critifol injection - Propofol (NA) medicine

critifol injection

4.3 (12 reviews)
๐Ÿญ Raman Weil Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is critifol injection used for?

Cleofol (Propofol) is used to treat PAIN ANALGESICS. It contains Propofol (NA), which Potentiates GABA-A receptor activity, inhibits NMDA receptors. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Propofol
  • Manufacturer: Raman Weil Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š critifol injection Uses & Benefits

Induction and maintenance of general anesthesia, sedation in ICU, procedural sedation

Off-label uses: Antiemetic, treatment of refractory status epilepticus, sedation for electroconvulsive therapy

๐Ÿ“‹ Drug Information

Generic Name(s)Propofol
Brand NameCleofol
ManufacturerRaman Weil Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassGeneral anaesthetic agents
Route of AdministrationIntravenous
StorageStore at 20-25ยฐC, protect from light, do not freeze
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intravenous administration
DistributionWidely distributed, high lipid solubility, crosses blood-brain barrier
Protein Binding97-99%
MetabolismHepatic, primarily via glucuronidation and hydroxylation
Half-Life30-60 minutes (initial), 2-24 hours (terminal)
ExcretionRenal (approximately 88% as metabolites, <1% unchanged)
Bioavailability100% (intravenous)
Onset of Action30-60 seconds
Peak Plasma TimeImmediately after bolus
Duration of Action3-10 minutes (single dose)

How It Works

Potentiates GABA-A receptor activity, inhibits NMDA receptors

Mechanism Steps

1Binds to GABA-A receptor beta subunits
2Enhances GABA-mediated chloride ion influx
3Hyperpolarizes postsynaptic membrane

๐Ÿ’ก How to Take critifol injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of critifol injection

โœ… Common Side Effects

  • Hypotension
  • Bradycardia
  • Apnea
  • Injection site pain
  • Nausea
  • Vomiting

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Cardiac arrest
  • Anaphylaxis
  • Propofol infusion syndrome

โš ๏ธ Rare Side Effects

  • Pancreatitis
  • Rhabdomyolysis
  • Hypertriglyceridemia
  • Seizures

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Benzodiazepines Major Additive CNS depression, respiratory depression
Opioids Major Additive CNS depression, hypotension
Barbiturates Major Additive CNS depression
Volatile anesthetics Major Additive anesthetic effect
Antihypertensives Moderate Increased hypotension
CNS depressants Moderate Enhanced sedation
Neuromuscular blockers Moderate Potentiated neuromuscular blockade
Corticosteroids Minor Possible increased propofol clearance
Theophylline Minor Possible antagonism of sedative effects

๐Ÿšจ Major Interactions

  • Benzodiazepines
  • Opioids
  • Barbiturates
  • Volatile anesthetics

โšก Moderate Interactions

  • Antihypertensives
  • CNS depressants
  • Neuromuscular blockers

โ„น๏ธ Minor Interactions

  • Corticosteroids
  • Theophylline

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

Enhanced CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to propofol or components, severe hypotension, unstable cardiovascular status, increased intracranial pressure

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, respiratory rate, oxygen saturation, level of consciousness

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution

๐Ÿ’Š Overdose Management

Supportive care, airway management, cardiovascular support

โฐ Missed Dose

Not applicable (administered by healthcare professional)

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

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