Advastat F 160mg/10mg Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Severe muscle pain, weakness, or dark urine
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain radiating to the back
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Unusual bleeding or bruising
- Persistent nausea, vomiting, or loss of appetite
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is consivas-f 10/160 tablet used for?
This medicine is a combination of fenofibrate and rosuvastatin used to treat mixed dyslipidemia. It lowers triglycerides, LDL cholesterol, and total cholesterol while raising HDL cholesterol. It is taken once daily with food and requires regular monitoring of liver and kidney function.
- Generic Name: Fenofibrate + Rosuvastatin
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 consivas-f 10/160 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फेनोफाइब्रेट और रोसुवास्टेटिन का संयोजन है, जिसका उपयोग रक्त में कोलेस्ट्रॉल और ट्राइग्लिसराइड के स्तर को कम करने के लिए किया जाता है। यह मिश्रित डिस्लिपिडेमिया के इलाज में मदद करती है, जिसमें एलडीएल कोलेस्ट्रॉल और ट्राइग्लिसराइड दोनों बढ़े हुए होते हैं। यह दवा हृदय रोग के जोखिम को कम करने में सहायक है। इसे भोजन के साथ लेना चाहिए। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, पेट दर्द, दस्त और मांसपेशियों में दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें मांसपेशियों का टूटना (रैब्डोमायोलिसिस), लीवर की क्षति, अग्नाशयशोथ और गंभीर एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको असामान्य मांसपेशी दर्द, कमजोरी, या गहरे रंग का मूत्र दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से लीवर या किडनी रोग, मधुमेह, और मांसपेशियों की समस्याएं। इस दवा के साथ शराब का सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या गर्भवती होने की योजना बना रही हैं, तो इस दवा का उपयोग न करें। अपने डॉक्टर को अपनी अन्य सभी दवाओं के बारे में बताएं। इस दवा को भोजन के साथ लें। इसे चबाएं नहीं, पूरा निगल लें। नियमित रूप से अपने डॉक्टर से मिलें और जांच कराएं।
💊 consivas-f 10/160 tablet Uses & Benefits
[{"condition":"Mixed dyslipidemia","description":"This medicine is used to treat combined high LDL cholesterol and high triglycerides in adults who have not achieved target lipid levels with statin or fibrate monotherapy.","evidence":"Well-established"},{"condition":"Hypertriglyceridemia with high LDL","description":"It effectively lowers very high triglyceride levels while also reducing LDL cholesterol, reducing the risk of pancreatitis and cardiovascular events.","evidence":"Well-established"},{"condition":"Primary hypercholesterolemia","description":"Used as an adjunct to diet and exercise to reduce elevated total cholesterol and LDL cholesterol in patients with primary hypercholesterolemia.","evidence":"Well-established"},{"condition":"Diabetic dyslipidemia","description":"Often prescribed for patients with type 2 diabetes who have a characteristic pattern of high triglycerides, low HDL, and small dense LDL particles.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Some studies suggest fenofibrate and statins may improve liver enzymes and lipid profiles in NAFLD, but this is not a standard approved indication.","evidence":"Limited"},{"condition":"Reduction of cardiovascular events in patients with metabolic syndrome","description":"The combination may be used off-label to reduce cardiovascular risk in patients with metabolic syndrome who have mixed dyslipidemia.","evidence":"Limited"}]
Primary treatment for: Mixed dyslipidemia
Also treats: Hypertriglyceridemia, Hypercholesterolemia, Diabetic dyslipidemia, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Fenofibrate + Rosuvastatin |
| Brand Name | Arvast F 10 Tablet |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Lipid-lowering agent (Fibrate + Statin) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in their original container, tightly closed. Protect from moisture, heat, and direct sunlight. Do not refrigerate. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary lipid-lowering actions. Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-alpha), which increases the activity of lipoprotein lipase and reduces apolipoprotein C-III production. This leads to increased breakdown of triglycerides and increased clearance of triglyceride-rich lipoproteins, while also raising HDL cholesterol. Rosuvastatin selectively inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis in the liver. This inhibition upregulates LDL receptors on hepatocytes, enhancing the clearance of LDL cholesterol from the blood. Together, these mechanisms provide broad control over multiple lipid fractions, addressing both elevated triglycerides and elevated LDL cholesterol.
Mechanism Steps
💡 How to Take consivas-f 10/160 tablet
Strength: Tablet containing fenofibrate 160 mg and rosuvastatin 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily with food. The dose may be adjusted by your doctor based on your lipid levels, kidney function, and response to treatment. The maximum recommended dose is one tablet of fenofibrate 160 mg and rosuvastatin 10 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Take the tablet at the same time each day to maintain consistent blood levels. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine. Dose selection should be cautious, usually starting at the lower end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. Regular monitoring of liver and kidney function is recommended. |
| Renal Impairment | In patients with mild to moderate renal impairment (eGFR 30-89 mL/min/1.73 m2), no dose adjustment is usually required, but caution is advised. In patients with severe renal impairment (eGFR <30 mL/min/1.73 m2), this medicine is contraindicated. Rosuvastatin dose should not exceed 10 mg in patients with severe renal impairment. Fenofibrate should be avoided in severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases. In patients with mild to moderate hepatic impairment, no specific dose adjustment is established, but use with caution and monitor liver function closely. In severe hepatic impairment, the medicine should not be used. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet containing fenofibrate 160 mg and rosuvastatin 10 mg. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of consivas-f 10/160 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| Protease inhibitors | Major | |
| Colchicine | Moderate | |
| Azole antifungals | Moderate | |
| Macrolide antibiotics | Moderate | |
| Bile acid sequestrants | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Warfarin and other oral anticoagulants
- Cyclosporine
- Gemfibrozil
- Protease inhibitors (e.g., ritonavir, lopinavir)
⚡ Moderate Interactions
- Colchicine
- Azole antifungals (e.g., fluconazole, itraconazole)
- Macrolide antibiotics (e.g., clarithromycin, erythromycin)
- Bile acid sequestrants (e.g., cholestyramine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of liver damage, especially when combined with statins and fibrates. It can also raise triglyceride levels, counteracting the beneficial effects of the medicine. If you consume alcohol, limit it to occasional and small amounts, and inform your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active liver disease or unexplained persistent elevations of serum transaminases.","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Muscle effects: Rhabdomyolysis with acute renal failure has been reported. Patients should be advised to report unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever.","Liver effects: Increases in serum transaminases have been reported. Liver function tests should be performed before and during treatment.","Renal effects: Rosuvastatin may cause proteinuria and hematuria. Fenofibrate may increase creatinine. Monitor renal function.","Endocrine effects: Fenofibrate may increase the risk of gallstones and may cause cholelithiasis. It can also increase the risk of hypoglycemia in diabetic patients on insulin or sulfonylureas.","Hematologic effects: Mild decreases in hemoglobin, hematocrit, and white blood cell count have been reported with fenofibrate.","Hypersensitivity reactions: Anaphylaxis, angioedema, and other severe allergic reactions have been reported.","Cognitive effects: Rare cases of memory loss and confusion have been reported with statins, usually reversible upon discontinuation.","Increased blood sugar: Statins may increase blood glucose levels and risk of diabetes. Monitor glycemic control in diabetic patients."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding. It is not known whether fenofibrate or rosuvastatin are excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, discontinue the medicine and seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor liver and kidney function, and creatine kinase levels. Hemodialysis is not expected to significantly enhance clearance of fenofibrate or rosuvastatin. Contact a poison control center or emergency department for further guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, consult your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, inform your doctor about all your medical conditions, especially liver or kidney disease, diabetes, thyroid disorders, and muscle problems. Avoid alcohol consumption while taking this medicine, as it can increase the risk of liver damage. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Use effective contraception during treatment. Inform your doctor about all other medications, supplements, and herbal products you are taking, as many can interact with this medicine. Do not start any new medicine without consulting your doctor. Take this medicine with food to enhance absorption and reduce stomach upset. Do not crush, chew, or break the tablet; swallow it whole. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for the next dose. Never double the dose. Store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children. Regular follow-up with your doctor is essential to monitor your lipid levels, liver function, and kidney function. Do not stop taking this medicine abruptly without your doctor's advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to muscle and liver side effects. Dose selection should be cautious, and regular monitoring of kidney and liver function is essential. Falls and muscle weakness should be monitored. The benefits of treatment should be weighed against the risks.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are planning pregnancy, consult your doctor to switch to a safer alternative. Use effective contraception while taking this medicine. If you become pregnant, stop the medicine immediately and contact your doctor.
