Docetere 120mg Injection: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fever of 38°C or higher, chills, or shivering after chemotherapy
- Difficulty breathing, chest tightness, or facial swelling during or after infusion
- Unusual bleeding, bruising, black stools, or blood in vomit
- Severe mouth sores that make eating or drinking difficult
- Yellowing of eyes or skin, dark urine, or severe abdominal pain
- New or worsening numbness, weakness, or difficulty walking
- Rapid weight gain, swelling of legs, or shortness of breath
- Palpitations, fainting, or chest pain
If experiencing severe symptoms, call emergency services immediately.
What is d-tail 120 injection used for?
This medicine is a prescription chemotherapy injection containing docetaxel, used to treat breast, lung, prostate, gastric, and head and neck cancers. It is given by a healthcare professional into a vein, usually every three weeks, and works by stopping cancer cells from dividing.
- Generic Name: Docetaxel (120mg)
- Manufacturer: Khandelwal Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 d-tail 120 injection के बारे में (Hindi Summary)
उपयोग: यह दवा डोसेटैक्सल नामक सक्रिय तत्व वाली कीमोथेरेपी इंजेक्शन है, जिसका उपयोग स्तन कैंसर, फेफड़ों के कैंसर, प्रोस्टेट कैंसर, पेट के कैंसर और सिर-गर्दन के कैंसर के इलाज में किया जाता है। यह दवा कैंसर कोशिकाओं को बढ़ने और बंटने से रोकती है, जिससे ट्यूमर छोटा होने में मदद मिलती है। यह दवा केवल अस्पताल या कैंसर डे-केयर सेंटर में योग्य ऑन्कोलॉजिस्ट की देखरेख में नस के माध्यम से दी जाती है। इसे घर पर स्वयं नहीं लगाया जा सकता। इलाज से पहले और बाद में खून की जांच और लीवर की जांच जरूरी होती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बाल झड़ना, थकान, जी मिचलाना, उल्टी, मुंह में छाले, हाथ-पैर में झनझनाहट, मांसपेशियों और जोड़ों में दर्द, पैरों में सूजन और खून की कोशिकाओं की कमी शामिल हैं। गंभीर दुष्प्रभावों में बुखार के साथ संक्रमण, सांस लेने में तकलीफ, तेज एलर्जी, त्वचा पर गंभीर दाने, लीवर की समस्या और दिल की धड़कन में बदलाव हो सकते हैं। अगर इंजेक्शन के दौरान या बाद में बुखार, सांस फूलना, चेहरे पर सूजन या कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्य कर्मियों द्वारा अस्पताल या कैंसर डे-केयर सेंटर में ही दी जानी चाहिए। हर इंजेक्शन से पहले स्टेरॉयड और कभी-कभी एलर्जी रोकने वाली दवाएं दी जाती हैं। हर साइकल से पहले खून और लीवर की जांच कराना जरूरी है। इलाज के दौरान संक्रमण से बचें, भीड़-भाड़ वाली जगहों पर मास्क पहनें और साफ-सफाई का ध्यान रखें। शराब न पिएं क्योंकि इससे लीवर पर और असर पड़ सकता है। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं दी जानी चाहिए। इलाज के दौरान गर्भधारण से बचने के लिए डॉक्टर की सलाह जरूर लें।
💊 d-tail 120 injection Uses & Benefits
[{"condition":"Breast cancer","description":"Used as adjuvant, neoadjuvant, or metastatic treatment, often in combination with other chemotherapy or targeted medicines.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Used after platinum-based therapy fails or as part of combination regimens in selected patients.","evidence":"Well-established"},{"condition":"Metastatic castration-resistant prostate cancer","description":"Given with prednisone or prednisolone to improve survival and symptom control in suitable patients.","evidence":"Well-established"},{"condition":"Gastric adenocarcinoma","description":"Used in combination chemotherapy regimens for advanced or metastatic disease.","evidence":"Well-established"},{"condition":"Head and neck squamous cell carcinoma","description":"Used in induction or combination regimens for locally advanced or recurrent disease.","evidence":"Established in selected regimens"},{"condition":"Ovarian cancer","description":"Used in some combination or salvage regimens for platinum-sensitive or resistant disease.","evidence":"Established in selected settings"}]
Off-label uses: [{"condition":"Bladder cancer","description":"Sometimes used in combination regimens for advanced urothelial cancer when standard options are unsuitable.","evidence":"Limited"},{"condition":"Esophageal cancer","description":"Occasionally included in chemotherapy combinations for advanced or recurrent disease.","evidence":"Limited"},{"condition":"Soft tissue sarcoma","description":"Used in selected patients after specialist multidisciplinary review.","evidence":"Limited"}]
Primary treatment for: Breast cancer
Also treats: Non-small cell lung cancer, Metastatic castration-resistant prostate cancer, Gastric adenocarcinoma, Head and neck squamous cell carcinoma, Ovarian cancer
📋 Drug Information
| Generic Name(s) | Docetaxel (120mg) |
| Brand Name | d-tail 120 injection |
| Manufacturer | Khandelwal Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Taxanes |
| Route of Administration | Parenteral |
