davaindia spironolactone+torasemide 50mg/20mg tablet - Spironolactone (50mg) + Torasemide (20mg) medicine

Dyloop Plus 20 Tablet: Comprehensive Medicine Guide

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🏭 Davaindia Generic Pharmacy 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for individual components; combination evidence is limited.
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe dizziness or fainting
  • Irregular heartbeat or palpitations
  • Muscle weakness or cramps
  • Decreased urine output
  • Severe abdominal pain
  • Signs of allergic reaction (rash, swelling, difficulty breathing)

If experiencing severe symptoms, call emergency services immediately.

What is davaindia spironolactone+torasemide 50mg/20mg tablet used for?

This medicine is a combination diuretic containing spironolactone and torasemide. It is used to treat fluid retention and heart failure by increasing urine output and balancing potassium levels.

  • Generic Name: Spironolactone (50mg) + Torasemide (20mg)
  • Manufacturer: Davaindia Generic Pharmacy
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 davaindia spironolactone+torasemide 50mg/20mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा स्पाइरोनोलैक्टोन और टोरासेमाइड का संयोजन है, जिसका उपयोग शरीर में अतिरिक्त तरल पदार्थ को निकालने के लिए किया जाता है। इसका उपयोग हृदय विफलता, लीवर सिरोसिस के कारण सूजन, नेफ्रोटिक सिंड्रोम और उच्च रक्तचाप के इलाज में किया जाता है। यह दवा पेशाब की मात्रा बढ़ाती है और पोटेशियम के स्तर को संतुलित रखने में मदद करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में बार-बार पेशाब आना, चक्कर आना, सिरदर्द, थकान, मतली और पेट खराब होना शामिल हैं। स्पाइरोनोलैक्टोन के कारण स्तनों में कोमलता या पुरुषों में स्तन वृद्धि हो सकती है। गंभीर दुष्प्रभावों में इलेक्ट्रोलाइट असंतुलन, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हैं।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पोटेशियम सप्लीमेंट या नमक के विकल्प बिना डॉक्टर की सलाह के न लें। पर्याप्त पानी पिएं लेकिन ज्यादा नहीं। शराब से बचें। नियमित रूप से रक्त परीक्षण कराएं। अचानक दवा बंद न करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 davaindia spironolactone+torasemide 50mg/20mg tablet Uses & Benefits

[{"condition":"Congestive heart failure","description":"Reduces fluid overload, improves symptoms, and may reduce hospitalizations.","evidence":"Well-established"},{"condition":"Edema due to liver cirrhosis","description":"Helps mobilize ascites and peripheral edema, often combined with other diuretics.","evidence":"Well-established"},{"condition":"Nephrotic syndrome","description":"Used to manage fluid retention when other diuretics are insufficient.","evidence":"Moderate"},{"condition":"Resistant hypertension","description":"Added to other antihypertensives to control blood pressure when standard therapy fails.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Spironolactone component may be used off-label for hyperandrogenism, but combination with torasemide is not standard.","evidence":"Limited"},{"condition":"Acne and hirsutism","description":"Spironolactone alone is sometimes used off-label; torasemide is not indicated for these conditions.","evidence":"Limited"}]

Primary treatment for: Congestive heart failure

Also treats: Edema due to liver cirrhosis, Nephrotic syndrome, Resistant hypertension

📋 Drug Information

Generic Name(s)Spironolactone (50mg) + Torasemide (20mg)
Brand Namedavaindia spironolactone+torasemide 50mg/20mg tablet
ManufacturerDavaindia Generic Pharmacy
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine in the morning to avoid frequent nighttime urination.
2
Monitor your blood pressure regularly and report any dizziness.
3
Get your potassium and kidney function tested as advised.
4
Avoid potassium-rich salt substitutes and supplements.
5
Do not stop this medicine suddenly without consulting your doctor.
6
Maintain a daily weight log to track fluid retention.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Swelling in legs or abdomen
This medicine is commonly prescribed for edema.
Likely Use
✅
Shortness of breath due to fluid overload
Used in heart failure to reduce fluid.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSpironolactone is absorbed from the gastrointestinal tract, with bioavailability approximately 90% when taken with food. Torasemide is rapidly absorbed orally, with bioavailability around 80-90%. Food may slightly delay absorption but does not significantly reduce overall exposure.
DistributionSpironolactone and its active metabolites are highly protein-bound and distribute widely into tissues. Torasemide is also highly protein-bound and has a volume of distribution of about 0.2 L/kg.
Protein BindingSpironolactone: >90% bound to plasma proteins. Torasemide: >99% bound to plasma proteins.
MetabolismSpironolactone is extensively metabolized in the liver to active metabolites including canrenone and 7-alpha-thiomethylspirolactone. Torasemide is metabolized in the liver by CYP2C9 to inactive metabolites.
Half-LifeSpironolactone: 1.4-1.6 hours for parent drug, but active metabolites have longer half-lives (up to 16 hours). Torasemide: 3.5-4 hours.
ExcretionSpironolactone and its metabolites are primarily excreted in urine and bile. Torasemide is excreted mainly in urine as unchanged drug and metabolites.
BioavailabilitySpironolactone: ~90% with food. Torasemide: ~80-90%.
Onset of ActionDiuretic effect begins within 1-2 hours for torasemide and within 1-2 days for spironolactone. Full therapeutic effect may take several days to weeks.
Peak Plasma TimeSpironolactone: 2-4 hours. Torasemide: 1-2 hours.
Duration of ActionTorasemide: 6-8 hours. Spironolactone: 2-3 days with chronic dosing.