🏥 Post-Surgery Considerations
This medicine may be temporarily stopped before surgery due to its effects on bleeding and muscle. Inform your surgeon and anesthesiologist about all medicines you are taking. Your doctor will advise when to restart after surgery, usually once you are eating and drinking normally.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, especially if you are also on blood thinners. There is no specific contraindication for dental procedures, but your dentist may take precautions to manage bleeding risk. Continue taking your medicine unless advised otherwise by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine. However, if you experience muscle pain, weakness, or cramps during exercise, stop and consult your doctor. Intense or prolonged exercise may increase the risk of muscle injury, especially when combined with statins. Stay well hydrated and warm up properly before exercising.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience dizziness, muscle weakness, or fatigue, avoid driving or operating heavy machinery until you feel better. Most people can continue their normal daily activities while taking this medicine. Inform your employer if you have any specific safety-sensitive job requirements.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe muscle pain, liver problems, or allergic reactions, your doctor may advise you to stop. In some cases, the medicine may be stopped temporarily before surgery or during pregnancy. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. It may increase the risk of gallstones, liver enzyme abnormalities, and muscle problems. Regular monitoring of liver and kidney function, lipid profile, and creatine kinase is recommended. Some patients may experience a slight increase in blood sugar levels. The benefits of reducing cardiovascular risk typically outweigh the risks. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight loss can significantly improve lipid levels and may reduce the need for medication.
Evidence: Well-establishedMay help lower triglycerides, but less effective than prescription fibrates.
Evidence: ModerateCan improve lipid profile but has significant side effects and limited use due to poor tolerability.
Evidence: ModerateCan lower LDL cholesterol but may increase triglycerides and have gastrointestinal side effects.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as recommended by your doctor. However, if you are scheduled for any vaccine, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same time each day as close as possible. If you are unsure, consult your doctor or pharmacist for guidance. Carry enough supply for the entire trip and a few extra days in case of delays. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 weeks, but maximum effects on cholesterol and triglycerides are usually seen after 4 to 6 weeks of consistent use.
A: No, you should not stop taking this medicine without consulting your doctor. High cholesterol often has no symptoms, and stopping the medicine can cause your lipid levels to rise again, increasing your risk of heart disease.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Do not take other cholesterol-lowering medicines without consulting your doctor, as this can increase the risk of side effects. Your doctor may adjust your treatment plan.
A: Statins like rosuvastatin may slightly increase blood sugar levels and the risk of developing diabetes, especially in people with risk factors. However, the cardiovascular benefits generally outweigh this risk. Monitor your blood sugar regularly if you have diabetes.
🤔 Common Patient Concerns
🔄 Substitutes for consivas-f 10/160 tablet
View AllAlternative brands with exact same active ingredient:
-
rosze fb 160mg/10mg tabletZeelab Pharmacy Pvt Ltd ₹25.00 89.1% CHEAPER
-
rosu f 160mg/10mg tabletDavaindia Generic Pharmacy ₹35.00 84.8% CHEAPER
-
rvsat fb tabletDR Best pharmaceuticals Pvt Ltd ₹36.56 84.1% CHEAPER
-
acmerose-f tabletAcmedix Pharma LLP ₹48.00 79.1% CHEAPER
-
Rosuka F 160mg/10mg TabletKosmed Formulations ₹56.00 75.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without food.
Fact: Fenofibrate absorption is significantly enhanced when taken with food. Taking it without food may reduce its effectiveness. - Myth: Once cholesterol levels are normal, you can stop the medicine.
Fact: This medicine manages cholesterol but does not cure the underlying condition. Stopping it can cause cholesterol levels to rise again. Always consult your doctor before stopping. - Myth: This medicine will cause immediate weight loss.
Fact: This medicine is not a weight-loss drug. It lowers cholesterol and triglycerides but does not directly cause weight loss. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol should be avoided as it increases the risk of liver damage and can raise triglyceride levels, reducing the medicine's effectiveness.
🔄 Alternative Options
Generic Alternatives
- Fenofibrate 160 mg + Rosuvastatin 10 mg tablet (various manufacturers)
Brand Alternatives
- Advastat F 160mg/10mg Tablet