davaindia amlodipine+bisoprolol 5mg/5mg tablet - Amlodipine (5mg) + Bisoprolol (5mg) medicine

Bisonext AM 5 Tablet: Complete Medicine Guide

No reviews yet
🏭 Davaindia Generic Pharmacy 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for the combination in hypertension.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe dizziness or fainting
  • Heart rate below 50 beats per minute
  • Difficulty breathing or wheezing
  • Chest pain that worsens or is not relieved by rest
  • Swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is davaindia amlodipine+bisoprolol 5mg/5mg tablet used for?

This medicine is a combination of Amlodipine and Bisoprolol used to treat high blood pressure and angina. It works by relaxing blood vessels and slowing the heart rate.

  • Generic Name: Amlodipine (5mg) + Bisoprolol (5mg)
  • Manufacturer: Davaindia Generic Pharmacy
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 davaindia amlodipine+bisoprolol 5mg/5mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) और एंजाइना (सीने में दर्द) के इलाज के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को आराम देकर और हृदय की गति को धीमा करके रक्तचाप को कम करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान और टखनों में सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि आपको सांस लेने में कठिनाई, धड़कन धीमी होना या बेहोशी महसूस हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हर दिन एक ही समय पर लें। डॉक्टर की सलाह के बिना इसे अचानक बंद न करें। शराब से बचें क्योंकि इससे चक्कर आ सकते हैं। यदि आपको अस्थमा, मधुमेह या गुर्दे की समस्या है तो अपने डॉक्टर को बताएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 davaindia amlodipine+bisoprolol 5mg/5mg tablet Uses & Benefits

[{"condition":"Hypertension","description":"Used to lower high blood pressure in adults when monotherapy is insufficient.","evidence":"Well-established"},{"condition":"Chronic stable angina","description":"Helps reduce the frequency of angina attacks and improves exercise tolerance.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Bisoprolol component may be used off-label in stable heart failure, but combination with amlodipine is not standard.","evidence":"Limited"}]

Primary treatment for: Hypertension

Also treats: Chronic stable angina

📋 Drug Information

Generic Name(s)Amlodipine (5mg) + Bisoprolol (5mg)
Brand Namedavaindia amlodipine+bisoprolol 5mg/5mg tablet
ManufacturerDavaindia Generic Pharmacy
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent blood levels.
2
Monitor your blood pressure regularly and keep a record.
3
Do not stop this medicine abruptly without consulting your doctor.
4
Avoid alcohol as it can increase dizziness and low blood pressure.
5
Inform your doctor if you experience persistent cough, swelling, or fatigue.
6
Use caution while driving or operating machinery until you know how this medicine affects you.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
High blood pressure
This medicine is commonly prescribed for this.
Likely Use
✅
Chest pain (angina)
This medicine helps reduce angina attacks.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAmlodipine is well absorbed after oral administration, with peak plasma levels reached in 6-12 hours. Bisoprolol is also well absorbed, with peak levels in 2-4 hours. Food does not significantly affect absorption.
DistributionAmlodipine is widely distributed in body tissues, with a large volume of distribution. Bisoprolol has a moderate volume of distribution. Both drugs cross the placenta and are excreted in breast milk.
Protein BindingAmlodipine is approximately 93% bound to plasma proteins. Bisoprolol is about 30% bound to plasma proteins.
MetabolismAmlodipine is extensively metabolized in the liver, primarily by CYP3A4. Bisoprolol is metabolized in the liver, partly to inactive metabolites, and is also excreted unchanged by the kidneys.
Half-LifeAmlodipine has a long half-life of 30-50 hours. Bisoprolol has a half-life of 9-12 hours.
ExcretionAmlodipine metabolites are excreted mainly in urine. Bisoprolol is excreted in both urine and feces.
BioavailabilityAmlodipine bioavailability is approximately 64-90%. Bisoprolol bioavailability is about 88%.
Onset of ActionAmlodipine onset is gradual, with antihypertensive effect within 24 hours. Bisoprolol onset is within 1-2 hours.
Peak Plasma TimeAmlodipine peak plasma time is 6-12 hours. Bisoprolol peak plasma time is 2-4 hours.
Duration of ActionAmlodipine duration is about 24 hours. Bisoprolol duration is about 24 hours, allowing once-daily dosing.

How It Works

This medicine combines two active ingredients with complementary actions. Amlodipine blocks calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and cardiac output. The combined effect lowers blood pressure and decreases myocardial oxygen demand.

Mechanism Steps

1
Calcium channel blockade: Amlodipine inhibits the influx of calcium ions into vascular smooth muscle cells, leading to relaxation and dilation of arteries.
2
Beta-1 receptor blockade: Bisoprolol selectively blocks beta-1 receptors in the heart, reducing heart rate and force of contraction.
3
Combined hemodynamic effect: The vasodilation from amlodipine and reduced cardiac output from bisoprolol work together to lower blood pressure and reduce cardiac oxygen demand.

💡 How to Take davaindia amlodipine+bisoprolol 5mg/5mg tablet

Strength: Tablet containing Amlodipine 5 mg and Bisoprolol 5 mg.

