💊 Overdose Management

Discontinue use; symptomatic treatment; for systemic salicylate toxicity, gastric lavage and activated charcoal.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose; do not double dose.

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