corfen ns tablet - Nimesulide (NA) medicine

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🏭 Cornel Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain; limited for long-term use due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding
  • Persistent nausea or vomiting

If experiencing severe symptoms, call emergency services immediately.

What is corfen ns tablet used for?

This medicine is an oral syrup containing nimesulide, an NSAID used for short-term relief of acute pain and inflammation. It works by inhibiting COX-2 enzymes. It is not recommended for children under 12, pregnant women, or those with liver, kidney, or heart disease. Always take with food and avoid alcohol.

  • Generic Name: Nimesulide
  • Manufacturer: Cornel Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 corfen ns tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड युक्त एक ओरल सिरप है, जिसका उपयोग तीव्र दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, जोड़ों के दर्द, मासिक धर्म के दर्द, और सर्जरी के बाद के दर्द में राहत देती है। यह दवा केवल 12 वर्ष से अधिक उम्र के लोगों के लिए है और इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, लीवर की समस्या, और किडनी की समस्या हो सकती है। यदि आपको काला मल, खून की उल्टी, पेट में तेज दर्द, या त्वचा का पीला पड़ना दिखे, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको लीवर, किडनी, या दिल की बीमारी है, तो डॉक्टर को बताएं। गर्भवती और स्तनपान कराने वाली महिलाएं इसका सेवन न करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 corfen ns tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation associated with sprains, strains, and other soft tissue injuries.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain following surgical procedures.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Provides symptomatic relief of pain and stiffness in osteoarthritis, but only for short-term use.","evidence":"Established for short-term use"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Fever","description":"Sometimes used to reduce fever, but not a first-line choice.","evidence":"Limited"},{"condition":"Migraine","description":"May be used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Osteoarthritis, Dysmenorrhea, Post-operative pain, Musculoskeletal injuries

📋 Drug Information

Generic Name(s)Nimesulide
Brand NameAulin 100mg Tablet
ManufacturerCornel Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's-Non-Selective COX 1&2 Inhibitors (Others)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight and moisture. Keep the bottle tightly closed. Do not refrigerate unless specified. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information. Nimesulide is not recommended by WHO for routine use due to safety concerns.
ICMR GuidelineNot established from the available information. ICMR does not recommend nimesulide as a first-line analgesic.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe nimesulide for the shortest duration possible, preferably not exceeding 15 days.
2
Take this medicine with food to minimize gastrointestinal irritation.
3
Avoid prescribing nimesulide to patients with a history of peptic ulcer or gastrointestinal bleeding.
4
Monitor liver function tests in patients requiring prolonged therapy.
5
Warn patients about the risk of dizziness and advise caution while driving.
6
Do not combine with other NSAIDs or anticoagulants due to increased bleeding risk.
7
Consider alternative analgesics in elderly patients and those with kidney or heart disease.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Menstrual cramps
This medicine can relieve dysmenorrhea.
Likely Use
❌
Headache
Not a first-line treatment for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is not well established but is considered high. Food may slightly delay the rate of absorption but does not significantly affect the extent of absorption.
DistributionNimesulide is highly bound to plasma proteins and is widely distributed into body tissues, including synovial fluid. It crosses the placenta and may be excreted in breast milk.
Protein BindingNimesulide is approximately 99% bound to plasma proteins, primarily to albumin.
MetabolismNimesulide is extensively metabolized in the liver, primarily by cytochrome P450 enzymes, including CYP2C9. The main metabolite is 4-hydroxynimesulide, which is pharmacologically active.
Half-LifeThe elimination half-life of nimesulide is approximately 2 to 5 hours, while its active metabolite has a longer half-life of about 6 to 8 hours.
ExcretionNimesulide and its metabolites are excreted primarily in the urine (about 70%) and feces (about 30%).
BioavailabilityThe oral bioavailability of nimesulide is approximately 80% to 90%.
Onset of ActionPain relief typically begins within 30 minutes to 1 hour after oral administration.
Peak Plasma TimePeak plasma concentrations are reached approximately 1.5 to 3 hours after oral administration.
Duration of ActionThe analgesic effect lasts for about 6 to 8 hours, allowing for twice-daily dosing.

How It Works

This medicine works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, which is responsible for producing prostaglandins that mediate pain and inflammation. By blocking COX-2, it reduces the synthesis of these pain-causing chemicals, thereby alleviating pain and swelling. It has less effect on COX-1, which is why it may have a lower risk of gastrointestinal side effects compared to non-selective NSAIDs, although the risk is not eliminated.

Mechanism Steps

1
Absorption: After oral administration, nimesulide is rapidly absorbed from the gastrointestinal tract.
2
COX-2 inhibition: Nimesulide selectively binds to and inhibits the COX-2 enzyme, reducing prostaglandin synthesis.
3
Reduced pain and inflammation: The decrease in prostaglandins leads to reduced pain, swelling, and fever.

💡 How to Take corfen ns tablet

Strength: Syrup, 100 mg/10 ml (10 mg/ml).