1Take the tablet at the same time each day.
2Swallow whole with a glass of water.
3Do not crush or chew the tablet.
4Can be taken with or without food.
5If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet once daily, taken orally, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor closely.
Renal ImpairmentIn patients with severe renal impairment, bisoprolol dose may need adjustment. Consult your doctor.
Hepatic ImpairmentIn patients with hepatic impairment, amlodipine clearance may be reduced. Use with caution and monitor.
Maximum Daily DoseThe maximum recommended daily dose is one tablet (Amlodipine 5 mg + Bisoprolol 5 mg). Do not exceed without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Take at the same time daily
Food does not significantly affect absorption.
Grapefruit juice
Avoid
May increase amlodipine levels.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of davaindia amlodipine+bisoprolol 5mg/5mg tablet

✅ Common Side Effects

Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid driving if affected.
Headache (Common (5-10%))
Usually resolves with continued use. Consult doctor if severe.
Fatigue (Common (5-10%))
Ensure adequate rest. Report if persistent.
Ankle swelling (Common (5-10%))
Elevate legs when sitting. Consult doctor if bothersome.

🚨 Serious Side Effects

Severe bradycardia (Rare (<0.1%))
Seek immediate medical attention if heart rate drops below 50 bpm or you feel faint.
Bronchospasm (Rare (<0.1%))
Seek emergency care if you experience difficulty breathing or wheezing.
Heart block (Rare (<0.1%))
Report symptoms like dizziness, fainting, or irregular heartbeat immediately.

⚠️ Rare Side Effects

Severe allergic reaction
Seek emergency help if you develop rash, swelling, or difficulty breathing.
Liver toxicity
Report yellowing of skin or eyes, dark urine, or abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Metoprolol Major
Ibuprofen Moderate
Clonidine Moderate
Antacids Minor

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  • Beta-blockers (e.g., metoprolol)

⚡ Moderate Interactions

  • NSAIDs
  • Clonidine

🍷 Alcohol Interaction

Alcohol may enhance the blood pressure-lowering effect and increase dizziness. Avoid or limit alcohol consumption.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe bradycardia","Second or third-degree heart block","Cardiogenic shock","Severe asthma","Known hypersensitivity to amlodipine or bisoprolol"]

⚠️ Warnings & Precautions

["Do not stop abruptly to avoid rebound hypertension or angina.","Use with caution in patients with asthma or COPD.","May mask symptoms of hypoglycemia in diabetics.","Avoid in patients with severe peripheral arterial disease.","Use with caution in elderly and those with renal impairment."]

🤱 Lactation Safety

Both amlodipine and bisoprolol are excreted in breast milk. Use with caution and only if clearly needed. Consult your doctor.

💊 Overdose Management

Overdose may cause severe hypotension, bradycardia, and heart failure. Seek immediate medical attention. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine at the same time each day, preferably in the morning. Do not stop taking it suddenly without consulting your doctor, as this can worsen your condition. Avoid alcohol as it may increase dizziness. Inform your doctor if you have asthma, diabetes, or kidney problems. Regular monitoring of blood pressure and heart rate is important.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to blood pressure lowering effects. Start with lower doses and monitor closely for dizziness and falls.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine may not be suitable during pregnancy; alternative treatments may be needed.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before surgery. It may need to be temporarily stopped.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may affect blood pressure and heart rate during treatment.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce heart strain.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Reduce salt intake to help control blood pressure.
💧
Practice stress-reduction techniques like meditation.
🧘
Get adequate sleep and avoid smoking.

🏋️ Exercise Considerations

Avoid strenuous exercise initially as this medicine may cause dizziness. Stay hydrated and rise slowly from sitting or lying positions.

🥗 Diet Recommendations

Include potassium-rich foods like bananas and spinach.
Reduce sodium intake.
Limit caffeine and alcohol.
Eat a balanced diet rich in fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue, affecting driving or operating machinery. Avoid these activities until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately for alternative treatment.

📅 Long-Term Use Effects

Long-term use requires regular monitoring of blood pressure, heart rate, and renal function. Do not stop without medical advice. Periodic check-ups are recommended.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress reduction can complement medicine.

Evidence: Well-established
Other antihypertensive classes

ACE inhibitors, ARBs, or diuretics may be alternatives.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions reported. Continue routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing times gradually under medical advice. Keep enough supply for the entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with hypertension not controlled on amlodipine alone.
He was prescribed this combination tablet. After 4 weeks, his blood pressure normalized and he had fewer angina episodes. He experienced mild ankle swelling initially, which resolved after elevating his legs.
💡 Lesson: Combination therapy can be more effective than monotherapy for blood pressure control.
👤 A 62-year-old woman with a history of asthma.
She was started on this medicine but developed wheezing. Her doctor switched her to a different class of antihypertensive.
💡 Lesson: Beta-blockers like bisoprolol should be used with caution in patients with asthma.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering blood pressure within 24 hours, but full effects may take 1-2 weeks.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop without consulting your doctor. Stopping suddenly can cause rebound hypertension or angina.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember if less than 12 hours have passed. Otherwise, skip and continue with your regular schedule.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my other blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for davaindia amlodipine+bisoprolol 5mg/5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be stopped once blood pressure is normal.
    Fact: High blood pressure often requires long-term treatment. Stopping suddenly can cause rebound hypertension.
  • Myth: This medicine causes kidney damage.
    Fact: This medicine is used to protect kidneys in hypertension. Regular monitoring is advised.

🔄 Alternative Options

Generic Alternatives

  • Amlodipine + Bisoprolol generic tablets

Brand Alternatives

  • Bisonext AM 5 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Amlodipine + Bisoprolol","composition":"Amlodipine 5 mg + Bisoprolol 5 mg","uses":"Hypertension, angina","notes":"Cardioselective beta-blocker"},{"medicine":"Amlodipine + Metoprolol","composition":"Amlodipine 5 mg + Metoprolol 50 mg","uses":"Hypertension, angina","notes":"Less cardioselective"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory