Aquadol TPM Gel: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction (swelling of face, lips, tongue, throat, difficulty breathing)
- Signs of gastrointestinal bleeding (black, tarry stools, vomiting blood)
- Severe skin reaction (blistering, peeling, severe rash)
- Chest pain, shortness of breath, or weakness
- Decreased urine output or swelling in legs
- Yellowing of skin or eyes (jaundice)
If experiencing severe symptoms, call emergency services immediately.
What is crispa gel used for?
This medicine is a topical gel containing diclofenac 1.16% w/w, an NSAID used to relieve localized pain and inflammation in conditions like osteoarthritis and soft tissue injuries. It works by inhibiting COX enzymes and reducing prostaglandins. Apply a thin layer to the affected area 3-4 times daily, or as directed by your doctor.
- Generic Name: Diclofenac
- Manufacturer: Imed Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 crispa gel के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक 1.16% w/w युक्त एक टॉपिकल जेल है, जिसका उपयोग स्थानीय दर्द और सूजन को कम करने के लिए किया जाता है। यह ऑस्टियोआर्थराइटिस, मोच, और मांसपेशियों की चोट जैसी स्थितियों में प्रभावी है। इसे प्रभावित क्षेत्र पर दिन में 3-4 बार लगाएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा पर हल्की जलन, लालिमा, खुजली या दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग केवल स्वस्थ त्वचा पर करें। आंखों, म्यूकस झिल्ली या खुले घावों पर न लगाएं। उपयोग के बाद हाथ धो लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 crispa gel Uses & Benefits
[{"condition":"Osteoarthritis of superficial joints","description":"Relieves pain and improves mobility in joints such as the knee, hand, and shoulder.","evidence":"Well-established"},{"condition":"Soft tissue injuries","description":"Reduces pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling associated with sprains, strains, and contusions.","evidence":"Well-established"},{"condition":"Localized musculoskeletal pain","description":"Provides targeted relief for conditions like tendinitis, bursitis, and myofascial pain.","evidence":"Moderate"},{"condition":"Actinic keratosis","description":"Sometimes used off-label in a different formulation for treating skin lesions, but not for this gel.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Not typically used for this purpose; oral formulations may be prescribed off-label, but topical gel is not standard.","evidence":"Limited"},{"condition":"Postherpetic neuralgia","description":"Topical NSAIDs are sometimes tried for nerve pain, but evidence is weak.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Soft tissue injuries, Tendinitis, Bursitis, Myofascial pain
📋 Drug Information
| Generic Name(s) | Diclofenac |
| Brand Name | Adiflam 50mg Tablet |
| Manufacturer | Imed Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Protect from direct sunlight and moisture. Keep the tube tightly closed when not in use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Diclofenac works by inhibiting the cyclooxygenase enzymes, specifically COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals that mediate inflammation, pain, and fever. By blocking these enzymes, diclofenac reduces the formation of prostaglandins, thereby decreasing inflammation and pain at the site of application. When applied topically, diclofenac penetrates the skin and reaches the underlying inflamed tissues, providing localized relief with less systemic absorption than oral NSAIDs.
Mechanism Steps
💡 How to Take crispa gel
Strength: Topical gel containing diclofenac 1.16% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer of this medicine to the affected area 3 to 4 times daily, or as directed by your doctor. The amount needed depends on the size of the area being treated. Typically, a 2-4 cm length of gel is sufficient for an area of about 10 cm x 10 cm. Massage gently until absorbed. Wash hands after application unless hands are the treated area. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects. Use with caution and follow the doctor's advice. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Renal Impairment | No specific dosage adjustment is provided for topical use. However, use with caution in patients with renal impairment. Consult your doctor. |
| Hepatic Impairment | No specific dosage adjustment is provided for topical use. However, use with caution in patients with hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose for topical diclofenac gel is not strictly defined, but it is recommended not to exceed 32 grams of gel per day (which corresponds to about 370 mg of diclofenac) over the entire body. Follow your doctor's instructions. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of crispa gel
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| Cyclosporine | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Corticosteroids | Moderate | |
| Topical corticosteroids | Minor |
🚨 Major Interactions
- Oral NSAIDs (e.g., ibuprofen, naproxen)
- Anticoagulants (e.g., warfarin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- Methotrexate
- Cyclosporine
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics
- Lithium
- Corticosteroids
🍷 Alcohol Interaction