1Shake the bottle well before use.
2Use the measuring cup or spoon provided to measure the correct dose.
3Take the medicine with food or milk to reduce stomach upset.
4Swallow the syrup directly; do not mix with other liquids unless advised.
5Wash the measuring cup after each use.
6Close the bottle tightly after use.
7Do not exceed the prescribed dose or duration.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 100 mg (10 ml of syrup) twice daily, preferably after meals. The maximum recommended duration is 15 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. This medicine is contraindicated in children under 12 years of age. Consult a pediatrician for appropriate pain relief in children.
Elderly DosageElderly patients (above 65 years) are at increased risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with mild to moderate kidney impairment. Dose reduction may be necessary. Contraindicated in severe kidney impairment (eGFR <30 mL/min). Consult a nephrologist for dosing adjustments.
Hepatic ImpairmentUse with caution in patients with mild to moderate liver impairment. Dose reduction may be necessary. Contraindicated in severe liver impairment. Monitor liver function regularly.
Maximum Daily Dose200 mg per day (20 ml of syrup).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver toxicity.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of corfen ns tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or persistent, contact your doctor.
Stomach pain (Common (5-10%))
Take with food. If pain is severe or accompanied by other symptoms, seek medical advice.
Heartburn (Common (5-10%))
Avoid spicy and fatty foods. If heartburn persists, consult your doctor.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor immediately.
Kidney problems (Rare (<0.1%))
Seek medical attention if you experience decreased urine output, swelling, or sudden weight gain.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you experience swelling of the face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood disorders (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor immediately.
Severe skin reactions (e.g., Stevens-Johnson syndrome)
Seek immediate medical attention if you develop a rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
ACE inhibitors Major
Diuretics Major
Lithium Moderate
Methotrexate Moderate
SSRIs Moderate
Antacids Minor
Aspirin Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • Corticosteroids
  • ACE inhibitors and ARBs
  • Diuretics

⚡ Moderate Interactions

  • Lithium
  • Methotrexate
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding, ulcers, and liver damage. It may also worsen dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to nimesulide or other NSAIDs","History of gastrointestinal bleeding or perforation related to NSAID use","Active peptic ulcer or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment (eGFR

⚠️ Warnings & Precautions

["Take with food to reduce gastrointestinal irritation.","Avoid alcohol consumption.","Do not exceed the recommended dose or duration.","Use with caution in elderly patients.","Monitor for signs of gastrointestinal bleeding.","Discontinue if liver injury is suspected.","Avoid in patients with cardiovascular risk factors.","Do not use for fever without medical advice.","Consult doctor before use in patients with asthma.","Not for long-term use; limit to shortest duration possible."]

🤱 Lactation Safety

Nimesulide is excreted in breast milk. It is not recommended during breastfeeding due to potential risks to the infant. Consult your doctor for safer alternatives.

💊 Overdose Management

Overdose of this medicine may cause nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. In severe cases, it can lead to liver or kidney failure. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be administered if the patient presents early. Monitor vital signs, liver and kidney function, and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or bleeding disorders. This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid in patients with pre-existing kidney or heart disease.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated during pregnancy, especially in the third trimester, due to risk of premature closure of the ductus arteriosus. If you are planning pregnancy or are pregnant, consult your doctor for safer alternatives for pain relief.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain, but it should be used with caution due to increased risk of bleeding and kidney impairment. Consult your surgeon before use. It may interact with other medications used after surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding during dental surgery. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Stay hydrated.
🚭
Avoid smoking.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are recommended. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Eat plenty of fruits and vegetables
Avoid alcohol

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it after meals to minimize stomach upset during work hours.

🛑 When to Stop This Medicine

Stop taking this medicine if you experience any serious side effects such as gastrointestinal bleeding, signs of liver injury, or allergic reactions. Do not stop abruptly without consulting your doctor if you have been taking it for a prolonged period. Always consult your doctor before stopping.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver toxicity, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If prolonged use is necessary, regular monitoring of liver and kidney function is required. Consult your doctor if you need to use this medicine for more than 15 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot/cold therapy

May help reduce inflammation and pain.

Evidence: Moderate
Acupuncture

Some evidence for pain relief in musculoskeletal conditions.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying prescription medicines. Keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old woman with severe menstrual cramps
Used this medicine for dysmenorrhea and experienced relief within an hour. However, she developed mild nausea, which subsided after taking it with a meal.
💡 Lesson: Taking this medicine with food can reduce common side effects like nausea.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine typically starts relieving pain within 30 minutes to 1 hour after oral administration.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce the risk of stomach upset.

Q: Is it safe for children?

A: No, this medicine is contraindicated in children under 12 years of age.

Q: Can I take it with other painkillers?

A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for corfen ns tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Nimesulide is safe for everyone.
    Fact: Nimesulide is contraindicated in children under 12, pregnant women, and patients with liver, kidney, or heart disease.
  • Myth: Nimesulide can be taken long-term for chronic pain.
    Fact: Nimesulide is only recommended for short-term use (up to 15 days) due to risks of liver toxicity and gastrointestinal bleeding.
  • Myth: Nimesulide is a safe alternative to other NSAIDs.
    Fact: Nimesulide carries a risk of serious liver injury and is not approved in many countries, including the US and UK.
  • Myth: Nimesulide can be taken without food.
    Fact: Nimesulide should be taken with food to reduce stomach upset and gastrointestinal irritation.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide 100 mg/10 ml syrup

Brand Alternatives

  • Auronim SF Syrup
  • Nise Syrup
  • Nimulid Syrup
  • Nimesulide Syrup

📊 Comparison with Similar Medicines

[{"medicine":"Nimesulide","class":"Preferential COX-2 inhibitor","common_uses":"Acute pain, inflammation","gi_risk":"Moderate","liver_risk":"High","kidney_risk":"Moderate","availability":"Prescription"},{"medicine":"Ibuprofen","class":"Non-selective NSAID","common_uses":"Pain, fever, inflammation","gi_risk":"High","liver_risk":"Low","kidney_risk":"Moderate","availability":"OTC/Prescription"},{"medicine":"Paracetamol","class":"Analgesic/Antipyretic","common_uses":"Pain, fever","gi_risk":"Low","liver_risk":"High (overdose)","kidney_risk":"Low","availability":"OTC"}]

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