depzil plus 5mg/5mg tablet - Uses, Price, Side Effects & Substitutes
What is depzil plus 5mg/5mg tablet used for?
Alzil-M 5 Tablet (Donepezil + Memantine) is used to treat NEURO CNS. It contains Donepezil (5mg) + Memantine (5mg), which Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels; Memant. Always consult your doctor before use. Take as prescribed.
- Generic Name: Donepezil + Memantine
- Manufacturer: Psycormedies
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ depzil plus 5mg/5mg tablet Uses & Benefits
Alzheimer's disease (moderate to severe), Dementia associated with Parkinson's disease (off-label)
Off-label uses: Vascular dementia, Dementia with Lewy bodies, Mild cognitive impairment
๐ Drug Information
| Generic Name(s) | Donepezil + Memantine |
| Brand Name | Alzil-M 5 Tablet |
| Manufacturer | Psycormedies |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Cholinesterase inhibitor + NMDA receptor antagonist |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels; Memantine is an NMDA receptor antagonist, reducing glutamate excitotoxicity.
Mechanism Steps
๐ก How to Take depzil plus 5mg/5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of depzil plus 5mg/5mg tablet
โ Common Side Effects
- Nausea
- Diarrhea
- Insomnia
- Fatigue
- Muscle cramps
- Headache
- Dizziness
- Confusion
๐จ Serious Side Effects
- Bradycardia
- Heart block
- Seizures
- GI bleeding
- Neuroleptic malignant syndrome (rare)
โ ๏ธ Rare Side Effects
- Hepatitis
- Pancreatitis
- Rhabdomyolysis
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Anticholinergics | Major | Reduced efficacy of donepezil |
| Succinylcholine | Major | Prolonged neuromuscular blockade |
| NMDA antagonists | Major | Increased risk of adverse effects |
| CYP3A4 inducers | Major | Decreased donepezil concentration |
| CYP3A4 inhibitors | Major | Increased donepezil concentration |
| NSAIDs | Moderate | Increased risk of GI bleeding |
| Antipsychotics | Moderate | Increased risk of extrapyramidal symptoms |
| Cholinergic agonists | Moderate | Synergistic cholinergic effects |
| CYP2D6 inhibitors | Moderate | Increased donepezil concentration |
| Cimetidine | Minor | Minor increase in donepezil concentration |
| Quinidine | Minor | Minor increase in donepezil concentration |
๐จ Major Interactions
- Anticholinergics
- Succinylcholine
- NMDA antagonists (e.g., amantadine, ketamine)
- CYP3A4 inducers/inhibitors (for donepezil)
โก Moderate Interactions
- NSAIDs
- Antipsychotics
- Cholinergic agonists
- CYP2D6 inhibitors
โน๏ธ Minor Interactions
- Cimetidine
- Quinidine
๐ฝ๏ธ Food Interactions
High-fat meals may delay absorption of donepezil
๐ท Alcohol Interaction
Avoid alcohol; may worsen CNS effects.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to donepezil, memantine, or piperidine derivatives, Severe hepatic impairment
๐ Monitoring Parameters
Cognitive function, GI symptoms, Heart rate, Weight, Renal function
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Supportive care; activated charcoal if recent ingestion; monitor for cholinergic crisis (donepezil) or CNS depression (memantine).
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose. Do not double dose.