corthenz 100 injection

4.6 (10 reviews)

Hydrocortisone (100mg)

🏭 Suncure Lifescience Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is corthenz 100 injection used for?

Atonide-H Cream (Hydrocortisone) is used to treat RESPIRATORY. It contains Hydrocortisone (100mg), which Binds to glucocorticoid receptors, leading to inhibition of phospholipase A2, re. Always consult your doctor before use. Take as prescribed.

Generic Name: Hydrocortisone
Manufacturer: Suncure Lifescience Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 corthenz 100 injection Uses & Benefits

Topical treatment of inflammatory and pruritic dermatoses such as eczema, dermatitis, psoriasis, and allergic reactions.

Off-label uses: Lichen planus, Lupus erythematosus, Alopecia areata

📋 Drug Information

Generic Name(s)	Hydrocortisone
Brand Name	Atonide-H Cream
Manufacturer	Suncure Lifescience Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	RESPIRATORY
Action Class	Glucocorticoids
Route of Administration	Topical
Storage	Store at 20-25°C (68-77°F); keep tube tightly closed; avoid freezing.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption may occur with prolonged use on large areas or occluded skin.

DistributionDistributes into tissues; crosses placenta and enters breast milk.

Protein BindingApproximately 90-95% bound to plasma proteins, primarily corticosteroid-binding globulin and albumin

MetabolismMetabolized primarily in the liver via reduction and conjugation.

Half-LifePlasma half-life: 1-2 hours; biological half-life: 8-12 hours.

ExcretionExcreted in urine as inactive metabolites; small amount excreted in feces.

BioavailabilitySystemic bioavailability is low (<1%) with topical application, but increases with occlusive dressin

Onset of ActionRapid; within hours for anti-inflammatory effect.

Peak Plasma TimeNot applicable for topical use; systemic levels peak within 1-2 hours after absorption.

Duration of ActionAnti-inflammatory effect lasts 8-12 hours after application.

How It Works

Binds to glucocorticoid receptors, leading to inhibition of phospholipase A2, reduced prostaglandin and leukotriene synthesis, and suppression of inflammatory cytokines.

Mechanism Steps

1Binds to glucocorticoid receptor in cytoplasm.

2Receptor-ligand complex translocates to nucleus.

3Binds to glucocorticoid response elements (GREs) on DNA.

💡 How to Take corthenz 100 injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of corthenz 100 injection

✅ Common Side Effects

Burning
itching
irritation
dryness
folliculitis
hypertrichosis
acneiform eruptions
hypopigmentation

🚨 Serious Side Effects

Allergic contact dermatitis
secondary infection
skin atrophy
striae
HPA axis suppression (with prolonged use)

⚠️ Rare Side Effects

Perioral dermatitis
maceration
miliaria
glaucoma (if applied near eyes)

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Rifampin	Major	Decreased corticosteroid efficacy due to increased metabolism.
Ketoconazole	Major	Increased corticosteroid exposure due to decreased metabolism.
Warfarin	Moderate	May alter anticoagulant effect; monitor INR.
Insulin	Moderate	May increase blood glucose; adjust insulin dose.

🚨 Major Interactions

CYP3A4 inducers (e.g., rifampin, phenytoin)
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

⚡ Moderate Interactions

Antidiabetic agents
Antihypertensives
Diuretics
NSAIDs

ℹ️ Minor Interactions

Vaccines (live attenuated)
Anticoagulants

🍽️ Food Interactions

No significant food interactions for topical use.

🍷 Alcohol Interaction

No known interaction with alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to hydrocortisone or any component; untreated bacterial, fungal, or viral skin infections; perioral dermatitis; rosacea.

📊 Monitoring Parameters

Monitor for skin atrophy, signs of systemic absorption (e.g., HPA axis suppression) with prolonged use.

🤱 Lactation Safety

Use with caution; minimal systemic absorption, but avoid application to breast area.

💊 Overdose Management

Acute overdose unlikely; chronic overuse may cause systemic effects. Discontinue use and treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose and resume regular schedule. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for corthenz 100 injection

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Alternative brands with exact same active ingredient (Hydrocortisone (100mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.