Alcohol does not directly interact with topically applied diclofenac. However, alcohol may increase the risk of gastrointestinal bleeding if you are also taking oral NSAIDs. It is advisable to limit alcohol consumption while using this medicine, especially if you have a history of stomach ulcers or bleeding.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diclofenac or other NSAIDs","Active peptic ulcer or history of recurrent ulcers","Severe renal impairment","Severe hepatic impairment","Third trimester of pregnancy","Use on broken skin or mucous membranes","Children under 14 years (unless directed by a doctor)"]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes and mucous membranes.","Do not apply to open wounds or damaged skin.","Do not use with occlusive dressings.","Avoid exposure to sunlight or sunlamps on treated areas.","Consult a doctor if symptoms persist or worsen.","Use with caution in elderly patients.","Use with caution in patients with a history of asthma, especially aspirin-sensitive asthma.","Do not use for more than 7 days without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
Diclofenac is excreted in breast milk in small amounts. Topical application is unlikely to result in significant systemic absorption, but caution is advised. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with topical diclofenac is unlikely due to low systemic absorption. If accidental ingestion occurs, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, abdominal pain, and drowsiness. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Use this medicine only on intact skin and avoid contact with eyes, mucous membranes, or open wounds. Wash your hands thoroughly after applying the gel, unless your hands are the treated area. Do not cover the treated area with airtight dressings or apply heat, as this may increase absorption and the risk of side effects. Avoid concurrent use of other topical products on the same area. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for more than the recommended duration without medical advice. Keep out of reach of children. If symptoms worsen or do not improve, seek medical attention.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to skin reactions and systemic side effects due to thinner skin and reduced renal function. Use with caution and follow your doctor's advice.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. NSAIDs may affect ovulation and are generally avoided during pregnancy, especially in the third trimester.
🏥 Post-Surgery Considerations
Consult your surgeon before using this medicine after surgery, especially if you have a healing wound. It should not be applied to surgical incisions unless directed.
🦷 Dental Procedures
This medicine is not typically used for dental pain. If you have dental procedures, inform your dentist about all medicines you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While using this medicine, you can continue with your normal exercise routine as tolerated. However, avoid strenuous activities that may worsen your condition. If you experience increased pain or swelling, rest and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (rare), avoid these activities until you feel normal.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if your symptoms do not improve after 7 days, if they worsen, or if you experience any severe side effects. Do not stop prescribed treatment without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of topical diclofenac is generally safe, but prolonged use over large areas may increase systemic absorption and the risk of NSAID-related side effects. Monitor for skin reactions and consult your doctor if you need to use it for more than a few weeks. Regular review of kidney and liver function may be advised in certain patients.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals with musculoskeletal pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations while using this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue your regular application schedule as closely as possible. Do not leave the medicine in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling pain relief within 30 minutes to 1 hour after application. However, the full anti-inflammatory effect may take several days of regular use.
A: No, this medicine should not be applied to the face or mucous membranes. It is intended for use on the body and limbs.
A: Consult your doctor before using this medicine during pregnancy, especially in the third trimester, as NSAIDs may pose risks to the fetus.
A: Using topical diclofenac with oral NSAIDs may increase the risk of side effects. Consult your doctor before combining them.
🤔 Common Patient Concerns
🔄 Substitutes for crispa gel
View AllAlternative brands with exact same active ingredient:
-
vovinsun gelSun Life Sciences Pvt Ltd ₹16.00 75.3% CHEAPER
-
pamagin plus gelCachet Pharmaceuticals Pvt Ltd ₹19.92 69.2% CHEAPER
-
diclogen plus gelAGIO Pharmaceuticals Ltd ₹22.32 65.5% CHEAPER
-
Novofen Topical GelMandar Pharmaceuticals Pvt Ltd ₹22.50 65.2% CHEAPER
-
diclogin gelAcron Pharmaceuticals ₹27.19 58% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Topical NSAIDs are completely safe and have no side effects.
Fact: Topical NSAIDs can cause skin irritation and, rarely, systemic side effects. They should be used as directed. - Myth: You can apply topical NSAIDs to any area of the body.
Fact: They should only be applied to intact skin and not on mucous membranes or open wounds. - Myth: Topical NSAIDs work immediately.
Fact: It may take 30 minutes to an hour for pain relief to begin, and several days for full anti-inflammatory effect.
🔄 Alternative Options
Generic Alternatives
- Diclofenac topical gel 1.16% w/w
Brand Alternatives
- Voltaren Emulgel
- Voveran Gel
- Diclomol Gel
- Nac Gel