cox p 60mg/325mg tablet - Uses, Price, Side Effects & Substitutes
What is cox p 60mg/325mg tablet used for?
Auxib P 60mg/325mg Tablet (Etoricoxib + Paracetamol) is used to treat PAIN ANALGESICS. It contains Etoricoxib (60mg) + Paracetamol (325mg), which Etoricoxib selectively inhibits COX-2, reducing prostaglandin synthesis; paracet. Always consult your doctor before use. Take as prescribed.
- Generic Name: Etoricoxib + Paracetamol
- Manufacturer: Krishlar Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cox p 60mg/325mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Etoricoxib + Paracetamol |
| Brand Name | Auxib P 60mg/325mg Tablet |
| Manufacturer | Krishlar Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID (COX-2 inhibitor) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Etoricoxib selectively inhibits COX-2, reducing prostaglandin synthesis; paracetamol inhibits COX in the CNS and modulates descending serotonergic pathways.
Mechanism Steps
๐ก How to Take cox p 60mg/325mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cox p 60mg/325mg tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Diarrhea
- Headache
- Dizziness
- Edema
๐จ Serious Side Effects
- GI bleeding
- Cardiovascular events
- Hepatotoxicity
- Renal failure
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Pancreatitis
- Hepatitis
- Aseptic meningitis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Major | Increased GI ulceration risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels |
| ACE inhibitors | Major | Reduced antihypertensive effect |
| Diuretics | Major | Reduced diuretic effect |
| Corticosteroids | Moderate | Increased GI ulceration risk |
| SSRIs | Moderate | Increased bleeding risk |
| Antiplatelet agents | Moderate | Increased bleeding risk |
| Alcohol | Moderate | Increased hepatotoxicity and GI bleeding |
| Antacids | Minor | Reduced absorption of etoricoxib |
| Cholestyramine | Minor | Reduced absorption of paracetamol |
๐จ Major Interactions
- Warfarin
- Aspirin
- Methotrexate
- Lithium
- ACE inhibitors
- Diuretics
โก Moderate Interactions
- Corticosteroids
- SSRIs
- Antiplatelet agents
- Alcohol
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Avoid high-fat meals (may delay absorption), Grapefruit juice (may increase etoricoxib levels)
๐ท Alcohol Interaction
Increased risk of hepatotoxicity (paracetamol) and GI bleeding (etoricoxib).
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active GI bleeding, severe hepatic impairment, severe renal impairment, pregnancy (third trimester), history of asthma with NSAIDs.
๐ Monitoring Parameters
Liver function, renal function, blood pressure, signs of GI bleeding.
๐คฑ Lactation Safety
Paracetamol is safe; etoricoxib is excreted in milk; use with caution.
๐ Overdose Management
Paracetamol: N-acetylcysteine; etoricoxib: symptomatic and supportive care.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose.