Clozole V6 Tablet (fluconazole): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- A spreading skin rash with blisters, peeling skin, or sores in the mouth or eyes.
- Yellowing of the skin or eyes, dark urine, or severe tiredness.
- Fainting, palpitations, or an irregular heartbeat.
- Severe stomach pain, persistent vomiting, or blood in vomit or stool.
- Unusual bruising or bleeding, fever, or persistent sore throat.
- Confusion, seizures, or a sudden severe headache.
If experiencing severe symptoms, call emergency services immediately.
What is cona tablet used for?
This medicine contains fluconazole, an antifungal that treats yeast and other fungal infections. It works by breaking down the fungal cell membrane. It is taken by mouth, usually once daily, and the dose depends on the type of infection. It should only be used when prescribed by a doctor.
- Generic Name: Fluconazole
- Manufacturer: Monokem Labs
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cona tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फ्लुकोनाज़ोल नामक एंटीफंगल दवा है, जो शरीर में फंगस (कवक) के संक्रमण के इलाज के लिए दी जाती है। यह योनि में होने वाले यीस्ट संक्रमण, मुँह के छाले (ओरल थ्रश), गले और भोजन नली के फंगल संक्रमण, और गंभीर फंगल संक्रमण जैसे क्रिप्टोकोकल मेनिनजाइटिस में उपयोग की जाती है। यह दवा फंगस की कोशिका की दीवार को कमजोर कर देती है, जिससे फंगस मर जाता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा से आमतौर पर हल्के दुष्प्रभाव होते हैं, जैसे सिरदर्द, जी मिचलाना, पेट में हल्की तकलीफ, दस्त, और स्वाद में बदलाव। कुछ लोगों को चक्कर आ सकते हैं या हल्के दाने पड़ सकते हैं। गंभीर दुष्प्रभाव कम होते हैं, लेकिन त्वचा पर गंभीर दाने, लिवर की समस्या, या दिल की धड़कन में बदलाव हो सकते हैं। अगर चेहरे, होंठ या गले में सूजन आए, सांस लेने में तकलीफ हो, या पीलिया दिखे, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पानी के साथ पूरा निगलें, चबाएँ नहीं। इसे खाने के साथ या बिना खाने के लिया जा सकता है। अगर पेट खराब लगे तो हल्के भोजन के साथ लें। पूरा कोर्स पूरा करें, भले ही आराम महसूस होने लगे। इस दवा के साथ शराब न लें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के यह दवा न लें। दवा को ठंडी, सूखी जगह पर, बच्चों की पहुंच से दूर रखें।
💊 cona tablet Uses & Benefits
- [{"condition":"Vaginal candidiasis (yeast infection)","description":"This medicine is used to treat uncomplicated vaginal yeast infections caused by Candida species.
- A single oral dose is often enough for a first episode, while recurrent infections may need a longer course.","evidence":"Well-established"},{"condition":"Oropharyngeal and esophageal candidiasis","description":"This medicine is used for fungal infections of the mouth, throat, and food pipe, especially in people with weakened immunity or those using inhaled steroids.","evidence":"Well-established"},{"condition":"Cryptococcal meningitis","description":"This medicine is used as part of treatment and long-term suppression for cryptococcal meningitis, a serious fungal infection of the brain coverings.","evidence":"Well-established"},{"condition":"Invasive candidiasis","description":"This medicine may be used for certain cases of candidemia and other deep Candida infections after the patient is stable enough for oral therapy.","evidence":"Established"},{"condition":"Prevention of fungal infections in immunocompromised patients","description":"This medicine is sometimes given to patients undergoing bone marrow transplant or intensive chemotherapy to reduce the risk of Candida infections.","evidence":"Established"}]
Off-label uses: [{"condition":"Tinea versicolor","description":"This medicine is sometimes prescribed off-label for widespread or recurrent tinea versicolor when topical treatment has failed.","evidence":"Limited"},{"condition":"Onychomycosis (nail fungus)","description":"This medicine has been studied for nail fungal infections, but it is not considered a first-line treatment and requires a long course.","evidence":"Limited"},{"condition":"Coccidioidomycosis","description":"This medicine may be used off-label for mild to moderate coccidioidomycosis in selected patients who cannot take other antifungals.","evidence":"Limited"}]
Primary treatment for: Fungal infections caused by Candida species
Also treats: Cryptococcal meningitis, Oropharyngeal candidiasis, Esophageal candidiasis, Vaginal candidiasis, Invasive candidiasis
📋 Drug Information
| Generic Name(s) | Fluconazole |
| Brand Name | AF 150 Tablet DT |
| Manufacturer | Monokem Labs |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Fungal ergosterol synthesis inhibitor |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in the original container, tightly closed, away from moisture, heat, and direct light. Do not store it in the bathroom. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Always check the expiry date on the pack before use. |
| WHO Guideline | The World Health Organization includes fluconazole in its essential medicines list and provides guidance for its use in cryptococcal meningitis and other fungal infections. Specific recommendations should be checked in the latest WHO guidelines, as they may be updated. |
| ICMR Guideline | The Indian Council of Medical Research has published guidance on the management of fungal infections, including the use of fluconazole for candidiasis and cryptococcosis. The exact recommendations should be confirmed from the latest ICMR documents. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively inhibiting fungal cytochrome P450-dependent 14-alpha-demethylase, an enzyme needed to convert lanosterol into ergosterol. Ergosterol is a key building block of the fungal cell membrane. When this step is blocked, the fungal membrane becomes weak and leaky, and the fungus cannot grow or divide properly. Because human cells use cholesterol instead of ergosterol, this medicine has much less effect on human cell membranes, which explains its selective antifungal action.
Mechanism Steps
💡 How to Take cona tablet
Strength: This medicine is an immediate-release tablet for oral use. The strength is not specified in the available information. The actual strength should be confirmed from the product label and the prescription.
Dosage Information
| Adult Dosage | The dose of this medicine depends on the type and severity of the fungal infection, your kidney function, and other medicines you take. For uncomplicated vaginal yeast infection, a single 150 mg dose is commonly used. For oral thrush, a typical course is 50 to 100 mg once daily for 7 to 14 days. For serious infections such as cryptococcal meningitis, higher doses are used under close medical supervision. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults may need a lower dose if kidney function is reduced. Kidney function should be checked before starting this medicine, and the dose should be adjusted by a doctor based on the result. Older adults are also more likely to take other medicines that can interact with this medicine, so a full medicine review is important. |
| Renal Impairment | This medicine is removed mainly by the kidneys, so the dose must be reduced in people with kidney impairment. For patients with a creatinine clearance below 50 mL/min, the usual approach is to give the normal loading dose on the first day and then reduce the maintenance dose or increase the dosing interval. The exact adjustment must be made by a qualified clinician based on the measured kidney function. |
| Hepatic Impairment | No specific dose adjustment is usually required for mild to moderate liver disease, but this medicine should be used with caution in people with liver problems. Liver function should be monitored, and the medicine should be stopped if signs of liver injury appear. In severe liver disease, the doctor may choose a different antifungal. |
| Maximum Daily Dose | The maximum daily dose depends on the indication and is determined by the treating doctor. For common mucosal infections, the usual maximum is 400 mg per day. Higher doses are used only in serious systemic infections under specialist supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cona tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Amiodarone | Major | |
| Tacrolimus | Major | |
| Rifampicin | Major | |
| Phenytoin | Major | |
| Glipizide | Moderate | |
| Atorvastatin | Moderate | |
| Midazolam | Moderate | |
| Nifedipine | Moderate | |
| Ibuprofen | Moderate |
🚨 Major Interactions
- Warfarin
- QT-prolonging medicines such as amiodarone, sotalol, or haloperidol
- Tacrolimus and cyclosporine
- Rifampicin
- Phenytoin
⚡ Moderate Interactions
- Sulfonylureas such as glipizide and glyburide
- Statins such as atorvastatin and simvastatin
- Benzodiazepines such as midazolam and triazolam
- Calcium channel blockers such as nifedipine and felodipine
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both alcohol and this medicine are processed by the liver, and combining them can increase the chance of liver irritation or damage. Alcohol can also worsen stomach upset, dizziness, and nausea. If you drink regularly, discuss this with your doctor before starting the medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to fluconazole or any other azole antifungal","Concomitant use with medicines that can cause dangerous heart rhythm changes when combined with this medicine","Concomitant use with certain medicines that are strongly affected by this medicine, such as cisapride or terfenadine","Pregnancy, especially high doses or long courses, unless clearly needed and approved by a doctor"]
⚠️ Warnings & Precautions
["This medicine can rarely cause serious liver injury. Report yellowing of the skin or eyes, dark urine, or severe tiredness immediately.","Serious skin reactions have been reported. Stop the medicine and seek urgent care if a rash spreads or blisters appear.","This medicine can affect heart rhythm. Tell your doctor if you have a heart condition or take heart medicines.","Dose adjustment is needed in kidney disease. Your doctor may check your kidney function.","This medicine interacts with many medicines. Always give your doctor a complete list of everything you take.","Do not use this medicine for a condition that has not been diagnosed by a doctor.","Avoid alcohol while taking this medicine to reduce the risk of liver problems.","If you are pregnant or breastfeeding, talk to your doctor before taking this medicine."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. Short courses are generally considered acceptable during breastfeeding, but a doctor should be consulted before use, especially for long courses or high doses.
