corpogest-depot 500 injection - Hydroxyprogesterone (500mg) medicine

Anin 500mg Injection: Complete Medicine Guide

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🏭 Cheminnova Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not applicable. This medicine is used in pregnancy only under specific medical supervision for the maintenance of early pregnancy in women with a history of recurrent miscarriage. Consult your doctor for individualized risk assessment. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited to moderate for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden shortness of breath or chest pain
  • Swelling, pain, or warmth in an arm or leg
  • Severe allergic reaction (rash, itching, swelling of face or throat, difficulty breathing)
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Unusual vaginal bleeding

If experiencing severe symptoms, call emergency services immediately.

What is corpogest-depot 500 injection used for?

This medicine is a hydroxyprogesterone injection used to treat menstrual disorders and support early pregnancy in women with recurrent miscarriage. It works by mimicking the natural hormone progesterone.

  • Generic Name: Hydroxyprogesterone
  • Manufacturer: Cheminnova Life Sciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 corpogest-depot 500 injection के बारे में (Hindi Summary)

उपयोग: यह दवा हाइड्रॉक्सीप्रोजेस्टेरोन का इंजेक्शन है, जिसका उपयोग मासिक धर्म संबंधी विकारों, बार-बार गर्भपात की समस्या और एंडोमेट्रियल हाइपरप्लासिया के इलाज में किया जाता है। यह प्रोजेस्टेरोन हार्मोन की तरह काम करती है और गर्भाशय की परत को सही बनाए रखने में मदद करती है। यह दवा केवल डॉक्टर की सलाह पर और स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, सूजन या लालिमा, सिरदर्द, मतली, स्तनों में कोमलता और मासिक धर्म में बदलाव शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें रक्त के थक्के बनना, एलर्जी प्रतिक्रिया और लिवर की समस्या शामिल हो सकती है। अगर आपको सांस लेने में तकलीफ, सीने में दर्द, या त्वचा का पीला पड़ना जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे स्वयं न लगाएं। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं तो अपने डॉक्टर को बताएं। इस दवा के साथ शराब का सेवन न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं जो आप ले रही हैं। अगर कोई खुराक छूट जाए तो डॉक्टर से संपर्क करें, दोहरी खुराक न लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 corpogest-depot 500 injection Uses & Benefits

[{"condition":"Recurrent miscarriage","description":"Used to support early pregnancy in women with a history of recurrent miscarriage, possibly due to luteal phase defect.","evidence":"Limited"},{"condition":"Menstrual disorders","description":"Helps regulate abnormal uterine bleeding and restore normal menstrual cycles.","evidence":"Moderate"},{"condition":"Endometrial hyperplasia","description":"Used to treat thickening of the uterine lining, often in combination with other therapies.","evidence":"Limited"}]

Off-label uses: [{"condition":"Preterm birth prevention","description":"Sometimes used off-label to prevent preterm birth in women with a history of spontaneous preterm delivery.","evidence":"Limited"}]

Primary treatment for: Recurrent miscarriage

Also treats: Menstrual disorders, Endometrial hyperplasia

📋 Drug Information

Generic Name(s)Hydroxyprogesterone
Brand NameAnin 500mg Injection
ManufacturerCheminnova Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassProgestins (First generation)
Route of AdministrationIntramuscular
StorageStore in a refrigerator (2-8°C). Do not freeze. Protect from light. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Administer this medicine only under the supervision of a qualified healthcare professional.
2
Monitor for signs of blood clots, such as leg pain or swelling, and report them immediately.
3
Assess liver function periodically if long-term therapy is required.
4
Counsel patients to avoid alcohol while using this medicine.
5
Evaluate the need for continued therapy regularly and discontinue if no benefit is observed.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Recurrent miscarriage
This medicine is commonly prescribed for this condition.
Likely Use
✅
Abnormal uterine bleeding
This medicine may be used to regulate menstrual bleeding.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNot established from the available information.
DistributionNot established from the available information.
Protein BindingNot established from the available information.
MetabolismNot established from the available information.
Half-LifeNot established from the available information.
ExcretionNot established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionNot established from the available information.
Peak Plasma TimeNot established from the available information.
Duration of ActionNot established from the available information.

How It Works

This medicine works by binding to progesterone receptors in the uterus, ovaries, and other reproductive tissues. By mimicking the action of natural progesterone, it helps to transform the endometrium from a proliferative to a secretory state, which is necessary for implantation and maintenance of early pregnancy. It also suppresses uterine contractions and reduces the risk of miscarriage. Additionally, it inhibits the release of gonadotropin-releasing hormone, which can suppress ovulation and alter the menstrual cycle.