How It Works

This medicine combines two diuretics with different mechanisms. Spironolactone is a competitive aldosterone receptor antagonist in the distal tubule, reducing sodium reabsorption and potassium excretion. Torasemide inhibits the Na+/K+/2Cl- symporter in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water. The combination produces a synergistic diuretic effect while spironolactone helps conserve potassium that torasemide would otherwise waste.

Mechanism Steps

1
Spironolactone blocks aldosterone receptors: Spironolactone competes with aldosterone at the mineralocorticoid receptor in the distal nephron, preventing sodium reabsorption and potassium secretion.
2
Torasemide inhibits NKCC2: Torasemide blocks the Na+/K+/2Cl- symporter in the thick ascending limb, reducing sodium, chloride, and water reabsorption.
3
Increased diuresis: The combined action leads to excretion of excess fluid, reducing edema and blood pressure.
4
Potassium balance: Spironolactone counteracts the potassium-wasting effect of torasemide, helping maintain normal potassium levels.

💡 How to Take davaindia spironolactone+torasemide 50mg/20mg tablet

Strength: Tablet containing Spironolactone 50 mg and Torasemide 20 mg.

1Take this medicine orally with a full glass of water.
2Take it at the same time each day, preferably in the morning to avoid nighttime urination.
3Take with food to reduce stomach upset.
4Swallow the tablet whole; do not crush or chew.
5Do not take potassium supplements or salt substitutes unless prescribed.
6Follow your doctor's instructions regarding fluid intake.

Dosage Information

Adult DosageThe usual adult dose is one tablet once daily, but the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of fluid retention, blood pressure, renal function, and electrolyte levels. Some patients may require twice-daily dosing. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to diuretic effects and electrolyte imbalances. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in renal impairment. Dose reduction may be necessary. Contraindicated in anuria and severe renal failure. Monitor renal function regularly.
Hepatic ImpairmentUse with caution in hepatic impairment. May precipitate hepatic coma in patients with cirrhosis. Dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum daily dose should not exceed the prescribed amount. Typically, spironolactone 50 mg and torasemide 20 mg once daily, but may be increased under medical supervision. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Potassium-rich foods
Moderate intake
May increase potassium levels.
Salt substitutes
Avoid
Contain potassium and can cause hyperkalemia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of davaindia spironolactone+torasemide 50mg/20mg tablet

✅ Common Side Effects

Increased urination (Very common (>10%))
Take earlier in the day to avoid nighttime urination.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid driving if dizzy.
Headache (Common (5-10%))
Usually resolves. Consult if persistent.
Fatigue (Common (5-10%))
Ensure adequate rest and hydration.
Nausea (Common (5-10%))
Take with food to reduce stomach upset.
Breast tenderness or gynecomastia (Uncommon (1-5%))
Report to doctor; may require dose adjustment or alternative.

🚨 Serious Side Effects

Severe electrolyte imbalance (e.g., hyperkalemia, hyponatremia) (Rare (<0.1%))
Seek immediate medical attention if you experience muscle weakness, irregular heartbeat, confusion, or seizures.
Acute kidney injury (Rare (<0.1%))
Contact doctor if you notice decreased urine output, swelling, or fatigue.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services if you have difficulty breathing, swelling of face/lips/throat, or severe rash.
Pancreatitis (Very rare (<0.01%))
Seek immediate care for severe abdominal pain radiating to back.

⚠️ Rare Side Effects

Agranulocytosis
Report fever, sore throat, or unusual infections.
Stevens-Johnson syndrome
Seek immediate care for rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Moderate
ACE inhibitors Major
NSAIDs Major
Lithium Major
Digoxin Moderate
Corticosteroids Moderate
Potassium supplements Major
Antidiabetics Moderate
Cholestyramine Minor
Antacids Minor

🚨 Major Interactions

  • Potassium supplements or potassium-sparing diuretics
  • ACE inhibitors or ARBs
  • Lithium
  • NSAIDs

