Cynerve PG 1500mcg/50mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, throat, or tongue
- Difficulty breathing or shortness of breath
- Suicidal thoughts or self-harm urges
- Severe dizziness or fainting
- Unusual muscle pain, weakness, or dark urine
- Signs of severe allergic reaction (rash, itching, hives)
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is cynerve pg 1500mcg/50mg tablet used for?
This medicine is a combination of Methylcobalamin (1500mcg) and Pregabalin (50mg) used to treat neuropathic pain and vitamin B12 deficiency. It works by reducing pain signals in the nervous system and supporting nerve repair. Take it exactly as prescribed, usually once or twice daily.
- Generic Name: Methylcobalamin + Pregabalin
- Manufacturer: Medrek Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cynerve pg 1500mcg/50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन 1500mcg और प्रेगाबालिन 50mg का संयोजन है, जिसका उपयोग न्यूरोपैथिक दर्द (नसों का दर्द), डायबिटिक न्यूरोपैथी, और विटामिन बी12 की कमी से जुड़े लक्षणों के इलाज के लिए किया जाता है। यह नसों को आराम पहुंचाने और उनकी मरम्मत में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, थकान, मुंह सूखना, और हाथ-पैरों में सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या आत्महत्या के विचार आते हैं तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। दवा लेने के बाद चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें। दवा अचानक बंद न करें। इसे बच्चों की पहुंच से दूर रखें।
💊 cynerve pg 1500mcg/50mg tablet Uses & Benefits
- [{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, tingling, and shooting pain in the feet and hands caused by nerve damage from diabetes.
- Methylcobalamin supports nerve repair while Pregabalin reduces pain signals.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"Used to manage persistent nerve pain that follows a shingles outbreak.
- Pregabalin reduces abnormal pain signaling, and Methylcobalamin aids nerve recovery.","evidence":"Well-established"},{"condition":"Vitamin B12 deficiency with neurological symptoms","description":"Methylcobalamin corrects B12 deficiency, which can cause numbness, tingling, and cognitive issues.
- Pregabalin may be added if neuropathic pain is present.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"Pregabalin is approved for fibromyalgia in some regions; Methylcobalamin may help with associated fatigue and nerve health.","evidence":"Moderate"},{"condition":"Spinal cord injury-related neuropathic pain","description":"May be prescribed to manage chronic nerve pain following spinal cord injury, though evidence is moderate.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Generalized anxiety disorder","description":"Pregabalin is sometimes used off-label for anxiety, but this combination is not first-line.","evidence":"Limited"},{"condition":"Chronic low back pain with neuropathic component","description":"May be prescribed off-label when nerve involvement is suspected.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Pregabalin has been studied off-label for RLS, but Methylcobalamin's role is unclear.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic peripheral neuropathy, Postherpetic neuralgia, Vitamin B12 deficiency with neurological symptoms, Fibromyalgia
📋 Drug Information
| Generic Name(s) | Methylcobalamin + Pregabalin |
| Brand Name | Axogurd-SR Tablet |
| Manufacturer | Medrek Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Neurotropic vitamin + Gabapentinoid |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Keep in original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This leads to decreased neuronal excitability and pain transmission. Methylcobalamin is a coenzyme form of vitamin B12 that participates in methylation reactions essential for myelin synthesis, nerve cell maintenance, and red blood cell production. It helps repair damaged nerves and improves nerve conduction velocity.
Mechanism Steps
💡 How to Take cynerve pg 1500mcg/50mg tablet
Strength: Tablet containing Methylcobalamin 1500mcg and Pregabalin 50mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your physician. The dose may be adjusted based on your condition, response to treatment, and kidney function. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require lower doses due to reduced renal function. Dose must be individualized by a qualified clinician based on renal function and overall health. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, reduce dose; for <30 mL/min, further reduction or alternative therapy may be needed. Consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but caution is advised. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 300mg of Pregabalin and 1500mcg of Methylcobalamin, but this may vary based on individual patient needs. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cynerve pg 1500mcg/50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Benzodiazepines | Major | |
| ACE inhibitors | Major | |
| Thiazolidinediones | Moderate | |
| Loop diuretics | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- CNS depressants (e.g., opioids, benzodiazepines, alcohol)
- Angiotensin-converting enzyme (ACE) inhibitors
⚡ Moderate Interactions
- Thiazolidinediones (e.g., pioglitazone)
- Loop diuretics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can enhance the sedative and dizziness effects of Pregabalin, leading to increased impairment of motor skills and potentially dangerous drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Pregabalin, Methylcobalamin, or any component of the formulation","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until effects are known.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","Use with caution in elderly patients due to increased risk of falls.","May increase risk of suicidal thoughts; monitor mood changes.","Can cause peripheral edema; monitor for swelling.","Use with caution in patients with heart failure.","May impair cognitive function; use caution in tasks requiring alertness."]
🤱 Lactation Safety
Pregabalin is excreted in breast milk; breastfeeding is not recommended during treatment. Methylcobalamin is safe in breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause excessive sedation, confusion, agitation, and respiratory depression. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. Hemodialysis may be considered for Pregabalin overdose.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always take this medicine exactly as prescribed. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause dizziness and drowsiness. Do not consume alcohol while taking this medicine, as it can increase sedation and impair motor skills. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not stop this medicine abruptly without consulting your doctor, as withdrawal symptoms may occur. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember unless it is almost time for your next dose; do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of dizziness, falls, and renal impairment. Dose adjustment may be necessary based on kidney function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor. Pregabalin may harm the fetus; effective contraception is recommended during treatment. Methylcobalamin is safe.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist about this medicine before surgery. It may interact with anesthetic agents and increase sedation. Your doctor may advise temporary discontinuation.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. It may interact with sedatives used during dental work. Local anesthesia is generally safe.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid high-impact exercises that may worsen nerve pain. Consult your doctor before starting any new exercise regimen. If you experience dizziness, avoid activities that require balance.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness and drowsiness, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also affect concentration; take precautions at work.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects or your condition improves, your doctor will guide you on tapering the dose gradually.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Regular monitoring of kidney function, vitamin B12 levels, and mood is recommended. Some patients may experience weight gain and peripheral edema. Periodic review by your doctor is essential to assess continued need and adjust dosage.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce neuropathic pain in some patients.
Evidence: ModerateMay provide symptomatic relief for nerve pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Keep enough supply for the entire trip and carry it in your hand luggage to avoid loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pregabalin may start relieving pain within a few hours, but full effects may take several days to weeks. Methylcobalamin's effects on nerve health may take weeks to months.
A: Consult your doctor before combining with other painkillers, especially opioids, as they can increase sedation and respiratory depression.
A: Pregabalin should be used during pregnancy only if the potential benefit justifies the risk. Methylcobalamin is generally safe. Consult your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller like paracetamol.
Fact: This medicine is not a simple painkiller; it targets nerve pain specifically and also corrects vitamin B12 deficiency. - Myth: You can stop taking it as soon as you feel better.
Fact: Stopping abruptly can cause withdrawal symptoms; always taper under medical supervision. - Myth: It is safe to drink alcohol while on this medicine.
Fact: Alcohol increases sedation and dizziness, and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin 1500mcg + Pregabalin 50mg tablet (generic)
Brand Alternatives
- Cynerve PG 1500mcg/50mg Tablet