Concor Plus Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Very slow heart rate (below 50 beats per minute) or fainting
- Sudden weight gain, swelling in legs, or shortness of breath
- Severe dizziness, confusion, or muscle weakness
- Chest pain, palpitations, or irregular heartbeat
- Difficulty breathing, wheezing, or chest tightness
- Severe abdominal pain, nausea, or vomiting
- Signs of allergic reaction: rash, itching, swelling of face, lips, or throat
- Decreased urine output or blood in urine
If experiencing severe symptoms, call emergency services immediately.
What is concor plus tablet used for?
This medicine is a combination of bisoprolol and hydrochlorothiazide used to treat high blood pressure. It works by slowing the heart rate and removing excess fluid from the body.
- Generic Name: Bisoprolol + Hydrochlorothiazide
- Manufacturer: Merck Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 concor plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें बिसोप्रोलोल और हाइड्रोक्लोरोथियाजाइड दो सक्रिय तत्व होते हैं। बिसोप्रोलोल दिल की धड़कन को धीमा करता है और रक्तचाप को कम करता है, जबकि हाइड्रोक्लोरोथियाजाइड शरीर से अतिरिक्त नमक और पानी को बाहर निकालता है। यह दवा उन रोगियों के लिए दी जाती है जिनका रक्तचाप एक दवा से नियंत्रित नहीं हो पाता। यह दवा स्ट्रोक और दिल के दौरे के खतरे को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार ही लें और अचानक बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द, हाथ-पैर ठंडे होना, बार-बार पेशाब आना और पेट खराब होना शामिल हैं। कुछ रोगियों में पोटैशियम या सोडियम की कमी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें बहुत धीमी हृदय गति, सांस लेने में कठिनाई, गंभीर एलर्जी, और इलेक्ट्रोलाइट असंतुलन शामिल हो सकते हैं। यदि आपको बेहोशी, गंभीर चक्कर, या सांस लेने में तकलीफ हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, खासकर अगर आपको हृदय रोग है। शराब का सेवन न करें क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। बैठने या लेटने से उठते समय धीरे-धीरे उठें। पर्याप्त पानी पिएं। अपने डॉक्टर को नियमित रूप से रक्तचाप, हृदय गति, गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट स्तर की जांच कराने दें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 concor plus tablet Uses & Benefits
- [{"condition":"Essential hypertension","description":"This medicine is used to lower high blood pressure in adults when a single agent is insufficient.
- It reduces cardiovascular risk and helps prevent stroke, heart attack, and kidney damage.","evidence":"Well-established"},{"condition":"Hypertension with high cardiovascular risk","description":"Often prescribed for patients with additional risk factors such as diabetes, obesity, or a history of cardiovascular events, where combination therapy is needed to achieve target blood pressure.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction (bisoprolol component)","description":"Bisoprolol alone is approved for stable chronic heart failure, but the combination with hydrochlorothiazide is not typically used for this indication due to the diuretic component.","evidence":"Limited"},{"condition":"Angina prophylaxis (bisoprolol component)","description":"Bisoprolol is used for angina, but the combination product is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Cardiovascular risk reduction, Heart failure (bisoprolol component)
📋 Drug Information
| Generic Name(s) | Bisoprolol + Hydrochlorothiazide |
| Brand Name | Bisobis H |
| Manufacturer | Merck Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Beta-blocker + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Bisoprolol is a cardioselective beta-1 adrenergic receptor blocker that reduces heart rate, myocardial contractility, and cardiac output, thereby lowering blood pressure and myocardial oxygen demand. Hydrochlorothiazide is a thiazide diuretic that inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, which reduces plasma volume and cardiac preload, leading to lower blood pressure. Over time, thiazides also reduce peripheral vascular resistance.