Mechanism Steps

1
Binding to progesterone receptors: This medicine binds to progesterone receptors in target tissues such as the endometrium, myometrium, and hypothalamus.
2
Receptor activation: Upon binding, the receptor undergoes a conformational change and translocates to the nucleus, where it interacts with specific DNA sequences.
3
Gene transcription modulation: This leads to altered transcription of target genes, resulting in changes in protein synthesis that affect cell growth, differentiation, and function.
4
Endometrial transformation: The endometrium undergoes secretory transformation, becoming more receptive to implantation and supporting early pregnancy.
5
Uterine relaxation: The medicine reduces uterine contractility, helping to prevent miscarriage and preterm labor.

💡 How to Take corpogest-depot 500 injection

Strength: 500 mg injection

1This medicine is given by a healthcare professional as an intramuscular injection.
2The injection is typically administered into the buttocks (gluteal muscle).
3Follow your doctor's instructions regarding the frequency and duration of treatment.

Dosage Information

Adult DosageThe dose of this medicine is individualized by a qualified clinician based on the condition being treated, the patient's age, weight, renal and hepatic function, and response to therapy. It is administered as an intramuscular injection, typically into the gluteal muscle. Common regimens may involve a single dose or repeated doses at intervals determined by the doctor. Do not self-administer; this medicine must be given by a healthcare professional.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Dose should be individualized by a clinician based on renal and hepatic function and overall health status.
Renal ImpairmentNo specific dose adjustment guidelines are available for renal impairment. Use with caution and monitor renal function.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Monitor liver function tests.
Maximum Daily DoseNot established from the available information. Dose must be individualized by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Grapefruit
Avoid
May increase drug levels by inhibiting CYP3A4 enzymes.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Contact your doctor to reschedule the missed dose as soon as possible.
💡 Do not attempt to self-administer.
📌 More than half the dosing interval has passed
→ Skip the missed dose and continue with the regular schedule.
💡 Do not double dose to catch up.

⚠️ Side Effects of corpogest-depot 500 injection

✅ Common Side Effects

Injection site pain (Common (5-10%))
Apply a cold pack to the area and avoid rubbing. Consult your doctor if pain persists.
Headache (Common (5-10%))
Rest and stay hydrated. Consult your doctor if headaches are severe or persistent.
Nausea (Common (5-10%))
Take with food if possible. Consult your doctor if nausea is severe or persistent.
Breast tenderness (Common (5-10%))
Wear a supportive bra. Consult your doctor if tenderness is severe or persistent.
Menstrual changes (Common (5-10%))
Track your cycle and report any unusual bleeding to your doctor.

🚨 Serious Side Effects

Blood clots (Rare (<0.1%))
Seek immediate medical attention if you experience pain, swelling, or warmth in an arm or leg, sudden shortness of breath, or chest pain.
Allergic reaction (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of the face or throat, or difficulty breathing.
Liver problems (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of the skin or eyes, dark urine, or abdominal pain.

⚠️ Rare Side Effects

Depression
Consult your doctor if you experience persistent sadness or loss of interest in activities.
Seizures
Seek immediate medical attention if you experience a seizure.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Carbamazepine Major
Rifampicin Major
Ketoconazole Moderate
St. John's wort Moderate

🚨 Major Interactions

  • Warfarin
  • Carbamazepine
  • Rifampicin

⚡ Moderate Interactions

  • Ketoconazole
  • St. John's wort

🍷 Alcohol Interaction

Alcohol may increase the risk of liver problems and dizziness when used with this medicine. It is advisable to avoid alcohol while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to hydroxyprogesterone or any ingredient in the formulation","History of or active blood clots (thrombophlebitis, pulmonary embolism, etc.)","Severe liver disease","Undiagnosed vaginal bleeding","Known or suspected breast cancer","Missed abortion"]

⚠️ Warnings & Precautions

["This medicine should be used only under medical supervision.","Inform your doctor if you have a history of blood clots, liver disease, or migraine.","This medicine may cause fluid retention; use with caution in patients with heart or kidney disease.","Do not use this medicine as a contraceptive.","Avoid alcohol while using this medicine.","Report any unusual vaginal bleeding, breast lumps, or severe headaches to your doctor."]

🤱 Lactation Safety

It is not known whether hydroxyprogesterone passes into breast milk. Consult your doctor before breastfeeding while using this medicine.