⚡ Moderate Interactions

  • Digoxin
  • Corticosteroids
  • Antidiabetic drugs

🍷 Alcohol Interaction

Alcohol can enhance the blood pressure-lowering and dehydrating effects of this medicine, leading to dizziness, fainting, and electrolyte imbalances. It is advisable to avoid alcohol or limit intake significantly while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to spironolactone, torasemide, or sulfonamides","Anuria (no urine output)","Acute renal failure","Severe hyperkalemia","Addison's disease","Severe hyponatremia","Hepatic coma or pre-coma","Pregnancy and breastfeeding (unless clearly indicated)"]

⚠️ Warnings & Precautions

["Regular monitoring of electrolytes and renal function is required.","Avoid potassium supplements and potassium-rich salt substitutes.","Use with caution in elderly patients and those with diabetes or gout.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not stop abruptly without medical advice.","Inform your doctor if you have diarrhea or vomiting, as this can worsen electrolyte imbalance."]

🤱 Lactation Safety

Spironolactone and its metabolites are excreted in breast milk. Torasemide may also pass into breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.

💊 Overdose Management

Overdose can cause severe dehydration, electrolyte imbalances, and hypotension. Treatment is supportive and symptomatic. Monitor vital signs, electrolytes, and renal function. There is no specific antidote. Contact a poison control center or emergency services immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not adjust the dose without medical advice. Avoid potassium supplements and potassium-rich salt substitutes unless your doctor approves. Drink adequate fluids but do not overhydrate. Stand up slowly to avoid dizziness. Avoid alcohol as it can worsen dehydration and low blood pressure. Inform your doctor if you have diabetes, gout, or kidney problems. Regular blood tests are essential to monitor potassium, sodium, and kidney function. Do not stop this medicine abruptly, as fluid can build up again.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of electrolyte imbalances, dehydration, and falls due to dizziness. Start with lower doses and monitor closely.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for alternative treatments. Use effective contraception while taking this medicine.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before surgery. It may need to be stopped temporarily to avoid electrolyte imbalances during surgery.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may cause dry mouth or dizziness. Maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce fluid retention.
🥗
Limit salt intake to prevent fluid buildup.
😴
Engage in regular low-impact exercise as advised.
💧
Monitor your weight daily and report sudden increases.
🧘
Avoid alcohol and smoking.
🌞
Get adequate rest and manage stress.

🏋️ Exercise Considerations

Avoid strenuous exercise in hot weather as it can worsen dehydration and electrolyte imbalance. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Limit sodium intake to less than 2 grams per day.
Avoid potassium-rich salt substitutes.
Include fresh fruits and vegetables but monitor potassium.
Stay adequately hydrated unless fluid restriction is advised.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or frequent urination, which can affect work and daily activities. Plan your dose timing to minimize disruption. Avoid driving if you feel dizzy.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping abruptly can cause fluid retention and worsening of heart failure. Your doctor may adjust or discontinue based on your condition.

📅 Long-Term Use Effects

Long-term use requires regular monitoring of kidney function, electrolytes, and blood pressure. It may cause gynecomastia in men and menstrual irregularities in women. Periodic dose adjustments may be needed. Do not stop without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary sodium restriction

Reduces fluid retention and complements diuretic therapy.

Evidence: Well-established
Compression stockings

Helps reduce peripheral edema.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, consult your doctor before receiving any live vaccines while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Keep enough supply for the entire trip. Declare it at customs if required.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 60-year-old man with heart failure and leg swelling
He was prescribed this medicine along with other heart medications. After a week, his leg swelling reduced significantly and he could breathe easier. He was advised to monitor his potassium levels regularly.
💡 Lesson: Regular monitoring and adherence are key to safe and effective treatment.
👤 A 45-year-old woman with liver cirrhosis and ascites
She started this medicine to reduce abdominal swelling. She experienced increased urination but felt much lighter. She was advised to avoid potassium supplements and to have regular blood tests.
💡 Lesson: Combination diuretics can effectively manage ascites but require close monitoring.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Diuretic effect starts within 1-2 hours, but full benefits may take days to weeks.

Q: Can I take it with food?

A: Yes, take with food to reduce stomach upset.

Q: What if I miss a dose?

A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for davaindia spironolactone+torasemide 50mg/20mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken without monitoring.
    Fact: Regular blood tests are essential to monitor potassium and kidney function.
  • Myth: It is safe to take potassium supplements with this medicine.
    Fact: Potassium supplements can cause dangerous hyperkalemia and should be avoided unless prescribed.

🔄 Alternative Options

Generic Alternatives

  • Spironolactone 50 mg + Torasemide 20 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Spironolactone 50 mg + Torasemide 20 mg","onset":"1-2 hours","duration":"6-8 hours","potassium_effect":"Potassium-sparing"},{"medicine":"Spironolactone + Furosemide","composition":"Spironolactone 50 mg + Furosemide 20 mg","onset":"30-60 minutes","duration":"4-6 hours","potassium_effect":"Potassium-sparing"}]

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