comzid m 80 mg/500 mg tablet - Uses, Price, Side Effects & Substitutes
What is comzid m 80 mg/500 mg tablet used for?
Azukon-M Tablet (Gliclazide + Metformin) is used to treat ANTI DIABETIC. It contains Gliclazide (80mg) + Metformin (500mg), which Gliclazide stimulates insulin secretion from pancreatic beta cells; Metformin de. Always consult your doctor before use. Take as prescribed.
- Generic Name: Gliclazide + Metformin
- Manufacturer: Comed Chemicals Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ comzid m 80 mg/500 mg tablet Uses & Benefits
Type 2 diabetes mellitus not controlled by monotherapy
Off-label uses: Polycystic ovary syndrome (metformin component)
๐ Drug Information
| Generic Name(s) | Gliclazide + Metformin |
| Brand Name | Azukon-M Tablet |
| Manufacturer | Comed Chemicals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Sulfonylurea + Biguanide |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gliclazide stimulates insulin secretion from pancreatic beta cells; Metformin decreases hepatic glucose production and increases insulin sensitivity
Mechanism Steps
๐ก How to Take comzid m 80 mg/500 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of comzid m 80 mg/500 mg tablet
โ Common Side Effects
- Hypoglycemia
- Gastrointestinal upset
- Nausea
- Diarrhea
- Weight gain
๐จ Serious Side Effects
- Lactic acidosis
- Severe hypoglycemia
- Hepatic injury
โ ๏ธ Rare Side Effects
- Aplastic anemia
- Agranulocytosis
- Hemolytic anemia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Miconazole | Major | Enhanced hypoglycemic effect |
| Phenylbutazone | Major | Increased sulfonylurea effect |
| ACE inhibitors | Moderate | Enhanced hypoglycemic effect |
| Beta-blockers | Moderate | Mask hypoglycemia symptoms |
| Corticosteroids | Moderate | Hyperglycemic effect |
| Cimetidine | Minor | Reduced metformin clearance |
| Ranitidine | Minor | Reduced metformin clearance |
๐จ Major Interactions
- Warfarin
- Miconazole
- Phenylbutazone
โก Moderate Interactions
- ACE inhibitors
- Beta-blockers
- Corticosteroids
โน๏ธ Minor Interactions
- Cimetidine
- Ranitidine
๐ฝ๏ธ Food Interactions
Food delays absorption of gliclazide; Metformin absorption reduced by food
๐ท Alcohol Interaction
Increased risk of lactic acidosis with metformin; may enhance hypoglycemic effect
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Renal impairment (eGFR <45 mL/min), hepatic impairment, diabetic ketoacidosis, hypersensitivity
๐ Monitoring Parameters
Blood glucose, HbA1c, renal function, liver function
๐คฑ Lactation Safety
Not recommended; metformin excreted in milk, gliclazide unknown
๐ Overdose Management
Monitor blood glucose; treat hypoglycemia with oral glucose; lactic acidosis requires hemodialysis
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose