corbis-h 2.5mg/6.25mg tablet - Uses, Price, Side Effects & Substitutes
What is corbis-h 2.5mg/6.25mg tablet used for?
Bisobis H (Bisoprolol + Hydrochlorothiazide) is used to treat CARDIAC. It contains Bisoprolol (2.5mg) + Hydrochlorothiazide (6.25mg), which Bisoprolol: selective beta1-blocker reducing heart rate and contractility; Hydro. Always consult your doctor before use. Take as prescribed.
- Generic Name: Bisoprolol + Hydrochlorothiazide
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ corbis-h 2.5mg/6.25mg tablet Uses & Benefits
Off-label uses: Heart failure (Bisoprolol alone), edema (Hydrochlorothiazide alone)
๐ Drug Information
| Generic Name(s) | Bisoprolol + Hydrochlorothiazide |
| Brand Name | Bisobis H |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Beta-blocker + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Bisoprolol: selective beta1-blocker reducing heart rate and contractility; Hydrochlorothiazide: inhibits Na+/Cl- reabsorption in distal tubule, reducing plasma volume
Mechanism Steps
๐ก How to Take corbis-h 2.5mg/6.25mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of corbis-h 2.5mg/6.25mg tablet
โ Common Side Effects
- Dizziness
- Fatigue
- Headache
- Hypokalemia
- Hyperuricemia
- Increased blood glucose
- Orthostatic hypotension
๐จ Serious Side Effects
- Bradycardia
- Heart block
- Bronchospasm
- Severe hypotension
- Electrolyte imbalance
- Acute renal failure
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Pancreatitis
- Photosensitivity
- Systemic lupus erythematosus
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Digitalis | Major | Increased risk of bradycardia and digitalis toxicity due to hypokalemia |
| Lithium | Major | Decreased renal clearance of lithium, increased toxicity |
| NSAIDs | Major | Reduced antihypertensive effect, increased risk of renal impairment |
| Corticosteroids | Major | Increased electrolyte depletion, hypokalemia |
| MAOIs | Major | Enhanced hypotensive effect, risk of hypertensive crisis |
| Antidiabetic agents | Moderate | Hyperglycemia, reduced insulin sensitivity |
| Calcium channel blockers | Moderate | Additive negative chronotropic effect, bradycardia |
| Clonidine | Moderate | Rebound hypertension if clonidine withdrawn |
| Cholestyramine | Moderate | Reduced absorption of Hydrochlorothiazide |
| Alcohol | Minor | Increased orthostatic hypotension |
๐จ Major Interactions
- Other antihypertensives
- Digitalis glycosides
- Lithium
- NSAIDs
- Corticosteroids
- MAOIs
โก Moderate Interactions
- Antidiabetic agents
- Calcium channel blockers
- Clonidine
- Reserpine
- Cholestyramine
- Colestipol
โน๏ธ Minor Interactions
- Alcohol
- Barbiturates
- Opioids
๐ฝ๏ธ Food Interactions
Food may increase absorption of Hydrochlorothiazide; avoid high-sodium foods
๐ท Alcohol Interaction
May potentiate orthostatic hypotension
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Sinus bradycardia, heart block, cardiogenic shock, severe asthma, anuria, hypersensitivity to sulfonamides
๐ Monitoring Parameters
Blood pressure, heart rate, serum electrolytes (K+, Na+), renal function, blood glucose, uric acid
๐คฑ Lactation Safety
Contraindicated; both drugs excreted in breast milk
๐ Overdose Management
Gastric lavage, activated charcoal, symptomatic treatment; for bradycardia: atropine; for hypotension: IV fluids, vasopressors
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose