Furosemide + Spironolactone 20mg/50mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Irregular or rapid heartbeat
- Muscle weakness or cramps
- Decreased urine output
- Confusion or extreme fatigue
- Swelling of face, lips, or throat
- Difficulty breathing
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is lactomide tablet used for?
This medicine is a combination diuretic containing furosemide (20 mg) and spironolactone (50 mg). It is used to treat fluid retention (edema) in conditions like heart failure, liver cirrhosis, and kidney disease. It works by increasing urine output while helping to maintain potassium levels.
- Generic Name: Furosemide (20mg) + Spironolactone (50mg)
- Manufacturer: S V Biovac Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 lactomide tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फ्यूरोसेमाइड और स्पाइरोनोलैक्टोन का संयोजन है, जिसका उपयोग शरीर में अतिरिक्त तरल पदार्थ (सूजन) को कम करने के लिए किया जाता है। यह हृदय विफलता, लिवर सिरोसिस, और किडनी रोग से जुड़ी सूजन के इलाज में मदद करती है। यह दवा पेशाब की मात्रा बढ़ाकर और पोटेशियम के स्तर को संतुलित रखकर काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में बार-बार पेशाब आना, चक्कर आना, सिरदर्द, मतली और मांसपेशियों में ऐंठन शामिल हैं। गंभीर दुष्प्रभावों में इलेक्ट्रोलाइट असंतुलन, किडनी की समस्या, और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि आपको मांसपेशियों में कमजोरी, अनियमित दिल की धड़कन, या पेशाब में कमी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक को स्वयं कम या ज्यादा न करें। पर्याप्त पानी पिएं जब तक डॉक्टर अन्यथा न कहें। शराब से बचें क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। अचानक उठने पर चक्कर आ सकते हैं, इसलिए धीरे-धीरे उठें। नियमित रूप से रक्त परीक्षण कराते रहें।
💊 lactomide tablet Uses & Benefits
[{"condition":"Congestive heart failure","description":"Reduces fluid overload and edema, improving symptoms like shortness of breath and inflammation" class="semantic-link" title="Medicines for swelling">swelling.","evidence":"Well-established"},{"condition":"Liver cirrhosis with ascites","description":"Helps mobilize and excrete excess abdominal fluid when used with other measures.","evidence":"Well-established"},{"condition":"Nephrotic syndrome","description":"Used to manage edema associated with kidney disease.","evidence":"Well-established"},{"condition":"Resistant edema","description":"Combination therapy may be used when a single diuretic is insufficient.","evidence":"Well-established"},{"condition":"Hypertension","description":"May be used as an adjunct in managing high blood pressure, especially with fluid retention.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Idiopathic edema","description":"Sometimes prescribed for fluid retention without clear cause, but diagnosis must exclude other conditions.","evidence":"Limited"},{"condition":"Premenstrual fluid retention","description":"Occasionally used short-term for cyclical edema, but not first-line.","evidence":"Limited"}]
Primary treatment for: Edema associated with congestive heart failure, liver cirrhosis, and nephrotic syndrome.
Also treats: Hypertension, Resistant edema, Ascites
📋 Drug Information
| Generic Name(s) | Furosemide (20mg) + Spironolactone (50mg) |
| Brand Name | lactomide tablet |
| Manufacturer | S V Biovac Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Diuretics, including loop diuretics and aldosterone antagonists, are recommended for managing fluid overload in heart failure and cirrhosis according to WHO guidelines. However, specific recommendations for this fixed-dose combination are not established from available information. |
| ICMR Guideline | ICMR guidelines for the management of heart failure and cirrhosis may include diuretics. However, specific recommendations for this fixed-dose combination are not established from available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two diuretics with complementary mechanisms. Furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water. Spironolactone is a competitive aldosterone antagonist that acts on the distal tubule and collecting duct, promoting sodium and water excretion while retaining potassium. Together, they produce a synergistic diuretic effect and help maintain potassium balance.
Mechanism Steps
💡 How to Take lactomide tablet
Strength: Furosemide 20 mg + Spironolactone 50 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this combination is one tablet (furosemide 20 mg + spironolactone 50 mg) taken orally once daily, preferably in the morning. However, the dose may be adjusted by your doctor based on your condition, response to treatment, and kidney function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of diuretics and are at higher risk of electrolyte imbalances, dehydration, and hypotension. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Furosemide may be less effective in severe renal impairment, and spironolactone can cause hyperkalemia. Dose adjustment and close monitoring are required. Consult a nephrologist. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Both drugs can precipitate hepatic encephalopathy due to electrolyte disturbances. Dose adjustment and close monitoring are required. Consult a hepatologist. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. Typically, the maximum recommended dose of this combination is one tablet daily, but in some cases, doctors may prescribe higher doses under close supervision. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of lactomide tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| ACE inhibitors | Major | |
| NSAIDs | Major | |
| Lithium | Major | |
| Digoxin | Major | |
| Corticosteroids | Moderate | |
| Aminoglycosides | Moderate | |
| Antihypertensives | Moderate | |
| Cholestyramine | Moderate | |
| Potassium supplements | Major |
🚨 Major Interactions
- Potassium supplements
- ACE inhibitors / ARBs
- Lithium
- Digoxin
- NSAIDs
⚡ Moderate Interactions
- Corticosteroids
- Aminoglycosides
- Antihypertensives
- Cholestyramine
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering and dizzy effects of this medicine. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Anuria (absence of urine production)","Acute renal failure","Severe electrolyte depletion (e.g., hypokalemia, hyponatremia)","Hyperkalemia","Addison's disease","Hypersensitivity to furosemide, spironolactone, or sulfonamides","Concomitant use with potassium supplements or other potassium-sparing diuretics (unless under strict medical supervision)","Severe hepatic impairment (risk of hepatic coma)"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","Monitor fluid and electrolyte balance closely, especially in elderly and debilitated patients.","Avoid in patients with a history of gout, as furosemide can increase uric acid levels.","May cause photosensitivity; advise sun protection.","Spironolactone can cause gynecomastia and menstrual irregularities; discuss with patients.","Furosemide may cause ototoxicity, especially with rapid intravenous administration or high doses.","Use with caution in patients with diabetes; may affect blood sugar control.","Do not use in patients with severe liver disease due to risk of hepatic encephalopathy."]
🤱 Lactation Safety
Furosemide is excreted in breast milk and may inhibit lactation. Spironolactone and its metabolites are also excreted in breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose can lead to severe dehydration, electrolyte imbalances, and hypotension. Treatment is supportive and symptomatic. Monitor vital signs, electrolytes, and renal function. There is no specific antidote. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. Drink adequate fluids unless your doctor advises otherwise. Avoid alcohol as it can worsen dizziness and low blood pressure. Stand up slowly to prevent dizziness. Inform your doctor if you experience muscle weakness, irregular heartbeat, or decreased urination. Regular blood tests are necessary to monitor kidney function and electrolyte levels.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of dehydration, electrolyte imbalances, and hypotension. Start with a lower dose and monitor closely. They may also be more susceptible to falls due to dizziness. Regular monitoring of kidney function and electrolytes is essential.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy unless clearly needed. Both furosemide and spironolactone may harm the fetus. If you are planning pregnancy, consult your doctor to discuss alternative treatments. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
After surgery, this medicine may be continued or adjusted based on your fluid status and kidney function. Inform your surgeon and anesthesiologist about this medicine before any surgery. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or increase bleeding risk if you are also on blood thinners. Your dentist may need to take precautions. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe, but avoid strenuous activities in hot environments as they can lead to dehydration and electrolyte imbalances. If you experience dizziness, muscle cramps, or fatigue during exercise, stop and consult your doctor. Swimming and walking are good low-impact options.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or frequent urination, which can affect your work and daily activities. You may need to take frequent bathroom breaks. Avoid driving or operating heavy machinery if you feel dizzy. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe electrolyte imbalance, allergic reaction, or kidney problems, your doctor may advise stopping or changing the medication. Always follow medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of kidney function, electrolytes, and blood pressure. Prolonged use may lead to electrolyte imbalances, kidney impairment, and in rare cases, hearing loss. Spironolactone can cause gynecomastia and menstrual irregularities in some patients. Your doctor will periodically assess the need for continued therapy and adjust the dose accordingly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Reducing salt intake can help manage fluid retention and complement diuretic therapy.
Evidence: Well-establishedCan help reduce peripheral edema in some patients.
Evidence: ModerateDepending on the condition, other diuretics or combinations may be prescribed.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with heart failure or liver disease should stay up to date with recommended vaccinations, such as influenza and pneumococcal vaccines, as advised by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the timing of your dose. Be prepared for increased urination during travel; choose aisle seats and stay hydrated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Furosemide starts working within 30-60 minutes, while spironolactone may take 1-2 days for full effect. You may notice increased urination soon after taking the dose.
A: It is best to take it in the morning to avoid frequent urination at night, which can disturb sleep.
A: If you remember within 12 hours, take it as soon as possible. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Limit high-sodium foods and avoid licorice. Monitor potassium-rich foods as spironolactone can increase potassium levels.
A: No, do not stop without consulting your doctor. Stopping suddenly can cause fluid to build up again and worsen your condition.
🤔 Common Patient Concerns
🔄 Substitutes for lactomide tablet
View AllAlternative brands with exact same active ingredient:
-
aldostix 20 mg/50 mg tabletBal Pharma Ltd ₹21.33 126% COSTLIER
-
spirotic 20mg/50mg tabletTalent Healthcare ₹21.84 131.4% COSTLIER
-
lactomide 20 mg/50 mg tabletInd Swift Laboratories Ltd ₹23.21 145.9% COSTLIER
-
urecton plus 20 mg/50 mg tabletDepsons Pharma ₹24.83 163% COSTLIER
-
aquamide 20 mg/50 mg tabletSun Pharmaceutical Industries Ltd ₹25.14 166.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken anytime of the day.
Fact: It is best taken in the morning to avoid frequent urination at night. - Myth: You can stop taking this medicine once swelling reduces.
Fact: You should not stop without consulting your doctor, as it may worsen your condition. - Myth: This medicine is safe for everyone with swelling.
Fact: It is not safe for people with certain kidney, liver, or electrolyte problems.
🔄 Alternative Options
Generic Alternatives
- Furosemide 20 mg + Spironolactone 50 mg tablet (various manufacturers)
Brand Alternatives
- Davaindia Furosemide + Spironolactone 20mg/50mg Tablet