cronodol 500mg tablet - Disulfiram (500mg) medicine

cronodol 500mg tablet

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Disulfiram (500mg)
🏭 Syncom Formulations I Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is cronodol 500mg tablet used for?

This medicine contains Disulfiram (500mg) and is used to treat NEURO CNS. Irreversibly inhibits aldehyde dehydrogenase, causing accumulation of acetaldehyde when alcohol is c. Always consult your doctor before use.

  • Generic Name: Disulfiram
  • Manufacturer: Syncom Formulations I Limited
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
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💊 cronodol 500mg tablet Uses & Benefits

Management of chronic alcohol dependence as an adjunct to psychosocial therapy.

Off-label uses: Treatment of cocaine dependence (limited evidence).

📋 Drug Information

Generic Name(s)Disulfiram
Brand NameAlcoban
ManufacturerSyncom Formulations I Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassAlcohol deaddiction
Route of AdministrationOral
StorageStore at room temperature (20-25°C) in a dry place, away from light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract.
DistributionWidely distributed throughout the body; crosses the blood-brain barrier.
Protein Binding96% bound to plasma proteins.
MetabolismMetabolized in the liver to diethyldithiocarbamate, which is further metabolized.
Half-Life7-10 hours; however, the duration of action is longer due to irreversible inhibition of aldehyde deh
ExcretionPrimarily excreted in urine as metabolites; small amount in feces.
BioavailabilityApproximately 80-90% after oral administration.
Onset of Action1-2 hours after ingestion.
Peak Plasma Time3-4 hours.
Duration of ActionUp to 14 days after last dose due to irreversible enzyme inhibition.

How It Works

Irreversibly inhibits aldehyde dehydrogenase, causing accumulation of acetaldehyde when alcohol is consumed, leading to unpleasant effects.

Mechanism Steps

1Disulfiram is absorbed and distributed to the liver.
2It irreversibly inhibits aldehyde dehydrogenase (ALDH) by binding to its active site.
3When alcohol is consumed, ethanol is metabolized to acetaldehyde by alcohol dehydrogenase.
4Acetaldehyde accumulates due to ALDH inhibition, leading to toxic levels.
5Elevated acetaldehyde causes the disulfiram-ethanol reaction (DER): flushing, nausea, vomiting, headache, hypotension, and palpitations.
6The unpleasant reaction deters alcohol consumption.

💡 How to Take cronodol 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cronodol 500mg tablet

✅ Common Side Effects

Drowsiness
Fatigue
Metallic taste
Headache
Impotence
Acneiform rash

🚨 Serious Side Effects

Hepatotoxicity
Peripheral neuropathy
Psychotic reactions
Optic neuritis

⚠️ Rare Side Effects

Allergic dermatitis
Thrombocytopenia
Cholestatic hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Alcohol Major Severe disulfiram-ethanol reaction (flushing, nausea, vomiting, hypotension, confusion, arrhythmias).
Metronidazole Major Increased risk of disulfiram-like reaction.
Warfarin Major Increased anticoagulant effect and bleeding risk.
Isoniazid Major Increased risk of hepatotoxicity and CNS effects.
Phenytoin Major Increased phenytoin levels and toxicity.

🚨 Major Interactions

  • Alcohol
  • Metronidazole
  • Paraldehyde
  • Warfarin
  • Isoniazid
  • Phenytoin
  • Benzodiazepines

⚡ Moderate Interactions

  • Anticoagulants
  • Theophylline
  • Cimetidine
  • Omeprazole
  • Oral hypoglycemics

🍷 Alcohol Interaction

Severe disulfiram-ethanol reaction (DER) can occur up to 14 days after last dose.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, severe myocardial disease, psychosis, alcohol intoxication, recent alcohol consumption (within 12 hours), severe liver disease.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; monitor vital signs; treat symptoms; no specific antidote.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose.

🔄 Substitutes for cronodol 500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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