| Storage | Store this medicine in its original carton in a refrigerator at 2°C to 8°C, protected from light. Do not freeze. Once prepared for infusion, use as directed by the hospital pharmacy and follow local handling guidelines for cytotoxic medicines. |
| Shelf Life | The shelf life of this medicine is usually 24 months from the date of manufacture when stored as directed. Always check the expiry date on the vial before use. |
| WHO Guideline | Docetaxel is included in several international cancer treatment guidelines for breast, lung, prostate, gastric, and head and neck cancers. The exact recommendation depends on the cancer type, stage, and previous treatments. Patients should follow the advice of their treating oncology team. |
| ICMR Guideline | Indian cancer treatment guidance recognises docetaxel as part of standard chemotherapy for several cancers, including breast, lung, and prostate cancer. Treatment should be given under the supervision of a qualified oncologist following institutional protocols. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is an antimicrotubule chemotherapy agent. It binds to the beta-tubulin subunit of microtubules and stabilises them, preventing normal disassembly. This disrupts the mitotic spindle, arrests cells in the G2/M phase of the cell cycle, and blocks cancer cell division, leading to cell death.
Mechanism Steps
💡 How to Take d-tail 120 injection
Strength: This medicine is supplied as a 120 mg strength concentrate for solution for intravenous infusion.
Dosage Information
| Adult Dosage | The dose of this medicine is decided by the treating oncologist and depends on the type of cancer, the treatment regimen, body surface area, blood counts, liver function, and previous treatments. Common regimens use doses such as 75 to 100 mg per square metre of body surface area every three weeks, or 35 to 40 mg per square metre weekly, but these are examples only. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially low blood counts, fatigue, fluid retention, and nerve damage. The treating oncologist may choose a lower dose or adjust the schedule based on general health, liver function, and other medicines. |
| Renal Impairment | Mild to moderate kidney problems usually do not require a dose change. Patients with severe kidney problems should be monitored closely, and the dose must be individualized by a qualified clinician based on renal function and overall health. |
| Hepatic Impairment | Patients with raised liver enzymes or bilirubin may need a reduced dose or delayed treatment. This medicine should not be given to patients with severe liver impairment. Dose must be individualized by a qualified clinician based on liver function tests. |
| Maximum Daily Dose | The maximum dose of this medicine depends on the treatment regimen and is decided by the treating oncologist. It is usually calculated per square metre of body surface area and given as a single infusion per cycle. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of d-tail 120 injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Live vaccines | Major | |
| Warfarin | Moderate | |
| Ciclosporin | Moderate | |
| Doxorubicin | Moderate | |
| Cimetidine | Moderate | |
| Phenytoin | Moderate | |
| Clarithromycin | Major | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
- Strong CYP3A4 inducers such as rifampicin, carbamazepine, and phenytoin
- Live vaccines
- Other myelosuppressive chemotherapy or radiotherapy
⚡ Moderate Interactions
- Warfarin and other anticoagulants
- Ciclosporin and tacrolimus
- Doxorubicin and other anthracyclines
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. It can increase the risk of liver injury, worsen fatigue and nausea, and make it harder for the body to recover between cycles. Patients should discuss any alcohol use with their treating oncologist.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to docetaxel or polysorbate 80","Severe liver impairment","Very low neutrophil count","Active serious infection","Pregnancy and breastfeeding","Previous severe hypersensitivity reaction to this medicine"]
⚠️ Warnings & Precautions
["This medicine must only be given by a qualified oncology team in a hospital or day-care setting.","Premedication with a corticosteroid is usually needed before each infusion to reduce allergic reactions and fluid retention.","Blood counts and liver function must be checked before each cycle.","Patients should avoid contact with people who have active infections.","Effective contraception is required for both men and women during treatment and for a period after the last dose.","Live vaccines should not be given during treatment.","Report fever, breathlessness, severe skin reactions, or unusual bleeding immediately.","This medicine can cause nerve damage, and the dose may need to be reduced or stopped if symptoms worsen."]
