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cromobact injection - Aztreonam (1gm) medicine

cromobact injection - Uses, Price, Side Effects & Substitutes

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Aztreonam (1gm)
๐Ÿญ Fusion Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jul 3, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jul 03, 2026

What is cromobact injection used for?

Azenam 1gm Injection (Aztreonam) is used to treat ANTI INFECTIVES. It contains Aztreonam (1gm), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding protein . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Aztreonam
  • Manufacturer: Fusion Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š cromobact injection Uses & Benefits

Treatment of infections caused by susceptible Gram-negative bacteria including urinary tract infections, lower respiratory tract infections, septicemia, skin and skin structure infections, intra-abdominal infections, and gynecologic infections.

Off-label uses: Febrile neutropenia (in combination), Meningitis (with inflamed meninges)

๐Ÿ“‹ Drug Information

Generic Name(s)Aztreonam
Brand NameAzenam 1gm Injection
ManufacturerFusion Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassMonobactams
Route of AdministrationIntravenous (IV) or intramuscular (IM) injection.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solutions stable for 48 hours at room temperature or 7 days under refrigeration.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntramuscular administration results in rapid and complete absorption; intravenous administration provides immediate systemic availability.
DistributionWidely distributed into body tissues and fluids including cerebrospinal fluid (with inflamed meninges), bile, sputum, and pleural fluid.
Protein BindingApproximately 56% bound to plasma proteins.
MetabolismMetabolized primarily by hydrolysis of the beta-lactam ring to inactive metabolites.
Half-LifeApproximately 1.7 hours in patients with normal renal function; prolonged in renal impairment.
ExcretionPrimarily excreted unchanged in urine (60-70%) via glomerular filtration and tubular secretion; small amount in feces.
Bioavailability100% (intravenous); approximately 100% (intramuscular).
Onset of ActionRapid; within 30 minutes after intravenous administration.
Peak Plasma TimeIntravenous: immediately after infusion; intramuscular: 1 hour.
Duration of ActionApproximately 6-8 hours depending on renal function.

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding protein 3 (PBP3), leading to cell lysis and death.

Mechanism Steps

1Aztreonam binds to penicillin-binding protein 3 (PBP3) on the inner membrane of Gram-negative bacteria.
2Inhibition of PBP3 prevents transpeptidation, a key step in peptidoglycan cross-linking.
3Disruption of cell wall synthesis leads to osmotic instability and bacterial cell lysis.

๐Ÿ’ก How to Take cromobact injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cromobact injection

โœ… Common Side Effects

  • Injection site reactions (pain, phlebitis)
  • Diarrhea
  • Nausea
  • Vomiting
  • Rash

๐Ÿšจ Serious Side Effects

  • Severe hypersensitivity reactions (anaphylaxis)
  • Clostridioides difficile-associated diarrhea
  • Seizures
  • Hepatotoxicity

โš ๏ธ Rare Side Effects

  • Pseudomembranous colitis
  • Blood dyscrasias (neutropenia, thrombocytopenia)
  • Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Live Typhoid Vaccine Major Reduced vaccine efficacy
BCG Vaccine Major Reduced vaccine efficacy
Probenecid Moderate Decreased renal excretion of aztreonam
Aminoglycosides Moderate Increased nephrotoxicity risk
Furosemide Moderate Increased nephrotoxicity risk
Chloramphenicol Minor Antagonistic effect
Tetracyclines Minor Antagonistic effect

๐Ÿšจ Major Interactions

  • Warfarin
  • Live Typhoid Vaccine
  • BCG Vaccine

โšก Moderate Interactions

  • Probenecid
  • Aminoglycosides
  • Furosemide

โ„น๏ธ Minor Interactions

  • Chloramphenicol
  • Tetracyclines

๐Ÿฝ๏ธ Food Interactions

No significant food interactions; injection only.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to aztreonam or any component of the formulation.

๐Ÿ“Š Monitoring Parameters

Renal function (especially in elderly or with concurrent nephrotoxic drugs), liver function tests, signs of hypersensitivity, and superinfection.

๐Ÿคฑ Lactation Safety

Excreted in breast milk in low concentrations; generally considered compatible with breastfeeding.

๐Ÿ’Š Overdose Management

Supportive care; hemodialysis may enhance elimination.

โฐ Missed Dose

Administer as soon as possible; if near next dose, skip missed dose and resume regular schedule.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jul 03, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for cromobact injection

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Alternative brands with exact same active ingredient (Aztreonam (1gm)):

Medical Note: Always consult your doctor before switching medications.

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