💊 Overdose Management
If you take too much of this medicine, contact your doctor or a poison control center right away. Symptoms of overdose may include nausea, vomiting, stomach pain, dizziness, and in severe cases, hallucinations or irregular heartbeat. Treatment is supportive, and there is no specific antidote. In a hospital, doctors may give activated charcoal if the overdose was recent and monitor vital signs and heart rhythm.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for the next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water, with or without food. Do not crush, chew, or split the tablet unless your doctor or pharmacist has told you it is safe to do so. Complete the full course even if you start feeling better after a few doses, because stopping early can allow the fungal infection to return. Keep all follow-up appointments, especially if you have liver or kidney problems. Tell your doctor about every other medicine you take, including herbal products and supplements, because this medicine can interact with many common drugs. Avoid alcohol while taking this medicine, as it can increase the chance of liver problems and stomach upset. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before taking this medicine. Store the tablets in their original container at room temperature, away from moisture and direct sunlight. Keep this medicine out of the reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to have reduced kidney function, so the dose of this medicine may need to be adjusted. They are also more likely to take other medicines that can interact with this medicine. A full medicine review and kidney function test are recommended before starting treatment.
🤰 Pregnancy Planning (TTC)
If you are trying to become pregnant, talk to your doctor before taking this medicine. Low single doses are generally considered low risk, but high doses or long courses in early pregnancy have been linked to a small increase in certain birth defects. Your doctor will help you weigh the benefits and risks.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, tell your surgeon and anesthesiologist that you are taking this medicine. It can interact with some medicines used during surgery and can affect heart rhythm. Your doctor may ask you to stop the medicine before surgery or adjust other medicines.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. This medicine can interact with some medicines used in dentistry and can rarely affect bleeding or heart rhythm. Your dentist may consult your doctor before prescribing other medicines.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness in some people. Avoid heavy exercise or activities that require balance until you know how the medicine affects you. If you feel dizzy or unwell, stop exercising and rest. There is no specific restriction on exercise for most people taking this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their normal work and daily activities while taking this medicine. If you feel dizzy or unusually tired, avoid driving or operating heavy machinery until you feel better. If your work involves close contact with others and you have a contagious fungal infection, follow your doctor's advice about when it is safe to return.
🛑 When to Stop This Medicine
Stop this medicine and contact your doctor immediately if you develop a spreading rash, blisters, swelling of the face or throat, yellowing of the eyes or skin, dark urine, severe tiredness, or an irregular heartbeat. Do not stop the medicine on your own for other reasons without talking to your doctor, because stopping early can allow the infection to return.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver problems, skin reactions, and drug interactions. It can also lead to the growth of fungi that are resistant to fluconazole. If long-term treatment is needed, your doctor will monitor your liver and kidney function and review your other medicines regularly. Do not continue this medicine for longer than prescribed without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild vaginal yeast infections, topical creams or suppositories may be used instead of oral medicine.
Evidence: Well-establishedKeeping the skin dry and clean can help prevent fungal infections from returning.
Evidence: Well-establishedKeeping blood sugar in a healthy range reduces the risk of fungal infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this medicine and routine vaccines. However, if you have a weakened immune system, your doctor will decide the best time for vaccinations. Live vaccines may need to be avoided in some immunocompromised patients. Discuss your vaccination schedule with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless the label says so.
✅ DO
Keep the tablets in the original container.
❌ DON'T
Do not transfer them to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of the reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label visible. Keep a copy of your prescription or a letter from your doctor, especially for international travel. Store the tablets in a cool, dry place, away from direct sunlight, and do not leave them in a hot car. If you are crossing time zones, continue taking your doses at the same interval as prescribed, but ask your doctor for specific advice if you are on a long course. Check the customs rules of your destination for prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 1 to 3 days for mild infections such as vaginal yeast infection or oral thrush. Serious infections may take longer. Complete the full course as prescribed.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a light meal.
A: If you remember within half the dosing interval, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not double dose.
A: It is best to avoid alcohol while taking this medicine, as it can increase the risk of liver problems and stomach upset.
A: This medicine should be used in pregnancy only when clearly needed and after discussing the risks and benefits with your doctor. Do not self-medicate.
A: Yes, this medicine can interact with several medicines, including blood thinners, heart medicines, and transplant medicines. Always tell your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for cona tablet
View AllAlternative brands with exact same active ingredient:
-
fluzen capsuleJaywin Remedies Pvt Ltd ₹2.26 79.1% CHEAPER
-
Fungonil TabletMars Therapeutics & Chemicals Ltd ₹11.58 6.9% COSTLIER
-
flucol p tabletSKN Organics ₹11.73 8.3% COSTLIER
-
monila f tabletMagnachem Pharmaceuticals Pvt Ltd ₹14.06 29.8% COSTLIER
-
clozole v6 tabletPsycormedies ₹15.73 45.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only treats fungal infections. It does not work against bacteria or viruses. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You should complete the full course prescribed by your doctor to prevent the infection from returning. - Myth: This medicine is safe to take with any other medicine.
Fact: This medicine can interact with many medicines, including blood thinners and heart medicines. Always tell your doctor about all medicines you take. - Myth: This medicine is a good treatment for a common cold or flu.
Fact: This medicine does not treat viral infections such as the common cold or flu.
🔄 Alternative Options
Generic Alternatives
- Fluconazole
Brand Alternatives
- Clozole V6 Tablet