🤱 Lactation Safety
This medicine passes into breast milk and can harm a nursing infant. Breastfeeding must be stopped before starting treatment and should not be resumed until the treating oncologist confirms it is safe.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, nerve damage, and other serious toxicities. There is no specific antidote. Treatment is supportive and may include blood count monitoring, antibiotics for infection, growth factor support, and hospital care. Any suspected overdose must be treated as a medical emergency.
⏰ Missed Dose
This medicine is given by a healthcare professional in a treatment centre, so a missed dose usually means a missed appointment. Contact the treating centre as soon as possible to reschedule. Do not try to catch up by taking extra doses at home. The treating oncologist will decide the safest timing for the next infusion.
Additional Safety Advice
This medicine must only be prepared and given by trained healthcare professionals in a properly equipped cancer treatment centre. Premedication with a corticosteroid, and sometimes antihistamines and H2 blockers, is usually given before each infusion to reduce allergic reactions and fluid retention. Blood tests are needed before every cycle to check blood counts, liver function, and kidney function. Patients should avoid contact with people who have active infections and should report fever, chills, sore throat, unusual bleeding, or breathlessness without delay. Alcohol should be avoided during treatment because it can worsen liver stress and fatigue. This medicine can harm an unborn baby, so effective contraception is required for both men and women during treatment and for a period after the last dose as advised by the treating oncologist.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may have a higher risk of low blood counts, fatigue, fluid retention, and nerve damage with this medicine. The treating oncologist may choose a lower dose or adjust the schedule based on general health, liver function, and other medicines. Close monitoring and support are important.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women should avoid pregnancy during treatment and for a period after the last dose as advised by the oncologist. Men should also use effective contraception because this medicine can affect sperm and may harm a partner's pregnancy. Discuss fertility preservation options before starting treatment if you plan to have children in the future.
🏥 Post-Surgery Considerations
This medicine can slow wound healing and increase infection risk because it lowers blood counts. If surgery is planned, the oncology team and surgeon will decide the safest timing around chemotherapy cycles. Report any signs of infection, delayed healing, or fever after surgery.
🦷 Dental Procedures
Dental work should be planned carefully during treatment with this medicine. Low blood counts and mouth sores increase the risk of bleeding and infection. Inform your dentist about your chemotherapy and get clearance from your oncologist before any dental procedure. Maintain gentle oral hygiene with a soft toothbrush.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Light activity such as short walks can help with fatigue, but avoid strenuous exercise during treatment, especially when blood counts are low. Patients with nerve tingling, dizziness, or weakness should avoid activities that increase the risk of falls. Always ask your oncology team before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause tiredness, nausea, and low blood counts, which may affect your ability to work during treatment. Many patients need rest days after infusion. Avoid driving or operating heavy machinery immediately after treatment, especially if premedication causes drowsiness. Discuss work schedules and safety-sensitive tasks with your oncology team.
🛑 When to Stop This Medicine
Do not stop or change treatment on your own. The treating oncologist may reduce, delay, or stop this medicine if blood counts are too low, liver tests are abnormal, nerve damage worsens, or serious side effects occur. Always discuss any decision to stop treatment with your oncology team.
📅 Long-Term Use Effects
Long-term effects of this medicine can include persistent nerve damage with numbness or tingling in hands and feet, ongoing fatigue, and rarely heart or liver problems. Some patients may have long-lasting changes in blood counts. Regular follow-up with the oncology team is important to monitor for late effects and to manage any symptoms that persist after treatment ends.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another taxane chemotherapy that may be used in some cancers instead of docetaxel.
Evidence: Well-establishedMedicines that target specific cancer markers may be used in selected patients, sometimes with or instead of chemotherapy.
Evidence: Established in selected cancersImmune checkpoint inhibitors may be used in some cancers, depending on the tumour type and markers.
Evidence: Established in selected cancersFocused on symptom control and quality of life, and can be combined with anticancer treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be given during treatment with this medicine because the immune system is weakened and live vaccines can cause serious infections. Inactivated vaccines may be given if needed, but the response may be weaker. Discuss all vaccines with the treating oncologist and plan them before starting chemotherapy or after recovery as advised.
📦 Storage Guide
✅ DO
Store in the original carton in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze the vial
✅ DO
Protect from light
❌ DON'T
Do not leave the vial in direct sunlight
✅ DO
Keep out of reach of children
❌ DON'T
Do not store near food or drinks
✅ DO
Follow hospital pharmacy instructions for prepared solutions
❌ DON'T
Do not prepare or store the infusion at home
✈️ Traveling with This Medicine
Patients receiving this medicine should carry a copy of their prescription and treatment summary when travelling. The medicine itself is usually stored and given at the treatment centre, so patients do not need to carry vials. If travel is planned between cycles, discuss the schedule with the treating oncologist in advance. Carry a list of medicines, allergies, and emergency contact numbers. Avoid travelling to places with high infection risk during periods of low blood counts. Drink safe water and eat freshly cooked food while travelling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given by a trained healthcare professional as a slow injection into a vein in a hospital or day-care chemotherapy unit. It is not taken at home.
A: The number of cycles depends on the type of cancer, response to treatment, and side effects. Your oncologist will decide the duration and schedule.
A: Common side effects include low blood counts, hair loss, tiredness, nausea, mouth sores, nerve tingling, and fluid retention. Most can be managed with supportive care.
A: You should avoid driving immediately after infusion, especially if premedication makes you drowsy. Ask your treating team when it is safe to drive.
A: Alcohol should be avoided because it can worsen liver stress, fatigue, and nausea during chemotherapy.
A: This medicine can harm an unborn baby and is not recommended during pregnancy. Effective contraception is needed during treatment and for a period after the last dose.
🤔 Common Patient Concerns
🔄 Substitutes for d-tail 120 injection
View AllAlternative brands with exact same active ingredient:
-
docetere 120mg solvent for injectionDr Reddy's Laboratories Ltd ₹29.50 99.8% CHEAPER
-
daxotel 120mg injectionFresenius Kabi India Pvt Ltd ₹30.00 99.8% CHEAPER
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solvent for docetaxel concentrate 120mg injectionDr Reddy's Laboratories Ltd ₹95.00 99.2% CHEAPER
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Relidoce 120mg InjectionReliance Formulation Pvt Ltd ₹1,453.13 88% CHEAPER
-
docax 120mg injectionNeon Laboratories Ltd ₹2,179.00 82% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a tablet at home.
Fact: This medicine is an intravenous injection and must only be given by a trained healthcare professional in a hospital or day-care setting. - Myth: This medicine cures all cancers.
Fact: This medicine is used for specific cancers and works best as part of a treatment plan designed by an oncologist. It does not cure every cancer. - Myth: Hair loss from this medicine is permanent.
Fact: Hair loss is usually temporary, and hair often regrows after treatment is completed. - Myth: Herbal medicines are always safe with chemotherapy.
Fact: Some herbal products can interact with this medicine and affect its safety or effectiveness. Always tell your oncologist about any supplements you take.
🔄 Alternative Options
Generic Alternatives
- Docetaxel injection
Brand Alternatives
- Docetere 120mg injection