Brutek P Tablet (Dexibuprofen 300 mg + Paracetamol 500 mg): Complete Information
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is debura 300 mg/500 mg tablet used for?
This medicine is a combination of Dexibuprofen 300 mg and Paracetamol 500 mg used for short-term relief of acute pain and fever. It works by reducing inflammation and pain through complementary mechanisms. Take it with food and do not exceed 3 tablets in 24 hours.
- Generic Name: Dexibuprofen (300mg) + Paracetamol (500mg)
- Manufacturer: Prochem Turnkey Projects Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 debura 300 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डेक्सिबुप्रोफेन 300 मिलीग्राम और पैरासिटामोल 500 मिलीग्राम का संयोजन है। इसका उपयोग तीव्र दर्द और सूजन के इलाज के लिए किया जाता है, जैसे कि मांसपेशियों में दर्द, दांत दर्द, मासिक धर्म में ऐंठन, और सर्जरी के बाद का दर्द। यह बुखार को भी कम करता है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो। इसका उपयोग केवल अल्पकालिक होना चाहिए और डॉक्टर की सलाह के बिना लंबे समय तक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, यकृत की समस्या, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और यकृत की क्षति का खतरा बढ़ सकता है। अन्य दर्द निवारक दवाओं या पैरासिटामोल युक्त उत्पादों के साथ इसका सेवन न करें। यदि आपको पेट अल्सर, गुर्दे या यकृत की बीमारी, हृदय रोग, या अस्थमा है तो डॉक्टर को बताएं। गर्भावस्था और स्तनपान के दौरान इसका उपयोग न करें।
💊 debura 300 mg/500 mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides effective relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Reduces menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Fever with pain","description":"Reduces fever and provides symptomatic relief when fever is accompanied by pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare","description":"May be used short-term for acute flares, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Dysmenorrhea, Dental pain, Post-operative pain, Musculoskeletal pain
📋 Drug Information
| Generic Name(s) | Dexibuprofen (300mg) + Paracetamol (500mg) |
| Brand Name | debura 300 mg/500 mg tablet |
| Manufacturer | Prochem Turnkey Projects Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Dexibuprofen, the active enantiomer of ibuprofen, reversibly inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, anti-inflammatory, and antipyretic effects. Paracetamol acts predominantly in the central nervous system by inhibiting prostaglandin synthesis, possibly through COX-3 or other central pathways, and also modulates descending serotonergic pathways. It provides analgesia and antipyresis with minimal anti-inflammatory activity. The combination provides additive pain relief through these distinct but complementary mechanisms.
Mechanism Steps
💡 How to Take debura 300 mg/500 mg tablet
Strength: Each immediate-release tablet contains Dexibuprofen 300 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain, not to exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of debura 300 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Corticosteroids
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Lithium
- Methotrexate
- SSRIs
- Anticoagulants (e.g., apixaban)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate paracetamol-induced hepatotoxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer disease or history of recurrent ulcers","Severe renal impairment","Severe hepatic impairment","History of aspirin-sensitive asthma","Third trimester of pregnancy","Known hypersensitivity to dexibuprofen, paracetamol, or any component","Severe heart failure"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients.","Avoid in patients with dehydration or hypovolemia.","Use with caution in patients with cardiovascular risk factors.","Do not exceed recommended dose or duration.","Avoid concurrent use with other NSAIDs or paracetamol-containing products.","Monitor for signs of gastrointestinal bleeding.","Use with caution in patients with asthma.","May impair ability to drive or operate machinery."]
🤱 Lactation Safety
Dexibuprofen and paracetamol are excreted in breast milk. Limited data suggest that short-term use may be acceptable, but consult your doctor before use during breastfeeding.
💊 Overdose Management
Overdose can cause severe liver damage from paracetamol and gastrointestinal bleeding from dexibuprofen. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Monitor liver and renal function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce the risk of stomach upset. Avoid alcohol while taking this medicine, as it can increase the risk of gastrointestinal bleeding and liver damage. Do not take other NSAIDs or paracetamol-containing products concurrently to avoid overdose. Inform your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma. Use with caution in elderly patients, who are more prone to side effects. Do not use this medicine during pregnancy, especially in the third trimester, unless specifically advised by your doctor. It may not be safe during breastfeeding; consult your doctor. If you experience any signs of allergic reaction such as rash, swelling, or difficulty breathing, stop the medicine and seek immediate medical help. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Store in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, renal impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
Avoid this medicine if you are planning pregnancy or are pregnant. Consult your doctor for alternative pain relief options.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but consult your surgeon before use, especially if you are on other medications or have bleeding risk.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you have pain or inflammation. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, worsens, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, renal impairment, and cardiovascular events. It is not recommended for chronic use without medical supervision. Regular monitoring of liver and kidney function may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce pain and inflammation.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. Consult your doctor if you have concerns.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Declare it to customs if required. Do not leave it in a hot car.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: Do not take other NSAIDs or paracetamol-containing products concurrently without consulting your doctor.
A: It should be avoided during pregnancy, especially in the third trimester, unless advised by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for debura 300 mg/500 mg tablet
View AllAlternative brands with exact same active ingredient:
-
ibusoft xt tablet 300 mg/500 mgEmcure Pharmaceuticals Ltd ₹15.08 74.3% CHEAPER
-
brutek p tablet 300 mg/500 mgZuventus Healthcare Ltd ₹16.09 72.5% CHEAPER
-
sibet p 300 mg/500 mg capsuleGlenmark Pharmaceuticals Ltd ₹54.95 6.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is intended for short-term use only. Long-term use requires medical supervision. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of gastrointestinal bleeding and liver damage. - Myth: It can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset.
🔄 Alternative Options
Generic Alternatives
- Dexibuprofen 300 mg + Paracetamol 500 mg tablet
Brand Alternatives
- Brutek P 300 mg/500 mg tablet