coralan 5mg tablet

4.5 (15 reviews)

Ivabradine (5mg)

🏭 Serdia Pharmaceuticals India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is coralan 5mg tablet used for?

Angibrad (Ivabradine) is used to treat CARDIAC. It contains Ivabradine (5mg), which Selective and specific inhibitor of the If current in the sinoatrial node, reduc. Always consult your doctor before use. Take as prescribed.

Generic Name: Ivabradine
Manufacturer: Serdia Pharmaceuticals India Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 coralan 5mg tablet Uses & Benefits

Chronic stable angina pectoris, chronic heart failure (NYHA II-IV) with reduced ejection fraction.

Off-label uses: Inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome (POTS).

📋 Drug Information

Generic Name(s)	Ivabradine
Brand Name	Angibrad
Manufacturer	Serdia Pharmaceuticals India Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	I F sodium channel (sinoatrial node) current blockers
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentration reached in about 1 hour under fasting conditions.

DistributionVolume of distribution at steady state is approximately 100 L; extensively distributed in tissues.

Protein BindingApproximately 70% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP3A4; major metabolite is N-desmethylivabradine.

Half-Life2-3 hours (parent drug); 11-13 hours for active metabolite.

ExcretionPrimarily excreted in urine (about 80%) and feces (about 20%).

BioavailabilityApproximately 40% due to first-pass metabolism.

Onset of ActionWithin 1-2 hours.

Peak Plasma Time1-1.5 hours under fasting conditions; 2-3 hours with food.

Duration of ActionApproximately 12 hours.

How It Works

Selective and specific inhibitor of the If current in the sinoatrial node, reducing heart rate.

Mechanism Steps

1Ivabradine binds to the If channel in the sinoatrial node.

2Inhibits the inward funny current (If) that controls diastolic depolarization.

3Reduces the slope of diastolic depolarization, thereby decreasing heart rate.

💡 How to Take coralan 5mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of coralan 5mg tablet

✅ Common Side Effects

Bradycardia
Phosphenes (visual brightness)
Headache
Dizziness
Blurred vision

🚨 Serious Side Effects

Atrial fibrillation
Heart block
Severe bradycardia
Hypotension

⚠️ Rare Side Effects

Angioedema
Eosinophilia
Skin rash
Liver enzyme elevation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ketoconazole	Major	Increased ivabradine exposure; risk of bradycardia
Clarithromycin	Major	Increased ivabradine exposure; risk of bradycardia
Rifampicin	Major	Decreased ivabradine efficacy
Verapamil	Major	Additive bradycardia
Diltiazem	Major	Additive bradycardia
Grapefruit juice	Moderate	Increased ivabradine exposure
Digoxin	Moderate	Additive bradycardia
Amiodarone	Moderate	Additive bradycardia
Beta-blockers	Moderate	Additive bradycardia
Warfarin	Minor	No significant interaction
Statins	Minor	No significant interaction
Metformin	Minor	No significant interaction

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
CYP3A4 inducers (e.g., rifampicin, phenytoin)
Verapamil
Diltiazem

⚡ Moderate Interactions

Grapefruit juice
Digoxin
Amiodarone
Beta-blockers

ℹ️ Minor Interactions

Warfarin
Statins
Metformin

🍽️ Food Interactions

Grapefruit juice increases exposure; food delays absorption.

🍷 Alcohol Interaction

No significant interaction reported.

🛡️ Safety & Warnings

🚫 Contraindications

Sick sinus syndrome, sinoatrial block, third-degree AV block, resting heart rate <60 bpm before treatment, severe hypotension, acute myocardial infarction, unstable angina, severe hepatic impairment, pregnancy, lactation.

📊 Monitoring Parameters

Heart rate, ECG, blood pressure, symptoms of bradycardia.

🤱 Lactation Safety

Not recommended; avoid use while breastfeeding.

💊 Overdose Management

Symptomatic treatment; severe bradycardia may require atropine or temporary pacing.

⏰ Missed Dose

Skip missed dose; do not double dose. Take next dose at usual time.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for coralan 5mg tablet

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Alternative brands with exact same active ingredient (Ivabradine (5mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.