Clobest-cm Cream: Comprehensive Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, or throat
- Difficulty breathing or swallowing
- Severe skin rash with blistering or peeling
- Signs of infection spreading (increased redness, swelling, pain, fever)
- No improvement after 7 days of use
- New or worsening symptoms
If experiencing severe symptoms, call emergency services immediately.
What is dermosav plus cream used for?
This medicine is a topical cream containing ciprofloxacin and metronidazole, used to treat bacterial skin infections. Apply a thin layer to the affected area 2-3 times daily as prescribed.
- Generic Name: Ciprofloxacin + Metronidazole
- Manufacturer: Bennet Mypher Pharmaceuticals LLP
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dermosav plus cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें सिप्रोफ्लोक्सासिन और मेट्रोनिडाजोल होते हैं। इसका उपयोग त्वचा के बैक्टीरियल संक्रमण, घावों और अल्सर के इलाज के लिए किया जाता है। यह संक्रमण पैदा करने वाले बैक्टीरिया को मारती है और सूजन व दर्द को कम करती है। इसे डॉक्टर के निर्देशानुसार प्रभावित हिस्से पर लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर जलन, खुजली, लालिमा या सूखापन शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको गंभीर एलर्जी, सूजन या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस क्रीम को केवल बाहरी उपयोग के लिए ही लगाएं। आंखों, नाक, मुंह और श्लेष्मा झिल्ली के संपर्क में न आने दें। लगाने से पहले और बाद में हाथ धोएं। डॉक्टर के बताए अनुसार ही इस्तेमाल करें। यदि कुछ दिनों में सुधार न हो तो डॉक्टर से मिलें।
💊 dermosav plus cream Uses & Benefits
[{"condition":"Infected skin wounds","description":"Used to treat bacterial infections in cuts, scrapes, and minor wounds.","evidence":"Well-established"},{"condition":"Infected ulcers","description":"Applied to infected pressure ulcers or diabetic foot ulcers to reduce bacterial load.","evidence":"Well-established"},{"condition":"Bacterial skin infections","description":"Effective against certain gram-positive and gram-negative bacteria causing skin infections.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Rosacea","description":"Sometimes prescribed off-label for rosacea due to anti-inflammatory and antimicrobial effects.","evidence":"Limited"},{"condition":"Perioral dermatitis","description":"Occasionally used off-label for perioral dermatitis.","evidence":"Limited"}]
Primary treatment for: Bacterial skin infections
Also treats: Infected wounds, Infected ulcers
📋 Drug Information
| Generic Name(s) | Ciprofloxacin + Metronidazole |
| Brand Name | Clobest-CM Cream |
| Manufacturer | Bennet Mypher Pharmaceuticals LLP |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C) in a dry place. Protect from direct sunlight and moisture. Keep the tube tightly closed when not in use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with distinct mechanisms. Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, recombination, and repair, leading to bacterial cell death. Metronidazole enters bacterial cells and is reduced by anaerobic organisms to reactive intermediates that bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis. The combination provides broad-spectrum activity against many aerobic and anaerobic bacteria.
Mechanism Steps
💡 How to Take dermosav plus cream
Strength: Cream containing ciprofloxacin 1% w/w and metronidazole 1% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer to the affected area 2-3 times daily or as directed by your physician. The duration of treatment depends on the type and severity of the infection. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended frequency or duration without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustments are required for elderly patients when used topically. However, elderly patients may be more susceptible to skin irritation. Use with caution and monitor for adverse effects. |
| Renal Impairment | No dose adjustment is required for topical use in patients with renal impairment, as systemic absorption is minimal. |
| Hepatic Impairment | No dose adjustment is required for topical use in patients with hepatic impairment, as systemic absorption is minimal. |
| Maximum Daily Dose | Not established from the available information. Use only as prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dermosav plus cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other topical antibiotics | Major | |
| Topical corticosteroids | Moderate | |
| Moisturizers | Minor |
🚨 Major Interactions
- Other topical antibiotics
⚡ Moderate Interactions
- Corticosteroids (topical)
🍷 Alcohol Interaction
No known interaction with alcohol when used topically. However, alcohol consumption may affect overall health and wound healing.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ciprofloxacin, metronidazole, or any component of the cream.","Not for use in the eyes, ears, or mucous membranes.","Do not use on large areas of broken skin without medical advice."]
⚠️ Warnings & Precautions
["For external use only.","Avoid contact with eyes and mucous membranes.","Do not use on deep puncture wounds, animal bites, or serious burns without medical advice.","Prolonged use may lead to bacterial resistance.","Discontinue if severe irritation or allergic reaction occurs.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. It is not known if this medicine passes into breast milk. Consult your doctor before use while breastfeeding. Avoid applying to the breast area to prevent infant exposure.
💊 Overdose Management
Overdose with topical application is unlikely. If accidental ingestion occurs, seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, and abdominal discomfort. Treatment is symptomatic and supportive.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
For external use only. Avoid contact with eyes, nose, mouth, and other mucous membranes. Wash hands thoroughly before and after applying the cream. Apply a thin layer to the affected area and gently rub it in as directed by your doctor. Do not cover the treated area with airtight dressings unless instructed. Do not use this medicine for longer than prescribed, as it may increase the risk of antibiotic resistance. If your condition does not improve within a few days or worsens, contact your healthcare provider. Keep out of reach of children. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have thinner skin and are more prone to irritation. Use with caution and monitor for adverse effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. The safety of topical ciprofloxacin and metronidazole during pregnancy is not well established.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat wound infections. Use only as directed by your surgeon.
🦷 Dental Procedures
No specific considerations for dental procedures. Inform your dentist if you are using this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise that may cause friction or sweating on the treated area. Keep the area clean and dry after exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience any side effects like dizziness, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Stop using this medicine if you experience a severe allergic reaction or if your doctor advises discontinuation. Do not stop prematurely even if symptoms improve, as this may lead to recurrence of infection.
📅 Long-Term Use Effects
Prolonged use of this medicine may lead to bacterial resistance and overgrowth of non-susceptible organisms. It should only be used for the prescribed duration. If long-term use is required, your doctor will monitor for signs of superinfection and adjust treatment accordingly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Keeping wounds clean and covered can prevent infection.
Evidence: Well-establishedDepending on the bacteria, other antibiotics may be prescribed.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, consult your doctor if you are due for any vaccination while using this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling to a different time zone, continue applying as per your usual schedule. Declare it at customs if required. Keep it in your carry-on luggage if you need it during the flight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start seeing improvement within 2-3 days. If no improvement after 7 days, consult your doctor.
A: It should only be used on the face if specifically prescribed by a doctor. Avoid contact with eyes and mucous membranes.
A: Consult your doctor before use if you are pregnant or planning pregnancy. The safety profile is not well established for topical use.
🤔 Common Patient Concerns
🔄 Substitutes for dermosav plus cream
View AllAlternative brands with exact same active ingredient:
-
igrose star creamLucrose Pharma Private Limited ₹23.44 66.7% CHEAPER
-
clearoz oz creamMediyork Pharma Pvt Ltd ₹66.56 5.3% CHEAPER
-
cipset mt creamUrochem Biotech ₹69.41 1.3% CHEAPER
-
elciderm creamElivia Life Sciences Pvt Ltd ₹70.00 0.4% CHEAPER
-
iiflow-tm creamI.I.F.A Health Care ₹75.00 6.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin problem.
Fact: It is specifically for bacterial infections and should only be used as prescribed. - Myth: More cream means faster healing.
Fact: Applying more than prescribed does not speed up healing and may increase side effects.
🔄 Alternative Options
Generic Alternatives
- Ciprofloxacin and metronidazole topical cream