Mechanism Steps
💡 How to Take concor plus tablet
Strength: Tablet containing bisoprolol 5 mg and hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of bisoprolol 5 mg and hydrochlorothiazide 12.5 mg taken orally once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Hydrochlorothiazide may not be effective in patients with severe renal impairment (eGFR < 30 mL/min). Dose adjustment may be required. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Bisoprolol is metabolized in the liver; dose reduction may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of bisoprolol 5 mg and hydrochlorothiazide 12.5 mg. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of concor plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Clonidine | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| Insulin | Moderate | |
| Digoxin | Moderate | |
| Corticosteroids | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor | |
| MAOIs | Major |
🚨 Major Interactions
- Calcium channel blockers (verapamil, diltiazem)
- Clonidine
- Monoamine oxidase inhibitors (MAOIs)
- Potassium-sparing diuretics, ACE inhibitors, ARBs, potassium supplements
- Lithium
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
⚡ Moderate Interactions
- Insulin and oral antidiabetics
- Corticosteroids
- Digoxin
- Anesthetic agents
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol or limit consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe asthma or chronic obstructive pulmonary disease with bronchospasm","Severe heart failure (NYHA class IV) or cardiogenic shock","Second or third-degree heart block without a pacemaker","Severe bradycardia (heart rate < 50 bpm)","Severe peripheral arterial disease","Severe kidney disease (eGFR < 30 mL/min) or anuria","Hypersensitivity to bisoprolol, hydrochlorothiazide, or sulfonamide-derived drugs","Severe liver disease (Child-Pugh C)"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it can worsen angina or precipitate a heart attack.","Use with caution in patients with diabetes, as it may mask hypoglycemia symptoms and increase blood glucose.","May worsen psoriasis and cause allergic reactions in patients with a history of allergy to sulfonamides.","Can cause electrolyte imbalances; monitor potassium and sodium levels regularly.","May increase uric acid levels and precipitate gout.","Use with caution in patients with a history of bronchospasm; cardioselectivity is dose-dependent.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are scheduled for surgery, as this medicine may interact with anesthetics."]
🤱 Lactation Safety
Bisoprolol and hydrochlorothiazide are excreted in breast milk. Hydrochlorothiazide may suppress lactation. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause severe bradycardia, hypotension, heart failure, bronchospasm, and electrolyte disturbances. Seek immediate medical attention. Treatment is supportive and symptomatic, including gastric lavage, activated charcoal, atropine for bradycardia, and intravenous fluids for hypotension. Hemodialysis may be considered for hydrochlorothiazide removal.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not stop taking this medicine suddenly, especially if you have heart disease, as abrupt withdrawal can cause chest pain, irregular heartbeat, or heart attack. Inform your doctor if you have asthma, kidney disease, liver disease, diabetes, gout, or lupus before taking this medicine. Avoid drinking alcohol while on this medicine as it can increase dizziness and low blood pressure. Stand up slowly from a sitting or lying position to prevent dizziness. Drink adequate water to stay hydrated, especially if you sweat a lot or have diarrhea or vomiting. Your doctor may check your blood pressure, heart rate, kidney function, and electrolyte levels regularly. Do not take potassium supplements or salt substitutes containing potassium without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep this medicine out of reach of children and store it as directed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to dizziness, electrolyte imbalances, and kidney problems. Start with a lower dose and monitor closely. Regular check-ups are essential.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It may not be safe during pregnancy. Your doctor may switch you to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate during surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may cause dry mouth or interact with local anesthetics containing adrenaline. Your dentist may need to adjust the anesthetic.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities initially as this medicine may cause dizziness or fatigue. Stay hydrated and avoid exercising in extreme heat. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities once they adjust to the medicine.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your blood pressure is well controlled for a long time, your doctor may consider adjusting or stopping the medicine. Abrupt withdrawal can be dangerous.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to electrolyte imbalances, increased blood sugar and uric acid levels, and reduced kidney function. Regular monitoring of blood pressure, heart rate, electrolytes, renal function, and blood glucose is recommended. Do not stop the medicine without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, calcium channel blockers, or other combinations may be alternatives if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your doctor about all medicines before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within a few hours, but the full effect may take 1-2 weeks. It is important to take it regularly.
A: No, you should not stop this medicine suddenly as it can cause rebound high blood pressure, chest pain, or heart attack. Always consult your doctor before stopping.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It is advisable to avoid alcohol while taking this medicine as it can increase dizziness and low blood pressure.
A: This medicine should be used during pregnancy only if clearly needed and under medical supervision. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for concor plus tablet
View AllAlternative brands with exact same active ingredient:
-
trubis h 5 mg/12.5 mg tabletTorrent Pharmaceuticals Ltd ₹44.33 76.1% CHEAPER
-
bisowin-h tabletHolymed Pharma ₹60.94 67.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls blood pressure but does not cure hypertension. Lifestyle changes and ongoing treatment are usually needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Stopping suddenly can cause dangerous rebound high blood pressure or heart problems. Always consult your doctor before stopping. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription medicine. It should only be taken under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Bisoprolol and hydrochlorothiazide combination tablets from other manufacturers
Brand Alternatives
- Concor Plus (Merck Ltd)
- Other brands containing bisoprolol and hydrochlorothiazide