💊 Overdose Management

Overdose with this medicine is unlikely due to its intramuscular route of administration. If accidental overdose occurs, seek immediate medical attention. Treatment is symptomatic and supportive.

⏰ Missed Dose

If you miss a dose, contact your doctor for instructions. Do not double the dose to catch up.

Additional Safety Advice

General Safety

This medicine must only be given by a healthcare professional. Do not attempt to self-administer. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine is not for use during pregnancy unless specifically prescribed for the maintenance of early pregnancy in women with a history of recurrent miscarriage. It is not known whether hydroxyprogesterone passes into breast milk, so consult your doctor before breastfeeding. Avoid alcohol while using this medicine, as it may increase the risk of liver problems and dizziness. Tell your doctor about all other medicines you are taking, especially blood thinners, antifungals, antibiotics, and seizure medicines, as they may interact. If you miss a dose, contact your doctor for instructions; do not double the dose. Store this medicine as directed by your pharmacist, typically refrigerated or at room temperature, protected from light. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine. Use with caution and monitor for side effects such as dizziness and fluid retention.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. It may be prescribed to support early pregnancy in women with a history of recurrent miscarriage.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are using this medicine. It may affect blood clotting and interact with other medications used during surgery.

🦷 Dental Procedures

Inform your dentist that you are using this medicine. It may affect bleeding and interact with medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the risk of blood clots.
🥗
Stay physically active with low-impact exercises like walking or swimming.
😴
Avoid smoking, as it increases the risk of blood clots.
💧
Limit alcohol consumption.
🧘
Get adequate sleep and manage stress.

🏋️ Exercise Considerations

This medicine may cause dizziness or fatigue. Avoid strenuous exercise if you experience these symptoms. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include plenty of fruits and vegetables.
Choose whole grains over refined grains.
Limit intake of processed and high-fat foods.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause mood swings, which can impact your work and personal life.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Your doctor will determine the appropriate duration of treatment based on your condition and response. If you experience serious side effects, seek immediate medical attention.

📅 Long-Term Use Effects

Long-term use of this medicine may be associated with a small increased risk of breast cancer and blood clots. Regular monitoring of liver function and breast examinations are recommended. The need for continued therapy should be reassessed periodically by your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Progesterone suppositories

May be used as an alternative for pregnancy support.

Evidence: Moderate
Oral progestins

May be used for menstrual disorders.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store in a refrigerator (2-8°C)

❌ DON'T

Do not freeze

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Protect from light

❌ DON'T

Do not store at room temperature for prolonged periods

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription and a letter from your doctor explaining the medical need. Store it in a cool, refrigerated place if possible; if not, use a cool bag. Check customs regulations for carrying prescription injections. Adjust dosing times if crossing time zones, but consult your doctor first.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with a history of two miscarriages
She was prescribed this medicine to support early pregnancy. She received weekly injections under medical supervision. She delivered a healthy baby at term. She reported mild injection site pain but no other significant side effects.
💡 Lesson: Consistent use under medical supervision can help support pregnancy in women with recurrent miscarriage.
👤 A 45-year-old woman with abnormal uterine bleeding
She was diagnosed with endometrial hyperplasia and started on this medicine. After three months of treatment, her bleeding normalized and follow-up biopsy showed improvement. She experienced mild nausea and breast tenderness, which resolved over time.
💡 Lesson: This medicine can effectively treat endometrial hyperplasia, but regular monitoring is essential.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The onset of action depends on the condition being treated. For menstrual regulation, effects may be seen within a few weeks. For pregnancy support, it works to maintain the uterine lining throughout early pregnancy.

Q: Is this medicine safe during pregnancy?

A: This medicine is used in pregnancy only under specific medical supervision for the maintenance of early pregnancy in women with a history of recurrent miscarriage. Consult your doctor for individualized risk assessment.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for corpogest-depot 500 injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a contraceptive.
    Fact: This medicine is not a contraceptive and should not be used for birth control.
  • Myth: This medicine can be self-administered.
    Fact: This medicine must be given by a healthcare professional as an intramuscular injection.

🔄 Alternative Options

Generic Alternatives

  • Hydroxyprogesterone injection

📊 Comparison with Similar Medicines

[{"medicine":"Hydroxyprogesterone injection","difference":"This medicine is a progestin used for similar indications but with specific dosing and administration."},{"medicine":"Progesterone injection","difference":"Natural progesterone may have different side effect profiles and uses."}]

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